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Protein

Matrix metalloproteinase

Gene

MMP13

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationSAAS annotation, Protease
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-1442490. Collagen degradation.
R-BTA-1474228. Degradation of the extracellular matrix.
R-BTA-1592389. Activation of Matrix Metalloproteinases.
R-BTA-2022090. Assembly of collagen fibrils and other multimeric structures.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP13Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_501075526220 – 471Matrix metalloproteinaseUniRule annotationAdd BLAST452

Keywords - PTMi

Disulfide bondSAAS annotation, ZymogenUniRule annotation

Proteomic databases

PaxDbiF1MW26.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015059.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 268ZnMcInterPro annotationAdd BLAST160
Repeati281 – 330HemopexinPROSITE-ProRule annotationAdd BLAST50
Repeati331 – 377HemopexinPROSITE-ProRule annotationAdd BLAST47
Repeati379 – 427HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati428 – 471HemopexinPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.
OMAiMLPDDDV.
OrthoDBiEOG091G03DP.
TreeFamiTF315428.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 2 hits.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR028711. Collagenase_3.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF185. PTHR10201:SF185. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.

Sequencei

Sequence statusi: Complete.

F1MW26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRVLAGFL FFSWTACWSL PLPSDGDSED LSEEDFQFAE SYLKSYYYPQ
60 70 80 90 100
NPAGILKKTA ASSVIDRLRE MQSFFGLEVT GRLDDNTLDI MKKPRCGVPD
110 120 130 140 150
VGEYNVFPRT LKWSKMNLTY RIVNYTPDLT HSEVEKAFRK AFKVWSDVTP
160 170 180 190 200
LNFTRIHNGT ADIMISFGTK EHGDFYPFDG PSGLLAHAFP PGPNYGGDAH
210 220 230 240 250
FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM FPIYTYTGKS
260 270 280 290 300
HFMLPDDDVQ GIQSLYGPGD EDPYSKHPKT PDKCDPSLSL DAITSLRGET
310 320 330 340 350
LIFKDRFFWR LHPQQVEAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR
360 370 380 390 400
GRKFWALSGY DILEDYPKKI SELGFPKHVK KISAALHFED SGKTLFFSEN
410 420 430 440 450
QVWSYDDTNH VMDKDYPRLI EEVFPGIGDK VDAVYQKNGY IYFFNGPIQF
460 470
EYSIWSNRIV RVMTTNSLLW C
Length:471
Mass (Da):54,069
Last modified:November 16, 2011 - v2
Checksum:i8177F112FE7FCEAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02039864 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSBTAT00000020045; ENSBTAP00000020045; ENSBTAG00000015059.

Similar proteinsi

Entry informationi

Entry nameiF1MW26_BOVIN
AccessioniPrimary (citable) accession number: F1MW26
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: September 27, 2017
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported