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F1NPV5

- F1NPV5_CHICK

UniProt

F1NPV5 - F1NPV5_CHICK

Protein
Submitted name:

Secreted frizzled-related protein 1

Gene

SFRP1

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: Ensembl
    2. drug binding Source: Ensembl
    3. heparin binding Source: Ensembl

    GO - Biological processi

    1. apoptotic DNA fragmentation Source: Ensembl
    2. bone trabecula formation Source: Ensembl
    3. canonical Wnt signaling pathway Source: Ensembl
    4. cellular response to BMP stimulus Source: Ensembl
    5. cellular response to estradiol stimulus Source: Ensembl
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to heparin Source: Ensembl
    8. cellular response to hypoxia Source: Ensembl
    9. cellular response to interleukin-1 Source: Ensembl
    10. cellular response to prostaglandin E stimulus Source: Ensembl
    11. cellular response to starvation Source: Ensembl
    12. cellular response to transforming growth factor beta stimulus Source: Ensembl
    13. cellular response to tumor necrosis factor Source: Ensembl
    14. cellular response to vitamin D Source: Ensembl
    15. cellular response to X-ray Source: Ensembl
    16. convergent extension involved in somitogenesis Source: Ensembl
    17. digestive tract morphogenesis Source: Ensembl
    18. dorsal/ventral axis specification Source: Ensembl
    19. female gonad development Source: Ensembl
    20. hematopoietic stem cell differentiation Source: Ensembl
    21. male gonad development Source: Ensembl
    22. menstrual cycle phase Source: Ensembl
    23. negative regulation of androgen receptor signaling pathway Source: Ensembl
    24. negative regulation of B cell differentiation Source: Ensembl
    25. negative regulation of BMP signaling pathway Source: Ensembl
    26. negative regulation of bone remodeling Source: Ensembl
    27. negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Source: Ensembl
    28. negative regulation of cell growth Source: Ensembl
    29. negative regulation of cell migration Source: Ensembl
    30. negative regulation of cysteine-type endopeptidase activity Source: Ensembl
    31. negative regulation of epithelial cell proliferation Source: Ensembl
    32. negative regulation of epithelial to mesenchymal transition Source: Ensembl
    33. negative regulation of fibroblast apoptotic process Source: Ensembl
    34. negative regulation of fibroblast proliferation Source: Ensembl
    35. negative regulation of insulin secretion Source: Ensembl
    36. negative regulation of JUN kinase activity Source: Ensembl
    37. negative regulation of ossification Source: Ensembl
    38. negative regulation of osteoblast differentiation Source: Ensembl
    39. negative regulation of osteoblast proliferation Source: Ensembl
    40. negative regulation of osteoclast differentiation Source: Ensembl
    41. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    42. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
    43. negative regulation of transcription, DNA-templated Source: Ensembl
    44. negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: Ensembl
    45. neural crest cell fate commitment Source: Ensembl
    46. neural tube closure Source: Ensembl
    47. osteoblast differentiation Source: Ensembl
    48. planar cell polarity pathway involved in neural tube closure Source: Ensembl
    49. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    50. positive regulation of cell growth Source: Ensembl
    51. positive regulation of epithelial cell proliferation Source: Ensembl
    52. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    53. positive regulation of fat cell differentiation Source: Ensembl
    54. positive regulation of fibroblast apoptotic process Source: Ensembl
    55. positive regulation of non-canonical Wnt signaling pathway Source: Ensembl
    56. positive regulation of smoothened signaling pathway Source: Ensembl
    57. positive regulation of transcription, DNA-templated Source: Ensembl
    58. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
    59. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    60. regulation of cell cycle process Source: Ensembl
    61. response to drug Source: Ensembl
    62. somatic stem cell maintenance Source: Ensembl
    63. stromal-epithelial cell signaling involved in prostate gland development Source: Ensembl
    64. ureteric bud development Source: Ensembl
    65. Wnt signaling pathway involved in somitogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_203925. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Secreted frizzled-related protein 1Imported
    Gene namesi
    Name:SFRP1Imported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 22

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytosol Source: Ensembl
    3. extracellular space Source: Ensembl
    4. proteinaceous extracellular matrix Source: Ensembl

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains FZ (frizzled) domain.SAAS annotation
    Contains NTR domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117588.
    OMAiDDVCIAM.
    OrthoDBiEOG789CBZ.
    TreeFamiTF350133.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026559. SFRP1.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF46. PTHR11309:SF46. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    F1NPV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    AVGVAMGRVR GALRALLSLA AGLLACGGAS EYDYVSYQSD LGPYPGGRFY    50
    TKPHQCVAIP ADLRLCHSVG YDKMVLPNLL DHETMAEVKH QASSWVPLLN 100
    KNCHMGTQVF LCSLFAPVCL DRPVYPCRWL CEAVRDSCEP VMQFFGFFWP 150
    EMLKCDQFPQ DDVCIAMTTP NATEVSRPKG TTVCPPCDNE MKSEAIVEHL 200
    CASEFALKMT IKEVKKENGD KVIIPRKRKA LKLGPIRKKN LKKLVLLLKN 250
    GADCPCHQLD NLGHHFLIMG RQVKTQHLLT AIYKWDKKNK EFKKFMKKVK 300
    APDCPTFPSV FK 312
    Length:312
    Mass (Da):35,047
    Last modified:May 3, 2011 - v1
    Checksum:i037CD606ED3B17A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03008089 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSGALT00000005499; ENSGALP00000005489; ENSGALG00000003473.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03008089 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000005499 ; ENSGALP00000005489 ; ENSGALG00000003473 .

    Phylogenomic databases

    GeneTreei ENSGT00750000117588.
    OMAi DDVCIAM.
    OrthoDBi EOG789CBZ.
    TreeFami TF350133.

    Enzyme and pathway databases

    Reactomei REACT_203925. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026559. SFRP1.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF46. PTHR11309:SF46. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      International Chicken Genome Sequencing Consortium
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Red jungle fowlImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Red jungle fowlImported.

    Entry informationi

    Entry nameiF1NPV5_CHICK
    AccessioniPrimary (citable) accession number: F1NPV5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3