F1NPV5 (F1NPV5_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Secreted frizzled-related protein 1 Ensembl ENSGALP00000005489

Gene names

Name:

SFRP1 Ensembl ENSGALP00000005489

Organism

Gallus gallus (Chicken) [Reference proteome] Ensembl ENSGALP00000005489

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	312 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities	Contains 1 FZ (frizzled) domain. SAAS SAAS015526 Contains 1 NTR domain.
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSGALP00000005489

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS015526
Cellular component	Secreted SAAS SAAS008993
Molecular function	Developmental protein SAAS SAAS015526
PTM	Disulfide bond SAAS SAAS015526
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway involved in somitogenesis Inferred from electronic annotation. Source: Compara apoptotic DNA fragmentation Inferred from electronic annotation. Source: Compara bone trabecula formation Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cellular response to BMP stimulus Inferred from electronic annotation. Source: Compara cellular response to X-ray Inferred from electronic annotation. Source: Compara cellular response to estradiol stimulus Inferred from electronic annotation. Source: Compara cellular response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to heparin Inferred from electronic annotation. Source: Compara cellular response to hypoxia Inferred from electronic annotation. Source: Compara cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cellular response to prostaglandin E stimulus Inferred from electronic annotation. Source: Compara cellular response to starvation Inferred from electronic annotation. Source: Compara cellular response to transforming growth factor beta stimulus Inferred from electronic annotation. Source: Compara cellular response to tumor necrosis factor Inferred from electronic annotation. Source: Compara cellular response to vitamin D Inferred from electronic annotation. Source: Compara convergent extension involved in somitogenesis Inferred from electronic annotation. Source: Compara digestive tract morphogenesis Inferred from electronic annotation. Source: Compara dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara female gonad development Inferred from electronic annotation. Source: Compara hematopoietic progenitor cell differentiation Inferred from electronic annotation. Source: Compara hematopoietic stem cell differentiation Inferred from electronic annotation. Source: Compara male gonad development Inferred from electronic annotation. Source: Compara menstrual cycle phase Inferred from electronic annotation. Source: Compara negative regulation of B cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of JUN kinase activity Inferred from electronic annotation. Source: Compara negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara negative regulation of androgen receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of bone remodeling Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cysteine-type endopeptidase activity Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of epithelial to mesenchymal transition Inferred from electronic annotation. Source: Compara negative regulation of fibroblast apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara negative regulation of insulin secretion Inferred from electronic annotation. Source: Compara negative regulation of ossification Inferred from electronic annotation. Source: Compara negative regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara negative regulation of osteoblast proliferation Inferred from electronic annotation. Source: Compara negative regulation of osteoclast differentiation Inferred from electronic annotation. Source: Compara negative regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in axis elongation Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara neural crest cell fate commitment Inferred from electronic annotation. Source: Compara neural tube closure Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in neural tube closure Inferred from electronic annotation. Source: Compara positive regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of fat cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of fibroblast apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of non-canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from electronic annotation. Source: Compara regulation of branching involved in prostate gland morphogenesis Inferred from electronic annotation. Source: Compara regulation of cell cycle process Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara somatic stem cell maintenance Inferred from electronic annotation. Source: Compara stromal-epithelial cell signaling involved in prostate gland development Inferred from electronic annotation. Source: Compara ureteric bud development Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara proteinaceous extracellular matrix Inferred from electronic annotation. Source: Compara
Molecular_function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: Compara drug binding Inferred from electronic annotation. Source: Compara heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	Ensembl ENSGALP00000005489

Sequences

	Sequence		Length	Mass (Da)
	F1NPV5 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 037CD606ED3B17A0	FASTA	312	35,047
	10 20 30 40 50 60 AVGVAMGRVR GALRALLSLA AGLLACGGAS EYDYVSYQSD LGPYPGGRFY TKPHQCVAIP 70 80 90 100 110 120 ADLRLCHSVG YDKMVLPNLL DHETMAEVKH QASSWVPLLN KNCHMGTQVF LCSLFAPVCL 130 140 150 160 170 180 DRPVYPCRWL CEAVRDSCEP VMQFFGFFWP EMLKCDQFPQ DDVCIAMTTP NATEVSRPKG 190 200 210 220 230 240 TTVCPPCDNE MKSEAIVEHL CASEFALKMT IKEVKKENGD KVIIPRKRKA LKLGPIRKKN 250 260 270 280 290 300 LKKLVLLLKN GADCPCHQLD NLGHHFLIMG RQVKTQHLLT AIYKWDKKNK EFKKFMKKVK 310 APDCPTFPSV FK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution." International Chicken Genome Sequencing Consortium Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K. Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Red jungle fowl Ensembl ENSGALP00000005489.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Red jungle fowl Ensembl ENSGALP00000005489.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AADN02054830 Genomic DNA. No translation available. AADN02054831 Genomic DNA. No translation available. AADN02054832 Genomic DNA. No translation available.
IPI	IPI00580686.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000005499; ENSGALP00000005489; ENSGALG00000003473.
Phylogenomic databases
GeneTree	ENSGT00560000076776.
OMA	KNCHAGT.
Family and domain databases
Gene3D	1.10.2000.10. 1 hit.
InterPro	IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR001134. Netrin_domain. IPR018933. Netrin_module_non-TIMP. IPR026559. SFRP1. IPR008993. TIMP-like_OB-fold. [Graphical view]
PANTHER	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF46. PTHR11309:SF46. 1 hit.
Pfam	PF01392. Fz. 1 hit. PF01759. NTR. 1 hit. [Graphical view]
SMART	SM00643. C345C. 1 hit. SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit. SSF50242. TIMP_like. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50189. NTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F1NPV5_CHICK

Accession

Primary (citable) accession number: F1NPV5

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	April 3, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)