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Protein
Submitted name:

Adaptor related protein complex 2 alpha 1 subunit

Gene

AP2A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiR-CFA-177504. Retrograde neurotrophin signalling.
R-CFA-2132295. MHC class II antigen presentation.
R-CFA-3928665. EPH-ephrin mediated repulsion of cells.
R-CFA-416993. Trafficking of GluR2-containing AMPA receptors.
R-CFA-437239. Recycling pathway of L1.
R-CFA-5099900. WNT5A-dependent internalization of FZD4.
R-CFA-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
R-CFA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-CFA-8856828. Clathrin-mediated endocytosis.
R-CFA-8866427. VLDLR internalisation and degradation.
R-CFA-8964038. LDL clearance.

Names & Taxonomyi

Protein namesi
Submitted name:
Adaptor related protein complex 2 alpha 1 subunitImported
Gene namesi
Name:AP2A1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Subcellular locationi

Keywords - Cellular componenti

MembraneSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF1PE67.
PRIDEiF1PE67.

Expressioni

Gene expression databases

BgeeiENSCAFG00000003541.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005278.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini746 – 859Alpha_adaptinC2InterPro annotationAdd BLAST114

Phylogenomic databases

eggNOGiKOG1077. Eukaryota.
ENOG410XNQE. LUCA.
GeneTreeiENSGT00550000074757.
InParanoidiF1PE67.
OMAiDFKTCIS.
OrthoDBiEOG091G01JZ.
TreeFamiTF300308.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR013041. Clathrin_app_Ig-like_sf.
IPR009028. Coatomer/calthrin_app_sub_C.
PfamiView protein in Pfam
PF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiView protein in SMART
SM00809. Alpha_adaptinC2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

F1PE67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL
60 70 80 90 100
DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV
110 120 130 140 150
LVNSNSELIR LINNAIKNDL ASRNPTFMCL ALHCIANVGS REMGEAFAAD
160 170 180 190 200
IPRILVAGDS MDSVKQSAAL CLLRLYKASP DLVPMGEWTA RVVHLLNDQH
210 220 230 240 250
MGVVTAAVSL ITCLCKKNPD DFKTCISLAV SRLSRIVSSA STDLQDYTYY
260 270 280 290 300
FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV
310 320 330 340 350
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL
360 370 380 390 400
ESMCTLASSE FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS
410 420 430 440 450
NAKQIVSEML RYLETADYAI REEIVLKVAI LAEKYAVDYS WYVDTILNLI
460 470 480 490 500
RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA KTVFEALQAP ACHENMVKVG
510 520 530 540 550
GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL LLSTYIKFIN
560 570 580 590 600
LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE
610 620 630 640 650
EMPPFPERES SILAKLKRKK GPGAGSALDD SRRDPSSNDI NGGVEPTPST
660 670 680 690 700
VSTPSPSADL LGLRAAPPPA APPATSGAGN LLVDVFSDGP AAQPSLGPTP
710 720 730 740 750
EEAFLSELEP PAPESPMALL ADPAPAADPG PDDIGPPIPE ADELLNKFVC
760 770 780 790 800
KNNGVLFENQ LLQIGVKSEF RQNLGRMYLF YGNKTSVQFQ NFSPTVVHPG
810 820 830 840 850
DLQTQLAVQT KRVAAQVDGG AQVQQVLNIE CLRDFLTPPL LSVRFRYGGA
860 870 880 890 900
PQSLTLKLPV TINKFFQPTE MAAQDFFQRW KQLSLPQQEA QKIFKANHPM
910 920 930 940 950
IWPPLTAALL PQLLGFGSAL LDNVDPNPEN FVGAGIIQTK ALQVGCLLRL
960 970 980
EPNAQAQMYR LTLRTSKEPV SRHLCELLAQ QF
Length:982
Mass (Da):108,136
Last modified:October 31, 2012 - v2
Checksum:iDF5F0F21CFB74C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000795 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCAFT00000005702; ENSCAFP00000005278; ENSCAFG00000003541.

Similar proteinsi

Entry informationi

Entry nameiF1PE67_CANLF
AccessioniPrimary (citable) accession number: F1PE67
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: October 25, 2017
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported