Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

F1NPV5

- F1NPV5_CHICK

UniProt

F1NPV5 - F1NPV5_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Secreted frizzled-related protein 1

Gene

SFRP1

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: Ensembl
  2. drug binding Source: Ensembl
  3. heparin binding Source: Ensembl

GO - Biological processi

  1. bone trabecula formation Source: Ensembl
  2. canonical Wnt signaling pathway Source: Ensembl
  3. cellular response to BMP stimulus Source: Ensembl
  4. cellular response to estradiol stimulus Source: Ensembl
  5. cellular response to fibroblast growth factor stimulus Source: Ensembl
  6. cellular response to heparin Source: Ensembl
  7. cellular response to hypoxia Source: Ensembl
  8. cellular response to interleukin-1 Source: Ensembl
  9. cellular response to prostaglandin E stimulus Source: Ensembl
  10. cellular response to starvation Source: Ensembl
  11. cellular response to transforming growth factor beta stimulus Source: Ensembl
  12. cellular response to tumor necrosis factor Source: Ensembl
  13. cellular response to vitamin D Source: Ensembl
  14. cellular response to X-ray Source: Ensembl
  15. convergent extension involved in somitogenesis Source: Ensembl
  16. digestive tract morphogenesis Source: Ensembl
  17. dorsal/ventral axis specification Source: Ensembl
  18. female gonad development Source: Ensembl
  19. hematopoietic stem cell differentiation Source: Ensembl
  20. male gonad development Source: Ensembl
  21. negative regulation of androgen receptor signaling pathway Source: Ensembl
  22. negative regulation of B cell differentiation Source: Ensembl
  23. negative regulation of BMP signaling pathway Source: Ensembl
  24. negative regulation of bone remodeling Source: Ensembl
  25. negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Source: Ensembl
  26. negative regulation of cell growth Source: Ensembl
  27. negative regulation of cell migration Source: Ensembl
  28. negative regulation of epithelial cell proliferation Source: Ensembl
  29. negative regulation of epithelial to mesenchymal transition Source: Ensembl
  30. negative regulation of fibroblast apoptotic process Source: Ensembl
  31. negative regulation of fibroblast proliferation Source: Ensembl
  32. negative regulation of insulin secretion Source: Ensembl
  33. negative regulation of JUN kinase activity Source: Ensembl
  34. negative regulation of ossification Source: Ensembl
  35. negative regulation of osteoblast differentiation Source: Ensembl
  36. negative regulation of osteoblast proliferation Source: Ensembl
  37. negative regulation of osteoclast differentiation Source: Ensembl
  38. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  39. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
  40. negative regulation of transcription, DNA-templated Source: Ensembl
  41. negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: Ensembl
  42. neural crest cell fate commitment Source: Ensembl
  43. neural tube closure Source: Ensembl
  44. osteoblast differentiation Source: Ensembl
  45. planar cell polarity pathway involved in neural tube closure Source: Ensembl
  46. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  47. positive regulation of cell growth Source: Ensembl
  48. positive regulation of epithelial cell proliferation Source: Ensembl
  49. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  50. positive regulation of fat cell differentiation Source: Ensembl
  51. positive regulation of fibroblast apoptotic process Source: Ensembl
  52. positive regulation of non-canonical Wnt signaling pathway Source: Ensembl
  53. positive regulation of smoothened signaling pathway Source: Ensembl
  54. positive regulation of transcription, DNA-templated Source: Ensembl
  55. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  56. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  57. regulation of cell cycle process Source: Ensembl
  58. response to drug Source: Ensembl
  59. somatic stem cell maintenance Source: Ensembl
  60. stromal-epithelial cell signaling involved in prostate gland development Source: Ensembl
  61. ureteric bud development Source: Ensembl
  62. Wnt signaling pathway involved in somitogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_203925. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Names & Taxonomyi

Protein namesi
Submitted name:
Secreted frizzled-related protein 1Imported
Gene namesi
Name:SFRP1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytosol Source: Ensembl
  3. extracellular space Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotation
Contains NTR domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118864.
OMAiDDVCIAM.
OrthoDBiEOG789CBZ.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF46. PTHR11309:SF46. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F1NPV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AVGVAMGRVR GALRALLSLA AGLLACGGAS EYDYVSYQSD LGPYPGGRFY
60 70 80 90 100
TKPHQCVAIP ADLRLCHSVG YDKMVLPNLL DHETMAEVKH QASSWVPLLN
110 120 130 140 150
KNCHMGTQVF LCSLFAPVCL DRPVYPCRWL CEAVRDSCEP VMQFFGFFWP
160 170 180 190 200
EMLKCDQFPQ DDVCIAMTTP NATEVSRPKG TTVCPPCDNE MKSEAIVEHL
210 220 230 240 250
CASEFALKMT IKEVKKENGD KVIIPRKRKA LKLGPIRKKN LKKLVLLLKN
260 270 280 290 300
GADCPCHQLD NLGHHFLIMG RQVKTQHLLT AIYKWDKKNK EFKKFMKKVK
310
APDCPTFPSV FK
Length:312
Mass (Da):35,047
Last modified:May 3, 2011 - v1
Checksum:i037CD606ED3B17A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03008089 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSGALT00000005499; ENSGALP00000005489; ENSGALG00000003473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03008089 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000005499 ; ENSGALP00000005489 ; ENSGALG00000003473 .

Phylogenomic databases

GeneTreei ENSGT00760000118864.
OMAi DDVCIAM.
OrthoDBi EOG789CBZ.
TreeFami TF350133.

Enzyme and pathway databases

Reactomei REACT_203925. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026559. SFRP1.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF46. PTHR11309:SF46. 1 hit.
Pfami PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiF1NPV5_CHICK
AccessioniPrimary (citable) accession number: F1NPV5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3