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Protein

Thyrotropin receptor

Gene

fshr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • activation of adenylate cyclase activity Source: GO_Central
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • female gonad development Source: ZFIN
  • hormone-mediated signaling pathway Source: GO_Central
  • male gonad development Source: ZFIN
  • ovarian follicle development Source: ZFIN
  • primary ovarian follicle growth Source: GO_Central
  • regulation of osteoclast differentiation Source: GO_Central
  • spermatogenesis Source: ZFIN

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-375281. Hormone ligand-binding receptors.
R-DRE-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin receptorUniRule annotation
Gene namesi
Name:fshrImported
Synonyms:TSHRUniRule annotation
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-020423-5. fshr.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei348 – 369HelicalUniRule annotationAdd BLAST22
Transmembranei381 – 405HelicalUniRule annotationAdd BLAST25
Transmembranei425 – 446HelicalUniRule annotationAdd BLAST22
Transmembranei467 – 490HelicalUniRule annotationAdd BLAST24
Transmembranei510 – 535HelicalUniRule annotationAdd BLAST26
Transmembranei556 – 578HelicalUniRule annotationAdd BLAST23
Transmembranei590 – 610HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_500512901217 – 668Thyrotropin receptorUniRule annotationAdd BLAST652

Proteomic databases

PaxDbiF1R4X9.

Expressioni

Gene expression databases

BgeeiENSDARG00000071494.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096529.

Structurei

3D structure databases

ProteinModelPortaliF1R4X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 607G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST248

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.UniRule annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
InParanoidiF1R4X9.
OMAiISSYMKV.
OrthoDBiEOG091G02BV.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR002272. FSH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR001611. Leu-rich_rpt.
IPR026906. LRR_5.
IPR032675. LRR_dom_sf.
IPR002274. TSH_rcpt.
IPR034298. TSHR/LHCGR/FSHR.
PANTHERiPTHR24372. PTHR24372. 2 hits.
PTHR24372:SF5. PTHR24372:SF5. 2 hits.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 1 hit.
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01145. TSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F1R4X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSMMLCFI LGCSMANTED TLAASQFCAF NGSTRSFICL GNKVLEIPRR
60 70 80 90 100
IPTNTTFVEI KLTQISVFRR AALSELHELK RIVVSENGAL ERIEALAFFN
110 120 130 140 150
LTELEEITIT KSKNLVMHKD AFWRLPKLRY LTISNTGLKI LPDFSKINSA
160 170 180 190 200
ALEFLFDLQD NMHIERIPSN AFLGLTNATI TELRLTKNGI REIDSHAFNG
210 220 230 240 250
TKIGKLFLMG NQQLNHIHSY AFKGAEGPVV LDISRTAVHT LPESMLKTLK
260 270 280 290 300
LLMAVSVYSL RKLPSLELFT ELTQANLTYP SHCCAFKNFK KHKSVKNQMC
310 320 330 340 350
NVTGAHEEPD FFNFFNDHCK DVIEVTCYPT PDAFNPCEDI MGFTFLRVLI
360 370 380 390 400
WFISVLAIVG NTVVLLVLLT SRYKLTVPRF LMCHLAFADL CMGIYLLLIA
410 420 430 440 450
AVDIHTQSRY YNYGIDWQTG AGCHVAGFFT VFSSELSVYT LTAITLERWH
460 470 480 490 500
TITYAMQLER QMRLRHACLV MATGWLFSLL TALMPMFGVS SYSKTSICLP
510 520 530 540 550
MDVETLLSQG YVVLLLLLNA AAFLVVCVCY TLIYLTVRNP AFVPANADMR
560 570 580 590 600
IAKRMAVLIF TDFLCMAPIS FFAISAAFKL PLITVSHAKV LLVLFYPINS
610 620 630 640 650
CSNPFLYAFF TKTFKRDFFI LTSRFGCFKR RAHIYRTEIS SGQNGAVVPS
660
PKTSDGTLYS LVHIAQVH
Length:668
Mass (Da):75,312
Last modified:May 3, 2011 - v1
Checksum:iFEE94AD4B3FBE4F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX677665 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSDART00000105751; ENSDARP00000096529; ENSDARG00000071494.

Similar proteinsi

Entry informationi

Entry nameiF1R4X9_DANRE
AccessioniPrimary (citable) accession number: F1R4X9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported