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Protein
Submitted name:

Calreticulin

Gene

calr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110CarbohydrateUniRule annotation1
Binding sitei112CarbohydrateUniRule annotation1
Binding sitei129CarbohydrateUniRule annotation1
Binding sitei136CarbohydrateUniRule annotation1
Binding sitei318CarbohydrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-1236974 ER-Phagosome pathway
R-DRE-901042 Calnexin/calreticulin cycle
R-DRE-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Submitted name:
CalreticulinImported
Gene namesi
Name:calrImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-030131-4042 calr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18UniRule annotationAdd BLAST18
ChainiPRO_500326966319 – 417UniRule annotationAdd BLAST399

Proteomic databases

PaxDbiF1Q8W8
PRIDEiF1Q8W8

Expressioni

Gene expression databases

BgeeiENSDARG00000076290

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092429

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili351 – 416Sequence analysisAdd BLAST66

Sequence similaritiesi

Belongs to the calreticulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG0674 Eukaryota
ENOG410XRR7 LUCA
GeneTreeiENSGT00430000030841
InParanoidiF1Q8W8
KOiK08057
OMAiDTWIYSK
OrthoDBiEOG091G0AP1
TreeFamiTF338438

Family and domain databases

Gene3Di2.10.250.10, 1 hit
InterProiView protein in InterPro
IPR001580 Calret/calnex
IPR018124 Calret/calnex_CS
IPR009169 Calreticulin
IPR009033 Calreticulin/calnexin_P_dom_sf
IPR013320 ConA-like_dom_sf
PANTHERiPTHR11073 PTHR11073, 1 hit
PfamiView protein in Pfam
PF00262 Calreticulin, 2 hits
PIRSFiPIRSF002356 Calreticulin, 1 hit
PRINTSiPR00626 CALRETICULIN
SUPFAMiSSF49899 SSF49899, 1 hit
SSF63887 SSF63887, 1 hit
PROSITEiView protein in PROSITE
PS00803 CALRETICULIN_1, 1 hit
PS00804 CALRETICULIN_2, 1 hit
PS00805 CALRETICULIN_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

F1Q8W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALSLLFMA VSVALITAES NVYFREQFED GDSWRSRWVE SKHKTDYGKF
60 70 80 90 100
VLSAGKFYGD AEKDKGLQTS QDAHFYAMSA RFGDFNNKDQ PLVIQFSVKH
110 120 130 140 150
EQNIDCGGGY IKLFPSDLNQ EDMHGDSTYN IMFGPDICGP GTKKVHVIFN
160 170 180 190 200
YKGKNHLINK DIRCKDDEYS HLYTLIVNPD NTYEVKIDNK KVESGSLEED
210 220 230 240 250
WDFLPSKKIK DPEAKKPEDW DEREKIDDPE DQKPEEWDKP ENIPDPDAKK
260 270 280 290 300
PDDWDEEMDG EWEPPMVTNP DYKGEWKPRQ IDNPAYKGKW VHPEIDNPEY
310 320 330 340 350
TADSEIYKYD SIGVIGLDLW QVKSGTIFDN FLITNDPKLA EEVGTETWGA
360 370 380 390 400
TKDAEKKMKE SQEEEDRKKH DEEEKSRKEE AKEEEEEEKE EEDEEEEEEE
410
EEEDEEEETD SKLKDEL
Length:417
Mass (Da):48,640
Last modified:May 3, 2011 - v1
Checksum:i7B51E5962F2421E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU467861 Genomic DNA No translation available.
RefSeqiNP_956007.2, NM_199713.2
UniGeneiDr.116048

Genome annotation databases

EnsembliENSDART00000101655; ENSDARP00000092429; ENSDARG00000076290
GeneIDi325317
KEGGidre:325317

Similar proteinsi

Entry informationi

Entry nameiF1Q8W8_DANRE
AccessioniPrimary (citable) accession number: F1Q8W8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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