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F1NYM0

- F1NYM0_CHICK

UniProt

F1NYM0 - F1NYM0_CHICK

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Protein
Submitted name: Angiotensin-converting enzyme
Gene
ACE
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation
Binds 2 zinc ions per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. metallopeptidase activity Source: InterPro
  2. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_198177. Metabolism of Angiotensinogen to Angiotensins.

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin-converting enzymeImported
Gene namesi
Name:ACEImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 27

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF1NYM0.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00520000055576.
KOiK01283.
OrthoDBiEOG76HQ13.
TreeFamiTF312861.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

F1NYM0-1 [UniParc]FASTAAdd to Basket

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MPAALGLLLP WLSLVGALQP GLEPPQSDPT EAGAVFFASE YNSTAEIVLF     50
RSVSASWEYN TNLTTANAAL QVEASLEEQN FTELWGKKAK ELYGNIWSNF 100
SDPQLKKIIG SIQTLGPSNL PLDKRQQYNT ILSDMDKIYS TAKVCLDNGT 150
CWDLEPDISD IMATSRSYKK LLYAWEGWHN AAGNPLRAKY QEFVTLSNEA 200
YQMDGFEDTG SYWRSWYDST TFEDDLEHLY NQLEPLYLNL HAFVRRKLYD 250
RYGPKYINLK GPIPAHLLGN MWAQQWNNIY DLMVPYPDKP NLDVTNTMVN 300
QGWNATHMFR VSEEFFTSLG LLEMPPEFWE KSMLEKPADG REVVCHASAW 350
DFYNRKDFRI KQCTTVTMEQ LFTVHHEMGH VQYYLQYKDQ PVSFRGGANP 400
GFHEAIGDVL SLSVSTPSHL QKIGLLSSAV EDEESNINYL LKMALEKIAF 450
LPFGYLIDQW RWNVFSGRTP PSRYNYDWWY LRTKYQGICA PVSRNESNFD 500
PGAKYHIPGN TPYIRYFVSF ILQFQFHKAL CQAANHTGPL HTCDIYMSKE 550
AGAKLREVLK AGSSKSWQEI LFNLTGTDKM DAGALLEYFS PVTTWLQEQN 600
NKTNEVLGWP EFDWRPPIPE GYPEGIDKIV DEAQAKEFLS EYNSTAEVVW 650
NAYTEASWEY NTNITDHNKE VMLEKNLAMS KHTIEYGMRA RQFDPSDFQD 700
ETVTRILNKL SVLERAALPE DELKEYNTLL SDMETTYSVA KVCRENNTCH 750
PLDPDLTDIL ATSRDYNELL FAWKGWRDAS GAKIKDKYKR YVELSNKAAV 800
LNGYTDNGAY WRSLYETPTF EEDLERLYLQ LQPLYLNLHA YVRRALYNKY 850
GAEHISLKGP IPAHLLGNMW AQSWSNIFDL VMPFPDATKV DATPAMKQQG 900
WTPKMMFEES DRFFTSLGLI PMPQEFWDKS MIEKPADGRE VVCHASAWDF 950
YNRKDFRIKQ CTVVNMDDLI TVHHEMGHVQ YFLQYMDQPI SFRDGANPGF 1000
HEAIGDVMAL SVSTPKHLHS INLLDQVTEN EESDINYLMS IALDKIAFLP 1050
FGYLMDQWRW KVFDGRIKED EYNQQWWNLR LKYQGLCPPV PRSEDDFDPG 1100
AKFHIPANVP YIRYFVSFVI QFQFHQALCK AAGHTGPLHT CDIYQSKEAG 1150
KLLGDAMKLG FSKPWPEAMQ LITGQPNMSA EALMSYFEPL MTWLVKKNTE 1200
NGEVLGWPEY SWTPYAVTEF HAATDTADFL GMSVGTKQAT AGAWVLLALA 1250
LVFLITSIFL GVKLFSSRRK AFKSSSEMEL K 1281
Length:1,281
Mass (Da):147,239
Last modified:June 26, 2013 - v2
Checksum:i8D601B3C85D0A709
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03008747 Genomic DNA. No translation available.
AADN03008812 Genomic DNA. No translation available.
JX218994 mRNA. Translation: AFP83450.1.
RefSeqiNP_001161204.1. NM_001167732.1.
UniGeneiGga.3781.

Genome annotation databases

EnsembliENSGALT00000040528; ENSGALP00000039731; ENSGALG00000000498.
GeneIDi419953.
KEGGigga:419953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03008747 Genomic DNA. No translation available.
AADN03008812 Genomic DNA. No translation available.
JX218994 mRNA. Translation: AFP83450.1 .
RefSeqi NP_001161204.1. NM_001167732.1.
UniGenei Gga.3781.

3D structure databases

ProteinModelPortali F1NYM0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000040528 ; ENSGALP00000039731 ; ENSGALG00000000498 .
GeneIDi 419953.
KEGGi gga:419953.

Organism-specific databases

CTDi 1636.

Phylogenomic databases

GeneTreei ENSGT00520000055576.
KOi K01283.
OrthoDBi EOG76HQ13.
TreeFami TF312861.

Enzyme and pathway databases

Reactomei REACT_198177. Metabolism of Angiotensinogen to Angiotensins.

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 2 hits.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.
  3. Peng J., Zhang H.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiF1NYM0_CHICK
AccessioniPrimary (citable) accession number: F1NYM0
Secondary accession number(s): J7GZN9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: September 3, 2014
This is version 21 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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