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Protein
Submitted name:

Protein Adam12

Gene

Adam12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM12.212.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Adam12Imported
Gene namesi
Name:Adam12Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1583652. Adam12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei685 – 70622HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1M9Z9.

PTM databases

PhosphoSiteiF1M9Z9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018384.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024974.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 393203Peptidase M12BInterPro annotationAdd
BLAST
Domaini401 – 48787DisintegrinInterPro annotationAdd
BLAST
Domaini633 – 66533EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.UniRule annotation
Contains 1 peptidase M12B domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
OMAiPPFCDKF.
OrthoDBiEOG091G01NX.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1M9Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIELNTSLG VSLWDQRGAY EVAKASLLTK DPGSPGQSIP AKDHPDVLTV
60 70 80 90 100
QLQLESRELI LSLERNEGLI ANGFTETHYL QDGSDVSFTR NYTDHCYYHG
110 120 130 140 150
HVQGDAASVV SLSTCSGLRG LIVFENKTYI LEPMKNTTDR YKLVPAENMK
160 170 180 190 200
NIQGLCGSHH NKSSLTMEDV FPEPSQMWGR RHKRETLKMT KYVELVIVAD
210 220 230 240 250
NREFQRQGKD LEKVKQRLIE IANHVDKFYR PLNIRIVLVG VEVWNDIDKC
260 270 280 290 300
SISQDPFTSL HEFLDWRKLK LLPRKSHDNA QLISGVYFQG TTIGMAPIMS
310 320 330 340 350
MCTAEQSGGV VMDHSDSPLG AAVTLAHELG HNFGMNHDTL ERGCSCRMAA
360 370 380 390 400
EKGGCIMNPS TGFPFPMVFS SCSRKDLEAS LEKGMGMCLF NLPEVKQAFG
410 420 430 440 450
GRKCGNGYVE DGEECDCGEP EECTNRCCNA TTCTLKPDAV CAHGQCCEDC
460 470 480 490 500
QLKPPGTACR GSSNSCDLPE FCTGTAPHCP ANVYLHDGHP CQGVDGYCYN
510 520 530 540 550
GICQTHEQQC VTLWGPGAKP APGICFERVN SAGDPYGNCG KDSKSSFVKC
560 570 580 590 600
ELRDAKCGKI QCQGGASRPV IGTNAVSIET NIPQQEGGRI LCRGTHVYLG
610 620 630 640 650
DDMPDPGLVL AGTKCAEGKI CLNRQCQNIS VFGVHKCAMQ CHGRGVCNNR
660 670 680 690 700
KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ ADNQGLTVGI LVSVLCLLAA
710 720 730 740 750
GFVVYLKRKT LMRLLFTHKK NTMEKLRCVH TSRTPSGPRP GQAHHILGKG
760 770 780 790 800
PLMSRPPHFN TTKDRHSLKC QNIDISRPLN ARVVPQPQSP QRVLLPLHQA
810 820 830 840 850
PRAPSGPARP LPANPAVRQA QGTHKPSPPQ KPLPADPLSR TSRLTGALVR
860 870 880
TPGQQESGHR PAPIRPAPKH QVPRLSHNAY IK
Length:882
Mass (Da):96,518
Last modified:July 22, 2015 - v3
Checksum:i1189270A5AB9B99D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005906 Genomic DNA. No translation available.
AABR07005907 Genomic DNA. No translation available.
AABR07005908 Genomic DNA. No translation available.
AABR07071993 Genomic DNA. No translation available.
AC111884 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000024974; ENSRNOP00000024974; ENSRNOG00000018384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005906 Genomic DNA. No translation available.
AABR07005907 Genomic DNA. No translation available.
AABR07005908 Genomic DNA. No translation available.
AABR07071993 Genomic DNA. No translation available.
AC111884 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024974.

Protein family/group databases

MEROPSiM12.212.

PTM databases

PhosphoSiteiF1M9Z9.

Proteomic databases

PaxDbiF1M9Z9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024974; ENSRNOP00000024974; ENSRNOG00000018384.

Organism-specific databases

RGDi1583652. Adam12.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
OMAiPPFCDKF.
OrthoDBiEOG091G01NX.
TreeFamiTF314733.

Gene expression databases

BgeeiENSRNOG00000018384.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1M9Z9_RAT
AccessioniPrimary (citable) accession number: F1M9Z9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: September 7, 2016
This is version 45 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.