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Protein
Submitted name:

Glutamate ionotropic receptor NMDA type subunit 2B

Gene

GRIN2B

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-BTA-442729. CREB phosphorylation through the activation of CaMKII.
R-BTA-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-BTA-5673001. RAF/MAP kinase cascade.
R-BTA-8849932. Synaptic adhesion-like molecules.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate ionotropic receptor NMDA type subunit 2BImported
Gene namesi
Name:GRIN2BImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei558 – 580HelicalSequence analysisAdd BLAST23
Transmembranei601 – 618HelicalSequence analysisAdd BLAST18
Transmembranei630 – 655HelicalSequence analysisAdd BLAST26
Transmembranei821 – 844HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500326728129 – 1497Sequence analysisAdd BLAST1469

Proteomic databases

PaxDbiF1MCL3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000219.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000263.

Structurei

3D structure databases

ProteinModelPortaliF1MCL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini431 – 799PBPeInterPro annotationAdd BLAST369
Domaini440 – 503Lig_chan-Glu_bdInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
InParanoidiF1MCL3.
KOiK05210.
OMAiRNNYPEM.
OrthoDBiEOG091G09KH.
TreeFamiTF314731.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
PRINTSiPR00177. NMDARECEPTOR.
SMARTiView protein in SMART
SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

F1MCL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPRAECCSP KFWLVLAVLA VSGSRARSQK SPPSIGIAVI LVGTSDEVAI
60 70 80 90 100
KDAHEKDDFH HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA
110 120 130 140 150
DDTDQEAIAQ ILDFISAQTL TPILGIHGGS SMIMADKDES SMFFQFGPSI
160 170 180 190 200
EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ DFVNKIRSTI ENSFVGWELE
210 220 230 240 250
EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI FEVANSVGLT
260 270 280 290 300
GYGYTWIVPS LVAGDTDTVP SEFPTGLVSV SYDEWDYGLP ARVRDGIAII
310 320 330 340 350
TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS
360 370 380 390 400
FSEDGYQMHP KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE
410 420 430 440 450
QEDDHLSIVT LEEAPFVIVE SVDPLSGTCM RNTVPCQKRI ISENKTDEEP
460 470 480 490 500
GYIKKCCKGF CIDILKKISK SVKFTYDLYL VTNGKHGKKI NGTWNGMIGE
510 520 530 540 550
VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR SNGTVSPSAF
560 570 580 590 600
LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF
610 620 630 640 650
TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL
660 670 680 690 700
AAFMIQEEYV DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA
710 720 730 740 750
EMHAYMGKFN QRGVDDALLS LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT
760 770 780 790 800
IGSGKVFAST GYGIAIQKDS GWKRQVDLAI LQLFGDGEME ELEALWLTGI
810 820 830 840 850
CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH LFYWQFRHCF
860 870 880 890 900
MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR
910 920 930 940 950
LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN
960 970 980 990 1000
NPPCEENLFS DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSASSI
1010 1020 1030 1040 1050
DGLYDCDNPP FTTQPRALGK KPLDIGLPSS KHSQLGDLYG KFSFKSDRYG
1060 1070 1080 1090 1100
GHDDLIRSDV SDISTHTVTY GNIEGNAAKR RKQQYKDSLK KRPASAKSRR
1110 1120 1130 1140 1150
EFDEIELAYR RRPPRSPDHK RYFRDKDGLR DFYLDQFRAK ETSPHWEHVD
1160 1170 1180 1190 1200
LTDLYKERGE DFKRDSVGGG GPCTNRAHHL KHGTGDKHGG GVVGGVPAPW
1210 1220 1230 1240 1250
EKNLTNVDWE ERPGGNFCRS CPSKLHNYST TTAATAVVAG QNSGRPACIR
1260 1270 1280 1290 1300
CEACKKAGNL YDISEDNSLQ ELDQPAAPVA AVTSAASKYP QSPTNSKAQK
1310 1320 1330 1340 1350
KPRNKLRRQH SYDTFVDLQK EEAALAPRSV SLKDKGRFLD GSPYAHMFEM
1360 1370 1380 1390 1400
PAGESAFSGS NDGKAAAPAA GHHHHGNPGG GGGYMLSKSL YPDRVTQNPF
1410 1420 1430 1440 1450
IPTFGDDQCL LHGSKSYFFR QPTVAGAPKA RPDFRALVSN KPVVSALHGA
1460 1470 1480 1490
VPGRFQKDIC IGNQSNPCVP NNKNPRAFNG SSNGHVYEKL SSIESDV
Length:1,497
Mass (Da):166,777
Last modified:November 16, 2011 - v2
Checksum:iFD04B2467E42CEDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02014253 Genomic DNA. No translation available.
DAAA02014254 Genomic DNA. No translation available.
DAAA02014255 Genomic DNA. No translation available.
DAAA02014256 Genomic DNA. No translation available.
DAAA02014257 Genomic DNA. No translation available.
DAAA02014258 Genomic DNA. No translation available.
DAAA02014259 Genomic DNA. No translation available.
DAAA02014260 Genomic DNA. No translation available.
DAAA02014261 Genomic DNA. No translation available.
DAAA02014262 Genomic DNA. No translation available.
RefSeqiNP_001179850.1. NM_001192921.1.
XP_005207045.1. XM_005206988.3.

Genome annotation databases

EnsembliENSBTAT00000000263; ENSBTAP00000000263; ENSBTAG00000000219.
GeneIDi537804.
KEGGibta:537804.

Similar proteinsi

Entry informationi

Entry nameiF1MCL3_BOVIN
AccessioniPrimary (citable) accession number: F1MCL3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: November 22, 2017
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported