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F1NB38

- ECHD1_CHICK

UniProt

F1NB38 - ECHD1_CHICK

Protein

Ethylmalonyl-CoA decarboxylase

Gene

ECHDC1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 2 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.By similarity

    Catalytic activityi

    (S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
    (S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

    GO - Molecular functioni

    1. carboxy-lyase activity Source: UniProtKB
    2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
    Alternative name(s):
    Enoyl-CoA hydratase domain-containing protein 1
    Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
    Short name:
    MMCD
    Gene namesi
    Name:ECHDC1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Ethylmalonyl-CoA decarboxylasePRO_0000416271Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliF1NB38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    OMAiHKHMGLV.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view]
    PfamiPF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1NB38-1 [UniParc]FASTAAdd to Basket

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    MAVFLWRNLF QTTKARMLQQ RRASLYNGAH DYDEELIKKK LQQFAGGSIN    50
    LSKEHSGIGI LTLNNSRLMN AFTGTMMLEL QERVTELENW KDGKGLIICG 100
    AGNTFCSGSD LNAVKAISNS QDGMNMCMFM QNTLTRLMRL PLISIALIQG 150
    KALGGGAELT TACDFRLMTP GSEIRFVHKH MGLVPGWGGA ARLVRIIGSR 200
    AALQLLSRAH GVDPERALHL GLSEGTLSSS DETGSLEEAR AWLSQYTEGP 250
    ASVIQAVKKV VTAGRELPLE AALRTEKDVF GTVWGGPANL EALTRRQK 298
    Length:298
    Mass (Da):32,517
    Last modified:March 21, 2012 - v2
    Checksum:i420ED5340D62D0A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN02001706 Genomic DNA. No translation available.
    AADN02001707 Genomic DNA. No translation available.
    AADN02001708 Genomic DNA. No translation available.
    AADN02001709 Genomic DNA. No translation available.
    AADN02001710 Genomic DNA. No translation available.
    AADN02001711 Genomic DNA. No translation available.
    AADN02001712 Genomic DNA. No translation available.
    AADN02001713 Genomic DNA. No translation available.
    AADN02001714 Genomic DNA. No translation available.
    AADN02001715 Genomic DNA. No translation available.
    AADN02001716 Genomic DNA. No translation available.
    AADN02001717 Genomic DNA. No translation available.
    AADN02001718 Genomic DNA. No translation available.
    AADN02001719 Genomic DNA. No translation available.
    AADN02001720 Genomic DNA. No translation available.
    AADN02001721 Genomic DNA. No translation available.
    UniGeneiGga.10129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN02001706 Genomic DNA. No translation available.
    AADN02001707 Genomic DNA. No translation available.
    AADN02001708 Genomic DNA. No translation available.
    AADN02001709 Genomic DNA. No translation available.
    AADN02001710 Genomic DNA. No translation available.
    AADN02001711 Genomic DNA. No translation available.
    AADN02001712 Genomic DNA. No translation available.
    AADN02001713 Genomic DNA. No translation available.
    AADN02001714 Genomic DNA. No translation available.
    AADN02001715 Genomic DNA. No translation available.
    AADN02001716 Genomic DNA. No translation available.
    AADN02001717 Genomic DNA. No translation available.
    AADN02001718 Genomic DNA. No translation available.
    AADN02001719 Genomic DNA. No translation available.
    AADN02001720 Genomic DNA. No translation available.
    AADN02001721 Genomic DNA. No translation available.
    UniGenei Gga.10129.

    3D structure databases

    ProteinModelPortali F1NB38.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OMAi HKHMGLV.

    Miscellaneous databases

    PROi F1NB38.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view ]
    Pfami PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Red jungle fowl.

    Entry informationi

    Entry nameiECHD1_CHICK
    AccessioniPrimary (citable) accession number: F1NB38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 18 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3