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Protein
Submitted name:

Plasminogen activator inhibitor 1

Gene

serpine1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: ZFIN

GO - Biological processi

  • negative regulation of plasminogen activation Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-114608 Platelet degranulation
R-DRE-3000178 ECM proteoglycans
R-DRE-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPSiI04.020

Names & Taxonomyi

Protein namesi
Submitted name:
Plasminogen activator inhibitor 1Imported
Submitted name:
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Imported
Gene namesi
Name:serpine1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-070912-60 serpine1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501430335819 – 392Sequence analysisAdd BLAST374

Expressioni

Gene expression databases

BgeeiENSDARG00000056795

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073803

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DTEX-ray1.96A/B19-392[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 389SERPINInterPro annotationAdd BLAST360

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
OMAiPYEKEVP
OrthoDBiEOG091G0ION
TreeFamiTF352620

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

F1QRB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSLSVLLIF ALCASSLCNL IQDKQTDFGL QVFAEAVQSA PDRNLALSPY
60 70 80 90 100
GIASVLGMAQ MGAYGATLKL LASKMGYSLQ ERGMPKLQRL LQRDLASEDG
110 120 130 140 150
VEVASGVMVD RKIILEKVFR RSLSKAFQSV PHQIDFSQPE MARQVINSWT
160 170 180 190 200
SDHTDGMISE FLPSGVLSEL TRLVFLNALH FHGVWKTPFD PRNTREQLFH
210 220 230 240 250
TVNGSAVSVP MMTTTQKFNY GEFVSKDGVD YDVIEMPYEG ESISMLLVTP
260 270 280 290 300
FEKDVPLSAL NKELSSSRIH QWRQEMRKIS KQLSIPRFSM DTEIDLKSTL
310 320 330 340 350
SRMGLGDIFS QSRADFSRIT TEEPLCVSKV LQRVKLEVNE EGTKGSSATA
360 370 380 390
AVIYSRMAVE EITLDRPFFF LIQHKPTGAL LFSGQLTQPQ EY
Length:392
Mass (Da):43,870
Last modified:May 3, 2011 - v1
Checksum:i583E1166BCCEA0F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470232 Genomic DNA No translation available.
JQ801452 mRNA Translation: AFL47814.1
RefSeqiXP_017212280.1, XM_017356791.1
UniGeneiDr.119909

Genome annotation databases

EnsembliENSDART00000079347; ENSDARP00000073803; ENSDARG00000056795

Similar proteinsi

Entry informationi

Entry nameiF1QRB8_DANRE
AccessioniPrimary (citable) accession number: F1QRB8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported