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F1NUG0

- F1NUG0_CHICK

UniProt

F1NUG0 - F1NUG0_CHICK

Protein
Submitted name:

Uncharacterized protein

Gene

PCSK2

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: Ensembl

    GO - Biological processi

    1. enkephalin processing Source: Ensembl
    2. insulin processing Source: Ensembl
    3. nervous system development Source: Ensembl
    4. protein autoprocessing Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:PCSK2Imported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. membrane Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S8 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117358.
    KOiK01360.
    OrthoDBiEOG7BW0JD.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1NUG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAGPPPLLL RGAFVLLLLV LLLLSLGAPA RAAVYTNQFL VELHSGDQAE    50
    AERVAADHGF GGVRKLPFLD TGYYFYHNGI AKVRRRRSFQ HKLHLEKDSR 100
    VKKAVQQEGF SRRKRGYRDI NDIDINMNDP LFTKQWYLIN TGQADGTPGL 150
    DLNVAEAWEL GYTGKGVTIG IMDDGIDYLH PDLASNYNAQ ASYDFSSNDP 200
    YPYPRYTDDW FNSHGTRCAG EVSAAANNNI CGVGVAYNSK VAGIRMLDQP 250
    FMTDIIEASS ISHMPQVIDI YSASWGPTDN GKTVDGPREL TLQAMADGVN 300
    KGRGGKGSIY VWASGDGGSY DDCNCDGYAS SMWTISINSA INDGRTALYD 350
    ESCSSTLAST FSNGRKRNPE AGVATTDLYG NCTLRHSGTS AAAPEAAGVF 400
    ALALEANLDL TWRDMQHLTV LTSKRNQLHD EVHRWRRNGV GLEFNHLFGY 450
    GVLDAGAMVK MAKDWKTVPE RFHCVGGSIQ EPEKIPPSGK LVLTLTTDAC 500
    EGKENFVRYL EHVQAVITVN STRRGDLNIN MTSPMGTKSI LLSRRPRDDD 550
    SKVGFDKWPF MTTHTWGEDP RGTWVLEIGF VGGVPQRGVL KEWTLMLHGT 600
    QSAPYIDQIV KDYQSKLAMS KKEELEEELD EAVERSLKSI LSKN 644
    Length:644
    Mass (Da):71,100
    Last modified:June 26, 2013 - v2
    Checksum:i264888B827C8D788
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03003503 Genomic DNA. No translation available.
    RefSeqiXP_004940271.1. XM_004940214.1.
    UniGeneiGga.50566.

    Genome annotation databases

    EnsembliENSGALT00000014214; ENSGALP00000014198; ENSGALG00000008734.
    GeneIDi395136.
    KEGGigga:395136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03003503 Genomic DNA. No translation available.
    RefSeqi XP_004940271.1. XM_004940214.1.
    UniGenei Gga.50566.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000014214 ; ENSGALP00000014198 ; ENSGALG00000008734 .
    GeneIDi 395136.
    KEGGi gga:395136.

    Organism-specific databases

    CTDi 5126.

    Phylogenomic databases

    GeneTreei ENSGT00750000117358.
    KOi K01360.
    OrthoDBi EOG7BW0JD.
    TreeFami TF314277.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      International Chicken Genome Sequencing Consortium
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Red jungle fowlImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Red jungle fowlImported.

    Entry informationi

    Entry nameiF1NUG0_CHICK
    AccessioniPrimary (citable) accession number: F1NUG0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 24 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3