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F1N989

- F1N989_CHICK

UniProt

F1N989 - F1N989_CHICK

Protein
Submitted name:

5-hydroxytryptamine (Serotonin) receptor 2C

Gene

HTR2C

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: Ensembl
    2. drug binding Source: Ensembl
    3. Gq/11-coupled serotonin receptor activity Source: Ensembl
    4. serotonin binding Source: Ensembl

    GO - Biological processi

    1. behavioral fear response Source: Ensembl
    2. cGMP biosynthetic process Source: Ensembl
    3. feeding behavior Source: Ensembl
    4. locomotory behavior Source: InterPro
    5. phospholipase C-activating serotonin receptor signaling pathway Source: Ensembl
    6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    7. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    8. positive regulation of phosphatidylinositol biosynthetic process Source: Ensembl
    9. regulation of appetite Source: Ensembl
    10. regulation of corticotropin-releasing hormone secretion Source: Ensembl
    11. regulation of neurological system process Source: Ensembl
    12. release of sequestered calcium ion into cytosol Source: Ensembl
    13. response to drug Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    5-hydroxytryptamine (Serotonin) receptor 2CImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:HTR2CImported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membraneSAAS annotation, Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF1N989.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117240.
    KOiK04157.
    OrthoDBiEOG70ZZN5.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000377. 5HT2C_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF32. PTHR24247:SF32. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00517. 5HT2CRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1N989-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTLSSTGIL LSLTTVSVTL DFSLHGGLMA WSLSTNLTLN QSLPTSDPLN    50
    ASEKGEVSRM SVREKNWPAL LILVVILLTI GGNILVIMAV SLEKKLQNAT 100
    NFFLMSLAVA DMLVGILVMP VSLIAVLYDY AWPLPKQLCP IWISLDVLFS 150
    TASIMHLCAI SLDRYVAIRN PIEHSRFNSR TKAIMKIAAV WTISIGISMP 200
    IPVIGLQDDS RVFINGTCVL NDENFVLIGS FMAFFIPLII MVITYCLTVQ 250
    VLQRQATVFM CGEVPKQRRS SVNCLKKENN TEHISMLHNH EGASHLNSPV 300
    SKEAVLFRKG TMQSINNERR ASKVLGIVFF LFLIMWCPFF ITNVMSVLCK 350
    EACDKDLLSE LLDVFVWVGY VCSGVNPLVY TLFNKTYRRA FSSYIRCQYK 400
    TSKKSALRQN QCLNVASTAL YGKDLTLTSY RNGNELNSME LDEAEEGLEM 450
    QPGTSELSIN SCNVVSERVS CV 472
    Length:472
    Mass (Da):52,524
    Last modified:June 26, 2013 - v2
    Checksum:i541F6FA84F3E8D21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03004008 Genomic DNA. No translation available.
    HQ438966 mRNA. Translation: AEC53544.1.
    RefSeqiXP_004940707.1. XM_004940650.1.
    XP_426265.2. XM_426265.4.
    UniGeneiGga.21015.

    Genome annotation databases

    EnsembliENSGALT00000009404; ENSGALP00000009390; ENSGALG00000005853.
    GeneIDi428707.
    KEGGigga:428707.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AADN03004008 Genomic DNA. No translation available.
    HQ438966 mRNA. Translation: AEC53544.1 .
    RefSeqi XP_004940707.1. XM_004940650.1.
    XP_426265.2. XM_426265.4.
    UniGenei Gga.21015.

    3D structure databases

    ProteinModelPortali F1N989.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000009404 ; ENSGALP00000009390 ; ENSGALG00000005853 .
    GeneIDi 428707.
    KEGGi gga:428707.

    Organism-specific databases

    CTDi 3358.

    Phylogenomic databases

    GeneTreei ENSGT00750000117240.
    KOi K04157.
    OrthoDBi EOG70ZZN5.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 20829630.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000377. 5HT2C_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF32. PTHR24247:SF32. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00517. 5HT2CRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
      International Chicken Genome Sequencing Consortium
      Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
      , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
      Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Red jungle fowlImported.
    2. "Molecular Characterization of Chicken 5-Hydroxytryptamine (Serotonin) Receptor 2C (HTR2C) Gene."
      Wong M.T., Kwok A.H.Y., Wang Y., Leung F.C.
      Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Red jungle fowlImported.

    Entry informationi

    Entry nameiF1N989_CHICK
    AccessioniPrimary (citable) accession number: F1N989
    Secondary accession number(s): F5ANP2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 29 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3