Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

F1M867

- F1M867_RAT

UniProt

F1M867 - F1M867_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Protein Itga3

Gene

Itga3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. collagen binding Source: RGD
  2. fibronectin binding Source: RGD
  3. integrin binding Source: RGD
  4. laminin binding Source: RGD
  5. protein domain specific binding Source: RGD
  6. protein heterodimerization activity Source: RGD

GO - Biological processi

  1. cell adhesion Source: RGD
  2. heart development Source: RGD
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
  4. maternal process involved in female pregnancy Source: RGD
  5. negative regulation of cell projection organization Source: RGD
  6. positive regulation of cell-substrate adhesion Source: RGD
  7. positive regulation of epithelial cell migration Source: RGD
  8. positive regulation of gene expression Source: RGD
  9. positive regulation of neuron projection development Source: RGD
  10. response to drug Source: RGD
  11. response to gonadotropin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_197259. Laminin interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Itga3Imported
Gene namesi
Name:Itga3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1310333. Itga3.

Subcellular locationi

Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

  1. cell surface Source: RGD
  2. growth cone Source: RGD
  3. integrin alpha3-beta1 complex Source: RGD
  4. perinuclear region of cytoplasm Source: RGD
  5. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiF1M867.

Expressioni

Gene expression databases

ExpressionAtlasiF1M867. baseline.

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotation
Contains FG-GAP repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118782.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F1M867-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SPCPEIADLQ DQREACKVRL THPPSFPSLL AGAPRDLAVD DDYTNRTGAV
60 70 80 90 100
YLCPLTALKN DCERMDISEK SDPDHHIIED MWLGVTVASQ GPAGRVLVCA
110 120 130 140 150
HRYTKVLWSG LEDQRRMVGK CYVRGNDLQL DPGDDWQTYH NEMCNSNTDY
160 170 180 190 200
LQTGMCQLGT SGGFTQNTVY FGAPGAYNWK GNSYMIQRKD WDLSEYSYRG
210 220 230 240 250
SEDQGNLYIG YTMQVGSAIL HPSEITLVTG APRHQHMGAV FLLKQESGGD
260 270 280 290 300
LQRRQVLKGT QVGAYFGSAI ALADLNNDGW QDLLVGAPYY FERKEEVGGA
310 320 330 340 350
VYVFMNQAGT SFPDQPSLLL HGPSRSAFGI SVASIGDINQ DGFQDIAVGA
360 370 380 390 400
PFEGLGKVYI YHSSSGGLLK QPQQIIHGET LGLPGLATFG YSLSGKMDVD
410 420 430 440 450
ENLYPDLLVG SLSDHIVLLR ARPVINILHR TLVARPAVLD PSLCTVTSCV
460 470 480 490 500
QVELCFAYNQ SAGNPNYRRN ITLAYTVEAD RDRRPPRLRF ARSQSSVFHG
510 520 530 540 550
FFSMPETHCQ TLELLLMDNV RDKLRPIVIT MNYSLPLRMP DRLKLGLRSL
560 570 580 590 600
DAYPVLNQAQ AMENHTEVHF QKECGPDNKC DSNLQMRAAF VSEQLQPLSR
610 620 630 640 650
LQYSRDTKKL FLSINVTNSP SRQRAGEDAH EALLTLEVSS ALLLSSVRPA
660 670 680 690 700
GTCQANETNT VCELGNPFKR NQRMELLIAF EVTGVTLHTR DLRAHLQLST
710 720 730 740 750
SSHQDNLQPM FLTLQVDYTL QASLSLMNHR LQSFFSGTVM GEAAMKTVKD
760 770 780 790 800
VGSPLKYEFQ VSPVGDGLAA LGTLVLGLEW PYEVTNGKWL LYPTEITIHS
810 820 830 840 850
NGSWPCQPHG NLVNPLNLTL SDPGVKPLSP QRRRRQLDPG GDQGPPPVTL
860 870 880 890 900
AAAKKAKSET VLTCSNGRAR CVWLECPLPD ASNITNVTVK ARVWNSTFIE
910 920 930 940 950
DYKDFDRVRV DGWATLFLRT SIPTINMENK TTWFSVDIDS ELVEELPAEI
960 970 980 990 1000
ELWLVLVAVG AGLLLLGLII ILLWKCGFFK RARTRALYEA KRQKAEMRSQ
1010
PSETERLTDD Y
Length:1,011
Mass (Da):112,421
Last modified:May 3, 2011 - v1
Checksum:i0F317A80B9AA65B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065349 Genomic DNA. No translation available.
AABR06065350 Genomic DNA. No translation available.
AABR06065351 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000055534; ENSRNOP00000052396; ENSRNOG00000004276.
UCSCiRGD:1310333. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065349 Genomic DNA. No translation available.
AABR06065350 Genomic DNA. No translation available.
AABR06065351 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1M867.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055534 ; ENSRNOP00000052396 ; ENSRNOG00000004276 .
UCSCi RGD:1310333. rat.

Organism-specific databases

RGDi 1310333. Itga3.

Phylogenomic databases

GeneTreei ENSGT00760000118782.

Enzyme and pathway databases

Reactomei REACT_197259. Laminin interactions.

Miscellaneous databases

NextBioi 35582486.

Gene expression databases

ExpressionAtlasi F1M867. baseline.

Family and domain databases

InterProi IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M867_RAT
AccessioniPrimary (citable) accession number: F1M867
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3