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Protein
Submitted name:

Uncharacterized protein

Gene

PCSK2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-GGA-264876. Insulin processing.

Protein family/group databases

MEROPSiS08.073.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PCSK2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 644612Sequence analysisPRO_5003268339Add
BLAST

Proteomic databases

PaxDbiF1NUG0.

Expressioni

Gene expression databases

BgeeiENSGALG00000008734.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 11578S8_pro-domainInterPro annotationAdd
BLAST
Domaini164 – 426263Peptidase S8InterPro annotationAdd
BLAST
Domaini510 – 59687P_proproteinInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation
Contains peptidase S8 domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
KOG3526. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
InParanoidiF1NUG0.
KOiK01360.
OMAiDAFPYPR.
OrthoDBiEOG091G05HI.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1NUG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGPPPLLL RGAFVLLLLV LLLLSLGAPA RAAVYTNQFL VELHSGDQAE
60 70 80 90 100
AERVAADHGF GGVRKLPFLD TGYYFYHNGI AKVRRRRSFQ HKLHLEKDSR
110 120 130 140 150
VKKAVQQEGF SRRKRGYRDI NDIDINMNDP LFTKQWYLIN TGQADGTPGL
160 170 180 190 200
DLNVAEAWEL GYTGKGVTIG IMDDGIDYLH PDLASNYNAQ ASYDFSSNDP
210 220 230 240 250
YPYPRYTDDW FNSHGTRCAG EVSAAANNNI CGVGVAYNSK VAGIRMLDQP
260 270 280 290 300
FMTDIIEASS ISHMPQVIDI YSASWGPTDN GKTVDGPREL TLQAMADGVN
310 320 330 340 350
KGRGGKGSIY VWASGDGGSY DDCNCDGYAS SMWTISINSA INDGRTALYD
360 370 380 390 400
ESCSSTLAST FSNGRKRNPE AGVATTDLYG NCTLRHSGTS AAAPEAAGVF
410 420 430 440 450
ALALEANLDL TWRDMQHLTV LTSKRNQLHD EVHRWRRNGV GLEFNHLFGY
460 470 480 490 500
GVLDAGAMVK MAKDWKTVPE RFHCVGGSIQ EPEKIPPSGK LVLTLTTDAC
510 520 530 540 550
EGKENFVRYL EHVQAVITVN STRRGDLNIN MTSPMGTKSI LLSRRPRDDD
560 570 580 590 600
SKVGFDKWPF MTTHTWGEDP RGTWVLEIGF VGGVPQRGVL KEWTLMLHGT
610 620 630 640
QSAPYIDQIV KDYQSKLAMS KKEELEEELD EAVERSLKSI LSKN
Length:644
Mass (Da):71,100
Last modified:June 26, 2013 - v2
Checksum:i264888B827C8D788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03003503 Genomic DNA. No translation available.
RefSeqiXP_004940271.1. XM_004940214.2.
UniGeneiGga.50566.

Genome annotation databases

EnsembliENSGALT00000014214; ENSGALP00000014198; ENSGALG00000008734.
GeneIDi395136.
KEGGigga:395136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03003503 Genomic DNA. No translation available.
RefSeqiXP_004940271.1. XM_004940214.2.
UniGeneiGga.50566.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014198.

Protein family/group databases

MEROPSiS08.073.

Proteomic databases

PaxDbiF1NUG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000014214; ENSGALP00000014198; ENSGALG00000008734.
GeneIDi395136.
KEGGigga:395136.

Organism-specific databases

CTDi5126.

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
KOG3526. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
InParanoidiF1NUG0.
KOiK01360.
OMAiDAFPYPR.
OrthoDBiEOG091G05HI.
TreeFamiTF314277.

Enzyme and pathway databases

ReactomeiR-GGA-264876. Insulin processing.

Gene expression databases

BgeeiENSGALG00000008734.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1NUG0_CHICK
AccessioniPrimary (citable) accession number: F1NUG0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: September 7, 2016
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.