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Protein

Estrogen receptor

Gene

esr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi200 – 275Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandLipid-binding, Metal-binding, Steroid-bindingUniRule annotation, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-1251985 Nuclear signaling by ERBB4
R-DRE-1257604 PIP3 activates AKT signaling
R-DRE-383280 Nuclear Receptor transcription pathway
R-DRE-5689896 Ovarian tumor domain proteases
R-DRE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DRE-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-DRE-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-DRE-8939211 ESR-mediated signaling
R-DRE-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptorUniRule annotation
Short name:
ERUniRule annotation
Alternative name(s):
ER-alphaUniRule annotation
Estradiol receptorUniRule annotation
Nuclear receptor subfamily 3 group A member 1UniRule annotation
Gene namesi
Name:esr1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-020806-5 esr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000004111
ExpressionAtlasiF1QL15 differential

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 275Nuclear receptorInterPro annotationAdd BLAST76
Domaini330 – 566NR LBDInterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
OrthoDBiEOG091G03V4

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1QL15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPACVFPVM SGGQTSGEAV GARQRRRTSP SPEREALEEP SSPPAAHKLS
60 70 80 90 100
PMYPKEEHSA GGISSSVNYL DGAYEYPNPT QTFGTSSPAE PASVGYYPAP
110 120 130 140 150
PDPHEEHLQT LGGGSSSPLM FAPSSPQLSP YLSHHGGHHT TPHQVSYYLD
160 170 180 190 200
SSSSTVYRSS VVSSQQAAVG LCEELCSATD RQELYTGSRA AGGFDSGKET
210 220 230 240 250
RFCAVCSDYA SGYHYGVWSC EGCKAFFKRS IQGHNDYVCP ATNQCTIDRN
260 270 280 290 300
RRKSCQACRL RKCYEVGMMK GGIRKDRGGR SVRRERRRSS NEDRDKSTSD
310 320 330 340 350
QCSRAGVRTT GPQDKRKKRS GGVVSTLCMS PDQVLLLLLG AEPPAVCSRQ
360 370 380 390 400
KHSRPYTEIT MMSLLTNMAD KELVHMIAWA KKVPGFQDLS LHDQVQLLES
410 420 430 440 450
SWLEVLMIGL IWRSIHSPGK LIFAQDLILD RSEGECVEGM AEIFDMLLAT
460 470 480 490 500
VARFRSLKLK LEEFVCLKAI ILINSGAFSF CSSPVEPLMD NFMVQCMLDN
510 520 530 540 550
ITDALIYCIS KSGASLQLQS RRQAQLLLLL SHIRHMSNKG MEHLYRMKCK
560 570 580 590 600
NRVPLYDLLL EMLDAQRFQS SGKVQRVWSQ SEKNPPSTPT TSSSSSNNSP
610 620
RGGAAAIQSN GACHSHSPDP
Length:620
Mass (Da):68,201
Last modified:May 3, 2011 - v1
Checksum:iE1DB9F8472828D2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470265 Genomic DNA No translation available.
CU179733 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSDART00000024518; ENSDARP00000024987; ENSDARG00000004111

Similar proteinsi

Entry informationi

Entry nameiF1QL15_DANRE
AccessioniPrimary (citable) accession number: F1QL15
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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