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Protein

Histone deacetylase

Gene

HDAC7

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi569ZincUniRule annotation1
Metal bindingi571ZincUniRule annotation1
Metal bindingi577ZincUniRule annotation1
Metal bindingi654ZincUniRule annotation1
Active sitei706UniRule annotation1
Sitei879Contributes to catalysisUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-BTA-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:HDAC7Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:49060 HDAC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF1N616

Expressioni

Gene expression databases

BgeeiENSBTAG00000026819

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038136

Structurei

3D structure databases

ProteinModelPortaliF1N616
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini577 – 894Hist_deacetylInterPro annotationAdd BLAST318

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
InParanoidiF1N616
KOiK11408
OMAiAFRIVVM
OrthoDBiEOG091G0EQO
TreeFamiTF106174

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 4 hits
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 2 hits
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

F1N616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGNHLDPDG TQVSPAAPCS SPPIIGWPRP RADTPGPQPQ PMDLRVGQRP
60 70 80 90 100
PVEPPPEPTL LALQHPQRLH HHLFLAGLQP QRSAEPMRLS MDTPMPELQM
110 120 130 140 150
GQQEQELRQL LNKDKSKRSA VASSVVKQKL AEVILKKQQA ALERTVHPNS
160 170 180 190 200
PSVPYRTLEP LETEGAARSM LSSFLPPVPS LPCDPPEHFP LRKTVSEPNL
210 220 230 240 250
KLRYKPKKSL ERRKNPLLRK ESAPPSLRRR PAETLGDSSP SSSSTPASGC
260 270 280 290 300
SSPNDSEHGP NPVLGSEALL GQRLRLQETS LAPFALLPTI TLGLPAPARA
310 320 330 340 350
DGDRRTHATL GPRGPVLGNP HAHLFLPHGL EPEAGGPLPS RLQPILLLDP
360 370 380 390 400
SVTHTPLLTV PGLGPLPFHF AQSLLTTERP SGSGLHRPLS RTRSEPLPPS
410 420 430 440 450
ATTPSLLGPL QPRLERLKPH VQLIKRSAKP SEKPRLRQIP SAEDLETDGG
460 470 480 490 500
SVGPLRDDGL EHRESSHGQQ EARGTVPLQQ HQQVFLWEQQ RLAGRLPRGA
510 520 530 540 550
TGDSVLLPLA PGSHRPLSRA QSSPAAPASL STPEPASQAR ILPSSETPAR
560 570 580 590 600
TLPFTTGLVY DSVMLKHQCS CGDNSRHPEH AGRIQSIWSR LLERGLRSQC
610 620 630 640 650
ESLRGRKASL EELQSVHSER HVLLYGTNPL SRLKLDNGKL AGLLAQRMFV
660 670 680 690 700
MLPCGGVGVD TDTIWNELHS SNAARWAAGS VTDLAFKVAS RELKNGFAVV
710 720 730 740 750
RPPGHHADHS TAMGFCFFNS VAIACRQLQQ QGKASKILIV DWDVHHGNGT
760 770 780 790 800
QQTFYQDPNV LYISLHRHDD GNFFPGSGAV DEVGAGSGEG FNVNVAWAGG
810 820 830 840 850
LDPPMGDPEY LAAFRIVVMP IAREFSPDLV LVSAGFDAAE GHPPPLGGYH
860 870 880 890 900
VSAKCFGYMT QQLMSLAGGA VVLALEGGHD LTAICDASEA CVAALLGNKV
910 920 930 940 950
DPLSEEGWKQ KPNLNAIRSL EAVIRVHSEY WGCMQRLASR PDSWVHRVPG
960 970 980
ADAEEVEAVT ALASLSVGIL AEERTSGQLV EEEEPMNL
Length:988
Mass (Da):106,852
Last modified:November 16, 2011 - v2
Checksum:iD0718D2FE4795A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02012987 Genomic DNA No translation available.
RefSeqiNP_001180070.1, NM_001193141.1

Genome annotation databases

EnsembliENSBTAT00000038321; ENSBTAP00000038136; ENSBTAG00000026819
GeneIDi509843
KEGGibta:509843

Similar proteinsi

Entry informationi

Entry nameiF1N616_BOVIN
AccessioniPrimary (citable) accession number: F1N616
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 49 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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