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Protein
Submitted name:

CYLD lysine 63 deubiquitinase

Gene

CYLD

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-5357786 TNFR1-induced proapoptotic signaling
R-GGA-5357905 Regulation of TNFR1 signaling
R-GGA-5357956 TNFR1-induced NFkappaB signaling pathway
R-GGA-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC67.001

Names & Taxonomyi

Protein namesi
Submitted name:
CYLD lysine 63 deubiquitinaseImported
Gene namesi
Name:CYLDImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiF1NH67

Expressioni

Gene expression databases

BgeeiENSGALG00000003753

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 199CAP-GlyInterPro annotationAdd BLAST39
Domaini490 – 533CAP-GlyInterPro annotationAdd BLAST44
Domaini590 – 948USPInterPro annotationAdd BLAST359

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 110Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000018123
InParanoidiF1NH67
KOiK08601
OrthoDBiEOG091G015D
TreeFamiTF318734

Family and domain databases

Gene3Di2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS50245 CAP_GLY_2, 2 hits
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

F1NH67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGLWSQEK GSSSYWEERI FYLLLQECSV IDKQTQKLLK VPKGSIGQFF
60 70 80 90 100
QDRSSMGHSR NIPCKGKKLQ IGLKILEQPH AVLFVDEKDV IEINEKLAEL
110 120 130 140 150
LLAITNCEER YSLFKSKSRL TKGIQIDIGS PVRVQLRSGE EKFPGVVRFR
160 170 180 190 200
GPLLQERSLT GIYFGVELLE EGRGQGFTDG QYQGKQLFRC DEDCGVFVAL
210 220 230 240 250
DKLELVEEDD NELESDYAAP VDAMQVELPP LEINSRVSLK IGESIEYGTV
260 270 280 290 300
IFCDVLPGNE SLGYVVGVDM DNPIGNWDGR YNGIQLCSFA SVESTLLLHI
310 320 330 340 350
NDVIPETVSQ DRRPPKLAYT ARGGGDKSLF NHSKPKATGS TSEPGNRNRS
360 370 380 390 400
EVFYTLNGSS VDSQPQAKTK PPWYIDEVAE DPAKSLTDSS SGFGHSSPPL
410 420 430 440 450
QPPLTNSVTT ENRFHSLPFS LTKASSTNGA IGHSPLSLSV QSVIGDVNTT
460 470 480 490 500
ANQESPSTGG PVGNSHGLEA GSLAEVKENP PFYGVIRWIG QPPGVNEVLA
510 520 530 540 550
GLELEDECAG CTDGTFKGTR YFTCAPKKAL FVKLKSCRPD SRFASLQPVS
560 570 580 590 600
NQIERCNSLA FGGYLSEVVE ENTPPKMEKE GLETMIGKKK GIQGHYNSCY
610 620 630 640 650
LDSTLFCLFS FSSVLDTVLL RPKEKNDVEY YSETQELLRT EIVNPLRIYG
660 670 680 690 700
YVCATKIMKL RKILEKVEAA SGFTSEEKDP EEFLNILFHH ILRVEPLLKI
710 720 730 740 750
RSAGQKVQDC YFYQIFMDKN EKVGVPTIQQ LLEWSFINSN LKFAEAPSCL
760 770 780 790 800
IIQMPRFGKD FKMFNKIFPS LELNITDLLE DTPRQCRICG GLAMYECREC
810 820 830 840 850
YEDADISAGK IKQFCKTCNT QVHLHPRRQS HKFNPLSLPK DLPDWDWRHG
860 870 880 890 900
CIPYQKMELF AVLCIETSHY VAFVKYGRDD SAWLFFDSMA DRDGGQNGFN
910 920 930 940 950
IPQVTPCPEV GEYLKMSVEE LHSLDSRKIQ GCARRLLCDA YMCMYQSPTM

SLYK
Length:954
Mass (Da):106,877
Last modified:November 30, 2016 - v3
Checksum:iF8E38A22E65C6651
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000302 Genomic DNA No translation available.
RefSeqiXP_004944232.1, XM_004944175.2
XP_015147884.1, XM_015292398.1
XP_414091.2, XM_414091.5
UniGeneiGga.10406
Gga.34876

Genome annotation databases

EnsembliENSGALT00000016123; ENSGALP00000016104; ENSGALG00000003753
GeneIDi415725
KEGGigga:415725

Similar proteinsi

Entry informationi

Entry nameiF1NH67_CHICK
AccessioniPrimary (citable) accession number: F1NH67
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 30, 2016
Last modified: June 20, 2018
This is version 57 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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