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F1M867

- F1M867_RAT

UniProt

F1M867 - F1M867_RAT

Protein
Submitted name:

Protein Itga3

Gene

Itga3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (03 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. collagen binding Source: RGD
    2. fibronectin binding Source: RGD
    3. integrin binding Source: RGD
    4. laminin binding Source: RGD
    5. protein domain specific binding Source: RGD
    6. protein heterodimerization activity Source: RGD

    GO - Biological processi

    1. cell adhesion Source: RGD
    2. heart development Source: RGD
    3. integrin-mediated signaling pathway Source: UniProtKB-KW
    4. maternal process involved in female pregnancy Source: RGD
    5. negative regulation of cell projection organization Source: RGD
    6. positive regulation of cell-substrate adhesion Source: RGD
    7. positive regulation of epithelial cell migration Source: RGD
    8. positive regulation of gene expression Source: RGD
    9. positive regulation of neuron projection development Source: RGD
    10. response to drug Source: RGD
    11. response to gonadotropin Source: RGD

    Keywords - Molecular functioni

    IntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation

    Keywords - Biological processi

    Cell adhesionUniRule annotationSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_197259. Laminin interactions.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Itga3Imported
    Gene namesi
    Name:Itga3Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1310333. Itga3.

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. growth cone Source: RGD
    3. integrin alpha3-beta1 complex Source: RGD
    4. perinuclear region of cytoplasm Source: RGD
    5. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiF1M867.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.UniRule annotation
    Contains FG-GAP repeats.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110529.

    Family and domain databases

    InterProiIPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    F1M867-1 [UniParc]FASTAAdd to Basket

    « Hide

    SPCPEIADLQ DQREACKVRL THPPSFPSLL AGAPRDLAVD DDYTNRTGAV     50
    YLCPLTALKN DCERMDISEK SDPDHHIIED MWLGVTVASQ GPAGRVLVCA 100
    HRYTKVLWSG LEDQRRMVGK CYVRGNDLQL DPGDDWQTYH NEMCNSNTDY 150
    LQTGMCQLGT SGGFTQNTVY FGAPGAYNWK GNSYMIQRKD WDLSEYSYRG 200
    SEDQGNLYIG YTMQVGSAIL HPSEITLVTG APRHQHMGAV FLLKQESGGD 250
    LQRRQVLKGT QVGAYFGSAI ALADLNNDGW QDLLVGAPYY FERKEEVGGA 300
    VYVFMNQAGT SFPDQPSLLL HGPSRSAFGI SVASIGDINQ DGFQDIAVGA 350
    PFEGLGKVYI YHSSSGGLLK QPQQIIHGET LGLPGLATFG YSLSGKMDVD 400
    ENLYPDLLVG SLSDHIVLLR ARPVINILHR TLVARPAVLD PSLCTVTSCV 450
    QVELCFAYNQ SAGNPNYRRN ITLAYTVEAD RDRRPPRLRF ARSQSSVFHG 500
    FFSMPETHCQ TLELLLMDNV RDKLRPIVIT MNYSLPLRMP DRLKLGLRSL 550
    DAYPVLNQAQ AMENHTEVHF QKECGPDNKC DSNLQMRAAF VSEQLQPLSR 600
    LQYSRDTKKL FLSINVTNSP SRQRAGEDAH EALLTLEVSS ALLLSSVRPA 650
    GTCQANETNT VCELGNPFKR NQRMELLIAF EVTGVTLHTR DLRAHLQLST 700
    SSHQDNLQPM FLTLQVDYTL QASLSLMNHR LQSFFSGTVM GEAAMKTVKD 750
    VGSPLKYEFQ VSPVGDGLAA LGTLVLGLEW PYEVTNGKWL LYPTEITIHS 800
    NGSWPCQPHG NLVNPLNLTL SDPGVKPLSP QRRRRQLDPG GDQGPPPVTL 850
    AAAKKAKSET VLTCSNGRAR CVWLECPLPD ASNITNVTVK ARVWNSTFIE 900
    DYKDFDRVRV DGWATLFLRT SIPTINMENK TTWFSVDIDS ELVEELPAEI 950
    ELWLVLVAVG AGLLLLGLII ILLWKCGFFK RARTRALYEA KRQKAEMRSQ 1000
    PSETERLTDD Y 1011
    Length:1,011
    Mass (Da):112,421
    Last modified:May 3, 2011 - v1
    Checksum:i0F317A80B9AA65B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065349 Genomic DNA. No translation available.
    AABR06065350 Genomic DNA. No translation available.
    AABR06065351 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000055534; ENSRNOP00000052396; ENSRNOG00000004276.
    UCSCiRGD:1310333. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065349 Genomic DNA. No translation available.
    AABR06065350 Genomic DNA. No translation available.
    AABR06065351 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F1M867.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055534 ; ENSRNOP00000052396 ; ENSRNOG00000004276 .
    UCSCi RGD:1310333. rat.

    Organism-specific databases

    RGDi 1310333. Itga3.

    Phylogenomic databases

    GeneTreei ENSGT00730000110529.

    Enzyme and pathway databases

    Reactomei REACT_197259. Laminin interactions.

    Miscellaneous databases

    NextBioi 35582486.

    Family and domain databases

    InterProi IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1M867_RAT
    AccessioniPrimary (citable) accession number: F1M867
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3