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Protein

Aminopeptidase

Gene

ERAP1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-BTA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
AminopeptidaseUniRule annotation (EC:3.4.11.-UniRule annotation)
Gene namesi
Name:ERAP1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:28560 ERAP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_500326760533 – 942AminopeptidaseSequence analysisAdd BLAST910

Proteomic databases

PaxDbiF1MU34

Expressioni

Gene expression databases

BgeeiENSBTAG00000013557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018026

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 525Peptidase_M1InterPro annotationAdd BLAST261
Domaini598 – 917ERAP1_CInterPro annotationAdd BLAST320

Sequence similaritiesi

Belongs to the peptidase M1 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1046 Eukaryota
COG0308 LUCA
GeneTreeiENSGT00760000119082
InParanoidiF1MU34
OMAiDTGYLWH
OrthoDBiEOG091G01GH
TreeFamiTF300395

Family and domain databases

CDDicd09601 M1_APN_2, 1 hit
InterProiView protein in InterPro
IPR033520 ERAP1
IPR024571 ERAP1-like_C_dom
IPR034016 M1_APN-typ
IPR001930 Peptidase_M1
IPR014782 Peptidase_M1_N
PANTHERiPTHR11533 PTHR11533, 1 hit
PTHR11533:SF156 PTHR11533:SF156, 1 hit
PfamiView protein in Pfam
PF11838 ERAP1_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE

Sequencei

Sequence statusi: Complete.

F1MU34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPSIKWSL GTRPLLLSTL LILLTVATPS SCQSREPTSP KASNGAPFPW
60 70 80 90 100
NKIRLPEHII PAHYDLMIHA NLTTLTFGGT TQIEITASKP TSTIILHSHR
110 120 130 140 150
LQISKAALRK GGGERQAEEP LRVLENPPQE QIALLASEPL VVGLPYTIVI
160 170 180 190 200
DYAGNLSESF HGFYKSTYRT KEGEVRILAS TQFEPTAARM AFPCFDEPAL
210 220 230 240 250
KASFLIKIRR EPRHLAISNM PLVKSVTVAE GLIEDHFDVT VRMSTYLVAF
260 270 280 290 300
IVSDFKSVSK MTKSGVKVSV YAVPDKINQA DYALDAAVTL LEFYEDYFSI
310 320 330 340 350
PYPLPKQDLA AIPDFQSGAM ENWGLTTYRE SSLLFDAEKS SASSKLGITM
360 370 380 390 400
IVSHELAHQW FGNLVTMEWW NDLWLNEGFA KFMEFVSVSV THPELKVEDY
410 420 430 440 450
FFGKCFNAME VDALNSSHPV STPVENPAQI REMFDEVSYD KGACILNMLR
460 470 480 490 500
DYLGADAFKS GIVNYLQKYS YKNTKNEDLW NSMASICPTD DTQHMDGFCS
510 520 530 540 550
RGEHASSTAH WRQEGLDVKT MMNTWTLQKG FPLITITVRG RNVHMKQEYY
560 570 580 590 600
VKGAADAPET GFLWHVPLTF ITSKSDAVQR FLLKTRTDVL ILPEEVEWIK
610 620 630 640 650
FNVGMNGYYI VHYEDDGWDS LTGLLKGTHT AISSNDRASL INNAFQLVSI
660 670 680 690 700
GKLSIEKALD LTLYLKHETE IMPVFQGLNE LIPMYKLMEK REMNEVETQF
710 720 730 740 750
KAFLIRLLRD LIDKQTWTDE GSVSERMLRS QLLFLACVRK YQPCVQKAEG
760 770 780 790 800
YFRQWQEAGG NLSLPNDVTL AVFAVGAQTL EGWDFLYSKY QSSLSSTEKN
810 820 830 840 850
QIEFALCISQ NKEKLQWLLD QSFKGDVIKT QEFPDILRAI GRNPVGYPLA
860 870 880 890 900
WQFLRENWNK LVQKFELGSN SIAYMVTGTT DQFSTRARLE EVKEFFSSLK
910 920 930 940
ENGSQLRCVQ QTIETIEENI RWMDKNFDKI RAWLQNEKLN LL
Length:942
Mass (Da):107,064
Last modified:May 3, 2011 - v1
Checksum:i2DFC7FE960BC8149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02021351 Genomic DNA No translation available.
RefSeqiXP_010805927.1, XM_010807625.2
XP_010805928.1, XM_010807626.2
XP_015327855.1, XM_015472369.1
UniGeneiBt.28338

Genome annotation databases

EnsembliENSBTAT00000018026; ENSBTAP00000018026; ENSBTAG00000013557
GeneIDi514617

Similar proteinsi

Entry informationi

Entry nameiF1MU34_BOVIN
AccessioniPrimary (citable) accession number: F1MU34
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health