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F1PNE0

- F1PNE0_CANFA

UniProt

F1PNE0 - F1PNE0_CANFA

Protein
Submitted name:

Uncharacterized protein

Gene

PTCH1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 2 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cholesterol binding Source: Ensembl
    2. hedgehog receptor activity Source: InterPro
    3. heparin binding Source: Ensembl

    GO - Biological processi

    1. brain development Source: Ensembl
    2. branching involved in ureteric bud morphogenesis Source: Ensembl
    3. cell differentiation involved in kidney development Source: Ensembl
    4. cell proliferation involved in metanephros development Source: Ensembl
    5. cellular response to cholesterol Source: Ensembl
    6. embryonic limb morphogenesis Source: Ensembl
    7. epidermis development Source: Ensembl
    8. glucose homeostasis Source: Ensembl
    9. heart morphogenesis Source: Ensembl
    10. hindlimb morphogenesis Source: Ensembl
    11. keratinocyte proliferation Source: Ensembl
    12. mammary gland duct morphogenesis Source: Ensembl
    13. mammary gland epithelial cell differentiation Source: Ensembl
    14. negative regulation of cell division Source: Ensembl
    15. negative regulation of epithelial cell proliferation Source: Ensembl
    16. negative regulation of multicellular organism growth Source: Ensembl
    17. negative regulation of osteoblast differentiation Source: Ensembl
    18. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    19. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    20. neural plate axis specification Source: Ensembl
    21. neural tube closure Source: Ensembl
    22. pharyngeal system development Source: Ensembl
    23. positive regulation of cholesterol efflux Source: Ensembl
    24. protein processing Source: Ensembl
    25. protein targeting to plasma membrane Source: Ensembl
    26. regulation of mitotic cell cycle Source: Ensembl
    27. regulation of protein localization Source: Ensembl
    28. regulation of smoothened signaling pathway Source: Ensembl
    29. response to chlorate Source: Ensembl
    30. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
    31. somite development Source: Ensembl
    32. spinal cord motor neuron differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:PTCH1Imported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. Golgi apparatus Source: Ensembl
    3. integral component of membrane Source: InterPro
    4. midbody Source: Ensembl
    5. perinuclear region of cytoplasm Source: Ensembl
    6. primary cilium Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00680000099777.
    OMAiPDRDYLH.
    OrthoDBiEOG7HMS06.
    TreeFamiTF106489.

    Family and domain databases

    InterProiIPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view]
    PfamiPF02460. Patched. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00918. 2A060602. 1 hit.
    PROSITEiPS50156. SSD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1PNE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAGNAAEP QDRGGGGGSG APGRPAGGGR RRRAGGLRRS AALDRDYLHR     50
    PSYCDAAFAL EQISKGKATG RKAPLWLRAK FQRLLFKLGC YIQKNCGKFL 100
    VVGLLIFGAF AVGLKAANLE TNVEELWVEV GGRVSRELNY TRQKIGEEAM 150
    FNPQLMIQTP KEEGANVLTT EALRQHLDSA LQASRVHVYM YNRQWKLEHL 200
    CYKSGELITE TGYMDQIIEY LYPCLIITPL DCFWEGAKLQ SGTAYLLGKP 250
    PLQWTNFDPL EFLEELKKIN YQVDSWEEML NKAEVGHGYM DRPCLNPADP 300
    DCPATAPNKN ATKPLDVALV LNGGCHGLSR KYMHWQEELI VGGTVKNSTG 350
    KLVSAHALQT MFQLMTPKQM YEHFKGYEYV SHINWNEDKA AAILEAWQRT 400
    YVEVVHQSVA PNSTQKVLSF TTTTLDDILK SFSDVSVIRV ASGYLLMLAY 450
    ACLTMLRWDC SKSQGAVGLA GVLLVALSVA AGLGLCSLIG ISFNAATTQV 500
    LPFLALGVGV DDVFLLAHAF SETGQNKRIP FEDRTGECLK RTGASVALTS 550
    ISNVTAFFMA ALIPIPALRA FSLQAAVVVV FNFAMVLLIF PAILSMDLYR 600
    REDRRLDIFC CFTSPCVSRV IQVEPQAYTE THDNTRYSPP PPYSSHSFTH 650
    ETQITMQSTV QLRTEYDPHT HVYYTTAEPR SEISVQPVTM TQDTLSCQSP 700
    ESTSSTRDLL SQFSDSSLHC LEPPCTKWTL SSFAEKHYAP FLLKPKAKVV 750
    VIFLFLGLLG VSLYGTTRVR DGLDLTDIVP RETREYDFIA AQFKYFSFYN 800
    MYIVTQKADY PNIQHLLYDL HKSFSNVKYV MLEENKQLPK MWLHYFRDWL 850
    QGLQDAFDSD WETGKSCNKF KKGSDDGVLA YKLLVQTGSR DKPIDISQLT 900
    KQRLVDAHGI INPSAFYIYL TAWVSNDPVA YAASQANIRP HRPEWVHDKA 950
    DYMPETRLRI PAAEPIEYAQ FPFYLNGLRD TSDFVEAIEK VRSICNNYTS 1000
    LGLSSYPNGY PFLFWEQYIG LRHWLLLSVS VVLACTFLVC AVFLLNPWTA 1050
    GIIVTVLALM TVELFGMMGL IGIKLSAVPV VILIASVGIG VEFTVHVALA 1100
    FLTAIGDKNR RAVLALEHMF APVLDGAVST LLGVLMLAGS EFDFIVRYFF 1150
    AVLAILTILG VLNGLVLLPV LLSFFGPYPE VSPANGLNRL PTPSPEPPPS 1200
    VVRFAVPPSH ANNGSDSSDS EYSSQTTVSG ISEELRHYEA QQGTRGPAHQ 1250
    VIVEATENPV FARSTVVHPE ARHHPPSNPR QQPPLDSEPL PPGRPGQQPR 1300
    REPPREGLRP PPYRPRRDAF EISTDGHPGP GSRDRAGPRG ARSNNPRHPV 1350
    FTAMGSSAPS YCQPITTVTA SASVTVAVHP PPAPGPGSAW NPRGGLCPGY 1400
    GDCPETDHRL FEDPHVPFNV RCERRDSKVE VIELQDVECE ERPRGGSSN 1449
    Length:1,449
    Mass (Da):160,645
    Last modified:October 31, 2012 - v2
    Checksum:iF5B9B749D2C82E6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03000490 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSCAFT00000001978; ENSCAFP00000001826; ENSCAFG00000001246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03000490 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000001978 ; ENSCAFP00000001826 ; ENSCAFG00000001246 .

    Phylogenomic databases

    GeneTreei ENSGT00680000099777.
    OMAi PDRDYLH.
    OrthoDBi EOG7HMS06.
    TreeFami TF106489.

    Family and domain databases

    InterProi IPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view ]
    Pfami PF02460. Patched. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00918. 2A060602. 1 hit.
    PROSITEi PS50156. SSD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
      Broad Sequencing Platform
      Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
      , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
      Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BoxerImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.

    Entry informationi

    Entry nameiF1PNE0_CANFA
    AccessioniPrimary (citable) accession number: F1PNE0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3