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F1N989

- F1N989_CHICK

UniProt

F1N989 - F1N989_CHICK

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Protein
Submitted name:

5-hydroxytryptamine (Serotonin) receptor 2C

Gene
HTR2C
Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: Ensembl
  2. drug binding Source: Ensembl
  3. Gq/11-coupled serotonin receptor activity Source: Ensembl
  4. serotonin binding Source: Ensembl

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. cGMP biosynthetic process Source: Ensembl
  3. feeding behavior Source: Ensembl
  4. locomotory behavior Source: InterPro
  5. phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
  6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  7. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  8. positive regulation of phosphatidylinositol biosynthetic process Source: Ensembl
  9. regulation of appetite Source: Ensembl
  10. regulation of corticotropin-releasing hormone secretion Source: Ensembl
  11. regulation of neurological system process Source: Ensembl
  12. release of sequestered calcium ion into cytosol Source: Ensembl
  13. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotations, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine (Serotonin) receptor 2CImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HTR2CImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotations, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliF1N989.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117240.
KOiK04157.
OrthoDBiEOG70ZZN5.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF32. PTHR24247:SF32. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1N989-1 [UniParc]FASTAAdd to Basket

« Hide

MSTLSSTGIL LSLTTVSVTL DFSLHGGLMA WSLSTNLTLN QSLPTSDPLN    50
ASEKGEVSRM SVREKNWPAL LILVVILLTI GGNILVIMAV SLEKKLQNAT 100
NFFLMSLAVA DMLVGILVMP VSLIAVLYDY AWPLPKQLCP IWISLDVLFS 150
TASIMHLCAI SLDRYVAIRN PIEHSRFNSR TKAIMKIAAV WTISIGISMP 200
IPVIGLQDDS RVFINGTCVL NDENFVLIGS FMAFFIPLII MVITYCLTVQ 250
VLQRQATVFM CGEVPKQRRS SVNCLKKENN TEHISMLHNH EGASHLNSPV 300
SKEAVLFRKG TMQSINNERR ASKVLGIVFF LFLIMWCPFF ITNVMSVLCK 350
EACDKDLLSE LLDVFVWVGY VCSGVNPLVY TLFNKTYRRA FSSYIRCQYK 400
TSKKSALRQN QCLNVASTAL YGKDLTLTSY RNGNELNSME LDEAEEGLEM 450
QPGTSELSIN SCNVVSERVS CV 472
Length:472
Mass (Da):52,524
Last modified:June 26, 2013 - v2
Checksum:i541F6FA84F3E8D21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03004008 Genomic DNA. No translation available.
HQ438966 mRNA. Translation: AEC53544.1.
RefSeqiXP_004940707.1. XM_004940650.1.
XP_426265.2. XM_426265.4.
UniGeneiGga.21015.

Genome annotation databases

EnsembliENSGALT00000009404; ENSGALP00000009390; ENSGALG00000005853.
GeneIDi428707.
KEGGigga:428707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AADN03004008 Genomic DNA. No translation available.
HQ438966 mRNA. Translation: AEC53544.1 .
RefSeqi XP_004940707.1. XM_004940650.1.
XP_426265.2. XM_426265.4.
UniGenei Gga.21015.

3D structure databases

ProteinModelPortali F1N989.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000009404 ; ENSGALP00000009390 ; ENSGALG00000005853 .
GeneIDi 428707.
KEGGi gga:428707.

Organism-specific databases

CTDi 3358.

Phylogenomic databases

GeneTreei ENSGT00750000117240.
KOi K04157.
OrthoDBi EOG70ZZN5.
TreeFami TF316350.

Miscellaneous databases

NextBioi 20829630.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF32. PTHR24247:SF32. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. "Molecular Characterization of Chicken 5-Hydroxytryptamine (Serotonin) Receptor 2C (HTR2C) Gene."
    Wong M.T., Kwok A.H.Y., Wang Y., Leung F.C.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiF1N989_CHICK
AccessioniPrimary (citable) accession number: F1N989
Secondary accession number(s): F5ANP2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: July 9, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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