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Protein

Tyrosine-protein kinase

Gene

SYK

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei400ATPUniRule annotation1
Active sitei492Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 383ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-114604. GPVI-mediated activation cascade.
R-CFA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-CFA-2029485. Role of phospholipids in phagocytosis.
R-CFA-2424491. DAP12 signaling.
R-CFA-2454202. Fc epsilon receptor (FCERI) signaling.
R-CFA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-CFA-2871796. FCERI mediated MAPK activation.
R-CFA-2871809. FCERI mediated Ca+2 mobilization.
R-CFA-354192. Integrin alphaIIb beta3 signaling.
R-CFA-9020558. Interleukin-2 signaling.
R-CFA-912631. Regulation of signaling by CBL.
R-CFA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:SYKImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:47021. SYK.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1PSC8.

Expressioni

Gene expression databases

BgeeiENSCAFG00000002171.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000003166.

Structurei

3D structure databases

ProteinModelPortaliF1PSC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 106SH2InterPro annotationAdd BLAST93
Domaini167 – 258SH2InterPro annotationAdd BLAST92
Domaini369 – 629Protein kinaseInterPro annotationAdd BLAST261

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH0T. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118799.
InParanoidiF1PSC8.
KOiK05855.
OMAiKPFNRPP.
OrthoDBiEOG091G07KU.
TreeFamiTF351629.

Family and domain databases

CDDicd09938. SH2_N-SH2_Zap70_Syk_like. 1 hit.
Gene3Di1.10.930.10. 1 hit.
3.30.505.10. 2 hits.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR023420. Kinase_SYK/ZAP-70_inter-SH2_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR035838. SYK/ZAP-70_N_SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR012234. Tyr_kinase_non-rcpt_SYK/ZAP70.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
PIRSFiPIRSF000604. TyrPK_SYK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.

Sequencei

Sequence statusi: Complete.

F1PSC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSTADSAN HLPFFFGNIT REEAEDYLVQ GGMSDGLYLL RQSRNYLGGF
60 70 80 90 100
ALSVAHGRKA HHYTIEREMN GTYAIAGGRT HGSPAELCHY HSQESDGLVC
110 120 130 140 150
LLKQPFHRPP GVQPKTGPFE DLKESLIREY VKQTWNLQGQ ALEQAIISQK
160 170 180 190 200
PQLEKLIATT AHEKMPWFHG KISRVESEQI VMIGSKTNGK FLIRDRNDNG
210 220 230 240 250
SYALCLLHEG KVLHYRIDKD KTGKLSIPDG KKFDTLWQLV EHYSYKPDGL
260 270 280 290 300
LRVLTVPCQK IGGQPGNINF GARAPLPGAH PATWSAGGII SRIKSYTFPK
310 320 330 340 350
PGHRKAASST GSRPESSFNP YEPDRGPWAT DRDAQREALP MDTEVYESPY
360 370 380 390 400
ADPEEIRPKE VYLDRKLLTL EDNELGSGNF GTVKKGYYQM KKVVKTVAVK
410 420 430 440 450
ILKNEANDPA LKDELLAEAN VMQQLDNPYI VRMIGICEAE SWMLVMEMAE
460 470 480 490 500
LGPLNKYLQQ NRHVKDKNII ELVHQVSMGM KYLEESNFVH RDLAARNVLL
510 520 530 540 550
VTQHYAKISD FGLSKALRAD ENYYKAQTHG KWPVKWYAPE CINYYKFSSK
560 570 580 590 600
SDVWSFGVLM WEAFSYGQKP YRGMKGSEVS AMLEKGERMG CPAGCPREMY
610 620 630
ELMKLCWTYE VDRRPGFEAV ELRLRNYYYD VVN
Length:633
Mass (Da):71,892
Last modified:May 3, 2011 - v1
Checksum:i887DAA6790DA5381
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000634 Genomic DNA. No translation available.
RefSeqiXP_005616010.1. XM_005615953.2.

Genome annotation databases

EnsembliENSCAFT00000003411; ENSCAFP00000003166; ENSCAFG00000002171.
KEGGicfa:484196.

Similar proteinsi

Entry informationi

Entry nameiF1PSC8_CANLF
AccessioniPrimary (citable) accession number: F1PSC8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported