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Protein
Submitted name:

Sterol regulatory element-binding protein 2

Gene

Srebf2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).

Names & Taxonomyi

Protein namesi
Submitted name:
Sterol regulatory element-binding protein 2Imported
Gene namesi
Name:Srebf2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307751. Srebf2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1MA23.
PRIDEiF1MA23.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007400.
ExpressionAtlasiF1MA23. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini322 – 372BHLHInterPro annotationAdd BLAST51

Phylogenomic databases

eggNOGiKOG2588. Eukaryota.
ENOG410XSVP. LUCA.
GeneTreeiENSGT00390000017651.
OMAiGEVDAWP.
OrthoDBiEOG091G01RE.
TreeFamiTF313894.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR003006. Ig/MHC_CS.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

F1MA23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDENSELGGL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFSDLFSEQL
60 70 80 90 100
CSSFPGGGGG SGSGGTSNNS SGRGTSGGAA DPAVQRSFSQ VPLSTFSPSS
110 120 130 140 150
TSPQAPALQV KVSPTPPRAT PVLQPRPQPQ PQPPAQLQQQ TVMITPTFST
160 170 180 190 200
APQTRIIQQP LIYQNAATSF QVLQPQVQSL VTSSQVQPVT IQQQVQTVQA
210 220 230 240 250
QRVLTQTANG TLQTLAPATV QTVATPQVQQ VPVLVQPQII KTDSLVLTTL
260 270 280 290 300
KTDGSPVMAA VQNPALTALT APIQTAALQV PTLVGSNGAI LTTMPVMMGQ
310 320 330 340 350
EKVPIKQVPG GVKQLEPPKE GERRTTHNII EKRYRSSIND KIIELKDLVM
360 370 380 390 400
GTDAKMHKSG VLRKAIDYIK YLQQVNHKLR QENMVLKLAN QKNKLLKGID
410 420 430 440 450
LGSLVDSDVD LKIDDFNQNV LLMSPPASDS GSQAGFSPYS IDSEPGSPLL
460 470 480 490 500
DDAKVKDEPD SPPVALGMVD RSRILLCVLT FLGLSFNPLT SLLQWGGAHN
510 520 530 540 550
PDQHPYSGSG RNVLSLESGS GGWFDWMMPT LLLWLLNGVI VLSVFVKLLV
560 570 580 590 600
HGEPVIRPHS RSSVTFWRHR KQADLDLAKG DFAAAAANLQ TCLSVLGRAL
610 620 630 640 650
PTSRLDLACS LSWNVIRYSL QKLRLVRWLL KKVFQRWRAT PATAAGFEDE
660 670 680 690 700
AKSSARDAAL AYHRLHQLHI TGKLPAGSAC SDVHMALCAV NLAECAEEKI
710 720 730 740 750
PPSTLVEIHL TAAMGLKTRC GGKLGFLASY FLNRAQSLCG PEHSAVPDSL
760 770 780 790 800
RWLCHPLGQK FFMERSWSIK SAAKDSLYCA QRNPADPIAQ VHQAFCKHLL
810 820 830 840 850
ERAVEALVKP QAKKKAGDRE EESCEFSSAL EFLKLLHSFV DSVGFVASPF
860 870 880 890 900
SSSSVLRSAL GPDVVCRWWT SAITVAISWL QGDDAAVRSH FTEVERVPKA
910 920 930 940 950
LEVTESPLVK AVFYACRAMH ASLSGKADGQ QNSFCHCERA SGHLWSSLNV
960 970 980 990 1000
SGTTSDPSLN HVVQLFTCDL LLSLRTTLWQ KQASASQLLG ETYHASGTEL
1010 1020 1030 1040 1050
AGFQRDLGSL RRLAHSFRPA YRKVFLHEAT VRLMAGASPT RTHQLLEHSL
1060 1070 1080 1090 1100
RRRTTQNTKH GEVDTWPGQR ERATAILLAC RHLPLSFLSS PGQRAVLLAE
1110 1120 1130
AARTLEKVGD RRSCSDCQQM IVKLGGGTAI AAS
Length:1,133
Mass (Da):123,010
Last modified:May 3, 2011 - v1
Checksum:iFC2D4C6194522A92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113253 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000056041; ENSRNOP00000052893; ENSRNOG00000007400.

Similar proteinsi

Entry informationi

Entry nameiF1MA23_RAT
AccessioniPrimary (citable) accession number: F1MA23
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 27, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported