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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 1

Gene

Map3k1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-166058 MyD88:Mal cascade initiated on plasma membrane
R-RNO-2871796 FCERI mediated MAPK activation
R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-RNO-975871 MyD88 cascade initiated on plasma membrane

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 1Imported
Gene namesi
Name:Map3k1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620966 Map3k1

Expressioni

Gene expression databases

BgeeiENSRNOG00000013177

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini328 – 356SWIM-typeInterPro annotationAdd BLAST29
Domaini433 – 482RING-typeInterPro annotationAdd BLAST50
Domaini1224 – 1489Protein kinaseInterPro annotationAdd BLAST266

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4279 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00800000124036
OMAiSTHFTRM
OrthoDBiEOG091G03WB
TreeFamiTF105112

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR007527 Znf_SWIM
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50966 ZF_SWIM, 1 hit

Sequencei

Sequence statusi: Complete.

F1M778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGDRAS SSGFPGAAAA SPEAGGGGGA LQGSGAPAAG AGLLRETGSA
60 70 80 90 100
GRERADWRRQ QLRKVRSVEL DQLPEQPLFL TASPPCPSTS PSPEPADAAA
110 120 130 140 150
GASGFQPAAG PPPPGAASRC GSHSAELAAA RDSGARSPAG AEPPSAAAPS
160 170 180 190 200
GREMENKETL KGLHKMDDRP EERMIREKLK ATCMPAWKHE WLERRNRRGP
210 220 230 240 250
VVVKPIPIKG DGSEMSNLAA ELQGEGQAGS AAPAPKGRRS PSPGSSPSGR
260 270 280 290 300
SGKPESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS PEETSRRVNK
310 320 330 340 350
VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCG RGTFCIHLLF
360 370 380 390 400
VMLRVFQLEP SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK
410 420 430 440 450
FVSRMSNCHT LSSSSTSTSS SENSIKDEEE QMCPICLLGM LDEESLTVCE
460 470 480 490 500
DGCRNKLHHH CMSIWAEECR RNREPLICPL CRSKWRSHDF YSHELSSPVD
510 520 530 540 550
SPTSLRGVQQ PSSPQQPVAG SQRRNQESNF NLTHYGTQQI PPAYKDLAEP
560 570 580 590 600
WIQAFGMELV GCLFSRNWNV REMALRRLSH DVSGALLLAN GESTGTSGGG
610 620 630 640 650
SGGSLSAGAA SGSSQPSISG DVVEACCSVL SIVCADPVYK VYVAALKTLR
660 670 680 690 700
AMLVYTPCHS LAERIKLQRL LRPVVDTILV KCADANSRTS QLSISTLLEL
710 720 730 740 750
CKGQAGELAV GREILKAGSI GVGGVDYVLS CILGNQAESN NWQELLGRLC
760 770 780 790 800
LIDRLLLEFP AEFYPHIVST DVSQAEPVEI RYKKLLSLLA FALQSIDNSH
810 820 830 840 850
SMVGKLSRRI YLSSARMVTT VPALFSKLVT MLSASGSSHF ARMRRRLMAI
860 870 880 890 900
ADEVEIAEVI QLGSEDTLDG QQDSSQALAP PRYPESSSLE HTAHVEKTGK
910 920 930 940 950
GLKATRLSAS SEDISDRLAG VSVGLPSSAT TEQPKPTVQT KGRPHSQCLN
960 970 980 990 1000
SSPLSPPQLM FPAISAPCSS APSVPAGSVT DASKHRPQAF VPCKIPSASP
1010 1020 1030 1040 1050
QTQRKFSLQF QRTCSENRDS EKLSPVFTQS RPPPSSNIHR PKPSRPVPGS
1060 1070 1080 1090 1100
TSKLGDASKN SMTLDLNSAS QCDDSFGSGS NSGGAVIPSE ETAFTPAEDK
1110 1120 1130 1140 1150
CRLDVNPELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE KAESDDTYKD
1160 1170 1180 1190 1200
DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII
1210 1220 1230 1240 1250
QQDTPETLPG HTKAKQPYRE DTEWLKGQQI GLGAFSSCYQ AQDVGTGTLM
1260 1270 1280 1290 1300
AVKQVTYVRN TSSEQEEVVE ALREEIRMMS HLNHPNIIRM LGATCEKSNY
1310 1320 1330 1340 1350
NLFIEWMAGG SVAHLLSKYG AFKESVVINY TEQLLRGLSY LHENQIIHRD
1360 1370 1380 1390 1400
VKGANLLIDS TGQRLRIADF GAAARLASKG TGAGEFQGQL LGTIAFMAPE
1410 1420 1430 1440 1450
VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA LIFKIASATT
1460 1470 1480 1490
APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW
Length:1,493
Mass (Da):161,283
Last modified:May 3, 2011 - v1
Checksum:i9AD531DA6CA0F246
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111653 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000017968; ENSRNOP00000017968; ENSRNOG00000013177

Similar proteinsi

Entry informationi

Entry nameiF1M778_RAT
AccessioniPrimary (citable) accession number: F1M778
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: June 20, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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