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Protein
Submitted name:

Secreted frizzled-related protein 1

Gene

SFRP1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation
Biological processWnt signaling pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Secreted frizzled-related protein 1Imported
Gene namesi
Name:SFRP1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 22

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_500968999235 – 315Sequence analysisAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 115PROSITE-ProRule annotation
Disulfide bondi134 ↔ 158PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiF1NPV5.

Expressioni

Gene expression databases

BgeeiENSGALG00000003473.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 170FZ (frizzled)InterPro annotationAdd BLAST117
Domaini187 – 307NTRInterPro annotationAdd BLAST121

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
OrthoDBiEOG091G0F7I.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF101. PTHR11309:SF101. 1 hit.
PfamiView protein in Pfam
PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
SMARTiView protein in SMART
SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Complete.

F1NPV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CRGRCRRGGG RVRGALRALL SLAAGLLACG GASEYDYVSY QSDLGPYPGG
60 70 80 90 100
RFYTKPHQCV AIPADLRLCH SVGYDKMVLP NLLDHETMAE VKHQASSWVP
110 120 130 140 150
LLNKNCHMGT QVFLCSLFAP VCLDRPVYPC RWLCEAVRDS CEPVMQFFGF
160 170 180 190 200
FWPEMLKCDQ FPQDDVCIAM TTPNATEVSR PKGTTVCPPC DNEMKSEAIV
210 220 230 240 250
EHLCASEFAL KMTIKEVKKE NGDKVIIPRK RKALKLGPIR KKNLKKLVLL
260 270 280 290 300
LKNGADCPCH QLDNLGHHFL IMGRQVKTQH LLTAIYKWDK KNKEFKKFMK
310
KVKAPDCPTF PSVFK
Length:315
Mass (Da):35,521
Last modified:February 15, 2017 - v3
Checksum:iB1791FC13252F9FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000387 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSGALT00000005499; ENSGALP00000005489; ENSGALG00000003473.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF1NPV5_CHICK
AccessioniPrimary (citable) accession number: F1NPV5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: February 15, 2017
Last modified: July 5, 2017
This is version 54 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported