Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein MOX-1

Gene

meox1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by mediating specification of endothelial cells of the endotome within the nascent somite, notably by repressing expression of cxcl12b.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi170 – 229HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: ZFIN
  • core promoter sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • hematopoietic stem cell differentiation Source: UniProtKB
  • hemopoiesis Source: ZFIN
  • muscle cell development Source: ZFIN
  • sclerotome development Source: UniProtKB
  • somite development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-1By similarity
Alternative name(s):
Mesenchyme homeobox 1By similarity
Protein choker1 Publication
Gene namesi
Name:meox1Imported
Synonyms:cho1 Publication
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-040718-149. meox1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Localizes predominantly in the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Defects in somite lineages. Secondary trunk myogenesis is reduced, as well as appendicular and hypaxial muscles and their progenitors. These cell types derive from the external cell layer (ECL) and ECL cell numbers are reduced. The endotome is expanded at the expense of a second somitic cell type. The resulting increase in endotome-derived cells that migrate to colonize the dorsal aorta generates a dramatic increase in chemokine-dependent hematopoietic stem cell (HSCs) induction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004308161 – 253Homeobox protein MOX-1Add BLAST253

Proteomic databases

PaxDbiF1Q4R9.

Expressioni

Developmental stagei

Expressed within the early somite and then becomes restricted to the external cell layer (ECL) and consequently to appendicular muscle populations.1 Publication

Gene expression databases

BgeeiENSDARG00000007891.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096438.

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000230987.
HOVERGENiHBG052456.
InParanoidiF1Q4R9.
KOiK09322.
OMAiQENRGKP.
OrthoDBiEOG091G0PFO.
TreeFamiTF351603.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: F1Q4R9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQSASSCMR SPHTGGALWG CVRSPHSGGS GAGIQPYQQA PFALHQKHDF
60 70 80 90 100
LAYTDFSSSC LVPAPHAYPR EDRLYPETHS GYQRTEWQFS PCEPRGRGQE
110 120 130 140 150
PCQGAAEAVG AEMDSAGGDR LAGAVTGCLE GDYSPQSVPA VDTEKKSSKR
160 170 180 190 200
KREVTDIQDS SFKADSNCKA RKERTAFTKE QLRELEAEFT HHNYLTRLRR
210 220 230 240 250
YEIAVNLDLT ERQVKVWFQN RRMKWKRVKG GQPASPHDLE ADELDSAASP

SSE
Length:253
Mass (Da):28,150
Last modified:May 3, 2011 - v1
Checksum:i36F788BDB2597576
GO
Isoform 2 (identifier: F1Q4R9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-27: Missing.

Show »
Length:240
Mass (Da):26,842
Checksum:i7D36EEF491AFDC4C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05709915 – 27Missing in isoform 2. Add BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847827 Genomic DNA. No translation available.
BC076021 mRNA. Translation: AAH76021.1.
RefSeqiNP_001002450.2. NM_001002450.2. [F1Q4R9-1]
UniGeneiDr.83318.

Genome annotation databases

EnsembliENSDART00000011252; ENSDARP00000027691; ENSDARG00000007891. [F1Q4R9-2]
ENSDART00000105661; ENSDARP00000096438; ENSDARG00000007891. [F1Q4R9-1]
GeneIDi436723.
KEGGidre:436723.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847827 Genomic DNA. No translation available.
BC076021 mRNA. Translation: AAH76021.1.
RefSeqiNP_001002450.2. NM_001002450.2. [F1Q4R9-1]
UniGeneiDr.83318.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096438.

Proteomic databases

PaxDbiF1Q4R9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000011252; ENSDARP00000027691; ENSDARG00000007891. [F1Q4R9-2]
ENSDART00000105661; ENSDARP00000096438; ENSDARG00000007891. [F1Q4R9-1]
GeneIDi436723.
KEGGidre:436723.

Organism-specific databases

CTDi4222.
ZFINiZDB-GENE-040718-149. meox1.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000230987.
HOVERGENiHBG052456.
InParanoidiF1Q4R9.
KOiK09322.
OMAiQENRGKP.
OrthoDBiEOG091G0PFO.
TreeFamiTF351603.

Miscellaneous databases

PROiF1Q4R9.

Gene expression databases

BgeeiENSDARG00000007891.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEOX1_DANRE
AccessioniPrimary (citable) accession number: F1Q4R9
Secondary accession number(s): Q6DHF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: May 3, 2011
Last modified: October 5, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.