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Protein
Submitted name:

5-hydroxytryptamine (Serotonin) receptor 2C

Gene

HTR2C

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-390666. Serotonin receptors.
R-GGA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine (Serotonin) receptor 2CImported
Submitted name:
5-hydroxytryptamine receptor 2CImported
Gene namesi
Name:HTR2CImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 90HelicalSequence analysisAdd BLAST24
Transmembranei102 – 128HelicalSequence analysisAdd BLAST27
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Transmembranei183 – 205HelicalSequence analysisAdd BLAST23
Transmembranei225 – 247HelicalSequence analysisAdd BLAST23
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei364 – 383HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501083125120 – 472Sequence analysisAdd BLAST453

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000005853.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009390.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 380G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST299

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139331.
KOiK04157.
OMAiLCGKACN.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Family and domain databases

InterProiView protein in InterPro
IPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PANTHERiPTHR24247:SF169. PTHR24247:SF169. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F1N989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLSSTGIL LSLTTVSVTL DFSLHGGLMA WSLSTNLTLN QSLPTSDPLN
60 70 80 90 100
ASEKGEVSRM SVREKNWPAL LILVVILLTI GGNILVIMAV SLEKKLQNAT
110 120 130 140 150
NFFLMSLAVA DMLVGILVMP VSLIAVLYDY AWPLPKQLCP IWISLDVLFS
160 170 180 190 200
TASIMHLCAI SLDRYVAIRN PIEHSRFNSR TKAIMKIAAV WTISIGISMP
210 220 230 240 250
IPVIGLQDDS RVFINGTCVL NDENFVLIGS FMAFFIPLII MVITYCLTVQ
260 270 280 290 300
VLQRQATVFM CGEVPKQRRS SVNCLKKENN TEHISMLHNH EGASHLNSPV
310 320 330 340 350
SKEAVLFRKG TMQSINNERR ASKVLGIVFF LFLIMWCPFF ITNVMSVLCK
360 370 380 390 400
EACDKDLLSE LLDVFVWVGY VCSGVNPLVY TLFNKTYRRA FSSYIRCQYK
410 420 430 440 450
TSKKSALRQN QCLNVASTAL YGKDLTLTSY RNGNELNSME LDEAEEGLEM
460 470
QPGTSELSIN SCNVVSERVS CV
Length:472
Mass (Da):52,524
Last modified:June 26, 2013 - v2
Checksum:i541F6FA84F3E8D21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000029 Genomic DNA. No translation available.
HQ438966 mRNA. Translation: AEC53544.1.
RefSeqiNP_001305350.1. NM_001318421.1.
XP_004940707.1. XM_004940650.2.
XP_015133917.1. XM_015278431.1.
UniGeneiGga.21015.

Genome annotation databases

EnsembliENSGALT00000009404; ENSGALP00000009390; ENSGALG00000005853.
GeneIDi428707.
KEGGigga:428707.

Similar proteinsi

Entry informationi

Entry nameiF1N989_CHICK
AccessioniPrimary (citable) accession number: F1N989
Secondary accession number(s): F5ANP2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: August 30, 2017
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported