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Protein
Submitted name:

Coagulation factor XIII A chain

Gene

F13A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Cofactori

Ca2+UniRule annotationNote: Binds 1 Ca2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei316UniRule annotation1
Active sitei375UniRule annotation1
Active sitei398UniRule annotation1
Metal bindingi438CalciumUniRule annotation1
Metal bindingi440CalciumUniRule annotation1
Metal bindingi487CalciumUniRule annotation1
Metal bindingi492CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-CFA-114608 Platelet degranulation
R-CFA-140875 Common Pathway of Fibrin Clot Formation

Names & Taxonomyi

Protein namesi
Submitted name:
Coagulation factor XIII A chainImported
Gene namesi
Name:F13A1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 35

Organism-specific databases

VGNCiVGNC:40545 F13A1

PTM / Processingi

Proteomic databases

PaxDbiF1PKX3
PRIDEiF1PKX3

Expressioni

Gene expression databases

BgeeiENSCAFG00000009509

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013985

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 401TGcInterPro annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00760000119108
InParanoidiF1PKX3
KOiK03917
OMAiCEEDAVY
OrthoDBiEOG091G030K
TreeFamiTF324278

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR034810 Factor_XIII_A
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PANTHERiPTHR11590:SF42 PTHR11590:SF42, 1 hit
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequencei

Sequence statusi: Complete.

F1PKX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETSGPAFG GRRALPRNAS NAAEDDLPTV ELQGGPVPRG VNLQDYLHVT
60 70 80 90 100
NIHLFKERWD TNKVDHHTDK YENNKLIVRR GQSFFIQIDF NRPYDPRRDL
110 120 130 140 150
FRVEYVIGRY PQENKGTYIP VPIVPELQRG KWGAKVIMRE NRSVRLSIQS
160 170 180 190 200
SPECIVGKFR MYVAVWTPYG ILRTSRNPET DTYILFNPWC EEDAVYLDGD
210 220 230 240 250
KEREEYVLND IGVIFYGDFN DIKSRSWSYG QFEDGILDAC LYVMDKAQMD
260 270 280 290 300
LSGRGNPIKV SRVGSAMVNA KDDEGVLVGS WDNIYAYGVP PSAWTGSVDI
310 320 330 340 350
LLEYQSTKSP VRYGQCWVFA GVFNTFLRCL GIPARVITNY FSAHDNDANL
360 370 380 390 400
QMDIFLEEDG NVNSKLTKDS VWNYHCWNEA WMTRPDLPVG FGGWQAVDST
410 420 430 440 450
PQENSDGMYR CGPASVQAIK HGHICFQFDA PFVFAEVNSD LIYITAKKDG
460 470 480 490 500
THVVETVDTT HIGKLIVTKE VGGDGIKDIT DTYKFQEGQE EERLALETAL
510 520 530 540 550
MYGAKKPLNI EGILKPRSDV DMNFDVENAV LGRDFKLTIT FQNNSPRRYT
560 570 580 590 600
LLAYLSGNIV FYTGVSKTEF KKETFEVTLE PLSFKREEVL IRAGEYMGQL
610 620 630 640 650
LEQAYLHFFV TARVNESKDI LAKQKSTVLT IPQLIIKVRG AKMVGSDMVV
660 670 680 690 700
TVEFTNPLKE TLRNVWIHLD GPGVIKPMRK MFREIQPSAT IQWEEVCRPW
710 720 730
VSGPRKLIAS MTSDSLRHVY GELNLQIQRR PSA
Length:733
Mass (Da):83,388
Last modified:October 31, 2012 - v2
Checksum:i2DC58958026EF078
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03017502 Genomic DNA No translation available.
AAEX03017503 Genomic DNA No translation available.
AAEX03017504 Genomic DNA No translation available.
AAEX03017505 Genomic DNA No translation available.
RefSeqiXP_535876.2, XM_535876.5

Genome annotation databases

EnsembliENSCAFT00000015113; ENSCAFP00000013985; ENSCAFG00000009509
KEGGicfa:478711

Similar proteinsi

Entry informationi

Entry nameiF1PKX3_CANLF
AccessioniPrimary (citable) accession number: F1PKX3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: April 25, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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