ID   F1M681_RAT              Unreviewed;      1159 AA.
AC   F1M681;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=ALF transcription elongation factor 3 {ECO:0000313|Ensembl:ENSRNOP00000047638.6};
GN   Name=Aff3 {ECO:0000313|Ensembl:ENSRNOP00000047638.6,
GN   ECO:0000313|RGD:1308527};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000047638.6, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000047638.6, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000047638.6,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0007829|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000047638.6}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000047638.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR   RefSeq; XP_008765259.2; XM_008767037.2.
DR   RefSeq; XP_017452002.1; XM_017596513.1.
DR   AlphaFoldDB; F1M681; -.
DR   jPOST; F1M681; -.
DR   PaxDb; 10116-ENSRNOP00000047638; -.
DR   Ensembl; ENSRNOT00000042227.5; ENSRNOP00000047638.6; ENSRNOG00000018830.8.
DR   AGR; RGD:1308527; -.
DR   RGD; 1308527; Aff3.
DR   VEuPathDB; HostDB:ENSRNOG00000018830; -.
DR   eggNOG; ENOG502QU9C; Eukaryota.
DR   GeneTree; ENSGT00950000182974; -.
DR   TreeFam; TF326216; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000018830; Expressed in frontal cortex and 16 other cell types or tissues.
DR   ExpressionAtlas; F1M681; baseline and differential.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0032783; C:super elongation complex; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0003690; F:double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; ISO:RGD.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0034612; P:response to tumor necrosis factor; ISO:RGD.
DR   InterPro; IPR007797; AF4/FMR2.
DR   InterPro; IPR043640; AF4/FMR2_CHD.
DR   InterPro; IPR043639; AF4_int.
DR   PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10528:SF16; AF4_FMR2 FAMILY MEMBER 3; 1.
DR   Pfam; PF05110; AF-4; 2.
DR   Pfam; PF18875; AF4_int; 1.
DR   Pfam; PF18876; AFF4_CHD; 1.
PE   1: Evidence at protein level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN          895..1158
FT                   /note="AF4/FMR2 C-terminal homology"
FT                   /evidence="ECO:0000259|Pfam:PF18876"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..898
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1033..1076
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        553..584
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..599
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        609..661
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..772
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..889
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1033..1051
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1058..1076
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1159 AA;  124946 MW;  A5B5C101BE80EEA3 CRC64;
     MKDFLTDRSN QSHLVGVPKP GVPQTPVNKI DDHFVAESRA QPQPSSVCST ASSTPAAVPV
     QQSKRGTMGW QKAGHPPSDG QQRAAQQGSL RTLLGDGVGR QQTRAKQVCN VETGLQTQER
     PPAMAAKHSG GGHCVQNFPP SLASKPSLGQ QKPTAYVRPM DGQDQAPDES PKLKSSTETA
     VHCTAYRGVP AGKPESARAK GKLAKFSIPK QGEENRSGET NSCVEEIIRE MTWLPPLSAI
     QAPAKVEPSK FPFPNKDSQL VSSGHSNPKK ADAEPESPDN GTSNTSTLED DLKLSSDDEE
     GEQQAAQRTV LRALADSSVV QQTNCRGSAP SSKGSSSSSG GSSSSSDSES TSGSDSETES
     SSSESESEGS KPPHCSSPEA EPASSNKWQL DKWLNKVNPH KPPILIQNES HGPERNQYYT
     PVKDEGQDCG KLPEICQASL RDKELKTACK EEQRPRTANK VPGSKSVKQK SPPAAVAVTA
     AAPPPAVPSA PTESAPAPTR RSAGKKPTRR TERTSAGDSA NCHRPEEPVA PDALGASVVG
     PLEPPKTRPC GNSRTGHRKE LRSSVTCEKR RTRGLSRIVP KSKEFIETES SSSSSSSDSD
     LESEQEEYIL SKAPSTTGSE QRLKEATSNN SSSSNSSSSS SSSSSSSSST SRASVGSINA
     RTTSDIAKEL EEQFYTLVPF GRNELLSPLK DSDEVRSLWV KIDLTLLSRI PEHLSQEPGV
     LSAPAAKDTD STPASHALDT PAEKTLPKSK RKRKCDNEDD YREIKKAQGK KEGASRLAAS
     TNNTFSGSHC NVSINSLAIP INKNEKMLRS PSSPLSDACK HKYSSEDVTS SSRPHGNGLL
     TSVSSNKEPK AESQLQSHAG DLTKISHNSS ENGILHSKSR PQTEPWSPGS NGHRDCKRQK
     LIFDDMPRSA DYFMREAKRM KHKADAMVEK FGKALNYAEA ALSFIECGNA MEQGPMESKS
     PYTMYSETVE LIRYAMRLKT HSGPNATPED KQLAALCYRC LALLYWRMFR LKRDHAVKYS
     KALIDYFKNS SKAAQAPSPW GSSGKSTGSP SPMSPNPSPA SSVGSQGSLS SSSGLSPSTI
     VSIPQRIHQM AANHVSITNS ILHSYDYWEM ADNLAKENRE FFNDLDLLMG PVTLHSSMEH
     LVQYSQQGLH WLRSSTHLS
//