Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F1M826

- F1M826_RAT

UniProt

F1M826 - F1M826_RAT

Protein
Submitted name:

Heart- and neural crest derivatives-expressed protein 2

Gene

Hand2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. E-box binding Source: Ensembl
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    4. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. adult heart development Source: Ensembl
    2. apoptotic process involved in heart morphogenesis Source: Ensembl
    3. cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
    4. cardiac right ventricle formation Source: Ensembl
    5. cartilage morphogenesis Source: Ensembl
    6. cell proliferation involved in outflow tract morphogenesis Source: Ensembl
    7. coronary artery morphogenesis Source: Ensembl
    8. embryonic digit morphogenesis Source: Ensembl
    9. heart looping Source: Ensembl
    10. in utero embryonic development Source: Ensembl
    11. mesenchymal cell proliferation Source: Ensembl
    12. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    13. negative regulation of DNA binding Source: Ensembl
    14. negative regulation of osteoblast differentiation Source: Ensembl
    15. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    16. odontogenesis of dentin-containing tooth Source: Ensembl
    17. palate development Source: Ensembl
    18. peripheral nervous system neuron development Source: Ensembl
    19. positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis Source: Ensembl
    20. positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process Source: Ensembl
    21. positive regulation of transcription regulatory region DNA binding Source: Ensembl
    22. regulation of secondary heart field cardioblast proliferation Source: Ensembl
    23. suckling behavior Source: Ensembl
    24. sympathetic nervous system development Source: Ensembl
    25. thymus development Source: Ensembl
    26. tongue development Source: Ensembl
    27. visceral serous pericardium development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Heart- and neural crest derivatives-expressed protein 2Imported
    Gene namesi
    Name:Hand2Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi621207. Hand2.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl
    2. transcription factor complex Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110394.
    OMAiKNNINGR.
    OrthoDBiEOG7G1V82.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    F1M826-1 [UniParc]FASTAAdd to Basket

    « Hide

    SITSALAELR ECIPNVPADT KLSKIKTLRL ATSYIAYLMD LLAKDDQNGE    50
    AEAFKAEIKK TDVKEEKRKK ELNEILKSTV SSNDKKTKGR TGWPQHVWAL 100
    ELKQ 104
    Length:104
    Mass (Da):11,759
    Last modified:May 3, 2011 - v1
    Checksum:iB6FA4123BCCA6BF8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06087639 Genomic DNA. No translation available.
    AABR06087640 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000030765; ENSRNOP00000033513; ENSRNOG00000022069.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06087639 Genomic DNA. No translation available.
    AABR06087640 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000030765 ; ENSRNOP00000033513 ; ENSRNOG00000022069 .

    Organism-specific databases

    RGDi 621207. Hand2.

    Phylogenomic databases

    GeneTreei ENSGT00730000110394.
    OMAi KNNINGR.
    OrthoDBi EOG7G1V82.

    Miscellaneous databases

    NextBioi 35582445.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1M826_RAT
    AccessioniPrimary (citable) accession number: F1M826
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3