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Protein
Submitted name:

TNF receptor superfamily member 11A

Gene

Tnfrsf11a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor superfamily member 11AImported
Gene namesi
Name:Tnfrsf11aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1563614 Tnfrsf11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei210 – 236HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500326917431 – 633Sequence analysisAdd BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 61PROSITE-ProRule annotation
Disulfide bondi51 ↔ 69PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiF1M8Z6

Expressioni

Gene expression databases

BgeeiENSRNOG00000015615

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021129

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 69TNFR-CysInterPro annotationAdd BLAST36
Repeati34 – 69TNFR-CysPROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHUN Eukaryota
ENOG41125ED LUCA
GeneTreeiENSGT00760000119204
InParanoidiF1M8Z6
KOiK05147
OMAiCPHWAAS
OrthoDBiEOG091G03XW
TreeFamiTF331157

Family and domain databases

CDDicd13411 TNFRSF11A, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR022361 TNFR_11A
IPR034040 TNFRSF11A_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01961 TNFACTORR11
PR01974 TNFACTORR11A
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

F1M8Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRARRRRQ FPAPLLALCV LLLPLQVTLQ VTLPCTQERH YEHLGRCCSR
60 70 80 90 100
CEPGKYLSSK CTPTSDSVCL PCGPDEYLDT WNEEDKCLLH KVCDAGKALV
110 120 130 140 150
AVDPGNHTAP RRCACTAGYH WNADCECCRR NTECAPGFGA QHPLQLNVDT
160 170 180 190 200
VCTPCLLGFF SDVFSSTDKC KPWTNCTVLG KMEAHQGTTE SDVVCSSSLT
210 220 230 240 250
LIKPPKEAQV YLPSLIVLLL FISVVVVAAI VFSIYYRKGG KTLTANLWNW
260 270 280 290 300
VNDACSSLSG NKESSGDHCV GSHSANSSQQ EVCEGILLMT REEKMVPEDC
310 320 330 340 350
AGVCGPVRAA SGPWAEGRDA RTFTLVSEVE TQGNLSRKIP TEDEYTDRPS
360 370 380 390 400
QPPNGSLFLI QPGSRSTPPF QEPLEVGEND SLSQCFTGTE SMVDSEGCDF
410 420 430 440 450
TEPPSRTDYM PASPEKLLTK EIEDDSCLPW VANSNSTDGY TGSGNTPGED
460 470 480 490 500
HEPLPGSLKC GPLPQCAYSI GLPSEAAASL AEVGAQPQDR ADAKLPSSER
510 520 530 540 550
GASGSGSSPS EQPPASGNVT GNSNSTFISS GQVMNFKGDI IVVYVSQTSQ
560 570 580 590 600
EGPGPAEPEP EPEPVGRPVQ EETLAHRDSF AGTAPRFPDA CTTGAGLQEK
610 620 630
GASRPKDWAS RPVQEQGGAQ ASLNTQGSGQ CAE
Length:633
Mass (Da):67,607
Last modified:July 22, 2015 - v2
Checksum:i07EF03CB4D791D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07020431 Genomic DNA No translation available.
AABR07020432 Genomic DNA No translation available.
AABR07020433 Genomic DNA No translation available.
AABR07020434 Genomic DNA No translation available.
RefSeqiNP_001258164.1, NM_001271235.1
UniGeneiRn.233922

Genome annotation databases

EnsembliENSRNOT00000021129; ENSRNOP00000021129; ENSRNOG00000015615
GeneIDi498206
KEGGirno:498206

Similar proteinsi

Entry informationi

Entry nameiF1M8Z6_RAT
AccessioniPrimary (citable) accession number: F1M8Z6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: May 23, 2018
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health