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F1M826

- F1M826_RAT

UniProt

F1M826 - F1M826_RAT

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Protein
Submitted name:

Heart- and neural crest derivatives-expressed protein 2

Gene

Hand2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. AT DNA binding Source: Ensembl
  2. E-box binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. adult heart development Source: Ensembl
  2. apoptotic process involved in heart morphogenesis Source: Ensembl
  3. cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
  4. cardiac right ventricle formation Source: Ensembl
  5. cartilage morphogenesis Source: Ensembl
  6. cell proliferation involved in outflow tract morphogenesis Source: Ensembl
  7. coronary artery morphogenesis Source: Ensembl
  8. embryonic digit morphogenesis Source: Ensembl
  9. heart looping Source: Ensembl
  10. in utero embryonic development Source: Ensembl
  11. mesenchymal cell proliferation Source: Ensembl
  12. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  13. negative regulation of DNA binding Source: Ensembl
  14. negative regulation of osteoblast differentiation Source: Ensembl
  15. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  16. odontogenesis of dentin-containing tooth Source: Ensembl
  17. palate development Source: Ensembl
  18. peripheral nervous system neuron development Source: Ensembl
  19. positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis Source: Ensembl
  20. positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process Source: Ensembl
  21. positive regulation of transcription regulatory region DNA binding Source: Ensembl
  22. regulation of secondary heart field cardioblast proliferation Source: Ensembl
  23. suckling behavior Source: Ensembl
  24. sympathetic nervous system development Source: Ensembl
  25. thymus development Source: Ensembl
  26. tongue development Source: Ensembl
  27. visceral serous pericardium development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Heart- and neural crest derivatives-expressed protein 2Imported
Gene namesi
Name:Hand2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi621207. Hand2.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119097.
OMAiKNNINGR.
OrthoDBiEOG7G1V82.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F1M826-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SITSALAELR ECIPNVPADT KLSKIKTLRL ATSYIAYLMD LLAKDDQNGE
60 70 80 90 100
AEAFKAEIKK TDVKEEKRKK ELNEILKSTV SSNDKKTKGR TGWPQHVWAL

ELKQ
Length:104
Mass (Da):11,759
Last modified:May 3, 2011 - v1
Checksum:iB6FA4123BCCA6BF8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06087639 Genomic DNA. No translation available.
AABR06087640 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000030765; ENSRNOP00000033513; ENSRNOG00000022069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06087639 Genomic DNA. No translation available.
AABR06087640 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000030765 ; ENSRNOP00000033513 ; ENSRNOG00000022069 .

Organism-specific databases

RGDi 621207. Hand2.

Phylogenomic databases

GeneTreei ENSGT00760000119097.
OMAi KNNINGR.
OrthoDBi EOG7G1V82.

Miscellaneous databases

NextBioi 35582445.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M826_RAT
AccessioniPrimary (citable) accession number: F1M826
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3