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Protein

Tyrosine-protein kinase

Gene

HCK

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-2029481. FCGR activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:HCKImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1MWN2.
PRIDEiF1MWN2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007932.
ExpressionAtlasiF1MWN2. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051020.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 136SH3InterPro annotationAdd BLAST61
Domaini142 – 239SH2InterPro annotationAdd BLAST98
Domaini260 – 513Protein kinaseInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
InParanoidiF1MWN2.
OMAiRPEHCPE.
OrthoDBiEOG091G0D46.
TreeFamiTF351634.

Family and domain databases

CDDicd10363. SH2_Src_HCK. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR035851. HCK_SH2.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

F1MWN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LGGRSSCEDP GCPPEEERAP RMGCVKSKFL RNGGKVSKTE PNTNPHSPLY
60 70 80 90 100
VPDPTSSGKR WPDSSNGNPP GSTEGSEDII VVALYDYDAI HHEDLSFQKG
110 120 130 140 150
DQMVVLEESG EWWRARSLAT RKEGYIPSNY VARVNSLETE EWFFKGISRK
160 170 180 190 200
DAERQLLAPG NVLGSFMIRD SETTKGSYSL SVRDYDPQHR DTVKHYKIRT
210 220 230 240 250
LDNGGFYISP RSTFGSLQEL VAHYKKASDG LCQKLTVPCM SSKPQKPWEK
260 270 280 290 300
DAWEIPRESL KMEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF
310 320 330 340 350
LAEANLMKTL QHDKLVKLHA VVTEEPIYII TEFMAKGSLL DFLKSEEGSR
360 370 380 390 400
QPLPKLIDFS AQIAEGMAFI ERRNYIHRDL RAANILVSAS LVCKIADFGL
410 420 430 440 450
ARVIEDNEYT AREGAKFPIK WTAPEAINFG SFTIKSDVWS FGILLMEIVT
460 470 480 490 500
YGRIPYPGMS NPEVIRALER GYRMPRPDNC PEELYNIMTR CWKNRPEERP
510 520
TFEYIQSVLD DFYTATESQY QQQP
Length:524
Mass (Da):59,406
Last modified:May 3, 2011 - v1
Checksum:iD23962929F5E2F44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02036397 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSBTAT00000056914; ENSBTAP00000051020; ENSBTAG00000007932.

Similar proteinsi

Entry informationi

Entry nameiF1MWN2_BOVIN
AccessioniPrimary (citable) accession number: F1MWN2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 22, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported