ID   F1MH16_BOVIN            Unreviewed;       434 AA.
AC   F1MH16;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Interleukin 5 receptor subunit alpha {ECO:0000313|Ensembl:ENSBTAP00000000339.5};
GN   Name=IL5RA {ECO:0000313|Ensembl:ENSBTAP00000000339.5,
GN   ECO:0000313|VGNC:VGNC:30165};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000000339.5, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000000339.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000339.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000000339.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000339.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   AlphaFoldDB; F1MH16; -.
DR   SMR; F1MH16; -.
DR   STRING; 9913.ENSBTAP00000000339; -.
DR   Ensembl; ENSBTAT00000000339.5; ENSBTAP00000000339.5; ENSBTAG00000000273.6.
DR   VEuPathDB; HostDB:ENSBTAG00000000273; -.
DR   VGNC; VGNC:30165; IL5RA.
DR   eggNOG; ENOG502QZNV; Eukaryota.
DR   GeneTree; ENSGT00940000160890; -.
DR   HOGENOM; CLU_039945_0_0_1; -.
DR   InParanoid; F1MH16; -.
DR   OMA; NKFRDPF; -.
DR   TreeFam; TF331549; -.
DR   Reactome; R-BTA-512988; Interleukin-3, Interleukin-5 and GM-CSF signaling.
DR   Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-BTA-912526; Interleukin receptor SHC signaling.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000000273; Expressed in neutrophil and 26 other cell types or tissues.
DR   ExpressionAtlas; F1MH16; baseline.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR   GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23037:SF7; INTERLEUKIN-21 RECEPTOR; 1.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 3.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          46..135
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
SQ   SEQUENCE   434 AA;  49816 MW;  17859BE954E2E583 CRC64;
     MVIRNERINR RRQVVIIMAP ELLILLGAAV ILQADLLPDK KFLLLPPVNF TIKAVNLAQV
     LLRWEPNPDQ EQSNIQLGYH VKINAPQEED YETRNTERNL ITILHKGFSA SVRTVPWNDH
     SLQASSWVSA ELKAPIGSPG TEIVNLTCTT NTKADNYTHL RPYQVSLHCT WLVGKDAPDD
     TQYFLYYRYR SWIEECQEYS KDVLQRNVAC WFPRTFINSK GRDYLAVYVN GSSKGAAIKP
     FDQLFALHAI DRVNSPANVT AEIKGTCLSI HWEKPVSAFP SHCFDYEVKI YNAKKGYFQT
     EKMTTNTLIT IIDDVSKYYI QVRAAVSPVC RATGLWSEWS RPIYVGKDDQ KPWTEWFLIA
     VMMTICFILL IFSLICRICH VWTKLFPPVP GPKSNINDFF VIINNEAMST ENWEMKHHLL
     LSVLRPTPST WGGK
//