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Protein
Submitted name:

Sterol regulatory element-binding protein 2

Gene

Srebf2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. E-box binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of cholesterol efflux Source: Ensembl
  2. positive regulation of cholesterol storage Source: Ensembl
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. regulation of cholesterol homeostasis Source: Ensembl
  5. regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. response to low-density lipoprotein particle Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_285313. PPARA activates gene expression.
REACT_306909. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_341940. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Submitted name:
Sterol regulatory element-binding protein 2Imported
Gene namesi
Name:Srebf2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307751. Srebf2.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: Ensembl
  2. SREBP-SCAP-Insig complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017651.
OMAiDVICRWW.
OrthoDBiEOG7D85VS.
TreeFamiTF313894.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003006. Ig/MHC_CS.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1MA23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDENSELGGL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFSDLFSEQL
60 70 80 90 100
CSSFPGGGGG SGSGGTSNNS SGRGTSGGAA DPAVQRSFSQ VPLSTFSPSS
110 120 130 140 150
TSPQAPALQV KVSPTPPRAT PVLQPRPQPQ PQPPAQLQQQ TVMITPTFST
160 170 180 190 200
APQTRIIQQP LIYQNAATSF QVLQPQVQSL VTSSQVQPVT IQQQVQTVQA
210 220 230 240 250
QRVLTQTANG TLQTLAPATV QTVATPQVQQ VPVLVQPQII KTDSLVLTTL
260 270 280 290 300
KTDGSPVMAA VQNPALTALT APIQTAALQV PTLVGSNGAI LTTMPVMMGQ
310 320 330 340 350
EKVPIKQVPG GVKQLEPPKE GERRTTHNII EKRYRSSIND KIIELKDLVM
360 370 380 390 400
GTDAKMHKSG VLRKAIDYIK YLQQVNHKLR QENMVLKLAN QKNKLLKGID
410 420 430 440 450
LGSLVDSDVD LKIDDFNQNV LLMSPPASDS GSQAGFSPYS IDSEPGSPLL
460 470 480 490 500
DDAKVKDEPD SPPVALGMVD RSRILLCVLT FLGLSFNPLT SLLQWGGAHN
510 520 530 540 550
PDQHPYSGSG RNVLSLESGS GGWFDWMMPT LLLWLLNGVI VLSVFVKLLV
560 570 580 590 600
HGEPVIRPHS RSSVTFWRHR KQADLDLAKG DFAAAAANLQ TCLSVLGRAL
610 620 630 640 650
PTSRLDLACS LSWNVIRYSL QKLRLVRWLL KKVFQRWRAT PATAAGFEDE
660 670 680 690 700
AKSSARDAAL AYHRLHQLHI TGKLPAGSAC SDVHMALCAV NLAECAEEKI
710 720 730 740 750
PPSTLVEIHL TAAMGLKTRC GGKLGFLASY FLNRAQSLCG PEHSAVPDSL
760 770 780 790 800
RWLCHPLGQK FFMERSWSIK SAAKDSLYCA QRNPADPIAQ VHQAFCKHLL
810 820 830 840 850
ERAVEALVKP QAKKKAGDRE EESCEFSSAL EFLKLLHSFV DSVGFVASPF
860 870 880 890 900
SSSSVLRSAL GPDVVCRWWT SAITVAISWL QGDDAAVRSH FTEVERVPKA
910 920 930 940 950
LEVTESPLVK AVFYACRAMH ASLSGKADGQ QNSFCHCERA SGHLWSSLNV
960 970 980 990 1000
SGTTSDPSLN HVVQLFTCDL LLSLRTTLWQ KQASASQLLG ETYHASGTEL
1010 1020 1030 1040 1050
AGFQRDLGSL RRLAHSFRPA YRKVFLHEAT VRLMAGASPT RTHQLLEHSL
1060 1070 1080 1090 1100
RRRTTQNTKH GEVDTWPGQR ERATAILLAC RHLPLSFLSS PGQRAVLLAE
1110 1120 1130
AARTLEKVGD RRSCSDCQQM IVKLGGGTAI AAS
Length:1,133
Mass (Da):123,010
Last modified:May 3, 2011 - v1
Checksum:iFC2D4C6194522A92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06052109 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000056041; ENSRNOP00000052893; ENSRNOG00000007400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06052109 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056041; ENSRNOP00000052893; ENSRNOG00000007400.

Organism-specific databases

RGDi1307751. Srebf2.

Phylogenomic databases

GeneTreeiENSGT00390000017651.
OMAiDVICRWW.
OrthoDBiEOG7D85VS.
TreeFamiTF313894.

Enzyme and pathway databases

ReactomeiREACT_285313. PPARA activates gene expression.
REACT_306909. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_341940. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

NextBioi35583108.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003006. Ig/MHC_CS.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1MA23_RAT
AccessioniPrimary (citable) accession number: F1MA23
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 29, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.