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Protein

Hexokinase

Gene

HKDC1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: GO_Central
  3. glucokinase activity Source: GO_Central
  4. mannokinase activity Source: GO_Central

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: GO_Central
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:HKDC1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 28

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: GO_Central
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 2 hexokinase type-1 domains.UniRule annotation
Contains 2 hexokinase type-2 domains.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017159.
InParanoidiF1MIM3.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1MIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAVHLMAFY FTKLKEDQIK KVDRFLYHMR LSDETLLDIM ARFQAEMQKG
60 70 80 90 100
LGKDTNPTAS VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSEE
110 120 130 140 150
GKRNVQMESQ FYPTPNEIIR GNGTELFEYV ADCLADFMKT KELMQKKLPL
160 170 180 190 200
GLTFSFPCKQ TKLEEGILLS WTKKFKARGV QGTDVVSSLT NAMKRHQDLD
210 220 230 240 250
VDILALVNDT VGTMMTCAYD DPYCEVGVII GTGTNACYME DMSNIDLVEG
260 270 280 290 300
DEGRMCVNTE WGAFGDDGAL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL
310 320 330 340 350
YLGELVRLIL LKMAKAGLLF GGEKSSALHI KGKIETRHVA AMERYKEGLA
360 370 380 390 400
NTREILTDLG LEPSDADCIA VQHVCTIVSF RSANLCAAAL AAILTRLREN
410 420 430 440 450
KKLVRLRTTV GVDGTLYKIH PQYPKRLHKV VRKLVPNCDV RFLLSESGST
460 470 480 490 500
KGAAMVTAVA SRLQAQRKQI DKVLALFRLT QEQLVGIRNK MRVEFEYGLK
510 520 530 540 550
KDTHPLATVK MLPTYVCGMP DGTEKGKFLA LDLGGTNFRV LLVKIRSGRR
560 570 580 590 600
SVRMYNKIFA IPLEIMQGTG EELFDHIVQC IADFLDYMGL KGAQLPLGFT
610 620 630 640 650
FSFPCRQANI DKGTLIEWTK GFKATDCEGE DVVDMLREAI KRRNEFDLDI
660 670 680 690 700
VAVVNDTVGT MMTCGYEDSN CEVGLIAGTG SNMCYMEEMR NIELVEGDEG
710 720 730 740 750
KMCINTEWGG FGDNGCLDDI HTQYDKEVDE GSLNPGKQRY EKMTSGMYLG
760 770 780 790 800
EIVRQILIDL TKQGLLFRGQ ISERLRTRGI FETKFLSQIE SDRLALLQVR
810 820 830 840 850
RILQQLGLDS TCEDSIVVKE VCGAVSRRAA QLYGAGLAAI VEKRREDQGL
860 870 880 890 900
EHMRITVGVD GTLYKLHPHF SRILRETVKE LAPQCDVMFM LSEDGSGKGA
910
ALITAVAKRL QQAQREH
Length:917
Mass (Da):102,579
Last modified:November 16, 2011 - v2
Checksum:iC6FA3C70CC00CFCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02061832 Genomic DNA. No translation available.
RefSeqiNP_001178413.1. NM_001191484.1.
UniGeneiBt.1522.

Genome annotation databases

EnsembliENSBTAT00000047474; ENSBTAP00000044680; ENSBTAG00000033398.
GeneIDi614824.
KEGGibta:614824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02061832 Genomic DNA. No translation available.
RefSeqiNP_001178413.1. NM_001191484.1.
UniGeneiBt.1522.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000047474; ENSBTAP00000044680; ENSBTAG00000033398.
GeneIDi614824.
KEGGibta:614824.

Organism-specific databases

CTDi80201.

Phylogenomic databases

GeneTreeiENSGT00390000017159.
InParanoidiF1MIM3.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
TreeFamiTF314238.

Miscellaneous databases

NextBioi20899309.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiF1MIM3_BOVIN
AccessioniPrimary (citable) accession number: F1MIM3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: March 4, 2015
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.