ID   F1QA79_DANRE            Unreviewed;      2055 AA.
AC   F1QA79; A0A8N7UUM6;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific {ECO:0000313|RefSeq:XP_683890.4};
DE   SubName: Full=Nuclear receptor-binding SET domain protein 1a {ECO:0000313|Ensembl:ENSDARP00000078549};
GN   Name=nsd1a {ECO:0000313|Ensembl:ENSDARP00000078549,
GN   ECO:0000313|RefSeq:XP_683890.4, ECO:0000313|ZFIN:ZDB-GENE-080519-3};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000078549};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000078549}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078549};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000078549, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078549};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:XP_683890.4}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_683890.4};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CU633762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU655965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU659412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_683890.4; XM_678798.8.
DR   PaxDb; 7955-ENSDARP00000078549; -.
DR   Ensembl; ENSDART00000084114; ENSDARP00000078549; ENSDARG00000060016.
DR   Ensembl; ENSDART00000084114.6; ENSDARP00000078549.4; ENSDARG00000060016.7.
DR   GeneID; 556086; -.
DR   KEGG; dre:556086; -.
DR   AGR; ZFIN:ZDB-GENE-080519-3; -.
DR   CTD; 556086; -.
DR   ZFIN; ZDB-GENE-080519-3; nsd1a.
DR   eggNOG; KOG1081; Eukaryota.
DR   HOGENOM; CLU_001380_0_0_1; -.
DR   OMA; MAYSPTQ; -.
DR   OrthoDB; 950362at2759; -.
DR   TreeFam; TF329088; -.
DR   Proteomes; UP000000437; Chromosome 14.
DR   Bgee; ENSDARG00000060016; Expressed in somite and 23 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046975; F:histone H3K36 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0031507; P:heterochromatin formation; IGI:ZFIN.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd15648; PHD1_NSD1_2; 1.
DR   CDD; cd15653; PHD3_NSD1; 1.
DR   CDD; cd15656; PHD4_NSD1; 1.
DR   CDD; cd15659; PHD5_NSD1; 1.
DR   CDD; cd20161; PWWP_NSD1_rpt1; 1.
DR   Gene3D; 2.30.30.140; -; 2.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR041306; C5HCH.
DR   InterPro; IPR047426; PHD1_NSD1_2.
DR   InterPro; IPR047429; PHD3_NSD1.
DR   InterPro; IPR047430; PHD4_NSD1.
DR   InterPro; IPR047432; PHD5_NSD1.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22884:SF511; HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 AND H4 LYSINE-20 SPECIFIC; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF17982; C5HCH; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00855; PWWP; 2.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00249; PHD; 4.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00293; PWWP; 2.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50812; PWWP; 2.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
PE   1: Evidence at protein level;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1QA79};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   DOMAIN          288..354
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   DOMAIN          1226..1272
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1390..1434
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1439..1501
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   DOMAIN          1573..1623
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          1625..1742
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          1749..1765
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          260..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          621..731
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          776..851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          918..977
