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Protein

Histone deacetylase

Gene

HDAC7

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi569 – 5691ZincUniRule annotation
Metal bindingi571 – 5711ZincUniRule annotation
Metal bindingi577 – 5771ZincUniRule annotation
Metal bindingi654 – 6541ZincUniRule annotation
Active sitei706 – 7061UniRule annotation

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  7. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. cell-cell junction assembly Source: Ensembl
  2. negative regulation of interleukin-2 production Source: Ensembl
  3. negative regulation of osteoblast differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
  7. vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_271632. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_311224. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_335989. NOTCH1 Intracellular Domain Regulates Transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:HDAC7Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 5

Subcellular locationi

  1. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. histone deacetylase complex Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliF1N616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000062809.
InParanoidiF1N616.
KOiK11408.
OMAiAFRIVVM.
OrthoDBiEOG7RFTH5.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

F1N616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGNHLDPDG TQVSPAAPCS SPPIIGWPRP RADTPGPQPQ PMDLRVGQRP
60 70 80 90 100
PVEPPPEPTL LALQHPQRLH HHLFLAGLQP QRSAEPMRLS MDTPMPELQM
110 120 130 140 150
GQQEQELRQL LNKDKSKRSA VASSVVKQKL AEVILKKQQA ALERTVHPNS
160 170 180 190 200
PSVPYRTLEP LETEGAARSM LSSFLPPVPS LPCDPPEHFP LRKTVSEPNL
210 220 230 240 250
KLRYKPKKSL ERRKNPLLRK ESAPPSLRRR PAETLGDSSP SSSSTPASGC
260 270 280 290 300
SSPNDSEHGP NPVLGSEALL GQRLRLQETS LAPFALLPTI TLGLPAPARA
310 320 330 340 350
DGDRRTHATL GPRGPVLGNP HAHLFLPHGL EPEAGGPLPS RLQPILLLDP
360 370 380 390 400
SVTHTPLLTV PGLGPLPFHF AQSLLTTERP SGSGLHRPLS RTRSEPLPPS
410 420 430 440 450
ATTPSLLGPL QPRLERLKPH VQLIKRSAKP SEKPRLRQIP SAEDLETDGG
460 470 480 490 500
SVGPLRDDGL EHRESSHGQQ EARGTVPLQQ HQQVFLWEQQ RLAGRLPRGA
510 520 530 540 550
TGDSVLLPLA PGSHRPLSRA QSSPAAPASL STPEPASQAR ILPSSETPAR
560 570 580 590 600
TLPFTTGLVY DSVMLKHQCS CGDNSRHPEH AGRIQSIWSR LLERGLRSQC
610 620 630 640 650
ESLRGRKASL EELQSVHSER HVLLYGTNPL SRLKLDNGKL AGLLAQRMFV
660 670 680 690 700
MLPCGGVGVD TDTIWNELHS SNAARWAAGS VTDLAFKVAS RELKNGFAVV
710 720 730 740 750
RPPGHHADHS TAMGFCFFNS VAIACRQLQQ QGKASKILIV DWDVHHGNGT
760 770 780 790 800
QQTFYQDPNV LYISLHRHDD GNFFPGSGAV DEVGAGSGEG FNVNVAWAGG
810 820 830 840 850
LDPPMGDPEY LAAFRIVVMP IAREFSPDLV LVSAGFDAAE GHPPPLGGYH
860 870 880 890 900
VSAKCFGYMT QQLMSLAGGA VVLALEGGHD LTAICDASEA CVAALLGNKV
910 920 930 940 950
DPLSEEGWKQ KPNLNAIRSL EAVIRVHSEY WGCMQRLASR PDSWVHRVPG
960 970 980
ADAEEVEAVT ALASLSVGIL AEERTSGQLV EEEEPMNL
Length:988
Mass (Da):106,852
Last modified:November 16, 2011 - v2
Checksum:iD0718D2FE4795A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02012987 Genomic DNA. No translation available.
RefSeqiNP_001180070.1. NM_001193141.1.
UniGeneiBt.2919.

Genome annotation databases

EnsembliENSBTAT00000038321; ENSBTAP00000038136; ENSBTAG00000026819.
GeneIDi509843.
KEGGibta:509843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02012987 Genomic DNA. No translation available.
RefSeqiNP_001180070.1. NM_001193141.1.
UniGeneiBt.2919.

3D structure databases

ProteinModelPortaliF1N616.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000038321; ENSBTAP00000038136; ENSBTAG00000026819.
GeneIDi509843.
KEGGibta:509843.

Organism-specific databases

CTDi51564.

Phylogenomic databases

GeneTreeiENSGT00530000062809.
InParanoidiF1N616.
KOiK11408.
OMAiAFRIVVM.
OrthoDBiEOG7RFTH5.
TreeFamiTF106174.

Enzyme and pathway databases

ReactomeiREACT_271632. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_311224. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_335989. NOTCH1 Intracellular Domain Regulates Transcription.

Miscellaneous databases

NextBioi20869160.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiF1N616_BOVIN
AccessioniPrimary (citable) accession number: F1N616
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: April 1, 2015
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.