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F1M8W5

- F1M8W5_RAT

UniProt

F1M8W5 - F1M8W5_RAT

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Protein
Submitted name:

Disintegrin and metalloproteinase domain-containing protein 10

Gene

Adam10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: Ensembl
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. constitutive protein ectodomain proteolysis Source: Ensembl
  2. in utero embryonic development Source: Ensembl
  3. monocyte activation Source: Ensembl
  4. negative regulation of cell adhesion Source: Ensembl
  5. Notch signaling pathway Source: Ensembl
  6. PMA-inducible membrane protein ectodomain proteolysis Source: Ensembl
  7. positive regulation of cell growth Source: Ensembl
  8. positive regulation of cell proliferation Source: Ensembl
  9. positive regulation of T cell chemotaxis Source: Ensembl
  10. protein phosphorylation Source: Ensembl
  11. response to tumor necrosis factor Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 10Imported
Gene namesi
Name:Adam10Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi2032. Adam10.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi-associated vesicle Source: Ensembl
  4. nucleus Source: Ensembl
  5. perinuclear endoplasmic reticulum Source: Ensembl
  6. postsynaptic density Source: Ensembl
  7. tetraspanin-enriched microdomain Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiF1M8W5.

Family & Domainsi

Sequence similaritiesi

Contains 1 peptidase M12B domain.UniRule annotation
Contains disintegrin domain.SAAS annotation
Contains peptidase M12B domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00670000097974.
OMAiHEDDIKY.
OrthoDBiEOG7SBNNQ.
TreeFamiTF352021.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR027053. ADAM_10.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PANTHERiPTHR11905:SF113. PTHR11905:SF113. 1 hit.
PfamiPF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
[Graphical view]
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F1M8W5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RQFNLRMKRD TSLFSDEFKV ETSNKVLDYD TSHIYTGHIY GEEGSFSHGS
60 70 80 90 100
VVDGRFEGFI QTRGGTFYIE PAERYIKDRI LPFHSVIYHE DDINYPHKYG
110 120 130 140 150
PQGGCADHSV FERMRKYQMT GVEEGTRAHS EEHAASMGPE LLRKKRTTLA
160 170 180 190 200
ERNTCQLYIQ TDHLFFKYYG TREAVIAQIS SHVKAIDTIY QTTDFSGIRN
210 220 230 240 250
ISFMVKRIRI NTTSDEKDPT NPFRFPNIGV EKFLELNSEQ NHDDYCLAYV
260 270 280 290 300
FTDRDFDDGV LGLAWVGAPS GSSGGICEKS KLYSDGKKKS LNTGIITVQN
310 320 330 340 350
YGSHVPPKVS HITFAHEVGH NFGSPHDSGT ECTPGESKNL GQKENGNYIM
360 370 380 390 400
YARATSGDKL NNNKFSLCSI RNISQVLEKK RNNCFVESGQ PICGNGMVEQ
410 420 430 440 450
GEECDCGYSD QCKDECCFDA NQPEGKKCKL KPGKQCSPSQ GPCCTAQCAF
460 470 480 490 500
KSKSEKCRDD SDCAKEGICN GFTALCPASD PKPNFTDCNR HTQVCINGQC
510 520 530 540 550
AGSICEKYDL EECTCASSDG KDDKELCHVC CMKKMAPSTC ASTGSLQWNK
560 570 580 590 600
QFNGRTITLQ PGSPCNDFRG YCDVFMRCRL VDADGPLARL KKAIFSPQLY
610 620 630 640 650
ENIAEWIVAH WWAVLLMGIA LIMLMAGFIK ICSVHTPSSN PKLPPPKPLP
660 670 680
GTLKRRRPPQ PIQQPPRQRP RESYQMGHMR R
Length:681
Mass (Da):76,366
Last modified:April 3, 2013 - v2
Checksum:i3EA145B27F4F80B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06055591 Genomic DNA. No translation available.
AABR06055592 Genomic DNA. No translation available.
AABR06055593 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000021066; ENSRNOP00000021066; ENSRNOG00000015038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06055591 Genomic DNA. No translation available.
AABR06055592 Genomic DNA. No translation available.
AABR06055593 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1M8W5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021066 ; ENSRNOP00000021066 ; ENSRNOG00000015038 .

Organism-specific databases

RGDi 2032. Adam10.

Phylogenomic databases

GeneTreei ENSGT00670000097974.
OMAi HEDDIKY.
OrthoDBi EOG7SBNNQ.
TreeFami TF352021.

Miscellaneous databases

NextBioi 35582725.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR027053. ADAM_10.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
PANTHERi PTHR11905:SF113. PTHR11905:SF113. 1 hit.
Pfami PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
[Graphical view ]
SMARTi SM00050. DISIN. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M8W5_RAT
AccessioniPrimary (citable) accession number: F1M8W5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: October 29, 2014
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3