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          989..1178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1200..1219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1768..1793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1979..2000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2032..2055
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..211
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..582
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..597
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..676
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        688..707
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        708..726
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..838
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        918..932
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        955..977
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1001..1029
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1071..1127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1135..1178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1200..1217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2032..2049
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2055 AA;  227772 MW;  FC5206F7F0DBDA1A CRC64;
     MNQSYKVAGR DGSECRGDPQ DSRALDVRIG SCGQQSTKAD QSSAMHFLNP GYKLSAPFAY
     NQRESTSNYS PLRRLQDLTT MVNHADGGLQ DKDFHGRNKL LMHSPIGGNE FGIGLYNTTN
     SQGNTAIQDL DKNGFSPVSS DSLEHFSPIS NGFLHFDSTL FDSGDSKDND EDVKGEVATF
     KDTSKKCQKR NVAKTETQSS HRLDANKHSS KNTAKSDPPA SPFHVPFTMM EDFDSMDDYS
     DSDCDLPSTE NCASIFNLSK RAHSPSDSHS NPSSSPKKKQ LLSVKYSIGD VVWAKFNRRP
     WWPCHVTTDP QIDVHTKMKD PSRRPCRLYF VRMFGEIVDQ AWVPAKATFP FEGGDQFEKL
     PVLRRRGRQK EKDYKYTVPK RLIPSWKASV LEAEASLTKQ LNSEPPLTLI QDVCVPITED
     KAHKKNPACP KSTTLSTPSS SLLSNGLNAS VKNRLKPGTA SKKKATKKMI QSQSIKLSET
     PSLFKSKSNP SSDKPSIATD PLDSPYSDID SVPRILCSKR IDESLQVELE KELSTKTTKV
     QACKKTSKNS VDKPGKKTDV KCLKNSKLKK STPKDKTLKA TSSRLKESSS PGSSDGSFAM
     HSHYLPASSG LIVRALAAGE ETKEKDLSHE PNSHSPSSEH SSQTNHELSK QNWEVKNNSE
     SSEESVDASD SPPNPTSIKR IKKRPQKNGI HKDPPPKSHE ESESKVNNES MFSDTSSSSI
     PSPSISPMDA FQDIKELSFR SLVKEECSSG ESPLRADSNY KFSTFLMLLK DLHDSREKEG
     KPLTLPPTSP SSLIKEEPSL IPVGEEPPNE VLCEKEFAEQ SSLPGKTSTP NNSKQSKAKL
     KSTVKKESQK PDVVIDSVSP LKKPISPVGL DVLDKSLPLL GDLPKSSDVS AAVTDVCAKG
     TISKVAPKKR WKTFESELGK SIKPKSDQVD STLDEVKSVS TEPNGVFKDG LQESAHSDVP
     NKKDASENKR LRKPSKRLIE CGEEYEQIFP SKKKTKKSTE SCKTGSCISN TTPEQPASDQ
     ITLDAVSSSS AEKPLDHVVA EEQKPPADVL VPPSAPKSPS CATSLETEPC EKKSAPLERK
     RPRKSVHKVL DCAIEGESVK IPKKGESRQH KTNPEESGVR DLEKQEEAGP PPSSPCAVSA
     QSEGELRTSS PIQPDVPSVS QIPVEGEQSS PSKPQINNED SLISEGFAAG LNDSAFSSRD
     SLSGDLSGLS TNKRSVERGG GASLKENVCQ VCEKTGELLL CEGQCCGAFH LQCIGLTETP
     KGRFICQECK MGVHTCFVCK KPDKEVRRCM IPVCGKFYHM DCILKYSPTV AQNRGFRCSI
     HVCLSCYITN PNNPGISKGR LTRCVRCPVA YHANDYCMAA GSVPLANNSF LCPNHFTPRK
     GCKNHEHINV SWCFVCSEGG SLLCCESCPA AFHRECLNIE MPQGSWFCND CRAGKKPHYK
     DILWVKVGRY RWWPAEVTQP KSVPENISRM KHEVGEFPVH FFGSKDYVWT YQARCFPYME
     GDANNKEKMG KGADAVYKKA LNEAADRFRE LLKEKEMRQL QEDRKNDKKP PPYKHIKVNK
     QIGKVLIITA DLSEIPRCNC KATDENPCGI DSECINRMLL YECHSQVCPA GERCQNQSFT
     KRQYTEVEIF RTLSRGWGLR SISDIKKGAF VNEYVGEVID EEECRSRIKN AQDNDICNFY
     MLTLDKDRII DAGPKGNESR FMNHSCQPNC ETQKWTVNGD TRVGLFALED IPKGVELTFN
     YNLECLGNGK TVCKCGAPNC SGFLGVRPKN QPPSDDKTRK LRRKVSGKRK SQSEVTKERE
     DECFYCGDGG QIVSCKKPGC PKVYHADCLN LSKRPAGRWE CPWHQCNECG REAASYCEMC
     PNSYCEQHRE GMLFISKLDG KLSCSEHDPC GPDPLEPGEI REYVPSTSIV GQAPNMSASG
     RITQPALPPA APLFIPAQNR PAFQSQRDPY GDEVVDNILP SSSPKDIKEE DMSDGEVVFE
     EGEEEEEDLE LVDDEDDEEE IDCRGMGLED EEEEEEFEDY EDDFVNVDFV GTEDGDEVEG
     DEQETSWDEL VEAEK
//