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F1NUG0

- F1NUG0_CHICK

UniProt

F1NUG0 - F1NUG0_CHICK

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Protein
Submitted name:

Uncharacterized protein

Gene

PCSK2

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: Ensembl

GO - Biological processi

  1. enkephalin processing Source: Ensembl
  2. insulin processing Source: Ensembl
  3. nervous system development Source: Ensembl
  4. protein autoprocessing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_254277. Insulin processing.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PCSK2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation
Contains peptidase S8 domain.SAAS annotation
Contains peptidase Sdomain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00750000117358.
InParanoidiF1NUG0.
KOiK01360.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1NUG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAGPPPLLL RGAFVLLLLV LLLLSLGAPA RAAVYTNQFL VELHSGDQAE
60 70 80 90 100
AERVAADHGF GGVRKLPFLD TGYYFYHNGI AKVRRRRSFQ HKLHLEKDSR
110 120 130 140 150
VKKAVQQEGF SRRKRGYRDI NDIDINMNDP LFTKQWYLIN TGQADGTPGL
160 170 180 190 200
DLNVAEAWEL GYTGKGVTIG IMDDGIDYLH PDLASNYNAQ ASYDFSSNDP
210 220 230 240 250
YPYPRYTDDW FNSHGTRCAG EVSAAANNNI CGVGVAYNSK VAGIRMLDQP
260 270 280 290 300
FMTDIIEASS ISHMPQVIDI YSASWGPTDN GKTVDGPREL TLQAMADGVN
310 320 330 340 350
KGRGGKGSIY VWASGDGGSY DDCNCDGYAS SMWTISINSA INDGRTALYD
360 370 380 390 400
ESCSSTLAST FSNGRKRNPE AGVATTDLYG NCTLRHSGTS AAAPEAAGVF
410 420 430 440 450
ALALEANLDL TWRDMQHLTV LTSKRNQLHD EVHRWRRNGV GLEFNHLFGY
460 470 480 490 500
GVLDAGAMVK MAKDWKTVPE RFHCVGGSIQ EPEKIPPSGK LVLTLTTDAC
510 520 530 540 550
EGKENFVRYL EHVQAVITVN STRRGDLNIN MTSPMGTKSI LLSRRPRDDD
560 570 580 590 600
SKVGFDKWPF MTTHTWGEDP RGTWVLEIGF VGGVPQRGVL KEWTLMLHGT
610 620 630 640
QSAPYIDQIV KDYQSKLAMS KKEELEEELD EAVERSLKSI LSKN
Length:644
Mass (Da):71,100
Last modified:June 26, 2013 - v2
Checksum:i264888B827C8D788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03003503 Genomic DNA. No translation available.
RefSeqiXP_004940271.1. XM_004940214.1.
UniGeneiGga.50566.

Genome annotation databases

EnsembliENSGALT00000014214; ENSGALP00000014198; ENSGALG00000008734.
GeneIDi395136.
KEGGigga:395136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03003503 Genomic DNA. No translation available.
RefSeqi XP_004940271.1. XM_004940214.1.
UniGenei Gga.50566.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000014214 ; ENSGALP00000014198 ; ENSGALG00000008734 .
GeneIDi 395136.
KEGGi gga:395136.

Organism-specific databases

CTDi 5126.

Phylogenomic databases

GeneTreei ENSGT00750000117358.
InParanoidi F1NUG0.
KOi K01360.
OrthoDBi EOG7BW0JD.
TreeFami TF314277.

Enzyme and pathway databases

Reactomei REACT_254277. Insulin processing.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiF1NUG0_CHICK
AccessioniPrimary (citable) accession number: F1NUG0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: November 26, 2014
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3