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F1MW26

- F1MW26_BOVIN

UniProt

F1MW26 - F1MW26_BOVIN

Protein
Submitted name:

Collagenase 3

Gene

MMP13

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei223 – 2231UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. metalloendopeptidase activity Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. bone mineralization Source: Ensembl
    2. cartilage development Source: Ensembl
    3. cellular protein metabolic process Source: Ensembl
    4. collagen catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, MetalloproteaseSAAS annotation, Protease

    Keywords - Ligandi

    CalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_201925. Degradation of the extracellular matrix.
    REACT_219138. Activation of Matrix Metalloproteinases.
    REACT_222620. Collagen degradation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Collagenase 3Imported
    Gene namesi
    Name:MMP13Imported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: InterPro
    2. extracellular region Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains hemopexin repeats.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117336.
    OMAiNQVWSYD.
    OrthoDBiEOG7XPZ57.
    TreeFamiTF315428.

    Family and domain databases

    Gene3Di2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR028711. Collagenase_3.
    IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR021158. Pept_M10A_Zn_BS.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view]
    PANTHERiPTHR10201:SF130. PTHR10201:SF130. 1 hit.
    PfamiPF00045. Hemopexin. 4 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSiPR00138. MATRIXIN.
    SMARTiSM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
    PS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1MW26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPRVLAGFL FFSWTACWSL PLPSDGDSED LSEEDFQFAE SYLKSYYYPQ    50
    NPAGILKKTA ASSVIDRLRE MQSFFGLEVT GRLDDNTLDI MKKPRCGVPD 100
    VGEYNVFPRT LKWSKMNLTY RIVNYTPDLT HSEVEKAFRK AFKVWSDVTP 150
    LNFTRIHNGT ADIMISFGTK EHGDFYPFDG PSGLLAHAFP PGPNYGGDAH 200
    FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM FPIYTYTGKS 250
    HFMLPDDDVQ GIQSLYGPGD EDPYSKHPKT PDKCDPSLSL DAITSLRGET 300
    LIFKDRFFWR LHPQQVEAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR 350
    GRKFWALSGY DILEDYPKKI SELGFPKHVK KISAALHFED SGKTLFFSEN 400
    QVWSYDDTNH VMDKDYPRLI EEVFPGIGDK VDAVYQKNGY IYFFNGPIQF 450
    EYSIWSNRIV RVMTTNSLLW C 471
    Length:471
    Mass (Da):54,069
    Last modified:November 16, 2011 - v2
    Checksum:i8177F112FE7FCEAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02039864 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSBTAT00000020045; ENSBTAP00000020045; ENSBTAG00000015059.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02039864 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000020045 ; ENSBTAP00000020045 ; ENSBTAG00000015059 .

    Phylogenomic databases

    GeneTreei ENSGT00750000117336.
    OMAi NQVWSYD.
    OrthoDBi EOG7XPZ57.
    TreeFami TF315428.

    Enzyme and pathway databases

    Reactomei REACT_201925. Degradation of the extracellular matrix.
    REACT_219138. Activation of Matrix Metalloproteinases.
    REACT_222620. Collagen degradation.

    Family and domain databases

    Gene3Di 2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR028711. Collagenase_3.
    IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR021158. Pept_M10A_Zn_BS.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view ]
    PANTHERi PTHR10201:SF130. PTHR10201:SF130. 1 hit.
    Pfami PF00045. Hemopexin. 4 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSi PR00138. MATRIXIN.
    SMARTi SM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEi PS00546. CYSTEINE_SWITCH. 1 hit.
    PS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiF1MW26_BOVIN
    AccessioniPrimary (citable) accession number: F1MW26
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 32 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3