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Protein
Submitted name:

Renin

Gene

REN

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104PROSITE-ProRule annotation1
Active sitei289PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-BTA-2022377 Metabolism of Angiotensinogen to Angiotensins

Names & Taxonomyi

Protein namesi
Submitted name:
ReninImported
Gene namesi
Name:RENImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:33865 REN

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500326770124 – 404Sequence analysisAdd BLAST381

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1MZL4

Expressioni

Gene expression databases

BgeeiENSBTAG00000021333

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028438

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 401Peptidase A1InterPro annotationAdd BLAST316

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
InParanoidiF1MZL4
OMAiLGKYYTE
OrthoDBiEOG091G0JP7
TreeFamiTF314990

Family and domain databases

CDDicd05487 renin_like, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
IPR034135 Renin-like_dom
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

F1MZL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VDQCSKMPLW GLLLVLWGSC TFSLPADTAA FRRIFLKKMP SVRESLKERG
60 70 80 90 100
VDMARLGAEW SQLTKTLSFG NRTSPVVLTN YLDTQYYGEI GIGTPPQTFK
110 120 130 140 150
VVFDTGSANL WVPSTKCSPL YTACEIHSLY DSLESSSYVE NGTEFTIHYG
160 170 180 190 200
SGKVKGFLSQ DLVTVGGITV TQTFGEVTEL PLLPFMLAKF DGVLGMGFPA
210 220 230 240 250
QAVGGVTPVF DHILAQRVLT DDVFSVYYSR NSHLLGGEIV LGGSDPQYYQ
260 270 280 290 300
ENFHYVSISK PGSWQIRMKG VSVRSTTLLC EEGCMVIVDT GASYISGPTS
310 320 330 340 350
SLRLLMEALG AKELSIDKYV VNCNQMPTLP DISFHLGGKA YTLTSADYVL
360 370 380 390 400
QDPYNNDDLC TLALHGMDIP PPTGPVWVLG ATFIRKFYTE FDRRNNRIGF

ALAR
Length:404
Mass (Da):44,462
Last modified:May 3, 2011 - v1
Checksum:i1CEDEF7917C49EEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02041912 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSBTAT00000028438; ENSBTAP00000028438; ENSBTAG00000021333

Similar proteinsi

Entry informationi

Entry nameiF1MZL4_BOVIN
AccessioniPrimary (citable) accession number: F1MZL4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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