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Protein

Alkaline phosphatase

Gene

alpl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • response to mechanical stimulus Source: ZFIN

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMagnesiumUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesi
Name:alplImported
Synonyms:alpImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-040420-1. alpl.

PTM / Processingi

Proteomic databases

PaxDbiF1Q5B5.

Expressioni

Gene expression databases

BgeeiENSDARG00000015546.
ExpressionAtlasiF1Q5B5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000117214.

Structurei

3D structure databases

ProteinModelPortaliF1Q5B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4126. Eukaryota.
COG1785. LUCA.
GeneTreeiENSGT00390000008704.
InParanoidiF1Q5B5.
KOiK01077.
OMAiEHTGTQL.
OrthoDBiEOG091G067H.
TreeFamiTF323513.

Family and domain databases

CDDicd00016. alkPPc. 1 hit.
Gene3Di3.40.720.10. 1 hit.
InterProiView protein in InterPro
IPR017849. Alkaline_Pase-like_a/b/a.
IPR001952. Alkaline_phosphatase.
IPR018299. Alkaline_phosphatase_AS.
IPR017850. Alkaline_phosphatase_core.
PANTHERiPTHR11596. PTHR11596. 1 hit.
PfamiView protein in Pfam
PF00245. Alk_phosphatase. 1 hit.
PRINTSiPR00113. ALKPHPHTASE.
SMARTiView protein in SMART
SM00098. alkPPc. 1 hit.
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiView protein in PROSITE
PS00123. ALKALINE_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

F1Q5B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWECGCFLVL WSELSVVWHP WNVKIRKRRL IDNKMKVVQL LILSCLVWEG
60 70 80 90 100
KTKVQFPEQE KRPDYWRDFA QRSLKDALKL QELNKNIAKN IILFLGDGMG
110 120 130 140 150
VPTVTAARIL KGQLSGQNGE ETQLEMDKFP HVALSKTYNT NAQVPDSAGT
160 170 180 190 200
ATAFLCGVKA NEGTVGVSAA AVRSQCNTTQ GNEVTSILKW AKDAGKSVGI
210 220 230 240 250
VTTTRVNHAT PSAAYAHCVD RDWYSDADMP NEALQSGCKD IARQLFENIP
260 270 280 290 300
DINVIMGGGR RSMYPKNTPD VEYPGDKKQN GTRKDGRNLV GEWIDRVKEK
310 320 330 340 350
RGFYVWNKKD LLSLNPNNVD YLLGLFEPAD LNYELERNTE NDPSLTEMVD
360 370 380 390 400
VAIKILKKNE RGFFLLVEGG RIDHGHHEGK AKQALHEAVE MDRAITRAGL
410 420 430 440 450
LTSEYDTLTV VTADHSHVFS FGGYTPRGNS IFGLAPTLSD VDQKPFTAIL
460 470 480 490 500
YGNGPGFKLV NGARENVSTV DYQQNNYQAQ SAVPLRMETH GGEDVAIFSK
510 520 530 540 550
GPMAHLLHGV QEQHYIPHVM AYAACIGQNK DHCRTNSGSS SYFSHISPAL
560
LFPLLVKWLL C
Length:561
Mass (Da):62,469
Last modified:May 3, 2011 - v1
Checksum:i4F148EE558E64BFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248318 Genomic DNA. No translation available.
RefSeqiNP_957301.2. NM_201007.2.
UniGeneiDr.116988.

Genome annotation databases

EnsembliENSDART00000146461; ENSDARP00000117214; ENSDARG00000015546.
GeneIDi393982.
KEGGidre:393982.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF1Q5B5_DANRE
AccessioniPrimary (citable) accession number: F1Q5B5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 7, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported