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F1M8W5

- F1M8W5_RAT

UniProt

F1M8W5 - F1M8W5_RAT

Protein
Submitted name:

Disintegrin and metalloproteinase domain-containing protein 10

Gene

Adam10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: Ensembl
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. constitutive protein ectodomain proteolysis Source: Ensembl
    2. in utero embryonic development Source: Ensembl
    3. monocyte activation Source: Ensembl
    4. negative regulation of cell adhesion Source: Ensembl
    5. Notch signaling pathway Source: Ensembl
    6. PMA-inducible membrane protein ectodomain proteolysis Source: Ensembl
    7. positive regulation of cell growth Source: Ensembl
    8. positive regulation of cell proliferation Source: Ensembl
    9. positive regulation of T cell chemotaxis Source: Ensembl
    10. protein phosphorylation Source: Ensembl
    11. response to tumor necrosis factor Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Disintegrin and metalloproteinase domain-containing protein 10Imported
    Gene namesi
    Name:Adam10Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi2032. Adam10.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. Golgi-associated vesicle Source: Ensembl
    3. nucleus Source: Ensembl
    4. postsynaptic density Source: Ensembl

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiF1M8W5.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 peptidase M12B domain.UniRule annotation
    Contains disintegrin domain.SAAS annotation
    Contains peptidase M12B domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00670000097974.
    OMAiHEDDIKY.
    OrthoDBiEOG7SBNNQ.
    TreeFamiTF352021.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR027053. ADAM_10.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PANTHERiPTHR11905:SF113. PTHR11905:SF113. 1 hit.
    PfamiPF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    [Graphical view]
    SMARTiSM00050. DISIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    F1M8W5-1 [UniParc]FASTAAdd to Basket

    « Hide

    RQFNLRMKRD TSLFSDEFKV ETSNKVLDYD TSHIYTGHIY GEEGSFSHGS    50
    VVDGRFEGFI QTRGGTFYIE PAERYIKDRI LPFHSVIYHE DDINYPHKYG 100
    PQGGCADHSV FERMRKYQMT GVEEGTRAHS EEHAASMGPE LLRKKRTTLA 150
    ERNTCQLYIQ TDHLFFKYYG TREAVIAQIS SHVKAIDTIY QTTDFSGIRN 200
    ISFMVKRIRI NTTSDEKDPT NPFRFPNIGV EKFLELNSEQ NHDDYCLAYV 250
    FTDRDFDDGV LGLAWVGAPS GSSGGICEKS KLYSDGKKKS LNTGIITVQN 300
    YGSHVPPKVS HITFAHEVGH NFGSPHDSGT ECTPGESKNL GQKENGNYIM 350
    YARATSGDKL NNNKFSLCSI RNISQVLEKK RNNCFVESGQ PICGNGMVEQ 400
    GEECDCGYSD QCKDECCFDA NQPEGKKCKL KPGKQCSPSQ GPCCTAQCAF 450
    KSKSEKCRDD SDCAKEGICN GFTALCPASD PKPNFTDCNR HTQVCINGQC 500
    AGSICEKYDL EECTCASSDG KDDKELCHVC CMKKMAPSTC ASTGSLQWNK 550
    QFNGRTITLQ PGSPCNDFRG YCDVFMRCRL VDADGPLARL KKAIFSPQLY 600
    ENIAEWIVAH WWAVLLMGIA LIMLMAGFIK ICSVHTPSSN PKLPPPKPLP 650
    GTLKRRRPPQ PIQQPPRQRP RESYQMGHMR R 681
    Length:681
    Mass (Da):76,366
    Last modified:April 3, 2013 - v2
    Checksum:i3EA145B27F4F80B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06055591 Genomic DNA. No translation available.
    AABR06055592 Genomic DNA. No translation available.
    AABR06055593 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000021066; ENSRNOP00000021066; ENSRNOG00000015038.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06055591 Genomic DNA. No translation available.
    AABR06055592 Genomic DNA. No translation available.
    AABR06055593 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1M8W5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021066 ; ENSRNOP00000021066 ; ENSRNOG00000015038 .

    Organism-specific databases

    RGDi 2032. Adam10.

    Phylogenomic databases

    GeneTreei ENSGT00670000097974.
    OMAi HEDDIKY.
    OrthoDBi EOG7SBNNQ.
    TreeFami TF352021.

    Miscellaneous databases

    NextBioi 35582725.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR027053. ADAM_10.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    PANTHERi PTHR11905:SF113. PTHR11905:SF113. 1 hit.
    Pfami PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    [Graphical view ]
    SMARTi SM00050. DISIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1M8W5_RAT
    AccessioniPrimary (citable) accession number: F1M8W5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 30 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3