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F1N989 (F1N989_CHICK) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Uncharacterized protein Ensembl ENSGALP00000009390
Gene names
Name:HTR2C EMBL AEC53544.1 Ensembl ENSGALP00000009390
OrganismGallus gallus (Chicken) [Reference proteome] Ensembl ENSGALP00000009390
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
   Cellular componentCell membrane SAAS SAAS002231
Membrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS002231
   Molecular functionG-protein coupled receptor SAAS SAAS002231 RuleBase RU000688
Receptor
Transducer
   PTMDisulfide bond SAAS SAAS002231
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbehavioral fear response

Inferred from electronic annotation. Source: Ensembl

cGMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

feeding behavior

Inferred from electronic annotation. Source: Ensembl

locomotory behavior

Inferred from electronic annotation. Source: InterPro

phospholipase C-activating serotonin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol biosynthetic process

Inferred from electronic annotation. Source: Ensembl

regulation of appetite

Inferred from electronic annotation. Source: Ensembl

regulation of corticotropin-releasing hormone secretion

Inferred from electronic annotation. Source: Ensembl

regulation of neurological system process

Inferred from electronic annotation. Source: Ensembl

release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Inferred from electronic annotation. Source: Ensembl

Gq/11-coupled serotonin receptor activity

Inferred from electronic annotation. Source: Ensembl

drug binding

Inferred from electronic annotation. Source: Ensembl

serotonin binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
F1N989 [UniParc].

Last modified June 26, 2013. Version 2.
Checksum: 541F6FA84F3E8D21

FASTA47252,524
        10         20         30         40         50         60 
MSTLSSTGIL LSLTTVSVTL DFSLHGGLMA WSLSTNLTLN QSLPTSDPLN ASEKGEVSRM 

        70         80         90        100        110        120 
SVREKNWPAL LILVVILLTI GGNILVIMAV SLEKKLQNAT NFFLMSLAVA DMLVGILVMP 

       130        140        150        160        170        180 
VSLIAVLYDY AWPLPKQLCP IWISLDVLFS TASIMHLCAI SLDRYVAIRN PIEHSRFNSR 

       190        200        210        220        230        240 
TKAIMKIAAV WTISIGISMP IPVIGLQDDS RVFINGTCVL NDENFVLIGS FMAFFIPLII 

       250        260        270        280        290        300 
MVITYCLTVQ VLQRQATVFM CGEVPKQRRS SVNCLKKENN TEHISMLHNH EGASHLNSPV 

       310        320        330        340        350        360 
SKEAVLFRKG TMQSINNERR ASKVLGIVFF LFLIMWCPFF ITNVMSVLCK EACDKDLLSE 

       370        380        390        400        410        420 
LLDVFVWVGY VCSGVNPLVY TLFNKTYRRA FSSYIRCQYK TSKKSALRQN QCLNVASTAL 

       430        440        450        460        470 
YGKDLTLTSY RNGNELNSME LDEAEEGLEM QPGTSELSIN SCNVVSERVS CV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
International Chicken Genome Sequencing Consortium
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. expand/collapse author list , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Red jungle fowl Ensembl ENSGALP00000009390.
[2]"Molecular Characterization of Chicken 5-Hydroxytryptamine (Serotonin) Receptor 2C (HTR2C) Gene."
Wong M.T., Kwok A.H.Y., Wang Y., Leung F.C.
Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Red jungle fowl Ensembl ENSGALP00000009390.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AADN03004008 Genomic DNA. No translation available.
HQ438966 mRNA. Translation: AEC53544.1.
RefSeqXP_004940707.1. XM_004940650.1.
XP_426265.2. XM_426265.4.
UniGeneGga.21015.

3D structure databases

ProteinModelPortalF1N989.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000009404; ENSGALP00000009390; ENSGALG00000005853.
GeneID428707.
KEGGgga:428707.

Organism-specific databases

CTD3358.

Phylogenomic databases

GeneTreeENSGT00750000117240.
KOK04157.
OrthoDBEOG70ZZN5.
TreeFamTF316350.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF32. PTHR24247:SF32. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20829630.

Entry information

Entry nameF1N989_CHICK
AccessionPrimary (citable) accession number: F1N989
Secondary accession number(s): F5ANP2
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: July 9, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)