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F1N616

- F1N616_BOVIN

UniProt

F1N616 - F1N616_BOVIN

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Protein
Submitted name:

Uncharacterized protein

Gene

HDAC7

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi569 – 5691ZincUniRule annotation
Metal bindingi571 – 5711ZincUniRule annotation
Metal bindingi577 – 5771ZincUniRule annotation
Metal bindingi654 – 6541ZincUniRule annotation
Active sitei706 – 7061UniRule annotation

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone deacetylase activity Source: InterPro
  3. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. cell-cell junction assembly Source: Ensembl
  2. negative regulation of interleukin-2 production Source: Ensembl
  3. negative regulation of osteoblast differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  6. vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_211655. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_221028. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_225370. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HDAC7Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. histone deacetylase complex Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliF1N616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
InParanoidiF1N616.
KOiK11408.
OMAiAFRIVVM.
OrthoDBiEOG7RFTH5.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

F1N616-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGNHLDPDG TQVSPAAPCS SPPIIGWPRP RADTPGPQPQ PMDLRVGQRP
60 70 80 90 100
PVEPPPEPTL LALQHPQRLH HHLFLAGLQP QRSAEPMRLS MDTPMPELQM
110 120 130 140 150
GQQEQELRQL LNKDKSKRSA VASSVVKQKL AEVILKKQQA ALERTVHPNS
160 170 180 190 200
PSVPYRTLEP LETEGAARSM LSSFLPPVPS LPCDPPEHFP LRKTVSEPNL
210 220 230 240 250
KLRYKPKKSL ERRKNPLLRK ESAPPSLRRR PAETLGDSSP SSSSTPASGC
260 270 280 290 300
SSPNDSEHGP NPVLGSEALL GQRLRLQETS LAPFALLPTI TLGLPAPARA
310 320 330 340 350
DGDRRTHATL GPRGPVLGNP HAHLFLPHGL EPEAGGPLPS RLQPILLLDP
360 370 380 390 400
SVTHTPLLTV PGLGPLPFHF AQSLLTTERP SGSGLHRPLS RTRSEPLPPS
410 420 430 440 450
ATTPSLLGPL QPRLERLKPH VQLIKRSAKP SEKPRLRQIP SAEDLETDGG
460 470 480 490 500
SVGPLRDDGL EHRESSHGQQ EARGTVPLQQ HQQVFLWEQQ RLAGRLPRGA
510 520 530 540 550
TGDSVLLPLA PGSHRPLSRA QSSPAAPASL STPEPASQAR ILPSSETPAR
560 570 580 590 600
TLPFTTGLVY DSVMLKHQCS CGDNSRHPEH AGRIQSIWSR LLERGLRSQC
610 620 630 640 650
ESLRGRKASL EELQSVHSER HVLLYGTNPL SRLKLDNGKL AGLLAQRMFV
660 670 680 690 700
MLPCGGVGVD TDTIWNELHS SNAARWAAGS VTDLAFKVAS RELKNGFAVV
710 720 730 740 750
RPPGHHADHS TAMGFCFFNS VAIACRQLQQ QGKASKILIV DWDVHHGNGT
760 770 780 790 800
QQTFYQDPNV LYISLHRHDD GNFFPGSGAV DEVGAGSGEG FNVNVAWAGG
810 820 830 840 850
LDPPMGDPEY LAAFRIVVMP IAREFSPDLV LVSAGFDAAE GHPPPLGGYH
860 870 880 890 900
VSAKCFGYMT QQLMSLAGGA VVLALEGGHD LTAICDASEA CVAALLGNKV
910 920 930 940 950
DPLSEEGWKQ KPNLNAIRSL EAVIRVHSEY WGCMQRLASR PDSWVHRVPG
960 970 980
ADAEEVEAVT ALASLSVGIL AEERTSGQLV EEEEPMNL
Length:988
Mass (Da):106,852
Last modified:November 16, 2011 - v2
Checksum:iD0718D2FE4795A26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02012987 Genomic DNA. No translation available.
RefSeqiNP_001180070.1. NM_001193141.1.
UniGeneiBt.2919.

Genome annotation databases

EnsembliENSBTAT00000038321; ENSBTAP00000038136; ENSBTAG00000026819.
GeneIDi509843.
KEGGibta:509843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02012987 Genomic DNA. No translation available.
RefSeqi NP_001180070.1. NM_001193141.1.
UniGenei Bt.2919.

3D structure databases

ProteinModelPortali F1N616.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000038321 ; ENSBTAP00000038136 ; ENSBTAG00000026819 .
GeneIDi 509843.
KEGGi bta:509843.

Organism-specific databases

CTDi 51564.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
InParanoidi F1N616.
KOi K11408.
OMAi AFRIVVM.
OrthoDBi EOG7RFTH5.
TreeFami TF106174.

Enzyme and pathway databases

Reactomei REACT_211655. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_221028. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_225370. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Miscellaneous databases

NextBioi 20869160.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiF1N616_BOVIN
AccessioniPrimary (citable) accession number: F1N616
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 23 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3