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F1MW26

- F1MW26_BOVIN

UniProt

F1MW26 - F1MW26_BOVIN

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Protein
Submitted name:

Collagenase 3

Gene

MMP13

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei223 – 2231UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. metalloendopeptidase activity Source: Ensembl
  3. zinc ion binding Source: Ensembl

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cartilage development Source: Ensembl
  3. cellular protein metabolic process Source: Ensembl
  4. collagen catabolic process Source: Ensembl
  5. endochondral ossification Source: Ensembl
  6. extracellular matrix disassembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseSAAS annotation, Protease

Keywords - Ligandi

CalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_201925. Degradation of the extracellular matrix.
REACT_219138. Activation of Matrix Metalloproteinases.
REACT_222620. Collagen degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Collagenase 3Imported
Gene namesi
Name:MMP13Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: InterPro
  2. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains hemopexin repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118870.
OMAiNQVWSYD.
OrthoDBiEOG7XPZ57.
TreeFamiTF315428.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR028711. Collagenase_3.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF130. PTHR10201:SF130. 1 hit.
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1MW26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPRVLAGFL FFSWTACWSL PLPSDGDSED LSEEDFQFAE SYLKSYYYPQ
60 70 80 90 100
NPAGILKKTA ASSVIDRLRE MQSFFGLEVT GRLDDNTLDI MKKPRCGVPD
110 120 130 140 150
VGEYNVFPRT LKWSKMNLTY RIVNYTPDLT HSEVEKAFRK AFKVWSDVTP
160 170 180 190 200
LNFTRIHNGT ADIMISFGTK EHGDFYPFDG PSGLLAHAFP PGPNYGGDAH
210 220 230 240 250
FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM FPIYTYTGKS
260 270 280 290 300
HFMLPDDDVQ GIQSLYGPGD EDPYSKHPKT PDKCDPSLSL DAITSLRGET
310 320 330 340 350
LIFKDRFFWR LHPQQVEAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR
360 370 380 390 400
GRKFWALSGY DILEDYPKKI SELGFPKHVK KISAALHFED SGKTLFFSEN
410 420 430 440 450
QVWSYDDTNH VMDKDYPRLI EEVFPGIGDK VDAVYQKNGY IYFFNGPIQF
460 470
EYSIWSNRIV RVMTTNSLLW C
Length:471
Mass (Da):54,069
Last modified:November 16, 2011 - v2
Checksum:i8177F112FE7FCEAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02039864 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSBTAT00000020045; ENSBTAP00000020045; ENSBTAG00000015059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02039864 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000020045 ; ENSBTAP00000020045 ; ENSBTAG00000015059 .

Phylogenomic databases

GeneTreei ENSGT00760000118870.
OMAi NQVWSYD.
OrthoDBi EOG7XPZ57.
TreeFami TF315428.

Enzyme and pathway databases

Reactomei REACT_201925. Degradation of the extracellular matrix.
REACT_219138. Activation of Matrix Metalloproteinases.
REACT_222620. Collagen degradation.

Family and domain databases

Gene3Di 2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR028711. Collagenase_3.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
PANTHERi PTHR10201:SF130. PTHR10201:SF130. 1 hit.
Pfami PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEi PS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiF1MW26_BOVIN
AccessioniPrimary (citable) accession number: F1MW26
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3