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Protein
Submitted name:

Plasminogen activator inhibitor 1

Gene

serpine1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: ZFIN

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GOC
  • negative regulation of plasminogen activation Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-3000178. ECM proteoglycans.
R-DRE-75205. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.020.

Names & Taxonomyi

Protein namesi
Submitted name:
Plasminogen activator inhibitor 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:serpine1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-070912-60. serpine1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 392374Sequence analysisPRO_5006724813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi203 – 2031N-linked (GlcNAc...)Combined sourcesCAR_5006524245

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073803.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DTEX-ray1.96A/B19-392[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 389360SERPINInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
OMAiQDKQTDF.
OrthoDBiEOG7327PB.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1QRB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSLSVLLIF ALCASSLCNL IQDKQTDFGL QVFAEAVQSA PDRNLALSPY
60 70 80 90 100
GIASVLGMAQ MGAYGATLKL LASKMGYSLQ ERGMPKLQRL LQRDLASEDG
110 120 130 140 150
VEVASGVMVD RKIILEKVFR RSLSKAFQSV PHQIDFSQPE MARQVINSWT
160 170 180 190 200
SDHTDGMISE FLPSGVLSEL TRLVFLNALH FHGVWKTPFD PRNTREQLFH
210 220 230 240 250
TVNGSAVSVP MMTTTQKFNY GEFVSKDGVD YDVIEMPYEG ESISMLLVTP
260 270 280 290 300
FEKDVPLSAL NKELSSSRIH QWRQEMRKIS KQLSIPRFSM DTEIDLKSTL
310 320 330 340 350
SRMGLGDIFS QSRADFSRIT TEEPLCVSKV LQRVKLEVNE EGTKGSSATA
360 370 380 390
AVIYSRMAVE EITLDRPFFF LIQHKPTGAL LFSGQLTQPQ EY
Length:392
Mass (Da):43,870
Last modified:May 3, 2011 - v1
Checksum:i583E1166BCCEA0F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470232 Genomic DNA. No translation available.
JQ801452 mRNA. Translation: AFL47814.1.
RefSeqiXP_009301297.1. XM_009303022.1.
UniGeneiDr.119909.
Dr.125717.

Genome annotation databases

EnsembliENSDART00000079347; ENSDARP00000073803; ENSDARG00000056795.
GeneIDi100136840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470232 Genomic DNA. No translation available.
JQ801452 mRNA. Translation: AFL47814.1.
RefSeqiXP_009301297.1. XM_009303022.1.
UniGeneiDr.119909.
Dr.125717.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DTEX-ray1.96A/B19-392[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073803.

Protein family/group databases

MEROPSiI04.020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000079347; ENSDARP00000073803; ENSDARG00000056795.
GeneIDi100136840.

Organism-specific databases

CTDi5054.
ZFINiZDB-GENE-070912-60. serpine1.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
OMAiQDKQTDF.
OrthoDBiEOG7327PB.
TreeFamiTF352620.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-3000178. ECM proteoglycans.
R-DRE-75205. Dissolution of Fibrin Clot.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Fish PAI-1."
    Bager R., Johansen J.S., Jensen J.K., Stensballe A., Jendroszek A., Sorensen H.P., Andreasen P.A.
    Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Protein conformational change delayed by steric hindrance from an N-linked glycan."
    Bager R., Johansen J.S., Jensen J.K., Stensballe A., Jendroszek A., Buxbom L., Sorensen H.P., Andreasen P.A.
    J. Mol. Biol. 425:2867-2877(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 19-392, GLYCOSYLATION AT ASN-203.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  4. Ensembl
    Submitted (NOV-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiF1QRB8_DANRE
AccessioniPrimary (citable) accession number: F1QRB8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 16, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.