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Protein

Chloride intracellular channel protein

Gene

CLIC6

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel proteinUniRule annotation
Gene namesi
Name:CLIC6Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

  • Membrane UniRule annotation; Single-pass membrane protein UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF1P2Y2.

Expressioni

Gene expression databases

BgeeiENSGALG00000016020.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025760.

Structurei

3D structure databases

ProteinModelPortaliF1P2Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 249175GST C-terminalInterPro annotationAdd
BLAST

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesi

Belongs to the chloride channel CLIC family.UniRule annotation
Contains 1 GST C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG410INGY. Eukaryota.
ENOG4110FKA. LUCA.
GeneTreeiENSGT00550000074477.
InParanoidiF1P2Y2.
OMAiVKDPNDG.
OrthoDBiEOG091G0IHT.
TreeFamiTF315438.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030263. CLIC-6.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF142. PTHR11260:SF142. 2 hits.
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1P2Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FILFIPLSAL DITSRFMPAG SDGESIGNCP FSQRLFMILW LKGVIFNVTT
60 70 80 90 100
VDLKRKPADL QNLAPGTNPP FMTFDGEVKT DVNKIEEFLE EKLAPPRYPK
110 120 130 140 150
LAPKHPESNS AGNDVFAKFS AFIKNPRKDA NENLEKSLLK ALRKLDNYLN
160 170 180 190 200
SPLPDEIDAY STEEITVSCR KFLDGDELTL ADCNLLPKLH IIKKKVVAKK
210 220 230 240
YRNFDFPPEM TGISRYLNNA YARDEFTNTC PADQEIEYAY LDVAKRMKK
Length:249
Mass (Da):28,278
Last modified:June 26, 2013 - v2
Checksum:i038E39720985F86E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03001194 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSGALT00000025807; ENSGALP00000025760; ENSGALG00000016020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03001194 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF1P2Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025760.

Proteomic databases

PaxDbiF1P2Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000025807; ENSGALP00000025760; ENSGALG00000016020.

Phylogenomic databases

eggNOGiENOG410INGY. Eukaryota.
ENOG4110FKA. LUCA.
GeneTreeiENSGT00550000074477.
InParanoidiF1P2Y2.
OMAiVKDPNDG.
OrthoDBiEOG091G0IHT.
TreeFamiTF315438.

Gene expression databases

BgeeiENSGALG00000016020.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030263. CLIC-6.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF142. PTHR11260:SF142. 2 hits.
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1P2Y2_CHICK
AccessioniPrimary (citable) accession number: F1P2Y2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: September 7, 2016
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.