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Protein
Submitted name:

ADAM metallopeptidase domain 12

Gene

Adam12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi327Zinc; catalyticPROSITE-ProRule annotation1
Active sitei328PROSITE-ProRule annotation1
Metal bindingi331Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi337Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-8941237. Invadopodia formation.

Protein family/group databases

MEROPSiM12.212.

Names & Taxonomyi

Protein namesi
Submitted name:
ADAM metallopeptidase domain 12Imported
Gene namesi
Name:Adam12Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1583652. Adam12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei685 – 706HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi459 ↔ 479PROSITE-ProRule annotation
Disulfide bondi637 ↔ 647PROSITE-ProRule annotation
Disulfide bondi655 ↔ 664PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiF1M9Z9.

PTM databases

PhosphoSitePlusiF1M9Z9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018384.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024974.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 393Peptidase M12BInterPro annotationAdd BLAST203
Domaini401 – 487DisintegrinInterPro annotationAdd BLAST87
Domaini633 – 665EGF-likeInterPro annotationAdd BLAST33

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
OMAiFTSLHEF.
OrthoDBiEOG091G01NX.
TreeFamiTF314733.

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

F1M9Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIELNTSLG VSLWDQRGAY EVAKASLLTK DPGSPGQSIP AKDHPDVLTV
60 70 80 90 100
QLQLESRELI LSLERNEGLI ANGFTETHYL QDGSDVSFTR NYTDHCYYHG
110 120 130 140 150
HVQGDAASVV SLSTCSGLRG LIVFENKTYI LEPMKNTTDR YKLVPAENMK
160 170 180 190 200
NIQGLCGSHH NKSSLTMEDV FPEPSQMWGR RHKRETLKMT KYVELVIVAD
210 220 230 240 250
NREFQRQGKD LEKVKQRLIE IANHVDKFYR PLNIRIVLVG VEVWNDIDKC
260 270 280 290 300
SISQDPFTSL HEFLDWRKLK LLPRKSHDNA QLISGVYFQG TTIGMAPIMS
310 320 330 340 350
MCTAEQSGGV VMDHSDSPLG AAVTLAHELG HNFGMNHDTL ERGCSCRMAA
360 370 380 390 400
EKGGCIMNPS TGFPFPMVFS SCSRKDLEAS LEKGMGMCLF NLPEVKQAFG
410 420 430 440 450
GRKCGNGYVE DGEECDCGEP EECTNRCCNA TTCTLKPDAV CAHGQCCEDC
460 470 480 490 500
QLKPPGTACR GSSNSCDLPE FCTGTAPHCP ANVYLHDGHP CQGVDGYCYN
510 520 530 540 550
GICQTHEQQC VTLWGPGAKP APGICFERVN SAGDPYGNCG KDSKSSFVKC
560 570 580 590 600
ELRDAKCGKI QCQGGASRPV IGTNAVSIET NIPQQEGGRI LCRGTHVYLG
610 620 630 640 650
DDMPDPGLVL AGTKCAEGKI CLNRQCQNIS VFGVHKCAMQ CHGRGVCNNR
660 670 680 690 700
KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ ADNQGLTVGI LVSVLCLLAA
710 720 730 740 750
GFVVYLKRKT LMRLLFTHKK NTMEKLRCVH TSRTPSGPRP GQAHHILGKG
760 770 780 790 800
PLMSRPPHFN TTKDRHSLKC QNIDISRPLN ARVVPQPQSP QRVLLPLHQA
810 820 830 840 850
PRAPSGPARP LPANPAVRQA QGTHKPSPPQ KPLPADPLSR TSRLTGALVR
860 870 880
TPGQQESGHR PAPIRPAPKH QVPRLSHNAY IK
Length:882
Mass (Da):96,518
Last modified:July 22, 2015 - v3
Checksum:i1189270A5AB9B99D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005906 Genomic DNA. No translation available.
AABR07005907 Genomic DNA. No translation available.
AABR07005908 Genomic DNA. No translation available.
AABR07071993 Genomic DNA. No translation available.
AC111884 Genomic DNA. No translation available.
RefSeqiXP_017445730.1. XM_017590241.1.
XP_017459529.1. XM_017604040.1.

Genome annotation databases

EnsembliENSRNOT00000024974; ENSRNOP00000024974; ENSRNOG00000018384.
GeneIDi679837.

Similar proteinsi

Entry informationi

Entry nameiF1M9Z9_RAT
AccessioniPrimary (citable) accession number: F1M9Z9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: August 30, 2017
This is version 55 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported