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Protein
Submitted name:

Uncharacterized protein

Gene

REN

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104PROSITE-ProRule annotation1
Active sitei289PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-BTA-2022377. Metabolism of Angiotensinogen to Angiotensins.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:RENImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500326770124 – 404Sequence analysisAdd BLAST381

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1MZL4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021333.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028438.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 401Peptidase A1InterPro annotationAdd BLAST316

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
InParanoidiF1MZL4.
OMAiNFIARYY.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

CDDicd05487. renin_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
IPR034135. Renin-like_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

F1MZL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VDQCSKMPLW GLLLVLWGSC TFSLPADTAA FRRIFLKKMP SVRESLKERG
60 70 80 90 100
VDMARLGAEW SQLTKTLSFG NRTSPVVLTN YLDTQYYGEI GIGTPPQTFK
110 120 130 140 150
VVFDTGSANL WVPSTKCSPL YTACEIHSLY DSLESSSYVE NGTEFTIHYG
160 170 180 190 200
SGKVKGFLSQ DLVTVGGITV TQTFGEVTEL PLLPFMLAKF DGVLGMGFPA
210 220 230 240 250
QAVGGVTPVF DHILAQRVLT DDVFSVYYSR NSHLLGGEIV LGGSDPQYYQ
260 270 280 290 300
ENFHYVSISK PGSWQIRMKG VSVRSTTLLC EEGCMVIVDT GASYISGPTS
310 320 330 340 350
SLRLLMEALG AKELSIDKYV VNCNQMPTLP DISFHLGGKA YTLTSADYVL
360 370 380 390 400
QDPYNNDDLC TLALHGMDIP PPTGPVWVLG ATFIRKFYTE FDRRNNRIGF

ALAR
Length:404
Mass (Da):44,462
Last modified:May 3, 2011 - v1
Checksum:i1CEDEF7917C49EEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02041912 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSBTAT00000028438; ENSBTAP00000028438; ENSBTAG00000021333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02041912 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028438.

Proteomic databases

PaxDbiF1MZL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028438; ENSBTAP00000028438; ENSBTAG00000021333.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
InParanoidiF1MZL4.
OMAiNFIARYY.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Enzyme and pathway databases

ReactomeiR-BTA-2022377. Metabolism of Angiotensinogen to Angiotensins.

Gene expression databases

BgeeiENSBTAG00000021333.

Family and domain databases

CDDicd05487. renin_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
IPR034135. Renin-like_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF1MZL4_BOVIN
AccessioniPrimary (citable) accession number: F1MZL4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 10, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.