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Protein
Submitted name:

Exostosin glycosyltransferase 2

Gene

ext2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Source: ZFIN

GO - Biological processi

  • cartilage development Source: ZFIN
  • chondroitin sulfate proteoglycan biosynthetic process Source: ZFIN
  • embryonic pectoral fin morphogenesis Source: ZFIN
  • extracellular matrix organization Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: ZFIN
  • heparan sulfate proteoglycan biosynthetic process Source: ZFIN
  • odontogenesis Source: ZFIN
  • ossification Source: ZFIN
  • osteoblast differentiation Source: ZFIN
  • pectoral fin development Source: ZFIN
  • pectoral fin morphogenesis Source: ZFIN
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
  • protein glycosylation Source: InterPro
  • proteoglycan biosynthetic process Source: ZFIN
  • regulation of axon extension Source: ZFIN
  • retinal ganglion cell axon guidance Source: ZFIN
  • sensory neuron axon guidance Source: ZFIN
  • skeletal system development Source: ZFIN
  • thymus development Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-2022928. HS-GAG biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Exostosin glycosyltransferase 2Imported
Gene namesi
Name:ext2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-041124-3. ext2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 46HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF1QUC2.

Expressioni

Gene expression databases

BgeeiENSDARG00000056648.
ExpressionAtlasiF1QUC2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073621.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini457 – 702Glyco_transf_64InterPro annotationAdd BLAST246

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1021. Eukaryota.
ENOG410XTFH. LUCA.
GeneTreeiENSGT00550000074496.
InParanoidiF1QUC2.
TreeFamiTF314231.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR004263. Exostosin.
IPR027673. Exostosin-2.
IPR015338. EXT_C.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR11062:SF128. PTHR11062:SF128. 1 hit.
PfamiView protein in Pfam
PF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

F1QUC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCASGKYGSR GPALIPRMKT KHRIYYITLF SVVLLGLIAT GMFQFWPHSI
60 70 80 90 100
ESSAEWSLDR RSVHDAPLVR IPVNSPIPGR GDLSCRMHTC FDVYRCGYNP
110 120 130 140 150
KNKIKVYIYP LQRFVDEVGV PISSTGLSRE YNDLLSAISD SDFYTDDVSR
160 170 180 190 200
ACLFVPSIDV LNQNSLRIRE TAQALAMLPR WDKGMNHLLF NMLPGGPPDY
210 220 230 240 250
NTALDVPRDR ALLAGGGFST WTYRQGYDVS IPVYSPLSAE VDLPERQPGP
260 270 280 290 300
RRYFILSSQT AIHREYRVEL ERLKDENGEA LLLLDKCSNL SQGLTSVRKR
310 320 330 340 350
CYKGQVYDYP QILQESSFCV VLRGARLGQA TLSDVLQAGC VPVIMADSYI
360 370 380 390 400
LPFSEVLDWK RASVVIPEEK LPEMYTILKS IPHRQVEEMQ RQARWFWEAY
410 420 430 440 450
FSSMKAIGMT TLQIINDRIY PYAAHTYEEW NNPPVVKWSS VNSPLFLPLI
460 470 480 490 500
PPRSPGFTAV VLTYDRIESL FRVITEISKV PSLAKLLVVW NNQNKSPPEE
510 520 530 540 550
SLWPKVAVPL KVVRTKENKL SNRFFPFDEI ETEAVLAIDD DIIMLTSDEL
560 570 580 590 600
QFGYEVWREF PDRLVGYPGR LHLWDHEMGK WKYESEWTNE VSMVLTGAAF
610 620 630 640 650
YHKYFNYLYT YKMPGDIKNW VDAHMNCEDI AMNFLVANIT GKAPIKVTPR
660 670 680 690 700
KKFKCPECTA IDGLSLDQTH MVERSECINK FASVFGTMPL KVVEHRADPV
710
LYKDDFPEKL KSFPNIGSL
Length:719
Mass (Da):82,288
Last modified:May 3, 2011 - v1
Checksum:iE2F16DAF6223CF4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510305 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSDART00000079165; ENSDARP00000073621; ENSDARG00000056648.
ENSDART00000174926; ENSDARP00000143618; ENSDARG00000056648.

Similar proteinsi

Entry informationi

Entry nameiF1QUC2_DANRE
AccessioniPrimary (citable) accession number: F1QUC2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 22, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported