ID   F1M656_RAT              Unreviewed;       463 AA.
AC   F1M656;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN   Name=Tulp3 {ECO:0000313|Ensembl:ENSRNOP00000007634.5,
GN   ECO:0000313|RGD:1585259};
GN   Synonyms=LOC100364088 {ECO:0000313|RGD:1585259,
GN   ECO:0000313|RGD:2321769};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000007634.5, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000007634.5, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007634.5,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0007829|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000007634.5}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007634.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC       ECO:0000256|RuleBase:RU361125}.
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DR   RefSeq; XP_006225128.1; XM_006225066.3.
DR   RefSeq; XP_008761560.1; XM_008763338.2.
DR   AlphaFoldDB; F1M656; -.
DR   STRING; 10116.ENSRNOP00000007634; -.
DR   PhosphoSitePlus; F1M656; -.
DR   PaxDb; 10116-ENSRNOP00000007634; -.
DR   Ensembl; ENSRNOT00000007634.7; ENSRNOP00000007634.5; ENSRNOG00000005767.8.
DR   KEGG; rno:688749; -.
DR   AGR; RGD:1585259; -.
DR   CTD; 7289; -.
DR   RGD; 2321769; LOC100364088.
DR   RGD; 1585259; Tulp3.
DR   eggNOG; KOG2502; Eukaryota.
DR   GeneTree; ENSGT00940000158155; -.
DR   HOGENOM; CLU_028236_1_1_1; -.
DR   OMA; FPTYFMH; -.
DR   TreeFam; TF314076; -.
DR   Reactome; R-RNO-5610787; Hedgehog 'off' state.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000005767; Expressed in ovary and 19 other cell types or tissues.
DR   ExpressionAtlas; F1M656; baseline and differential.
DR   GO; GO:0097731; C:9+0 non-motile cilium; ISO:RGD.
DR   GO; GO:0005930; C:axoneme; ISO:RGD.
DR   GO; GO:0097546; C:ciliary base; ISO:RGD.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:RGD.
DR   GO; GO:0120160; F:intraciliary transport particle A binding; ISO:RGD.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISO:RGD.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0060348; P:bone development; ISO:RGD.
DR   GO; GO:0007420; P:brain development; ISO:RGD.
DR   GO; GO:0060434; P:bronchus morphogenesis; ISO:RGD.
DR   GO; GO:0021953; P:central nervous system neuron differentiation; ISO:RGD.
DR   GO; GO:0021904; P:dorsal/ventral neural tube patterning; ISO:RGD.
DR   GO; GO:0031076; P:embryonic camera-type eye development; ISO:RGD.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR   GO; GO:0048702; P:embryonic neurocranium morphogenesis; ISO:RGD.
DR   GO; GO:0061548; P:ganglion development; ISO:RGD.
DR   GO; GO:0060173; P:limb development; ISO:RGD.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; ISO:RGD.
DR   GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR   GO; GO:0021915; P:neural tube development; ISO:RGD.
DR   GO; GO:0001841; P:neural tube formation; ISO:RGD.
DR   GO; GO:0061512; P:protein localization to cilium; ISO:RGD.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR   GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; ISO:RGD.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   InterPro; IPR005398; Tubby_N.
DR   PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR   PANTHER; PTHR16517:SF138; TUBBY-RELATED PROTEIN 3; 1.
DR   Pfam; PF01167; Tub; 1.
DR   Pfam; PF16322; Tub_N; 2.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   PRINTS; PR01574; TUBBYPROTEIN.
DR   SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          30..82
FT                   /note="Tubby N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16322"
FT   DOMAIN          84..193
FT                   /note="Tubby N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16322"
FT   DOMAIN          215..458
FT                   /note="Tubby C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01167"
SQ   SEQUENCE   463 AA;  51503 MW;  21861F63457C2C07 CRC64;
     MEAARCAPGS RGDSAFEDET LRLRQLKLDN QRALLEKKQR KKRLEPLMVQ PNPEARLRRL
     KPRGSEEHTP LVDPQTPCSD VILHGIDGPA AFLKPEAQDL ESKPQVLSVG SSPTPEEGTE
     GSADGESPVE TASKPDLQEI LQKHGILSSV NYDEEPDEEA EDEGENLSSL PAQSEKESAG
     ASQKAASDTG ASGMTAQQGD AQLGEVENLE DFAYSPAPRG VTVKCRVTRD KKGMDRGLFP
     TYYMHLEKEE NRKIFLLAGR KRKKSKTSNY LVSTDPTDLS REGESYIGKL RSNLMGTKFT
     VYDHGVNPVK AQGLVEKAHT RQELAAICYE TNVLGFKGPR KMSVIIPGMN MNHERIPFRP
     RNEHESLLSK WQNKSMENLI ELHNKAPVWN DDTQSYVLNF HGRVTQASVK NFQIVHGNDP
     DYIVMQFGRV ADDVFTLDYN YPLCALQAFA IGLSSFDSKL ACE
//