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Protein
Submitted name:

CYLD lysine 63 deubiquitinase

Gene

CYLD

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-5357786. TNFR1-induced proapoptotic signaling.
R-GGA-5357905. Regulation of TNFR1 signaling.
R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-GGA-5689880. Ub-specific processing proteases.

Protein family/group databases

MEROPSiC67.001.

Names & Taxonomyi

Protein namesi
Submitted name:
CYLD lysine 63 deubiquitinaseImported
Gene namesi
Name:CYLDImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000003753.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 199CAP-GlyInterPro annotationAdd BLAST39
Domaini490 – 533CAP-GlyInterPro annotationAdd BLAST44
Domaini590 – 948USPInterPro annotationAdd BLAST359

Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000018123.
InParanoidiF1NH67.
OrthoDBiEOG091G015D.
TreeFamiTF318734.

Family and domain databases

Gene3Di2.30.30.190. 3 hits.
InterProiView protein in InterPro
IPR036859. CAP-Gly_dom_sf.
IPR000938. CAP-Gly_domain.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF01302. CAP_GLY. 2 hits.
PF00443. UCH. 1 hit.
SMARTiView protein in SMART
SM01052. CAP_GLY. 3 hits.
SUPFAMiSSF74924. SSF74924. 3 hits.
PROSITEiView protein in PROSITE
PS50245. CAP_GLY_2. 2 hits.
PS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

F1NH67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGLWSQEK GSSSYWEERI FYLLLQECSV IDKQTQKLLK VPKGSIGQFF
60 70 80 90 100
QDRSSMGHSR NIPCKGKKLQ IGLKILEQPH AVLFVDEKDV IEINEKLAEL
110 120 130 140 150
LLAITNCEER YSLFKSKSRL TKGIQIDIGS PVRVQLRSGE EKFPGVVRFR
160 170 180 190 200
GPLLQERSLT GIYFGVELLE EGRGQGFTDG QYQGKQLFRC DEDCGVFVAL
210 220 230 240 250
DKLELVEEDD NELESDYAAP VDAMQVELPP LEINSRVSLK IGESIEYGTV
260 270 280 290 300
IFCDVLPGNE SLGYVVGVDM DNPIGNWDGR YNGIQLCSFA SVESTLLLHI
310 320 330 340 350
NDVIPETVSQ DRRPPKLAYT ARGGGDKSLF NHSKPKATGS TSEPGNRNRS
360 370 380 390 400
EVFYTLNGSS VDSQPQAKTK PPWYIDEVAE DPAKSLTDSS SGFGHSSPPL
410 420 430 440 450
QPPLTNSVTT ENRFHSLPFS LTKASSTNGA IGHSPLSLSV QSVIGDVNTT
460 470 480 490 500
ANQESPSTGG PVGNSHGLEA GSLAEVKENP PFYGVIRWIG QPPGVNEVLA
510 520 530 540 550
GLELEDECAG CTDGTFKGTR YFTCAPKKAL FVKLKSCRPD SRFASLQPVS
560 570 580 590 600
NQIERCNSLA FGGYLSEVVE ENTPPKMEKE GLETMIGKKK GIQGHYNSCY
610 620 630 640 650
LDSTLFCLFS FSSVLDTVLL RPKEKNDVEY YSETQELLRT EIVNPLRIYG
660 670 680 690 700
YVCATKIMKL RKILEKVEAA SGFTSEEKDP EEFLNILFHH ILRVEPLLKI
710 720 730 740 750
RSAGQKVQDC YFYQIFMDKN EKVGVPTIQQ LLEWSFINSN LKFAEAPSCL
760 770 780 790 800
IIQMPRFGKD FKMFNKIFPS LELNITDLLE DTPRQCRICG GLAMYECREC
810 820 830 840 850
YEDADISAGK IKQFCKTCNT QVHLHPRRQS HKFNPLSLPK DLPDWDWRHG
860 870 880 890 900
CIPYQKMELF AVLCIETSHY VAFVKYGRDD SAWLFFDSMA DRDGGQNGFN
910 920 930 940 950
IPQVTPCPEV GEYLKMSVEE LHSLDSRKIQ GCARRLLCDA YMCMYQSPTM

SLYK
Length:954
Mass (Da):106,877
Last modified:November 30, 2016 - v3
Checksum:iF8E38A22E65C6651
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000302 Genomic DNA. No translation available.
RefSeqiXP_004944232.1. XM_004944175.2.
XP_015147884.1. XM_015292398.1.
XP_414091.2. XM_414091.5.
UniGeneiGga.10406.
Gga.34876.

Genome annotation databases

EnsembliENSGALT00000016123; ENSGALP00000016104; ENSGALG00000003753.
GeneIDi415725.

Similar proteinsi

Entry informationi

Entry nameiF1NH67_CHICK
AccessioniPrimary (citable) accession number: F1NH67
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 30, 2016
Last modified: October 25, 2017
This is version 52 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported