Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase

Gene

HCK

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:HCKImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1PSI2.

Expressioni

Gene expression databases

BgeeiENSCAFG00000007122.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000032817.

Structurei

3D structure databases

ProteinModelPortaliF1PSI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 239SH3InterPro annotationAdd BLAST61
Domaini245 – 342SH2InterPro annotationAdd BLAST98
Domaini363 – 616Protein kinaseInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
InParanoidiF1PSI2.
KOiK08893.
OMAiRPEHCPE.
OrthoDBiEOG091G0D46.
TreeFamiTF351634.

Family and domain databases

CDDicd10363. SH2_Src_HCK. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR035851. HCK_SH2.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

F1PSI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVHAVGSES SGAGLGYTGV GLASLRARLR SPDGLWVPPS PRSQPERTAE
60 70 80 90 100
AEASRRGRRG FSARGAREAA RRPSPSEAAL CLFSKVSPSP FGCGRPGSPG
110 120 130 140 150
AAELGGRSSC EDPGCPQEEE RAPRMGCMKS KFLQDRGKVS KTEPSANSHS
160 170 180 190 200
PVYVPDPTSA NKRRPDHSND NLPGSKEGPD DIIVIALYDY EAIHHEDLSF
210 220 230 240 250
QKGDQMVVLE ESGEWWKARS LTTRKEGYIP SNYVARVDSL ETEEWFFKGI
260 270 280 290 300
SRKDAERQLL APGNVLGSFM IRDSETTKGS YSLSVRDYDP QHRDSVKHYK
310 320 330 340 350
IRTLDSGGFY ISPRSTFNSL QELVAHYKKG SDGLCQKLTV PCMSSKPQKP
360 370 380 390 400
WEKDAWEIPR ESLKLEKKLG AGQFGEVWMA TYNKHTKVAV KTMKPGSMSV
410 420 430 440 450
EAFLAEANLM KTLQHDKLVK LHAVVTEEPI YIITEFMAKG SLLDFLKSSE
460 470 480 490 500
GSKQPLPKLI DFSAQIAEGM AFIEQRNYIH RDLRAANILV SASLVCKIAD
510 520 530 540 550
FGLARVIEDN EYTAREGAKF PIKWTAPEAI NFGSFTIKSD VWSFGVLLME
560 570 580 590 600
IVTYGRIPYP GMSNPEVIRA LERGYRMPRP EHCPEELYNI MTRCWKNRPE
610 620
ERPTFEYIQS VLEDFYTATE SQYQQQP
Length:627
Mass (Da):70,186
Last modified:October 31, 2012 - v2
Checksum:i9D5B89AEF75CE946
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013880 Genomic DNA. No translation available.
AAEX03013881 Genomic DNA. No translation available.
RefSeqiXP_542952.2. XM_542952.5.

Genome annotation databases

EnsembliENSCAFT00000037329; ENSCAFP00000032817; ENSCAFG00000007122.
GeneIDi485828.
KEGGicfa:485828.

Similar proteinsi

Entry informationi

Entry nameiF1PSI2_CANLF
AccessioniPrimary (citable) accession number: F1PSI2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported