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Protein
Submitted name:

Calcium-sensing receptor

Gene

casr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • calcium ion homeostasis Source: ZFIN
  • skeletal system development Source: ZFIN

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-416476. G alpha (q) signalling events.
R-DRE-418594. G alpha (i) signalling events.
R-DRE-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium-sensing receptorImported
Gene namesi
Name:casrImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-050119-8. casr.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei601 – 626HelicalSequence analysisAdd BLAST26
Transmembranei638 – 659HelicalSequence analysisAdd BLAST22
Transmembranei671 – 693HelicalSequence analysisAdd BLAST23
Transmembranei714 – 733HelicalSequence analysisAdd BLAST20
Transmembranei760 – 780HelicalSequence analysisAdd BLAST21
Transmembranei792 – 814HelicalSequence analysisAdd BLAST23
Transmembranei820 – 842HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501169462024 – 946Sequence analysisAdd BLAST923

Proteomic databases

PaxDbiF1R4B8.

Expressioni

Gene expression databases

BgeeiENSDARG00000013649.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013946.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
InParanoidiF1R4B8.
OMAiGYTCLLA.
OrthoDBiEOG091G01NA.
TreeFamiTF331269.

Family and domain databases

Gene3Di2.10.50.30. 1 hit.
InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR038550. GPCR_3_9-Cys_sf.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

F1R4B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFHLKFYLH YLVLLGSSCV ISTYGPNQRA QKTGDILLGG LFPMHFGVAS
60 70 80 90 100
KDQDLAARPE STECVRYNFR GFRWLQSMIF AIEEINNSST LLPNITLGYR
110 120 130 140 150
IFDTCNTVSK ALEASLSFVA QNKIDSLNLD EFCNCTGNIP STIAVVGASG
160 170 180 190 200
SAVSTAVADL LGLFYIPQIS YASSSRLLSN KNQYKSFMRT IPTDEYQAIA
210 220 230 240 250
MAAIIEHFQW NWVIAIASDD EYGRPGIEKF ENEMFHRDIC IDLNVLISQY
260 270 280 290 300
VDEAEIRRLA DRIQNSSAKV IVVFASGPDI EPLVKEMVRR NITDRVWLAS
310 320 330 340 350
EAWASSSLVA KPEYLDVMGG TIGFALRAGH IPGFKDFLQQ VHPKKSSHNE
360 370 380 390 400
FVREFWEETF NCYLEDSPRN ADSENGSTSF RPLCTGEEDI ASVETPYLDY
410 420 430 440 450
THLRISYNVY VAVYAIAQAL QDILTCTPGK GLFSNGSCAD IRKVEAWQVL
460 470 480 490 500
KQLRHLNFID SMGERVRFDN GSELSANYTI INWHRSPEDG SVVFKEVGYY
510 520 530 540 550
SIHNKNVAKL SIDKSKILWN GRLTEVPFSN CSVECEPGTR KGIIDGEPTC
560 570 580 590 600
CFECTECSDG EYSDHKDASF CVKCPNNSWS NGNHTSCFLK QIEFLSWTEP
610 620 630 640 650
FGIALALFAV LGVLLTAFVL GVFVQFRDTP IVKASNRELS FLLLFSLICC
660 670 680 690 700
FSSSLIFIGE PQDWTCRVRQ PAFGISFVLC ISCILVKTNR VLLVFEAKIP
710 720 730 740 750
TSLHRKWWGL NLQFLLVFLF TFVQVMICVV WLYNAPPGSY KNYDIDEIIF
760 770 780 790 800
ITCNEGSMMA LGFLIGYTCL LAAICFFFAF KSRKLPENFT EAKFITFSML
810 820 830 840 850
IFFIVWISFI PAYFSTYGKF VSAVEVIAIL ASSFSLLACI FFNKVYIILL
860 870 880 890 900
KPSRNTIEEV RCSTAAHAFK AAAKATLRHS SGFRKRSSSV GGSSASSPSS
910 920 930 940
SISMKTNGNE MESPSTRRHG SKPRVSFGSG TVSLSLSFEE ARNSMK
Length:946
Mass (Da):105,928
Last modified:November 22, 2017 - v3
Checksum:iBDAB9C55160CBEF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01062203 Genomic DNA. No translation available.
FQ790224 Genomic DNA. No translation available.
RefSeqiXP_689097.1. XM_684005.5.

Genome annotation databases

EnsembliENSDART00000010934; ENSDARP00000013946; ENSDARG00000013649.

Similar proteinsi

Entry informationi

Entry nameiF1R4B8_DANRE
AccessioniPrimary (citable) accession number: F1R4B8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 55 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported