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F1NYM0

- F1NYM0_CHICK

UniProt

F1NYM0 - F1NYM0_CHICK

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Protein
Submitted name:

Angiotensin-converting enzyme

Gene

ACE

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation
Binds 2 zinc ions per subunit.UniRule annotation

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
  4. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_198177. Metabolism of Angiotensinogen to Angiotensins.

Protein family/group databases

MEROPSiM02.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin-converting enzymeImported
Gene namesi
Name:ACEImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 27

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF1NYM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00520000055576.
KOiK01283.
OrthoDBiEOG76HQ13.
TreeFamiTF312861.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

F1NYM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAALGLLLP WLSLVGALQP GLEPPQSDPT EAGAVFFASE YNSTAEIVLF
60 70 80 90 100
RSVSASWEYN TNLTTANAAL QVEASLEEQN FTELWGKKAK ELYGNIWSNF
110 120 130 140 150
SDPQLKKIIG SIQTLGPSNL PLDKRQQYNT ILSDMDKIYS TAKVCLDNGT
160 170 180 190 200
CWDLEPDISD IMATSRSYKK LLYAWEGWHN AAGNPLRAKY QEFVTLSNEA
210 220 230 240 250
YQMDGFEDTG SYWRSWYDST TFEDDLEHLY NQLEPLYLNL HAFVRRKLYD
260 270 280 290 300
RYGPKYINLK GPIPAHLLGN MWAQQWNNIY DLMVPYPDKP NLDVTNTMVN
310 320 330 340 350
QGWNATHMFR VSEEFFTSLG LLEMPPEFWE KSMLEKPADG REVVCHASAW
360 370 380 390 400
DFYNRKDFRI KQCTTVTMEQ LFTVHHEMGH VQYYLQYKDQ PVSFRGGANP
410 420 430 440 450
GFHEAIGDVL SLSVSTPSHL QKIGLLSSAV EDEESNINYL LKMALEKIAF
460 470 480 490 500
LPFGYLIDQW RWNVFSGRTP PSRYNYDWWY LRTKYQGICA PVSRNESNFD
510 520 530 540 550
PGAKYHIPGN TPYIRYFVSF ILQFQFHKAL CQAANHTGPL HTCDIYMSKE
560 570 580 590 600
AGAKLREVLK AGSSKSWQEI LFNLTGTDKM DAGALLEYFS PVTTWLQEQN
610 620 630 640 650
NKTNEVLGWP EFDWRPPIPE GYPEGIDKIV DEAQAKEFLS EYNSTAEVVW
660 670 680 690 700
NAYTEASWEY NTNITDHNKE VMLEKNLAMS KHTIEYGMRA RQFDPSDFQD
710 720 730 740 750
ETVTRILNKL SVLERAALPE DELKEYNTLL SDMETTYSVA KVCRENNTCH
760 770 780 790 800
PLDPDLTDIL ATSRDYNELL FAWKGWRDAS GAKIKDKYKR YVELSNKAAV
810 820 830 840 850
LNGYTDNGAY WRSLYETPTF EEDLERLYLQ LQPLYLNLHA YVRRALYNKY
860 870 880 890 900
GAEHISLKGP IPAHLLGNMW AQSWSNIFDL VMPFPDATKV DATPAMKQQG
910 920 930 940 950
WTPKMMFEES DRFFTSLGLI PMPQEFWDKS MIEKPADGRE VVCHASAWDF
960 970 980 990 1000
YNRKDFRIKQ CTVVNMDDLI TVHHEMGHVQ YFLQYMDQPI SFRDGANPGF
1010 1020 1030 1040 1050
HEAIGDVMAL SVSTPKHLHS INLLDQVTEN EESDINYLMS IALDKIAFLP
1060 1070 1080 1090 1100
FGYLMDQWRW KVFDGRIKED EYNQQWWNLR LKYQGLCPPV PRSEDDFDPG
1110 1120 1130 1140 1150
AKFHIPANVP YIRYFVSFVI QFQFHQALCK AAGHTGPLHT CDIYQSKEAG
1160 1170 1180 1190 1200
KLLGDAMKLG FSKPWPEAMQ LITGQPNMSA EALMSYFEPL MTWLVKKNTE
1210 1220 1230 1240 1250
NGEVLGWPEY SWTPYAVTEF HAATDTADFL GMSVGTKQAT AGAWVLLALA
1260 1270 1280
LVFLITSIFL GVKLFSSRRK AFKSSSEMEL K
Length:1,281
Mass (Da):147,239
Last modified:June 26, 2013 - v2
Checksum:i8D601B3C85D0A709
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03008747 Genomic DNA. No translation available.
AADN03008812 Genomic DNA. No translation available.
JX218994 mRNA. Translation: AFP83450.1.
RefSeqiNP_001161204.1. NM_001167732.1.
UniGeneiGga.3781.

Genome annotation databases

EnsembliENSGALT00000040528; ENSGALP00000039731; ENSGALG00000000498.
GeneIDi419953.
KEGGigga:419953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03008747 Genomic DNA. No translation available.
AADN03008812 Genomic DNA. No translation available.
JX218994 mRNA. Translation: AFP83450.1 .
RefSeqi NP_001161204.1. NM_001167732.1.
UniGenei Gga.3781.

3D structure databases

ProteinModelPortali F1NYM0.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M02.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000040528 ; ENSGALP00000039731 ; ENSGALG00000000498 .
GeneIDi 419953.
KEGGi gga:419953.

Organism-specific databases

CTDi 1636.

Phylogenomic databases

GeneTreei ENSGT00520000055576.
KOi K01283.
OrthoDBi EOG76HQ13.
TreeFami TF312861.

Enzyme and pathway databases

Reactomei REACT_198177. Metabolism of Angiotensinogen to Angiotensins.

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 2 hits.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.
  3. Peng J., Zhang H.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiF1NYM0_CHICK
AccessioniPrimary (citable) accession number: F1NYM0
Secondary accession number(s): J7GZN9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: October 29, 2014
This is version 23 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3