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F1NYM0

- F1NYM0_CHICK

UniProt

F1NYM0 - F1NYM0_CHICK

Protein
Submitted name:

Angiotensin-converting enzyme

Gene

ACE

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation
    Binds 2 zinc ions per subunit.UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: InterPro
    2. peptidyl-dipeptidase activity Source: InterPro

    Keywords - Molecular functioni

    CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

    Keywords - Ligandi

    Metal-bindingUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_198177. Metabolism of Angiotensinogen to Angiotensins.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Angiotensin-converting enzymeImported
    Gene namesi
    Name:ACEImported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 27

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    GlycoproteinUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF1NYM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M2 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00520000055576.
    KOiK01283.
    OrthoDBiEOG76HQ13.
    TreeFamiTF312861.

    Family and domain databases

    InterProiIPR001548. Peptidase_M2.
    [Graphical view]
    PANTHERiPTHR10514. PTHR10514. 1 hit.
    PfamiPF01401. Peptidase_M2. 2 hits.
    [Graphical view]
    PRINTSiPR00791. PEPDIPTASEA.

    Sequencei

    Sequence statusi: Complete.

    F1NYM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAALGLLLP WLSLVGALQP GLEPPQSDPT EAGAVFFASE YNSTAEIVLF     50
    RSVSASWEYN TNLTTANAAL QVEASLEEQN FTELWGKKAK ELYGNIWSNF 100
    SDPQLKKIIG SIQTLGPSNL PLDKRQQYNT ILSDMDKIYS TAKVCLDNGT 150
    CWDLEPDISD IMATSRSYKK LLYAWEGWHN AAGNPLRAKY QEFVTLSNEA 200
    YQMDGFEDTG SYWRSWYDST TFEDDLEHLY NQLEPLYLNL HAFVRRKLYD 250
    RYGPKYINLK GPIPAHLLGN MWAQQWNNIY DLMVPYPDKP NLDVTNTMVN 300
    QGWNATHMFR VSEEFFTSLG LLEMPPEFWE KSMLEKPADG REVVCHASAW 350
    DFYNRKDFRI KQCTTVTMEQ LFTVHHEMGH VQYYLQYKDQ PVSFRGGANP 400
    GFHEAIGDVL SLSVSTPSHL QKIGLLSSAV EDEESNINYL LKMALEKIAF 450
    LPFGYLIDQW RWNVFSGRTP PSRYNYDWWY LRTKYQGICA PVSRNESNFD 500
    PGAKYHIPGN TPYIRYFVSF ILQFQFHKAL CQAANHTGPL HTCDIYMSKE 550
    AGAKLREVLK AGSSKSWQEI LFNLTGTDKM DAGALLEYFS PVTTWLQEQN 600
    NKTNEVLGWP EFDWRPPIPE GYPEGIDKIV DEAQAKEFLS EYNSTAEVVW 650
    NAYTEASWEY NTNITDHNKE VMLEKNLAMS KHTIEYGMRA RQFDPSDFQD 700
    ETVTRILNKL SVLERAALPE DELKEYNTLL SDMETTYSVA KVCRENNTCH 750
    PLDPDLTDIL ATSRDYNELL FAWKGWRDAS GAKIKDKYKR YVELSNKAAV 800
    LNGYTDNGAY WRSLYETPTF EEDLERLYLQ LQPLYLNLHA YVRRALYNKY 850
    GAEHISLKGP IPAHLLGNMW AQSWSNIFDL VMPFPDATKV DATPAMKQQG 900
    WTPKMMFEES DRFFTSLGLI PMPQEFWDKS MIEKPADGRE VVCHASAWDF 950
    YNRKDFRIKQ CTVVNMDDLI TVHHEMGHVQ YFLQYMDQPI SFRDGANPGF 1000
    HEAIGDVMAL SVSTPKHLHS INLLDQVTEN EESDINYLMS IALDKIAFLP 1050
    FGYLMDQWRW KVFDGRIKED EYNQQWWNLR LKYQGLCPPV PRSEDDFDPG 1100
    AKFHIPANVP YIRYFVSFVI QFQFHQALCK AAGHTGPLHT CDIYQSKEAG 1150
    KLLGDAMKLG FSKPWPEAMQ LITGQPNMSA EALMSYFEPL MTWLVKKNTE 1200
    NGEVLGWPEY SWTPYAVTEF HAATDTADFL GMSVGTKQAT AGAWVLLALA 1250
    LVFLITSIFL GVKLFSSRRK AFKSSSEMEL K 1281
    Length:1,281
    Mass (Da):147,239
    Last modified:June 26, 2013 - v2
    Checksum:i8D601B3C85D0A709
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03008747 Genomic DNA. No translation available.
    AADN03008812 Genomic DNA. No translation available.
    JX218994 mRNA. Translation: AFP83450.1.
    RefSeqiNP_001161204.1. NM_001167732.1.
    UniGeneiGga.3781.

    Genome annotation databases

    EnsembliENSGALT00000040528; ENSGALP00000039731; ENSGALG00000000498.
    GeneIDi419953.
    KEGGigga:419953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03008747 Genomic DNA. No translation available.
    AADN03008812 Genomic DNA. No translation available.
    JX218994 mRNA. Translation: AFP83450.1 .
    RefSeqi NP_001161204.1. NM_001167732.1.
    UniGenei Gga.3781.

    3D structure databases

    ProteinModelPortali F1NYM0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000040528 ; ENSGALP00000039731 ; ENSGALG00000000498 .
    GeneIDi 419953.
    KEGGi gga:419953.

    Organism-specific databases

    CTDi 1636.

    Phylogenomic databases

    GeneTreei ENSGT00520000055576.
    KOi K01283.
    OrthoDBi EOG76HQ13.
    TreeFami TF312861.

    Enzyme and pathway databases

    Reactomei REACT_198177. Metabolism of Angiotensinogen to Angiotensins.

    Family and domain databases

    InterProi IPR001548. Peptidase_M2.
    [Graphical view ]
    PANTHERi PTHR10514. PTHR10514. 1 hit.
    Pfami PF01401. Peptidase_M2. 2 hits.
    [Graphical view ]
    PRINTSi PR00791. PEPDIPTASEA.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      International Chicken Genome Sequencing Consortium
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Red jungle fowlImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Red jungle fowlImported.
    3. Peng J., Zhang H.
      Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiF1NYM0_CHICK
    AccessioniPrimary (citable) accession number: F1NYM0
    Secondary accession number(s): J7GZN9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 22 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3