F1MA23 (F1MA23_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Sterol regulatory element-binding protein 2 Ensembl ENSRNOP00000052893

Gene names

Name:

Srebf2 Ensembl ENSRNOP00000052893 RGD 1307751

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000052893

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1133 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000052893

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SREBP signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cholesterol efflux Inferred from electronic annotation. Source: Compara positive regulation of cholesterol storage Inferred from electronic annotation. Source: Compara regulation of cholesterol homeostasis Inferred from electronic annotation. Source: Compara regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara response to low-density lipoprotein particle stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	SREBP-SCAP-Insig complex Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	E-box binding Inferred from electronic annotation. Source: Compara RNA polymerase II core promoter proximal region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F1MA23 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: FC2D4C6194522A92	FASTA	1,133	123,010
	10 20 30 40 50 60 MDENSELGGL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFSDLFSEQL CSSFPGGGGG 70 80 90 100 110 120 SGSGGTSNNS SGRGTSGGAA DPAVQRSFSQ VPLSTFSPSS TSPQAPALQV KVSPTPPRAT 130 140 150 160 170 180 PVLQPRPQPQ PQPPAQLQQQ TVMITPTFST APQTRIIQQP LIYQNAATSF QVLQPQVQSL 190 200 210 220 230 240 VTSSQVQPVT IQQQVQTVQA QRVLTQTANG TLQTLAPATV QTVATPQVQQ VPVLVQPQII 250 260 270 280 290 300 KTDSLVLTTL KTDGSPVMAA VQNPALTALT APIQTAALQV PTLVGSNGAI LTTMPVMMGQ 310 320 330 340 350 360 EKVPIKQVPG GVKQLEPPKE GERRTTHNII EKRYRSSIND KIIELKDLVM GTDAKMHKSG 370 380 390 400 410 420 VLRKAIDYIK YLQQVNHKLR QENMVLKLAN QKNKLLKGID LGSLVDSDVD LKIDDFNQNV 430 440 450 460 470 480 LLMSPPASDS GSQAGFSPYS IDSEPGSPLL DDAKVKDEPD SPPVALGMVD RSRILLCVLT 490 500 510 520 530 540 FLGLSFNPLT SLLQWGGAHN PDQHPYSGSG RNVLSLESGS GGWFDWMMPT LLLWLLNGVI 550 560 570 580 590 600 VLSVFVKLLV HGEPVIRPHS RSSVTFWRHR KQADLDLAKG DFAAAAANLQ TCLSVLGRAL 610 620 630 640 650 660 PTSRLDLACS LSWNVIRYSL QKLRLVRWLL KKVFQRWRAT PATAAGFEDE AKSSARDAAL 670 680 690 700 710 720 AYHRLHQLHI TGKLPAGSAC SDVHMALCAV NLAECAEEKI PPSTLVEIHL TAAMGLKTRC 730 740 750 760 770 780 GGKLGFLASY FLNRAQSLCG PEHSAVPDSL RWLCHPLGQK FFMERSWSIK SAAKDSLYCA 790 800 810 820 830 840 QRNPADPIAQ VHQAFCKHLL ERAVEALVKP QAKKKAGDRE EESCEFSSAL EFLKLLHSFV 850 860 870 880 890 900 DSVGFVASPF SSSSVLRSAL GPDVVCRWWT SAITVAISWL QGDDAAVRSH FTEVERVPKA 910 920 930 940 950 960 LEVTESPLVK AVFYACRAMH ASLSGKADGQ QNSFCHCERA SGHLWSSLNV SGTTSDPSLN 970 980 990 1000 1010 1020 HVVQLFTCDL LLSLRTTLWQ KQASASQLLG ETYHASGTEL AGFQRDLGSL RRLAHSFRPA 1030 1040 1050 1060 1070 1080 YRKVFLHEAT VRLMAGASPT RTHQLLEHSL RRRTTQNTKH GEVDTWPGQR ERATAILLAC 1090 1100 1110 1120 1130 RHLPLSFLSS PGQRAVLLAE AARTLEKVGD RRSCSDCQQM IVKLGGGTAI AAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000052893.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000052893.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06052109 Genomic DNA. No translation available.
IPI	IPI00366445.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000056041; ENSRNOP00000052893; ENSRNOG00000007400.
Organism-specific databases
RGD	1307751. Srebf2.
Phylogenomic databases
GeneTree	ENSGT00390000017651.
OMA	ECAEEKI.
Gene expression databases
ArrayExpress	F1MA23.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR003006. Ig/MHC_CS. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35583108.

Entry information

Entry name

F1MA23_RAT

Accession

Primary (citable) accession number: F1MA23

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)