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F1PNE0

- F1PNE0_CANFA

UniProt

F1PNE0 - F1PNE0_CANFA

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Protein
Submitted name:

Uncharacterized protein

Gene

PTCH1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. cholesterol binding Source: Ensembl
  2. hedgehog receptor activity Source: InterPro
  3. heparin binding Source: Ensembl

GO - Biological processi

  1. brain development Source: Ensembl
  2. branching involved in ureteric bud morphogenesis Source: Ensembl
  3. cell differentiation involved in kidney development Source: Ensembl
  4. cell proliferation involved in metanephros development Source: Ensembl
  5. cellular response to cholesterol Source: Ensembl
  6. embryonic limb morphogenesis Source: Ensembl
  7. embryonic organ development Source: Ensembl
  8. epidermis development Source: Ensembl
  9. glucose homeostasis Source: Ensembl
  10. heart morphogenesis Source: Ensembl
  11. hindlimb morphogenesis Source: Ensembl
  12. in utero embryonic development Source: Ensembl
  13. keratinocyte proliferation Source: Ensembl
  14. mammary gland duct morphogenesis Source: Ensembl
  15. mammary gland epithelial cell differentiation Source: Ensembl
  16. negative regulation of cell division Source: Ensembl
  17. negative regulation of epithelial cell proliferation Source: Ensembl
  18. negative regulation of multicellular organism growth Source: Ensembl
  19. negative regulation of osteoblast differentiation Source: Ensembl
  20. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  21. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  22. neural plate axis specification Source: Ensembl
  23. neural tube closure Source: Ensembl
  24. pharyngeal system development Source: Ensembl
  25. positive regulation of cholesterol efflux Source: Ensembl
  26. protein processing Source: Ensembl
  27. protein targeting to plasma membrane Source: Ensembl
  28. regulation of mitotic cell cycle Source: Ensembl
  29. regulation of protein localization Source: Ensembl
  30. regulation of smoothened signaling pathway Source: Ensembl
  31. response to chlorate Source: Ensembl
  32. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
  33. somite development Source: Ensembl
  34. spinal cord motor neuron differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PTCH1Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. integral component of membrane Source: InterPro
  4. midbody Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
  6. primary cilium Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119174.
InParanoidiF1PNE0.
OMAiPDRDYLH.
OrthoDBiEOG7HMS06.
TreeFamiTF106489.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1PNE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASAGNAAEP QDRGGGGGSG APGRPAGGGR RRRAGGLRRS AALDRDYLHR
60 70 80 90 100
PSYCDAAFAL EQISKGKATG RKAPLWLRAK FQRLLFKLGC YIQKNCGKFL
110 120 130 140 150
VVGLLIFGAF AVGLKAANLE TNVEELWVEV GGRVSRELNY TRQKIGEEAM
160 170 180 190 200
FNPQLMIQTP KEEGANVLTT EALRQHLDSA LQASRVHVYM YNRQWKLEHL
210 220 230 240 250
CYKSGELITE TGYMDQIIEY LYPCLIITPL DCFWEGAKLQ SGTAYLLGKP
260 270 280 290 300
PLQWTNFDPL EFLEELKKIN YQVDSWEEML NKAEVGHGYM DRPCLNPADP
310 320 330 340 350
DCPATAPNKN ATKPLDVALV LNGGCHGLSR KYMHWQEELI VGGTVKNSTG
360 370 380 390 400
KLVSAHALQT MFQLMTPKQM YEHFKGYEYV SHINWNEDKA AAILEAWQRT
410 420 430 440 450
YVEVVHQSVA PNSTQKVLSF TTTTLDDILK SFSDVSVIRV ASGYLLMLAY
460 470 480 490 500
ACLTMLRWDC SKSQGAVGLA GVLLVALSVA AGLGLCSLIG ISFNAATTQV
510 520 530 540 550
LPFLALGVGV DDVFLLAHAF SETGQNKRIP FEDRTGECLK RTGASVALTS
560 570 580 590 600
ISNVTAFFMA ALIPIPALRA FSLQAAVVVV FNFAMVLLIF PAILSMDLYR
610 620 630 640 650
REDRRLDIFC CFTSPCVSRV IQVEPQAYTE THDNTRYSPP PPYSSHSFTH
660 670 680 690 700
ETQITMQSTV QLRTEYDPHT HVYYTTAEPR SEISVQPVTM TQDTLSCQSP
710 720 730 740 750
ESTSSTRDLL SQFSDSSLHC LEPPCTKWTL SSFAEKHYAP FLLKPKAKVV
760 770 780 790 800
VIFLFLGLLG VSLYGTTRVR DGLDLTDIVP RETREYDFIA AQFKYFSFYN
810 820 830 840 850
MYIVTQKADY PNIQHLLYDL HKSFSNVKYV MLEENKQLPK MWLHYFRDWL
860 870 880 890 900
QGLQDAFDSD WETGKSCNKF KKGSDDGVLA YKLLVQTGSR DKPIDISQLT
910 920 930 940 950
KQRLVDAHGI INPSAFYIYL TAWVSNDPVA YAASQANIRP HRPEWVHDKA
960 970 980 990 1000
DYMPETRLRI PAAEPIEYAQ FPFYLNGLRD TSDFVEAIEK VRSICNNYTS
1010 1020 1030 1040 1050
LGLSSYPNGY PFLFWEQYIG LRHWLLLSVS VVLACTFLVC AVFLLNPWTA
1060 1070 1080 1090 1100
GIIVTVLALM TVELFGMMGL IGIKLSAVPV VILIASVGIG VEFTVHVALA
1110 1120 1130 1140 1150
FLTAIGDKNR RAVLALEHMF APVLDGAVST LLGVLMLAGS EFDFIVRYFF
1160 1170 1180 1190 1200
AVLAILTILG VLNGLVLLPV LLSFFGPYPE VSPANGLNRL PTPSPEPPPS
1210 1220 1230 1240 1250
VVRFAVPPSH ANNGSDSSDS EYSSQTTVSG ISEELRHYEA QQGTRGPAHQ
1260 1270 1280 1290 1300
VIVEATENPV FARSTVVHPE ARHHPPSNPR QQPPLDSEPL PPGRPGQQPR
1310 1320 1330 1340 1350
REPPREGLRP PPYRPRRDAF EISTDGHPGP GSRDRAGPRG ARSNNPRHPV
1360 1370 1380 1390 1400
FTAMGSSAPS YCQPITTVTA SASVTVAVHP PPAPGPGSAW NPRGGLCPGY
1410 1420 1430 1440
GDCPETDHRL FEDPHVPFNV RCERRDSKVE VIELQDVECE ERPRGGSSN
Length:1,449
Mass (Da):160,645
Last modified:October 31, 2012 - v2
Checksum:iF5B9B749D2C82E6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03000490 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCAFT00000001978; ENSCAFP00000001826; ENSCAFG00000001246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEX03000490 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000001978 ; ENSCAFP00000001826 ; ENSCAFG00000001246 .

Phylogenomic databases

GeneTreei ENSGT00760000119174.
InParanoidi F1PNE0.
OMAi PDRDYLH.
OrthoDBi EOG7HMS06.
TreeFami TF106489.

Family and domain databases

InterProi IPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view ]
Pfami PF02460. Patched. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00918. 2A060602. 1 hit.
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiF1PNE0_CANFA
AccessioniPrimary (citable) accession number: F1PNE0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: October 29, 2014
This is version 18 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3