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Protein
Submitted name:

Nuclear receptor-binding SET domain protein 1a

Gene

nsd1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseSAAS annotation, Transferase
LigandMetal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor-binding SET domain protein 1aImported
Gene namesi
Name:nsd1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-080519-3 nsd1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF1QA79
PRIDEiF1QA79

Expressioni

Gene expression databases

BgeeiENSDARG00000060016

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078549

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 354PWWPInterPro annotationAdd BLAST67
Domaini1226 – 1272PHD-typeInterPro annotationAdd BLAST47
Domaini1390 – 1434PHD-typeInterPro annotationAdd BLAST45
Domaini1439 – 1501PWWPInterPro annotationAdd BLAST63
Domaini1573 – 1623AWSInterPro annotationAdd BLAST51
Domaini1625 – 1742SETInterPro annotationAdd BLAST118
Domaini1749 – 1765Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1518 – 1538Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1081 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00780000121845
InParanoidiF1QA79
KOiK15588
OMAiAMECTIE
OrthoDBiEOG091G00XD
TreeFamiTF329088

Family and domain databases

Gene3Di3.30.40.10, 4 hits
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR003616 Post-SET_dom
IPR000313 PWWP_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00855 PWWP, 2 hits
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00293 PWWP, 2 hits
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS50812 PWWP, 2 hits
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

Sequencei

Sequence statusi: Complete.

F1QA79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQSYKVAGR DGSECRGDPQ DSRALDVRIG SCGQQSTKAD QSSAMHFLNP
60 70 80 90 100
GYKLSAPFAY NQRESTSNYS PLRRLQDLTT MVNHADGGLQ DKDFHGRNKL
110 120 130 140 150
LMHSPIGGNE FGIGLYNTTN SQGNTAIQDL DKNGFSPVSS DSLEHFSPIS
160 170 180 190 200
NGFLHFDSTL FDSGDSKDND EDVKGEVATF KDTSKKCQKR NVAKTETQSS
210 220 230 240 250
HRLDANKHSS KNTAKSDPPA SPFHVPFTMM EDFDSMDDYS DSDCDLPSTE
260 270 280 290 300
NCASIFNLSK RAHSPSDSHS NPSSSPKKKQ LLSVKYSIGD VVWAKFNRRP
310 320 330 340 350
WWPCHVTTDP QIDVHTKMKD PSRRPCRLYF VRMFGEIVDQ AWVPAKATFP
360 370 380 390 400
FEGGDQFEKL PVLRRRGRQK EKDYKYTVPK RLIPSWKASV LEAEASLTKQ
410 420 430 440 450
LNSEPPLTLI QDVCVPITED KAHKKNPACP KSTTLSTPSS SLLSNGLNAS
460 470 480 490 500
VKNRLKPGTA SKKKATKKMI QSQSIKLSET PSLFKSKSNP SSDKPSIATD
510 520 530 540 550
PLDSPYSDID SVPRILCSKR IDESLQVELE KELSTKTTKV QACKKTSKNS
560 570 580 590 600
VDKPGKKTDV KCLKNSKLKK STPKDKTLKA TSSRLKESSS PGSSDGSFAM
610 620 630 640 650
HSHYLPASSG LIVRALAAGE ETKEKDLSHE PNSHSPSSEH SSQTNHELSK
660 670 680 690 700
QNWEVKNNSE SSEESVDASD SPPNPTSIKR IKKRPQKNGI HKDPPPKSHE
710 720 730 740 750
ESESKVNNES MFSDTSSSSI PSPSISPMDA FQDIKELSFR SLVKEECSSG
760 770 780 790 800
ESPLRADSNY KFSTFLMLLK DLHDSREKEG KPLTLPPTSP SSLIKEEPSL
810 820 830 840 850
IPVGEEPPNE VLCEKEFAEQ SSLPGKTSTP NNSKQSKAKL KSTVKKESQK
860 870 880 890 900
PDVVIDSVSP LKKPISPVGL DVLDKSLPLL GDLPKSSDVS AAVTDVCAKG
910 920 930 940 950
TISKVAPKKR WKTFESELGK SIKPKSDQVD STLDEVKSVS TEPNGVFKDG
960 970 980 990 1000
LQESAHSDVP NKKDASENKR LRKPSKRLIE CGEEYEQIFP SKKKTKKSTE
1010 1020 1030 1040 1050
SCKTGSCISN TTPEQPASDQ ITLDAVSSSS AEKPLDHVVA EEQKPPADVL
1060 1070 1080 1090 1100
VPPSAPKSPS CATSLETEPC EKKSAPLERK RPRKSVHKVL DCAIEGESVK
1110 1120 1130 1140 1150
IPKKGESRQH KTNPEESGVR DLEKQEEAGP PPSSPCAVSA QSEGELRTSS
1160 1170 1180 1190 1200
PIQPDVPSVS QIPVEGEQSS PSKPQINNED SLISEGFAAG LNDSAFSSRD
1210 1220 1230 1240 1250
SLSGDLSGLS TNKRSVERGG GASLKENVCQ VCEKTGELLL CEGQCCGAFH
1260 1270 1280 1290 1300
LQCIGLTETP KGRFICQECK MGVHTCFVCK KPDKEVRRCM IPVCGKFYHM
1310 1320 1330 1340 1350
DCILKYSPTV AQNRGFRCSI HVCLSCYITN PNNPGISKGR LTRCVRCPVA
1360 1370 1380 1390 1400
YHANDYCMAA GSVPLANNSF LCPNHFTPRK GCKNHEHINV SWCFVCSEGG
1410 1420 1430 1440 1450
SLLCCESCPA AFHRECLNIE MPQGSWFCND CRAGKKPHYK DILWVKVGRY
1460 1470 1480 1490 1500
RWWPAEVTQP KSVPENISRM KHEVGEFPVH FFGSKDYVWT YQARCFPYME
1510 1520 1530 1540 1550
GDANNKEKMG KGADAVYKKA LNEAADRFRE LLKEKEMRQL QEDRKNDKKP
1560 1570 1580 1590 1600
PPYKHIKVNK QIGKVLIITA DLSEIPRCNC KATDENPCGI DSECINRMLL
1610 1620 1630 1640 1650
YECHSQVCPA GERCQNQSFT KRQYTEVEIF RTLSRGWGLR SISDIKKGAF
1660 1670 1680 1690 1700
VNEYVGEVID EEECRSRIKN AQDNDICNFY MLTLDKDRII DAGPKGNESR
1710 1720 1730 1740 1750
FMNHSCQPNC ETQKWTVNGD TRVGLFALED IPKGVELTFN YNLECLGNGK
1760 1770 1780 1790 1800
TVCKCGAPNC SGFLGVRPKN QPPSDDKTRK LRRKVSGKRK SQSEVTKERE
1810 1820 1830 1840 1850
DECFYCGDGG QIVSCKKPGC PKVYHADCLN LSKRPAGRWE CPWHQCNECG
1860 1870 1880 1890 1900
REAASYCEMC PNSYCEQHRE GMLFISKLDG KLSCSEHDPC GPDPLEPGEI
1910 1920 1930 1940 1950
REYVPSTSIV GQAPNMSASG RITQPALPPA APLFIPAQNR PAFQSQRDPY
1960 1970 1980 1990 2000
GDEVVDNILP SSSPKDIKEE DMSDGEVVFE EGEEEEEDLE LVDDEDDEEE
2010 2020 2030 2040 2050
IDCRGMGLED EEEEEEFEDY EDDFVNVDFV GTEDGDEVEG DEQETSWDEL

VEAEK
Length:2,055
Mass (Da):227,772
Last modified:May 3, 2011 - v1
Checksum:iFC5206F7F0DBDA1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633762 Genomic DNA No translation available.
CU655965 Genomic DNA No translation available.
CU659412 Genomic DNA No translation available.
RefSeqiXP_683890.4, XM_678798.7
UniGeneiDr.83733

Genome annotation databases

EnsembliENSDART00000084114; ENSDARP00000078549; ENSDARG00000060016
GeneIDi556086
KEGGidre:556086

Similar proteinsi

Entry informationi

Entry nameiF1QA79_DANRE
AccessioniPrimary (citable) accession number: F1QA79
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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