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F1N989

- F1N989_CHICK

UniProt

F1N989 - F1N989_CHICK

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Protein
Submitted name:

5-hydroxytryptamine (Serotonin) receptor 2C

Gene

HTR2C

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: Ensembl
  2. drug binding Source: Ensembl
  3. Gq/11-coupled serotonin receptor activity Source: Ensembl
  4. serotonin binding Source: Ensembl

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. cGMP biosynthetic process Source: Ensembl
  3. feeding behavior Source: Ensembl
  4. locomotory behavior Source: InterPro
  5. phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
  6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  7. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  8. positive regulation of phosphatidylinositol biosynthetic process Source: Ensembl
  9. regulation of appetite Source: Ensembl
  10. regulation of corticotropin-releasing hormone secretion Source: Ensembl
  11. regulation of neurological system process Source: Ensembl
  12. release of sequestered calcium ion into cytosol Source: Ensembl
  13. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_229888. Serotonin receptors.
REACT_249636. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine (Serotonin) receptor 2CImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HTR2CImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF1N989.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00770000120457.
InParanoidiF1N989.
KOiK04157.
OrthoDBiEOG70ZZN5.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF32. PTHR24247:SF32. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1N989-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTLSSTGIL LSLTTVSVTL DFSLHGGLMA WSLSTNLTLN QSLPTSDPLN
60 70 80 90 100
ASEKGEVSRM SVREKNWPAL LILVVILLTI GGNILVIMAV SLEKKLQNAT
110 120 130 140 150
NFFLMSLAVA DMLVGILVMP VSLIAVLYDY AWPLPKQLCP IWISLDVLFS
160 170 180 190 200
TASIMHLCAI SLDRYVAIRN PIEHSRFNSR TKAIMKIAAV WTISIGISMP
210 220 230 240 250
IPVIGLQDDS RVFINGTCVL NDENFVLIGS FMAFFIPLII MVITYCLTVQ
260 270 280 290 300
VLQRQATVFM CGEVPKQRRS SVNCLKKENN TEHISMLHNH EGASHLNSPV
310 320 330 340 350
SKEAVLFRKG TMQSINNERR ASKVLGIVFF LFLIMWCPFF ITNVMSVLCK
360 370 380 390 400
EACDKDLLSE LLDVFVWVGY VCSGVNPLVY TLFNKTYRRA FSSYIRCQYK
410 420 430 440 450
TSKKSALRQN QCLNVASTAL YGKDLTLTSY RNGNELNSME LDEAEEGLEM
460 470
QPGTSELSIN SCNVVSERVS CV
Length:472
Mass (Da):52,524
Last modified:June 26, 2013 - v2
Checksum:i541F6FA84F3E8D21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03004008 Genomic DNA. No translation available.
HQ438966 mRNA. Translation: AEC53544.1.
RefSeqiXP_004940707.1. XM_004940650.1.
XP_426265.2. XM_426265.4.
UniGeneiGga.21015.

Genome annotation databases

EnsembliENSGALT00000009404; ENSGALP00000009390; ENSGALG00000005853.
GeneIDi428707.
KEGGigga:428707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03004008 Genomic DNA. No translation available.
HQ438966 mRNA. Translation: AEC53544.1 .
RefSeqi XP_004940707.1. XM_004940650.1.
XP_426265.2. XM_426265.4.
UniGenei Gga.21015.

3D structure databases

ProteinModelPortali F1N989.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000009404 ; ENSGALP00000009390 ; ENSGALG00000005853 .
GeneIDi 428707.
KEGGi gga:428707.

Organism-specific databases

CTDi 3358.

Phylogenomic databases

GeneTreei ENSGT00770000120457.
InParanoidi F1N989.
KOi K04157.
OrthoDBi EOG70ZZN5.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_229888. Serotonin receptors.
REACT_249636. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 20829630.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF32. PTHR24247:SF32. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  2. "Molecular Characterization of Chicken 5-Hydroxytryptamine (Serotonin) Receptor 2C (HTR2C) Gene."
    Wong M.T., Kwok A.H.Y., Wang Y., Leung F.C.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiF1N989_CHICK
AccessioniPrimary (citable) accession number: F1N989
Secondary accession number(s): F5ANP2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: November 26, 2014
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3