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Protein

Alkaline phosphatase

Gene

alpl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesi
Name:alplImported
Synonyms:alpImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-040420-1. alpl.

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiF1Q5B5.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000117214.

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000008704.
InParanoidiF1Q5B5.
OMAiMQEALVP.
OrthoDBiEOG7SN8CH.
TreeFamiTF323513.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1Q5B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWECGCFLVL WSELSVVWHP WNVKIRKRRL IDNKMKVVQL LILSCLVWEG
60 70 80 90 100
KTKVQFPEQE KRPDYWRDFA QRSLKDALKL QELNKNIAKN IILFLGDGMG
110 120 130 140 150
VPTVTAARIL KGQLSGQNGE ETQLEMDKFP HVALSKTYNT NAQVPDSAGT
160 170 180 190 200
ATAFLCGVKA NEGTVGVSAA AVRSQCNTTQ GNEVTSILKW AKDAGKSVGI
210 220 230 240 250
VTTTRVNHAT PSAAYAHCVD RDWYSDADMP NEALQSGCKD IARQLFENIP
260 270 280 290 300
DINVIMGGGR RSMYPKNTPD VEYPGDKKQN GTRKDGRNLV GEWIDRVKEK
310 320 330 340 350
RGFYVWNKKD LLSLNPNNVD YLLGLFEPAD LNYELERNTE NDPSLTEMVD
360 370 380 390 400
VAIKILKKNE RGFFLLVEGG RIDHGHHEGK AKQALHEAVE MDRAITRAGL
410 420 430 440 450
LTSEYDTLTV VTADHSHVFS FGGYTPRGNS IFGLAPTLSD VDQKPFTAIL
460 470 480 490 500
YGNGPGFKLV NGARENVSTV DYQQNNYQAQ SAVPLRMETH GGEDVAIFSK
510 520 530 540 550
GPMAHLLHGV QEQHYIPHVM AYAACIGQNK DHCRTNSGSS SYFSHISPAL
560
LFPLLVKWLL C
Length:561
Mass (Da):62,469
Last modified:May 3, 2011 - v1
Checksum:i4F148EE558E64BFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248318 Genomic DNA. No translation available.
RefSeqiXP_005169329.1. XM_005169272.2.
UniGeneiDr.116988.

Genome annotation databases

EnsembliENSDART00000146461; ENSDARP00000117214; ENSDARG00000015546.
GeneIDi393982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248318 Genomic DNA. No translation available.
RefSeqiXP_005169329.1. XM_005169272.2.
UniGeneiDr.116988.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000117214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000146461; ENSDARP00000117214; ENSDARG00000015546.
GeneIDi393982.

Organism-specific databases

CTDi249.
ZFINiZDB-GENE-040420-1. alpl.

Phylogenomic databases

GeneTreeiENSGT00390000008704.
InParanoidiF1Q5B5.
OMAiMQEALVP.
OrthoDBiEOG7SN8CH.
TreeFamiTF323513.

Miscellaneous databases

PROiF1Q5B5.

Gene expression databases

BgeeiF1Q5B5.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
[Graphical view]
PfamiPF00245. Alk_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00113. ALKPHPHTASE.
SMARTiSM00098. alkPPc. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiF1Q5B5_DANRE
AccessioniPrimary (citable) accession number: F1Q5B5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 24, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.