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F1N5V1

- UBP37_BOVIN

UniProt

F1N5V1 - UBP37_BOVIN

Protein

Ubiquitin carboxyl-terminal hydrolase 37

Gene

USP37

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-630 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei352 – 3521NucleophilePROSITE-ProRule annotation
    Active sitei908 – 9081Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: UniProtKB
    2. mitotic nuclear division Source: UniProtKB-KW
    3. protein K11-linked deubiquitination Source: UniProtKB
    4. protein K48-linked deubiquitination Source: UniProtKB
    5. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 37 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 37
    Ubiquitin thioesterase 37
    Ubiquitin-specific-processing protease 37
    Gene namesi
    Name:USP37
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 981981Ubiquitin carboxyl-terminal hydrolase 37PRO_0000412644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei630 – 6301Phosphoserine; by CDK2By similarity
    Modified residuei652 – 6521PhosphoserineBy similarity
    Modified residuei654 – 6541PhosphoserineBy similarity

    Post-translational modificationi

    Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination By similarity.By similarity
    Phosphorylated at Ser-630 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-630 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiF1N5V1.

    Interactioni

    Subunit structurei

    Interacts with FZR1/CDH1.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini343 – 953611USPAdd
    BLAST
    Repeati706 – 72520UIM 1Add
    BLAST
    Repeati808 – 82720UIM 2Add
    BLAST
    Repeati830 – 84920UIM 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi32 – 343KEN box 1By similarity
    Motifi71 – 799D-box 1By similarity
    Motifi96 – 10510D-box 2By similarity
    Motifi160 – 1689D-box 3By similarity
    Motifi223 – 2253KEN box 2By similarity
    Motifi784 – 7863KEN box 3By similarity

    Domaini

    The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.By similarity

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    GeneTreeiENSGT00440000033542.
    KOiK11850.
    OMAiLQEFNNS.
    OrthoDBiEOG7HMS09.
    TreeFamiTF323032.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR003903. Ubiquitin-int_motif.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02809. UIM. 3 hits.
    [Graphical view]
    SMARTiSM00726. UIM. 4 hits.
    [Graphical view]
    PROSITEiPS50330. UIM. 3 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1N5V1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPLKIHGPI RIRSMQTGIT KWKEGSFEVV EKENKVSLVV HYNTGGIPRI    50
    FQLSHNIKNV VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD 100
    AVHQNRLNAA MKPSQGSGSF GAILGSRTSQ KETNRQLSYS DNQVSSKRGS 150
    LETKDDTPFR KVLGNPSRGS IKAAAGNGVT PARTIPSLTS TSTPLRSGLL 200
    ENRTEKRKRM LSSGSELNED YPKENDSSSN NKAMTDPSRK YLTSSREKQL 250
    SLKQSEENRT SGLLPLQSSS FYGSRTAAKD YSPGSTNLDR TNISSQTPSA 300
    KRSLGFLPQP APLSVKKLRC NQDYTGWNKP RVPLSSHQQQ QLQGFSNLGN 350
    TCYMNAILQS LFSLQSFAND LLKQGIPWKK IPLNALIRRF AHLLVKKDIC 400
    NSETKKDLLK KVKNAISATA ERFSGYMQND AHEFLSQCLD QLKEDMEKLN 450
    KTWKIEPVPG EENSPDISAT RVYTCPVITN LEFEVQHSII CKVCGEIIPK 500
    REQFNDLSID LPRRKKPLPP RSIQDSLDLF FRAEELEYSC EKCGGKCALV 550
    RHKFNRLPRI LILHLKRYSF NVALSLNNKI GQQVIIPRYL TLSSHCTENT 600
    KPPFNLGWSA QMAVSRPLKA SQMVNSCITS PSTPSKNFTF KSKTSLALSL 650
    DSDSEDELKR SVALSHRLCE MSGSEQQQED LEKDSKSCRI EPDKSELENS 700
    GFDGMSEEEL LAAVLEISKR EASPSLSHED DDKPTSSPDT GFAEDDIQEM 750
    PENPDSVETE KPKTITEPDP ASFTEITKDC DENKENKTPE GSQGEVDWLQ 800
    QYDMEREREE QELQQALAQS LQEQEAWEQK EDDDLKRATE LSLQEFNNSF 850
    VDSLGSDEDS GNEDVLDMEY TEAEAEELKR NAETGNLPHS YRLISVVSHI 900
    GSTSSSGHYI SDVYDIKKQA WFTYNDLEVS KIQEASVQSD RDRSGYIFFY 950
    MHKEIFDELL ETEKNSQALN LEVGKTTRQV S 981
    Length:981
    Mass (Da):110,398
    Last modified:May 3, 2011 - v1
    Checksum:i4F678FE4C1D0B5E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03077731 Genomic DNA. No translation available.
    AAFC03103854 Genomic DNA. No translation available.
    AAFC03103857 Genomic DNA. No translation available.
    RefSeqiNP_001258921.1. NM_001271992.1.
    XP_005202866.1. XM_005202809.1.
    XP_005202867.1. XM_005202810.1.
    UniGeneiBt.25209.

    Genome annotation databases

    EnsembliENSBTAT00000038243; ENSBTAP00000038058; ENSBTAG00000016572.
    GeneIDi407168.
    KEGGibta:407168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03077731 Genomic DNA. No translation available.
    AAFC03103854 Genomic DNA. No translation available.
    AAFC03103857 Genomic DNA. No translation available.
    RefSeqi NP_001258921.1. NM_001271992.1.
    XP_005202866.1. XM_005202809.1.
    XP_005202867.1. XM_005202810.1.
    UniGenei Bt.25209.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1N5V1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000038243 ; ENSBTAP00000038058 ; ENSBTAG00000016572 .
    GeneIDi 407168.
    KEGGi bta:407168.

    Organism-specific databases

    CTDi 57695.

    Phylogenomic databases

    GeneTreei ENSGT00440000033542.
    KOi K11850.
    OMAi LQEFNNS.
    OrthoDBi EOG7HMS09.
    TreeFami TF323032.

    Miscellaneous databases

    NextBioi 20818424.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR003903. Ubiquitin-int_motif.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02809. UIM. 3 hits.
    [Graphical view ]
    SMARTi SM00726. UIM. 4 hits.
    [Graphical view ]
    PROSITEi PS50330. UIM. 3 hits.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
      The bovine genome sequencing and analysis consortium
      Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUBP37_BOVIN
    AccessioniPrimary (citable) accession number: F1N5V1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3