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F1NB38

- ECHD1_CHICK

UniProt

F1NB38 - ECHD1_CHICK

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Protein
Ethylmalonyl-CoA decarboxylase
Gene
ECHDC1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:ECHDC1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Ethylmalonyl-CoA decarboxylase
PRO_0000416271Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliF1NB38.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OMAiHKHMGLV.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1NB38-1 [UniParc]FASTAAdd to Basket

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MAVFLWRNLF QTTKARMLQQ RRASLYNGAH DYDEELIKKK LQQFAGGSIN    50
LSKEHSGIGI LTLNNSRLMN AFTGTMMLEL QERVTELENW KDGKGLIICG 100
AGNTFCSGSD LNAVKAISNS QDGMNMCMFM QNTLTRLMRL PLISIALIQG 150
KALGGGAELT TACDFRLMTP GSEIRFVHKH MGLVPGWGGA ARLVRIIGSR 200
AALQLLSRAH GVDPERALHL GLSEGTLSSS DETGSLEEAR AWLSQYTEGP 250
ASVIQAVKKV VTAGRELPLE AALRTEKDVF GTVWGGPANL EALTRRQK 298
Length:298
Mass (Da):32,517
Last modified:March 21, 2012 - v2
Checksum:i420ED5340D62D0A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN02001706 Genomic DNA. No translation available.
AADN02001707 Genomic DNA. No translation available.
AADN02001708 Genomic DNA. No translation available.
AADN02001709 Genomic DNA. No translation available.
AADN02001710 Genomic DNA. No translation available.
AADN02001711 Genomic DNA. No translation available.
AADN02001712 Genomic DNA. No translation available.
AADN02001713 Genomic DNA. No translation available.
AADN02001714 Genomic DNA. No translation available.
AADN02001715 Genomic DNA. No translation available.
AADN02001716 Genomic DNA. No translation available.
AADN02001717 Genomic DNA. No translation available.
AADN02001718 Genomic DNA. No translation available.
AADN02001719 Genomic DNA. No translation available.
AADN02001720 Genomic DNA. No translation available.
AADN02001721 Genomic DNA. No translation available.
UniGeneiGga.10129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN02001706 Genomic DNA. No translation available.
AADN02001707 Genomic DNA. No translation available.
AADN02001708 Genomic DNA. No translation available.
AADN02001709 Genomic DNA. No translation available.
AADN02001710 Genomic DNA. No translation available.
AADN02001711 Genomic DNA. No translation available.
AADN02001712 Genomic DNA. No translation available.
AADN02001713 Genomic DNA. No translation available.
AADN02001714 Genomic DNA. No translation available.
AADN02001715 Genomic DNA. No translation available.
AADN02001716 Genomic DNA. No translation available.
AADN02001717 Genomic DNA. No translation available.
AADN02001718 Genomic DNA. No translation available.
AADN02001719 Genomic DNA. No translation available.
AADN02001720 Genomic DNA. No translation available.
AADN02001721 Genomic DNA. No translation available.
UniGenei Gga.10129.

3D structure databases

ProteinModelPortali F1NB38.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OMAi HKHMGLV.

Miscellaneous databases

PROi F1NB38.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view ]
Pfami PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowl.

Entry informationi

Entry nameiECHD1_CHICK
AccessioniPrimary (citable) accession number: F1NB38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: June 11, 2014
This is version 17 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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