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Protein
Submitted name:

Sodium/calcium exchanger 2

Gene

Slc8a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransportSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-418359. Reduction of cytosolic Ca++ levels.
R-RNO-425561. Sodium/Calcium exchangers.
R-RNO-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium/calcium exchanger 2Imported
Gene namesi
Name:Slc8a2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620194. Slc8a2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 90HelicalSequence analysisAdd BLAST19
Transmembranei160 – 185HelicalSequence analysisAdd BLAST26
Transmembranei197 – 220HelicalSequence analysisAdd BLAST24
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei749 – 770HelicalSequence analysisAdd BLAST22
Transmembranei823 – 843HelicalSequence analysisAdd BLAST21
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Transmembranei895 – 914HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500326917721 – 919Sequence analysisAdd BLAST899

Proteomic databases

PaxDbiF1M9A2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001492.
ExpressionAtlasiF1M9A2. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini383 – 483Calx-betaInterPro annotationAdd BLAST101
Domaini512 – 612Calx-betaInterPro annotationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili305 – 325Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
GeneTreeiENSGT00730000110414.
OMAiAVYWAVQ.
OrthoDBiEOG091G0EC1.

Family and domain databases

InterProiView protein in InterPro
IPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
PfamiView protein in Pfam
PF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
PRINTSiPR01259. NACAEXCHNGR.
SMARTiView protein in SMART
SM00237. Calx_beta. 2 hits.
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequencei

Sequence statusi: Complete.

F1M9A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLALVGVA LLLGAPHCLG EATPTPSLPP PPANDSDASP GGCQGSYRCQ
60 70 80 90 100
PGVLLPVWEP DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMASIEVI
110 120 130 140 150
TSKEKEITIT KANGETSVGT VRIWNETVSN LTLMALGSSA PEILLSVIEV
160 170 180 190 200
CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC VYVIPAGESR KIKHLRVFFV
210 220 230 240 250
TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV VFAWMADKRL
260 270 280 290 300
LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGTE VPGELGALGT
310 320 330 340 350
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIAKY YALLHQQKSR
360 370 380 390 400
AFYRIQATRL MTGAGNVLRR HAADAARRPG ANDGAPDDED DGASRIFFEP
410 420 430 440 450
SLYHCLENCG SVLLSVACQG GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT
460 470 480 490 500
LVFKPGETQK ELRIGIIDDD IFEEDEHFFV RLLNLRVGDA QGMFEPDGGG
510 520 530 540 550
RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT VDVRVVRSSG
560 570 580 590 600
ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE
610 620 630 640 650
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EAQRIAEMGK
660 670 680 690 700
PVLGENCRLE VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAVT
710 720 730 740 750
VSAGDEEEDE DGSREERLPS CFDYVMHFLT VFWKVLFACV PPTEYCHGWA
760 770 780 790 800
CFGVCILVIG LLTALIGDLA SHFGCTVGLK DSVNAVVFVA LGTSIPDTFA
810 820 830 840 850
SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY WAVQGRPFEV
860 870 880 890 900
RTGTLAFSVT LFTVFAFVGI AVLLYRAHIG GELGGPRGPK LATTALFLGL
910
WFLYILFASL EAYCHIRGF
Length:919
Mass (Da):100,157
Last modified:July 22, 2015 - v3
Checksum:iC8D99AA6C4F07FA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07002626 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000047289; ENSRNOP00000042012; ENSRNOG00000001492.

Similar proteinsi

Entry informationi

Entry nameiF1M9A2_RAT
AccessioniPrimary (citable) accession number: F1M9A2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: December 20, 2017
This is version 46 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported