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Protein
Submitted name:

Plasminogen activator inhibitor 1

Gene

serpine1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: ZFIN

GO - Biological processi

  • negative regulation of plasminogen activation Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-3000178. ECM proteoglycans.
R-DRE-75205. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.020.

Names & Taxonomyi

Protein namesi
Submitted name:
Plasminogen activator inhibitor 1Imported
Submitted name:
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Imported
Gene namesi
Name:serpine1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-070912-60. serpine1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501011421119 – 392Sequence analysisAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_5009996624203N-linked (GlcNAc...)Combined sources1

Expressioni

Gene expression databases

BgeeiENSDARG00000056795.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073803.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DTEX-ray1.96A/B19-392[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 389SERPINInterPro annotationAdd BLAST360

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
OMAiQDKQTDF.
OrthoDBiEOG091G0ION.
TreeFamiTF352620.

Family and domain databases

InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

F1QRB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSLSVLLIF ALCASSLCNL IQDKQTDFGL QVFAEAVQSA PDRNLALSPY
60 70 80 90 100
GIASVLGMAQ MGAYGATLKL LASKMGYSLQ ERGMPKLQRL LQRDLASEDG
110 120 130 140 150
VEVASGVMVD RKIILEKVFR RSLSKAFQSV PHQIDFSQPE MARQVINSWT
160 170 180 190 200
SDHTDGMISE FLPSGVLSEL TRLVFLNALH FHGVWKTPFD PRNTREQLFH
210 220 230 240 250
TVNGSAVSVP MMTTTQKFNY GEFVSKDGVD YDVIEMPYEG ESISMLLVTP
260 270 280 290 300
FEKDVPLSAL NKELSSSRIH QWRQEMRKIS KQLSIPRFSM DTEIDLKSTL
310 320 330 340 350
SRMGLGDIFS QSRADFSRIT TEEPLCVSKV LQRVKLEVNE EGTKGSSATA
360 370 380 390
AVIYSRMAVE EITLDRPFFF LIQHKPTGAL LFSGQLTQPQ EY
Length:392
Mass (Da):43,870
Last modified:May 3, 2011 - v1
Checksum:i583E1166BCCEA0F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470232 Genomic DNA. No translation available.
JQ801452 mRNA. Translation: AFL47814.1.
RefSeqiXP_017212280.1. XM_017356791.1.
UniGeneiDr.119909.

Genome annotation databases

EnsembliENSDART00000079347; ENSDARP00000073803; ENSDARG00000056795.
GeneIDi100136840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470232 Genomic DNA. No translation available.
JQ801452 mRNA. Translation: AFL47814.1.
RefSeqiXP_017212280.1. XM_017356791.1.
UniGeneiDr.119909.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DTEX-ray1.96A/B19-392[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073803.

Protein family/group databases

MEROPSiI04.020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000079347; ENSDARP00000073803; ENSDARG00000056795.
GeneIDi100136840.

Organism-specific databases

CTDi5054.
ZFINiZDB-GENE-070912-60. serpine1.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
OMAiQDKQTDF.
OrthoDBiEOG091G0ION.
TreeFamiTF352620.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-3000178. ECM proteoglycans.
R-DRE-75205. Dissolution of Fibrin Clot.

Gene expression databases

BgeeiENSDARG00000056795.

Family and domain databases

InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF1QRB8_DANRE
AccessioniPrimary (citable) accession number: F1QRB8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 10, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.