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F1QRB8

- F1QRB8_DANRE

UniProt

F1QRB8 - F1QRB8_DANRE

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Protein
Submitted name:

Plasminogen activator inhibitor 1

Gene

serpine1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: ZFIN

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GOC
  2. negative regulation of plasminogen activation Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_223985. ECM proteoglycans.
REACT_226214. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Protein family/group databases

MEROPSiI04.020.

Names & Taxonomyi

Protein namesi
Submitted name:
Plasminogen activator inhibitor 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:serpine1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-070912-60. serpine1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi203 – 2031N-linked (GlcNAc...)Imported

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DTEX-ray1.96A/B19-392[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118789.
KOiK03982.
OMAiNAWVSDH.
OrthoDBiEOG7327PB.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1QRB8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSLSVLLIF ALCASSLCNL IQDKQTDFGL QVFAEAVQSA PDRNLALSPY
60 70 80 90 100
GIASVLGMAQ MGAYGATLKL LASKMGYSLQ ERGMPKLQRL LQRDLASEDG
110 120 130 140 150
VEVASGVMVD RKIILEKVFR RSLSKAFQSV PHQIDFSQPE MARQVINSWT
160 170 180 190 200
SDHTDGMISE FLPSGVLSEL TRLVFLNALH FHGVWKTPFD PRNTREQLFH
210 220 230 240 250
TVNGSAVSVP MMTTTQKFNY GEFVSKDGVD YDVIEMPYEG ESISMLLVTP
260 270 280 290 300
FEKDVPLSAL NKELSSSRIH QWRQEMRKIS KQLSIPRFSM DTEIDLKSTL
310 320 330 340 350
SRMGLGDIFS QSRADFSRIT TEEPLCVSKV LQRVKLEVNE EGTKGSSATA
360 370 380 390
AVIYSRMAVE EITLDRPFFF LIQHKPTGAL LFSGQLTQPQ EY
Length:392
Mass (Da):43,870
Last modified:May 3, 2011 - v1
Checksum:i583E1166BCCEA0F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX470232 Genomic DNA. No translation available.
JQ801452 mRNA. Translation: AFL47814.1.
RefSeqiXP_005172302.1. XM_005172245.1.
UniGeneiDr.119909.
Dr.125717.

Genome annotation databases

EnsembliENSDART00000079347; ENSDARP00000073803; ENSDARG00000056795.
GeneIDi100136840.
KEGGidre:100136840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX470232 Genomic DNA. No translation available.
JQ801452 mRNA. Translation: AFL47814.1 .
RefSeqi XP_005172302.1. XM_005172245.1.
UniGenei Dr.119909.
Dr.125717.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DTE X-ray 1.96 A/B 19-392 [» ]
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000079347 ; ENSDARP00000073803 ; ENSDARG00000056795 .
GeneIDi 100136840.
KEGGi dre:100136840.

Organism-specific databases

CTDi 5054.
ZFINi ZDB-GENE-070912-60. serpine1.

Phylogenomic databases

GeneTreei ENSGT00760000118789.
KOi K03982.
OMAi NAWVSDH.
OrthoDBi EOG7327PB.
TreeFami TF352620.

Enzyme and pathway databases

Reactomei REACT_223985. ECM proteoglycans.
REACT_226214. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Miscellaneous databases

PROi F1QRB8.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  2. "Characterization of Fish PAI-1."
    Bager R., Johansen J.S., Jensen J.K., Stensballe A., Jendroszek A., Sorensen H.P., Andreasen P.A.
    Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Protein conformational change delayed by steric hindrance from an N-linked glycan."
    Bager R., Johansen J.S., Jensen J.K., Stensballe A., Jendroszek A., Buxbom L., Sorensen H.P., Andreasen P.A.
    J. Mol. Biol. 425:2867-2877(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 19-392, GLYCOSYLATION AT ASN-203.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiF1QRB8_DANRE
AccessioniPrimary (citable) accession number: F1QRB8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3