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Protein
Submitted name:

Disintegrin and metalloproteinase domain-containing protein 10

Gene

Adam10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_274120. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_291344. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_304041. Collagen degradation.
REACT_304205. Signaling by NOTCH3.
REACT_313117. EPH-ephrin mediated repulsion of cells.
REACT_319794. Degradation of the extracellular matrix.
REACT_321246. Signaling by NOTCH4.
REACT_322147. Signaling by EGFR.

Names & Taxonomyi

Protein namesi
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 10Imported
Gene namesi
Name:Adam10Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unassembled WGS sequence

Organism-specific databases

RGDi2032. Adam10.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiF1M8W5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021066.

Family & Domainsi

Sequence similaritiesi

Contains 1 peptidase M12B domain.UniRule annotation
Contains disintegrin domain.SAAS annotation
Contains peptidase M12B domain.SAAS annotation

Phylogenomic databases

OMAiEGFIQTH.
OrthoDBiEOG7SBNNQ.
TreeFamiTF352021.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR027053. ADAM_10.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PANTHERiPTHR11905:SF113. PTHR11905:SF113. 1 hit.
PfamiPF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
[Graphical view]
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1M8W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RQFNLRMKRD TSLFSDEFKV ETSNKVLDYD TSHIYTGHIY GEEGSFSHGS
60 70 80 90 100
VVDGRFEGFI QTRGGTFYIE PAERYIKDRI LPFHSVIYHE DDINYPHKYG
110 120 130 140 150
PQGGCADHSV FERMRKYQMT GVEEGTRAHS EEHAASMGPE LLRKKRTTLA
160 170 180 190 200
ERNTCQLYIQ TDHLFFKYYG TREAVIAQIS SHVKAIDTIY QTTDFSGIRN
210 220 230 240 250
ISFMVKRIRI NTTSDEKDPT NPFRFPNIGV EKFLELNSEQ NHDDYCLAYV
260 270 280 290 300
FTDRDFDDGV LGLAWVGAPS GSSGGICEKS KLYSDGKKKS LNTGIITVQN
310 320 330 340 350
YGSHVPPKVS HITFAHEVGH NFGSPHDSGT ECTPGESKNL GQKENGNYIM
360 370 380 390 400
YARATSGDKL NNNKFSLCSI RNISQVLEKK RNNCFVESGQ PICGNGMVEQ
410 420 430 440 450
GEECDCGYSD QCKDECCFDA NQPEGKKCKL KPGKQCSPSQ GPCCTAQCAF
460 470 480 490 500
KSKSEKCRDD SDCAKEGICN GFTALCPASD PKPNFTDCNR HTQVCINGQC
510 520 530 540 550
AGSICEKYDL EECTCASSDG KDDKELCHVC CMKKMAPSTC ASTGSLQWNK
560 570 580 590 600
QFNGRTITLQ PGSPCNDFRG YCDVFMRCRL VDADGPLARL KKAIFSPQLY
610 620 630 640 650
ENIAEWIVAH WWAVLLMGIA LIMLMAGFIK ICSVHTPSSN PKLPPPKPLP
660 670 680
GTLKRRRPPQ PIQQPPRQRP RESYQMGHMR R
Length:681
Mass (Da):76,366
Last modified:April 3, 2013 - v2
Checksum:i3EA145B27F4F80B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06055591 Genomic DNA. No translation available.
AABR06055592 Genomic DNA. No translation available.
AABR06055593 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000021066; ENSRNOP00000021066; ENSRNOG00000015038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06055591 Genomic DNA. No translation available.
AABR06055592 Genomic DNA. No translation available.
AABR06055593 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021066.

Proteomic databases

PRIDEiF1M8W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021066; ENSRNOP00000021066; ENSRNOG00000015038.

Organism-specific databases

RGDi2032. Adam10.

Phylogenomic databases

OMAiEGFIQTH.
OrthoDBiEOG7SBNNQ.
TreeFamiTF352021.

Enzyme and pathway databases

ReactomeiREACT_274120. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_291344. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_304041. Collagen degradation.
REACT_304205. Signaling by NOTCH3.
REACT_313117. EPH-ephrin mediated repulsion of cells.
REACT_319794. Degradation of the extracellular matrix.
REACT_321246. Signaling by NOTCH4.
REACT_322147. Signaling by EGFR.

Miscellaneous databases

NextBioi35582725.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR027053. ADAM_10.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PANTHERiPTHR11905:SF113. PTHR11905:SF113. 1 hit.
PfamiPF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
[Graphical view]
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M8W5_RAT
AccessioniPrimary (citable) accession number: F1M8W5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: July 22, 2015
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.