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F1M867 (F1M867_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length1011 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein By similarity RuleBase RU003762.

Sequence similarities

Belongs to the integrin alpha chain family. RuleBase RU003762

Contains FG-GAP repeats. SAAS SAAS013649

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000052396

Ontologies

Keywords
   Biological processCell adhesion RuleBase RU003762 SAAS SAAS013649
   Cellular componentMembrane
   DomainRepeat SAAS SAAS013649
Transmembrane
Transmembrane helix SAAS SAAS013649
   Molecular functionIntegrin RuleBase RU003762 SAAS SAAS013649
Receptor RuleBase RU003762 SAAS SAAS013649
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from mutant phenotype PubMed 2223092. Source: RGD

heart development

Inferred from expression pattern PubMed 1835909. Source: RGD

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

maternal process involved in female pregnancy

Inferred from expression pattern PubMed 20353731. Source: RGD

negative regulation of cell projection organization

Inferred from mutant phenotype PubMed 20039268. Source: RGD

positive regulation of cell-substrate adhesion

Inferred from mutant phenotype PubMed 2223092. Source: RGD

positive regulation of epithelial cell migration

Inferred from mutant phenotype PubMed 20470260. Source: RGD

positive regulation of gene expression

Inferred from direct assay PubMed 16938651. Source: RGD

positive regulation of neuron projection development

Inferred from mutant phenotype PubMed 2223092. Source: RGD

response to drug

Inferred from expression pattern PubMed 20525748. Source: RGD

response to gonadotropin

Inferred from expression pattern PubMed 20189708. Source: RGD

   Cellular_componentalpha3-beta1 integrin complex

Inferred from direct assay PubMed 1835909. Source: RGD

cell surface

Inferred from direct assay PubMed 2223092. Source: RGD

growth cone

Inferred from direct assay PubMed 16987960. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 20470260. Source: RGD

plasma membrane

Inferred from direct assay PubMed 20470260. Source: RGD

   Molecular_functioncollagen binding

Inferred from direct assay PubMed 1835909. Source: RGD

fibronectin binding

Inferred from direct assay PubMed 1835909. Source: RGD

integrin binding

Inferred from physical interaction PubMed 2223092. Source: RGD

laminin binding

Inferred from direct assay PubMed 1835909. Source: RGD

protein domain specific binding

Inferred from mutant phenotype PubMed 2223092. Source: RGD

protein heterodimerization activity

Inferred from physical interaction PubMed 2223092. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 Ensembl ENSRNOP00000052396

Sequences

Sequence LengthMass (Da)Tools
F1M867 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 0F317A80B9AA65B5

FASTA1,011112,421
        10         20         30         40         50         60 
SPCPEIADLQ DQREACKVRL THPPSFPSLL AGAPRDLAVD DDYTNRTGAV YLCPLTALKN 

        70         80         90        100        110        120 
DCERMDISEK SDPDHHIIED MWLGVTVASQ GPAGRVLVCA HRYTKVLWSG LEDQRRMVGK 

       130        140        150        160        170        180 
CYVRGNDLQL DPGDDWQTYH NEMCNSNTDY LQTGMCQLGT SGGFTQNTVY FGAPGAYNWK 

       190        200        210        220        230        240 
GNSYMIQRKD WDLSEYSYRG SEDQGNLYIG YTMQVGSAIL HPSEITLVTG APRHQHMGAV 

       250        260        270        280        290        300 
FLLKQESGGD LQRRQVLKGT QVGAYFGSAI ALADLNNDGW QDLLVGAPYY FERKEEVGGA 

       310        320        330        340        350        360 
VYVFMNQAGT SFPDQPSLLL HGPSRSAFGI SVASIGDINQ DGFQDIAVGA PFEGLGKVYI 

       370        380        390        400        410        420 
YHSSSGGLLK QPQQIIHGET LGLPGLATFG YSLSGKMDVD ENLYPDLLVG SLSDHIVLLR 

       430        440        450        460        470        480 
ARPVINILHR TLVARPAVLD PSLCTVTSCV QVELCFAYNQ SAGNPNYRRN ITLAYTVEAD 

       490        500        510        520        530        540 
RDRRPPRLRF ARSQSSVFHG FFSMPETHCQ TLELLLMDNV RDKLRPIVIT MNYSLPLRMP 

       550        560        570        580        590        600 
DRLKLGLRSL DAYPVLNQAQ AMENHTEVHF QKECGPDNKC DSNLQMRAAF VSEQLQPLSR 

       610        620        630        640        650        660 
LQYSRDTKKL FLSINVTNSP SRQRAGEDAH EALLTLEVSS ALLLSSVRPA GTCQANETNT 

       670        680        690        700        710        720 
VCELGNPFKR NQRMELLIAF EVTGVTLHTR DLRAHLQLST SSHQDNLQPM FLTLQVDYTL 

       730        740        750        760        770        780 
QASLSLMNHR LQSFFSGTVM GEAAMKTVKD VGSPLKYEFQ VSPVGDGLAA LGTLVLGLEW 

       790        800        810        820        830        840 
PYEVTNGKWL LYPTEITIHS NGSWPCQPHG NLVNPLNLTL SDPGVKPLSP QRRRRQLDPG 

       850        860        870        880        890        900 
GDQGPPPVTL AAAKKAKSET VLTCSNGRAR CVWLECPLPD ASNITNVTVK ARVWNSTFIE 

       910        920        930        940        950        960 
DYKDFDRVRV DGWATLFLRT SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG 

       970        980        990       1000       1010 
AGLLLLGLII ILLWKCGFFK RARTRALYEA KRQKAEMRSQ PSETERLTDD Y 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000052396.
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000052396.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06065349 Genomic DNA. No translation available.
AABR06065350 Genomic DNA. No translation available.
AABR06065351 Genomic DNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEF1M867.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000055534; ENSRNOP00000052396; ENSRNOG00000004276.
UCSCRGD:1310333. rat.

Organism-specific databases

RGD1310333. Itga3.

Phylogenomic databases

GeneTreeENSGT00730000110529.

Family and domain databases

InterProIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35582486.

Entry information

Entry nameF1M867_RAT
AccessionPrimary (citable) accession number: F1M867
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)