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F1M867

- F1M867_RAT

UniProt

F1M867 - F1M867_RAT

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Protein
Submitted name:

Protein Itga3

Gene
Itga3
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. collagen binding Source: RGD
  2. fibronectin binding Source: RGD
  3. integrin binding Source: RGD
  4. laminin binding Source: RGD
  5. protein domain specific binding Source: RGD
  6. protein heterodimerization activity Source: RGD

GO - Biological processi

  1. cell adhesion Source: RGD
  2. heart development Source: RGD
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
  4. maternal process involved in female pregnancy Source: RGD
  5. negative regulation of cell projection organization Source: RGD
  6. positive regulation of cell-substrate adhesion Source: RGD
  7. positive regulation of epithelial cell migration Source: RGD
  8. positive regulation of gene expression Source: RGD
  9. positive regulation of neuron projection development Source: RGD
  10. response to drug Source: RGD
  11. response to gonadotropin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotations, ReceptorUniRule annotationSAAS annotations

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_197259. Laminin interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Itga3Imported
Gene namesi
Name:Itga3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1310333. Itga3.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: RGD
  2. growth cone Source: RGD
  3. integrin alpha3-beta1 complex Source: RGD
  4. perinuclear region of cytoplasm Source: RGD
  5. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiF1M867.

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotation
Contains FG-GAP repeats.SAAS annotations

Keywords - Domaini

RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110529.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F1M867-1 [UniParc]FASTAAdd to Basket

« Hide

SPCPEIADLQ DQREACKVRL THPPSFPSLL AGAPRDLAVD DDYTNRTGAV     50
YLCPLTALKN DCERMDISEK SDPDHHIIED MWLGVTVASQ GPAGRVLVCA 100
HRYTKVLWSG LEDQRRMVGK CYVRGNDLQL DPGDDWQTYH NEMCNSNTDY 150
LQTGMCQLGT SGGFTQNTVY FGAPGAYNWK GNSYMIQRKD WDLSEYSYRG 200
SEDQGNLYIG YTMQVGSAIL HPSEITLVTG APRHQHMGAV FLLKQESGGD 250
LQRRQVLKGT QVGAYFGSAI ALADLNNDGW QDLLVGAPYY FERKEEVGGA 300
VYVFMNQAGT SFPDQPSLLL HGPSRSAFGI SVASIGDINQ DGFQDIAVGA 350
PFEGLGKVYI YHSSSGGLLK QPQQIIHGET LGLPGLATFG YSLSGKMDVD 400
ENLYPDLLVG SLSDHIVLLR ARPVINILHR TLVARPAVLD PSLCTVTSCV 450
QVELCFAYNQ SAGNPNYRRN ITLAYTVEAD RDRRPPRLRF ARSQSSVFHG 500
FFSMPETHCQ TLELLLMDNV RDKLRPIVIT MNYSLPLRMP DRLKLGLRSL 550
DAYPVLNQAQ AMENHTEVHF QKECGPDNKC DSNLQMRAAF VSEQLQPLSR 600
LQYSRDTKKL FLSINVTNSP SRQRAGEDAH EALLTLEVSS ALLLSSVRPA 650
GTCQANETNT VCELGNPFKR NQRMELLIAF EVTGVTLHTR DLRAHLQLST 700
SSHQDNLQPM FLTLQVDYTL QASLSLMNHR LQSFFSGTVM GEAAMKTVKD 750
VGSPLKYEFQ VSPVGDGLAA LGTLVLGLEW PYEVTNGKWL LYPTEITIHS 800
NGSWPCQPHG NLVNPLNLTL SDPGVKPLSP QRRRRQLDPG GDQGPPPVTL 850
AAAKKAKSET VLTCSNGRAR CVWLECPLPD ASNITNVTVK ARVWNSTFIE 900
DYKDFDRVRV DGWATLFLRT SIPTINMENK TTWFSVDIDS ELVEELPAEI 950
ELWLVLVAVG AGLLLLGLII ILLWKCGFFK RARTRALYEA KRQKAEMRSQ 1000
PSETERLTDD Y 1011
Length:1,011
Mass (Da):112,421
Last modified:May 3, 2011 - v1
Checksum:i0F317A80B9AA65B5
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065349 Genomic DNA. No translation available.
AABR06065350 Genomic DNA. No translation available.
AABR06065351 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000055534; ENSRNOP00000052396; ENSRNOG00000004276.
UCSCiRGD:1310333. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065349 Genomic DNA. No translation available.
AABR06065350 Genomic DNA. No translation available.
AABR06065351 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F1M867.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055534 ; ENSRNOP00000052396 ; ENSRNOG00000004276 .
UCSCi RGD:1310333. rat.

Organism-specific databases

RGDi 1310333. Itga3.

Phylogenomic databases

GeneTreei ENSGT00730000110529.

Enzyme and pathway databases

Reactomei REACT_197259. Laminin interactions.

Miscellaneous databases

NextBioi 35582486.

Family and domain databases

InterProi IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M867_RAT
AccessioniPrimary (citable) accession number: F1M867
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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