ID   F1PCR0_CANLF            Unreviewed;       152 AA.
AC   F1PCR0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Microsomal glutathione S-transferase 3 {ECO:0000313|Ensembl:ENSCAFP00845034121.1};
GN   Name=MGST3 {ECO:0000313|Ensembl:ENSCAFP00845034121.1};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845034121.1, ECO:0000313|Proteomes:UP000805418};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00845034121.1}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845034121.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MAPEG family.
CC       {ECO:0000256|ARBA:ARBA00010459}.
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DR   RefSeq; NP_001239339.1; NM_001252410.1.
DR   AlphaFoldDB; F1PCR0; -.
DR   STRING; 9615.ENSCAFP00000019687; -.
DR   PaxDb; 9612-ENSCAFP00000019687; -.
DR   Ensembl; ENSCAFT00845043555.1; ENSCAFP00845034121.1; ENSCAFG00845024662.1.
DR   GeneID; 609050; -.
DR   KEGG; cfa:609050; -.
DR   CTD; 4259; -.
DR   VEuPathDB; HostDB:ENSCAFG00845024662; -.
DR   GeneTree; ENSGT00390000008608; -.
DR   OMA; ACQHLGW; -.
DR   OrthoDB; 5487436at2759; -.
DR   Reactome; R-CFA-156590; Glutathione conjugation.
DR   Reactome; R-CFA-5423646; Aflatoxin activation and detoxification.
DR   Proteomes; UP000805418; Chromosome 38.
DR   Bgee; ENSCAFG00000000798; Expressed in cardiac muscle of left ventricle and 15 other cell types or tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IBA:GO_Central.
DR   GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0004464; F:leukotriene-C4 synthase activity; IEA:Ensembl.
DR   GO; GO:0019370; P:leukotriene biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006692; P:prostanoid metabolic process; IEA:Ensembl.
DR   Gene3D; 1.20.120.550; Membrane associated eicosanoid/glutathione metabolism-like domain; 1.
DR   InterPro; IPR023352; MAPEG-like_dom_sf.
DR   InterPro; IPR001129; Membr-assoc_MAPEG.
DR   PANTHER; PTHR10250; MICROSOMAL GLUTATHIONE S-TRANSFERASE; 1.
DR   PANTHER; PTHR10250:SF27; MICROSOMAL GLUTATHIONE S-TRANSFERASE 3; 1.
DR   Pfam; PF01124; MAPEG; 1.
DR   SUPFAM; SSF161084; MAPEG domain-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000805418};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ   SEQUENCE   152 AA;  16540 MW;  1880B4D82084F54E CRC64;
     MAVLSKEYGF VVLTGAASFI MVAHLAINVS KARKKYKVEY PTMYSTDPEN GHLFNCIQRA
     HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY AYGYYTGEPS KRSRGALGSL
     ALIGLMGTTV FSAFQHLGWV KTGLGGGSKC CH
//