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Protein
Submitted name:

TEK receptor tyrosine kinase

Gene

TEK

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-210993 Tie2 Signaling
R-GGA-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Submitted name:
TEK receptor tyrosine kinaseImported
Gene namesi
Name:TEKImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei749 – 773HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi242 ↔ 251PROSITE-ProRule annotation
Disulfide bondi331 ↔ 340PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiF1NFQ9

Expressioni

Gene expression databases

BgeeiENSGALG00000001840

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002841

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 252EGF-likeInterPro annotationAdd BLAST37
Domaini307 – 341EGF-likeInterPro annotationAdd BLAST35
Domaini350 – 440Ig-likeInterPro annotationAdd BLAST91
Domaini447 – 541Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini545 – 639Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini644 – 737Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini828 – 1100Protein kinaseInterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00910000144091
InParanoidiF1NFQ9
KOiK05121
OMAiAIEYAPH
OrthoDBiEOG091G00RL
TreeFamiTF317568

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR018941 Tyr_kin_Tie2_Ig-like_dom-1_N
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF10430 Ig_Tie2_1, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00060 FN3, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

F1NFQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLAPLVLY GFSLIISGKV EAALDLILIN SFPLVGNSET SLICITSKWR
60 70 80 90 100
SRESITIDRD QEDVTNQHRE PLEVSEDSKR ATAKMVIWKR EKASETIGAY
110 120 130 140 150
YCEGKLKDEV TRIHTMKMPR GASFHPVALT VTANKGEHVN ISFIRMAAKE
160 170 180 190 200
EDAVIYKNGS FIHSVPRHEV PGELEVSYPH VQLQDAGVYS ARYIGGNLFT
210 220 230 240 250
SAYTRLIVRR CEAQKWGPSC SSHCPSCMNN GICHEDTGEC ICPPGFMGKT
260 270 280 290 300
CEKACGANTF GKTCEESCKE NYGCKNYMFC LPDPYGCSCA TGWMGLECDK
310 320 330 340 350
ECKPGYYGSD CKLKCNCHNR GTCDRYKGCV CSYGWHGLQC EKEGSADLSP
360 370 380 390 400
QIENLLDPVE LNSGVEFKPY CIASGMPLPK SEEFKLLKQD GTVLRPSLIV
410 420 430 440 450
TSNRSEAMFT INRVLPRDTG TWVCSVQTVA GMAEKPFQVT VKVPPVPQYA
460 470 480 490 500
PRLTNSGHNF LIIDINAELH TGDGPVVSTK LLYKPAKRYQ SWMSVEVKGS
510 520 530 540 550
TKRLDNLEPK TEYQFCVQLS RQGEGGEGHP GPQASFTTAA LGLPPPEGLT
560 570 580 590 600
LLPKSMTSLN LSWHPLTLRT DDDIRVEVER KSVNDNGDES SVITQVPGNM
610 620 630 640 650
STLIIKDLEP RQQYMCRVRV NTRSQGEWSN YLYAWTFSDR IPPAPYNIKF
660 670 680 690 700
FNTTDTSSVI SWTTAEGHSI SSIIISYKIY GKAEYNHIDI IIKNSTITQY
710 720 730 740 750
HLKGLEPNTV YQVQINAQNN IGLSNPNTSF ELKTLPEMKA PYESKGGKML
760 770 780 790 800
LIAILGSAGM TCVTILLAFL IMLQLKRANF QRRMAQAFQN VVREEPAVQF
810 820 830 840 850
NSGTLTLSRK AKNSPDPTIY PVLEWNDIKF QDVIGEGNFG QVLKARIKKD
860 870 880 890 900
GLRMDAAIKR MKEYASKDDH RDFAGELEVL CKLGHHPNII NLLGACEHRG
910 920 930 940 950
YLYLAIEYAP HGNLLDFLRK SRVLETDPAF AIANSTASTL SSQQLLHFAA
960 970 980 990 1000
DVARGMDYLS QKQFIHRDLA ARNILVGENY VAKIADFGLS RGQEVYVKKT
1010 1020 1030 1040 1050
MGRLPVRWMA IESLNYSVYT TNSDVWSYGV LLWEIVSLGG TPYCGMTCAE
1060 1070 1080 1090 1100
LYEKLPQGYR LEKPLNCDDE VYDLMRQCWR EKPYERPSFA QILVSLNRML
1110 1120
EERKTYVNTT LYEKFTYAGI DCSAEEAA
Length:1,128
Mass (Da):126,361
Last modified:June 26, 2013 - v2
Checksum:iC3A1905776F6D75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC187768 Genomic DNA No translation available.
AC188769 Genomic DNA No translation available.
RefSeqiXP_004949637.1, XM_004949580.2

Genome annotation databases

EnsembliENSGALT00000002845; ENSGALP00000002841; ENSGALG00000001840
GeneIDi427368
KEGGigga:427368

Similar proteinsi

Entry informationi

Entry nameiF1NFQ9_CHICK
AccessioniPrimary (citable) accession number: F1NFQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: May 23, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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