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Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-2022377. Metabolism of Angiotensinogen to Angiotensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
Gene namesi
Name:ACEImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501011414918 – 1281Angiotensin-converting enzymeSequence analysisAdd BLAST1264

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000000498.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
GeneTreeiENSGT00520000055576.
KOiK01283.
OMAiVTMEQLF.
OrthoDBiEOG091G033S.
TreeFamiTF312861.

Family and domain databases

CDDicd06461. M2_ACE. 2 hits.
InterProiView protein in InterPro
IPR001548. Peptidase_M2.
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiView protein in Pfam
PF01401. Peptidase_M2. 2 hits.
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

F1NYM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAALGLLLP WLSLVGALQP GLEPPQSDPT EAGAVFFASE YNSTAEIVLF
60 70 80 90 100
RSVSASWEYN TNLTTANAAL QVEASLEEQN FTELWGKKAK ELYGNIWSNF
110 120 130 140 150
SDPQLKKIIG SIQTLGPSNL PLDKRQQYNT ILSDMDKIYS TAKVCLDNGT
160 170 180 190 200
CWDLEPDISD IMATSRSYKK LLYAWEGWHN AAGNPLRAKY QEFVTLSNEA
210 220 230 240 250
YQMDGFEDTG SYWRSWYDST TFEDDLEHLY NQLEPLYLNL HAFVRRKLYD
260 270 280 290 300
RYGPKYINLK GPIPAHLLGN MWAQQWNNIY DLMVPYPDKP NLDVTNTMVN
310 320 330 340 350
QGWNATHMFR VSEEFFTSLG LLEMPPEFWE KSMLEKPADG REVVCHASAW
360 370 380 390 400
DFYNRKDFRI KQCTTVTMEQ LFTVHHEMGH VQYYLQYKDQ PVSFRGGANP
410 420 430 440 450
GFHEAIGDVL SLSVSTPSHL QKIGLLSSAV EDEESNINYL LKMALEKIAF
460 470 480 490 500
LPFGYLIDQW RWNVFSGRTP PSRYNYDWWY LRTKYQGICA PVSRNESNFD
510 520 530 540 550
PGAKYHIPGN TPYIRYFVSF ILQFQFHKAL CQAANHTGPL HTCDIYMSKE
560 570 580 590 600
AGAKLREVLK AGSSKSWQEI LFNLTGTDKM DAGALLEYFS PVTTWLQEQN
610 620 630 640 650
NKTNEVLGWP EFDWRPPIPE GYPEGIDKIV DEAQAKEFLS EYNSTAEVVW
660 670 680 690 700
NAYTEASWEY NTNITDHNKE VMLEKNLAMS KHTIEYGMRA RQFDPSDFQD
710 720 730 740 750
ETVTRILNKL SVLERAALPE DELKEYNTLL SDMETTYSVA KVCRENNTCH
760 770 780 790 800
PLDPDLTDIL ATSRDYNELL FAWKGWRDAS GAKIKDKYKR YVELSNKAAV
810 820 830 840 850
LNGYTDNGAY WRSLYETPTF EEDLERLYLQ LQPLYLNLHA YVRRALYNKY
860 870 880 890 900
GAEHISLKGP IPAHLLGNMW AQSWSNIFDL VMPFPDATKV DATPAMKQQG
910 920 930 940 950
WTPKMMFEES DRFFTSLGLI PMPQEFWDKS MIEKPADGRE VVCHASAWDF
960 970 980 990 1000
YNRKDFRIKQ CTVVNMDDLI TVHHEMGHVQ YFLQYMDQPI SFRDGANPGF
1010 1020 1030 1040 1050
HEAIGDVMAL SVSTPKHLHS INLLDQVTEN EESDINYLMS IALDKIAFLP
1060 1070 1080 1090 1100
FGYLMDQWRW KVFDGRIKED EYNQQWWNLR LKYQGLCPPV PRSEDDFDPG
1110 1120 1130 1140 1150
AKFHIPANVP YIRYFVSFVI QFQFHQALCK AAGHTGPLHT CDIYQSKEAG
1160 1170 1180 1190 1200
KLLGDAMKLG FSKPWPEAMQ LITGQPNMSA EALMSYFEPL MTWLVKKNTE
1210 1220 1230 1240 1250
NGEVLGWPEY SWTPYAVTEF HAATDTADFL GMSVGTKQAT AGAWVLLALA
1260 1270 1280
LVFLITSIFL GVKLFSSRRK AFKSSSEMEL K
Length:1,281
Mass (Da):147,239
Last modified:June 26, 2013 - v2
Checksum:i8D601B3C85D0A709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000381 Genomic DNA. No translation available.
JX218994 mRNA. Translation: AFP83450.1.
RefSeqiNP_001161204.1. NM_001167732.1.
UniGeneiGga.3781.

Genome annotation databases

EnsembliENSGALT00000040528; ENSGALP00000039731; ENSGALG00000000498.
GeneIDi419953.
KEGGigga:419953.

Similar proteinsi

Entry informationi

Entry nameiF1NYM0_CHICK
AccessioniPrimary (citable) accession number: F1NYM0
Secondary accession number(s): J7GZN9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: September 27, 2017
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported