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F1N5V1

- UBP37_BOVIN

UniProt

F1N5V1 - UBP37_BOVIN

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Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

USP37

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-630 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei352 – 3521NucleophilePROSITE-ProRule annotation
Active sitei908 – 9081Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein K11-linked deubiquitination Source: UniProtKB
  4. protein K48-linked deubiquitination Source: UniProtKB
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 37
Ubiquitin thioesterase 37
Ubiquitin-specific-processing protease 37
Gene namesi
Name:USP37
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 981981Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei630 – 6301Phosphoserine; by CDK2By similarity
Modified residuei652 – 6521PhosphoserineBy similarity
Modified residuei654 – 6541PhosphoserineBy similarity

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination (By similarity).By similarity
Phosphorylated at Ser-630 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-630 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiF1N5V1.

Interactioni

Subunit structurei

Interacts with FZR1/CDH1.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini343 – 953611USPAdd
BLAST
Repeati706 – 72520UIM 1Add
BLAST
Repeati808 – 82720UIM 2Add
BLAST
Repeati830 – 84920UIM 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 343KEN box 1By similarity
Motifi71 – 799D-box 1By similarity
Motifi96 – 10510D-box 2By similarity
Motifi160 – 1689D-box 3By similarity
Motifi223 – 2253KEN box 2By similarity
Motifi784 – 7863KEN box 3By similarity

Domaini

The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00440000033542.
InParanoidiF1N5V1.
KOiK11850.
OMAiLQEFNNS.
OrthoDBiEOG7HMS09.
TreeFamiTF323032.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM00726. UIM. 4 hits.
[Graphical view]
PROSITEiPS50330. UIM. 3 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1N5V1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPLKIHGPI RIRSMQTGIT KWKEGSFEVV EKENKVSLVV HYNTGGIPRI
60 70 80 90 100
FQLSHNIKNV VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD
110 120 130 140 150
AVHQNRLNAA MKPSQGSGSF GAILGSRTSQ KETNRQLSYS DNQVSSKRGS
160 170 180 190 200
LETKDDTPFR KVLGNPSRGS IKAAAGNGVT PARTIPSLTS TSTPLRSGLL
210 220 230 240 250
ENRTEKRKRM LSSGSELNED YPKENDSSSN NKAMTDPSRK YLTSSREKQL
260 270 280 290 300
SLKQSEENRT SGLLPLQSSS FYGSRTAAKD YSPGSTNLDR TNISSQTPSA
310 320 330 340 350
KRSLGFLPQP APLSVKKLRC NQDYTGWNKP RVPLSSHQQQ QLQGFSNLGN
360 370 380 390 400
TCYMNAILQS LFSLQSFAND LLKQGIPWKK IPLNALIRRF AHLLVKKDIC
410 420 430 440 450
NSETKKDLLK KVKNAISATA ERFSGYMQND AHEFLSQCLD QLKEDMEKLN
460 470 480 490 500
KTWKIEPVPG EENSPDISAT RVYTCPVITN LEFEVQHSII CKVCGEIIPK
510 520 530 540 550
REQFNDLSID LPRRKKPLPP RSIQDSLDLF FRAEELEYSC EKCGGKCALV
560 570 580 590 600
RHKFNRLPRI LILHLKRYSF NVALSLNNKI GQQVIIPRYL TLSSHCTENT
610 620 630 640 650
KPPFNLGWSA QMAVSRPLKA SQMVNSCITS PSTPSKNFTF KSKTSLALSL
660 670 680 690 700
DSDSEDELKR SVALSHRLCE MSGSEQQQED LEKDSKSCRI EPDKSELENS
710 720 730 740 750
GFDGMSEEEL LAAVLEISKR EASPSLSHED DDKPTSSPDT GFAEDDIQEM
760 770 780 790 800
PENPDSVETE KPKTITEPDP ASFTEITKDC DENKENKTPE GSQGEVDWLQ
810 820 830 840 850
QYDMEREREE QELQQALAQS LQEQEAWEQK EDDDLKRATE LSLQEFNNSF
860 870 880 890 900
VDSLGSDEDS GNEDVLDMEY TEAEAEELKR NAETGNLPHS YRLISVVSHI
910 920 930 940 950
GSTSSSGHYI SDVYDIKKQA WFTYNDLEVS KIQEASVQSD RDRSGYIFFY
960 970 980
MHKEIFDELL ETEKNSQALN LEVGKTTRQV S
Length:981
Mass (Da):110,398
Last modified:May 3, 2011 - v1
Checksum:i4F678FE4C1D0B5E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03077731 Genomic DNA. No translation available.
AAFC03103854 Genomic DNA. No translation available.
AAFC03103857 Genomic DNA. No translation available.
RefSeqiNP_001258921.1. NM_001271992.1.
XP_005202866.1. XM_005202809.1.
XP_005202867.1. XM_005202810.1.
UniGeneiBt.25209.

Genome annotation databases

EnsembliENSBTAT00000038243; ENSBTAP00000038058; ENSBTAG00000016572.
GeneIDi407168.
KEGGibta:407168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03077731 Genomic DNA. No translation available.
AAFC03103854 Genomic DNA. No translation available.
AAFC03103857 Genomic DNA. No translation available.
RefSeqi NP_001258921.1. NM_001271992.1.
XP_005202866.1. XM_005202809.1.
XP_005202867.1. XM_005202810.1.
UniGenei Bt.25209.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1N5V1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000038243 ; ENSBTAP00000038058 ; ENSBTAG00000016572 .
GeneIDi 407168.
KEGGi bta:407168.

Organism-specific databases

CTDi 57695.

Phylogenomic databases

GeneTreei ENSGT00440000033542.
InParanoidi F1N5V1.
KOi K11850.
OMAi LQEFNNS.
OrthoDBi EOG7HMS09.
TreeFami TF323032.

Miscellaneous databases

NextBioi 20818424.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR003903. Ubiquitin-int_motif.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view ]
SMARTi SM00726. UIM. 4 hits.
[Graphical view ]
PROSITEi PS50330. UIM. 3 hits.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP37_BOVIN
AccessioniPrimary (citable) accession number: F1N5V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3