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Protein
Submitted name:

Stromal interaction molecule 1

Gene

STIM1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-5578775 Ion homeostasis
R-CFA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Submitted name:
Stromal interaction molecule 1Imported
Gene namesi
Name:STIM1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:46901 STIM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei214 – 232HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500327171323 – 685Sequence analysisAdd BLAST663

Proteomic databases

PaxDbiF1PIS1

Expressioni

Gene expression databases

BgeeiENSCAFG00000005895

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000008827

Structurei

3D structure databases

ProteinModelPortaliF1PIS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 190SAMInterPro annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili251 – 310Sequence analysisAdd BLAST60
Coiled coili314 – 341Sequence analysisAdd BLAST28
Coiled coili366 – 386Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4403 Eukaryota
ENOG410XRM6 LUCA
GeneTreeiENSGT00390000000214
InParanoidiF1PIS1
OMAiPKPPQMV
OrthoDBiEOG091G0CO0
TreeFamiTF313487

Family and domain databases

CDDicd09573 SAM_STIM1, 1 hit
cd11722 SOAR, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032393 SOAR
IPR037608 STIM
IPR037609 STIM1_SAM
IPR030463 STM1
PANTHERiPTHR15136 PTHR15136, 1 hit
PTHR15136:SF9 PTHR15136:SF9, 1 hit
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF16533 SOAR, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

F1PIS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVCARVALW LLWGLLLHHG QSFSHSHSEK ATGAGSGATS EESTAAEFCR
60 70 80 90 100
IDKPLCHSED EKLSFDAVRS IHKLMDDDAN GDVDVEESDE FLREDLNYHD
110 120 130 140 150
PTVKHSTFHG EDKLISVEDL WKAWKSSEVY NWTVDEVVQW LITYVELPQY
160 170 180 190 200
EETFRKLQLS GHAMPRLAVT NTTMTGTVLK MTDRSHRQKL QLKALDTVLF
210 220 230 240 250
GPPLLTRHNH LKDFMLVVSI VIGVGGCWFA YIQNRYSKEH MKKMMKDLEG
260 270 280 290 300
LHRAEQSLHD LQERLHKAQE EHRTVEVEKV HLEKKLRDEI NLAKQEAQRL
310 320 330 340 350
KELREGTENE RSRQKYAEEE LEQVREALRK AEKELESHSS WYAPEALQKW
360 370 380 390 400
LQLTHEVEVQ YYNIKKQNAE KQLLVAKEGA EKIKKKRNTL FGTFHVAHSS
410 420 430 440 450
SLDDVDHKIL TAKQALSEVT AALRERLHRW QQIEILCGFQ IVNNPGIHSL
460 470 480 490 500
VAALNIDPSW MGSTRPNPAH FIMTDDVDDM DEEIVSPLSM QSPTLQCSVR
510 520 530 540 550
QRLTEPQHGL GSQRDLTLSD SESSLHMSDR QRLVPKPPQM VRAVDEALSA
560 570 580 590 600
MTSNGSHRLI EGVHPGSLVE KLPDSPALAK KALLALNHGL DKAHSLMELS
610 620 630 640 650
PSAPPGGSPL LDSSRSHSSS SPDPDMPSPI GDSRAQQASR NTRIPHLAGK
660 670 680
KAVADEDNGS IGEETDSSPG RKKFPLKIFK KPLKK
Length:685
Mass (Da):77,383
Last modified:October 31, 2012 - v2
Checksum:i2698D2396D0AD232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03012833 Genomic DNA No translation available.
AAEX03012834 Genomic DNA No translation available.
AAEX03012835 Genomic DNA No translation available.
AAEX03012836 Genomic DNA No translation available.
RefSeqiXP_850663.1, XM_845570.4

Genome annotation databases

EnsembliENSCAFT00000009508; ENSCAFP00000008827; ENSCAFG00000005895
GeneIDi608643

Similar proteinsi

Entry informationi

Entry nameiF1PIS1_CANLF
AccessioniPrimary (citable) accession number: F1PIS1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: May 23, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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