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F1QRB8

- F1QRB8_DANRE

UniProt

F1QRB8 - F1QRB8_DANRE

Protein
Submitted name:

Plasminogen activator inhibitor 1

Gene

serpine1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: ZFIN

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: GOC
    2. negative regulation of plasminogen activation Source: ZFIN

    Enzyme and pathway databases

    ReactomeiREACT_223985. ECM proteoglycans.
    REACT_226214. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Protein family/group databases

    MEROPSiI04.020.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Plasminogen activator inhibitor 1Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:serpine1Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 7

    Organism-specific databases

    ZFINiZDB-GENE-070912-60. serpine1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi203 – 2031N-linked (GlcNAc...)Imported

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DTEX-ray1.96A/B19-392[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115460.
    KOiK03982.
    OMAiNAWVSDH.
    OrthoDBiEOG7327PB.
    TreeFamiTF352620.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1QRB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSLSVLLIF ALCASSLCNL IQDKQTDFGL QVFAEAVQSA PDRNLALSPY    50
    GIASVLGMAQ MGAYGATLKL LASKMGYSLQ ERGMPKLQRL LQRDLASEDG 100
    VEVASGVMVD RKIILEKVFR RSLSKAFQSV PHQIDFSQPE MARQVINSWT 150
    SDHTDGMISE FLPSGVLSEL TRLVFLNALH FHGVWKTPFD PRNTREQLFH 200
    TVNGSAVSVP MMTTTQKFNY GEFVSKDGVD YDVIEMPYEG ESISMLLVTP 250
    FEKDVPLSAL NKELSSSRIH QWRQEMRKIS KQLSIPRFSM DTEIDLKSTL 300
    SRMGLGDIFS QSRADFSRIT TEEPLCVSKV LQRVKLEVNE EGTKGSSATA 350
    AVIYSRMAVE EITLDRPFFF LIQHKPTGAL LFSGQLTQPQ EY 392
    Length:392
    Mass (Da):43,870
    Last modified:May 3, 2011 - v1
    Checksum:i583E1166BCCEA0F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX470232 Genomic DNA. No translation available.
    JQ801452 mRNA. Translation: AFL47814.1.
    RefSeqiXP_005172302.1. XM_005172245.1.
    UniGeneiDr.119909.
    Dr.125717.

    Genome annotation databases

    EnsembliENSDART00000079347; ENSDARP00000073803; ENSDARG00000056795.
    GeneIDi100136840.
    KEGGidre:100136840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX470232 Genomic DNA. No translation available.
    JQ801452 mRNA. Translation: AFL47814.1 .
    RefSeqi XP_005172302.1. XM_005172245.1.
    UniGenei Dr.119909.
    Dr.125717.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DTE X-ray 1.96 A/B 19-392 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000079347 ; ENSDARP00000073803 ; ENSDARG00000056795 .
    GeneIDi 100136840.
    KEGGi dre:100136840.

    Organism-specific databases

    CTDi 5054.
    ZFINi ZDB-GENE-070912-60. serpine1.

    Phylogenomic databases

    GeneTreei ENSGT00740000115460.
    KOi K03982.
    OMAi NAWVSDH.
    OrthoDBi EOG7327PB.
    TreeFami TF352620.

    Enzyme and pathway databases

    Reactomei REACT_223985. ECM proteoglycans.
    REACT_226214. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Miscellaneous databases

    PROi F1QRB8.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    2. "Characterization of Fish PAI-1."
      Bager R., Johansen J.S., Jensen J.K., Stensballe A., Jendroszek A., Sorensen H.P., Andreasen P.A.
      Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Protein conformational change delayed by steric hindrance from an N-linked glycan."
      Bager R., Johansen J.S., Jensen J.K., Stensballe A., Jendroszek A., Buxbom L., Sorensen H.P., Andreasen P.A.
      J. Mol. Biol. 425:2867-2877(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 19-392, GLYCOSYLATION AT ASN-203.
    4. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiF1QRB8_DANRE
    AccessioniPrimary (citable) accession number: F1QRB8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3