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Protein
Submitted name:

Laminin subunit alpha 2

Gene

Lama2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-3000157 Laminin interactions
R-RNO-8874081 MET activates PTK2 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Laminin subunit alpha 2Imported
Gene namesi
Name:Lama2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308889 Lama2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501408918822 – 3121Sequence analysisAdd BLAST3100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi308 ↔ 317PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi413 ↔ 425PROSITE-ProRule annotation
Disulfide bondi443 ↔ 452PROSITE-ProRule annotation
Disulfide bondi487 ↔ 496PROSITE-ProRule annotation
Disulfide bondi775 ↔ 784PROSITE-ProRule annotation
Disulfide bondi834 ↔ 843PROSITE-ProRule annotation
Disulfide bondi888 ↔ 897PROSITE-ProRule annotation
Disulfide bondi900 ↔ 914PROSITE-ProRule annotation
Disulfide bondi917 ↔ 929PROSITE-ProRule annotation
Disulfide bondi919 ↔ 936PROSITE-ProRule annotation
Disulfide bondi938 ↔ 947PROSITE-ProRule annotation
Disulfide bondi966 ↔ 978PROSITE-ProRule annotation
Disulfide bondi986 ↔ 995PROSITE-ProRule annotation
Disulfide bondi1031 ↔ 1040PROSITE-ProRule annotation
Disulfide bondi1059 ↔ 1071PROSITE-ProRule annotation
Disulfide bondi1061 ↔ 1078PROSITE-ProRule annotation
Disulfide bondi1080 ↔ 1089PROSITE-ProRule annotation
Disulfide bondi1105 ↔ 1117PROSITE-ProRule annotation
Disulfide bondi1135 ↔ 1144PROSITE-ProRule annotation
Disulfide bondi1381 ↔ 1390PROSITE-ProRule annotation
Disulfide bondi1438 ↔ 1447PROSITE-ProRule annotation
Disulfide bondi1496 ↔ 1505PROSITE-ProRule annotation
Disulfide bondi1526 ↔ 1538PROSITE-ProRule annotation
Disulfide bondi1528 ↔ 1545PROSITE-ProRule annotation
Disulfide bondi1547 ↔ 1556PROSITE-ProRule annotation
Disulfide bondi2682 ↔ 2709PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiF1M614
PRIDEiF1M614

Expressioni

Gene expression databases

BgeeiENSRNOG00000011134

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014917

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 285Laminin N-terminalInterPro annotationAdd BLAST252
Domaini286 – 342Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini343 – 412Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini413 – 467Laminin EGF-likeInterPro annotationAdd BLAST55
Domaini468 – 516Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini537 – 722Laminin IV type AInterPro annotationAdd BLAST186
Domaini756 – 805Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini806 – 863Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini864 – 916Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini917 – 965Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini966 – 1012Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1013 – 1058Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1059 – 1104Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1105 – 1164Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini1179 – 1378Laminin IV type AInterPro annotationAdd BLAST200
Domaini1370 – 1409Laminin EGF-likeInterPro annotationAdd BLAST40
Domaini1419 – 1467Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini1468 – 1525Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini1526 – 1572Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini2144 – 2327LAM_G_DOMAINInterPro annotationAdd BLAST184
Domaini2339 – 2520LAM_G_DOMAINInterPro annotationAdd BLAST182
Domaini2525 – 2709LAM_G_DOMAINInterPro annotationAdd BLAST185
Domaini2762 – 2933LAM_G_DOMAINInterPro annotationAdd BLAST172
Domaini2938 – 3118LAM_G_DOMAINInterPro annotationAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1699 – 1756Sequence analysisAdd BLAST58
Coiled coili1761 – 1784Sequence analysisAdd BLAST24
Coiled coili1813 – 1844Sequence analysisAdd BLAST32
Coiled coili1866 – 1886Sequence analysisAdd BLAST21
Coiled coili1930 – 1954Sequence analysisAdd BLAST25
Coiled coili2030 – 2074Sequence analysisAdd BLAST45
Coiled coili2091 – 2139Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00780000121851
InParanoidiF1M614
OMAiTYKPEIK
OrthoDBiEOG091G005L
TreeFamiTF335359

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 2 hits
PF00053 Laminin_EGF, 16 hits
PF00054 Laminin_G_1, 4 hits
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 16 hits
SM00281 LamB, 2 hits
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF49899 SSF49899, 5 hits
SSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 6 hits
PS50027 EGF_LAM_2, 16 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 2 hits
PS51117 LAMININ_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

F1M614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAAGGILLL LLLGILEGSQ TQRPQQRRQS PAHQQRGLFP AVLNLASNAL
60 70 80 90 100
ITTNATCGEK GPEMYCKLVE HVPGQPVRNP QCRICNQNSS HPYQRHPITN
110 120 130 140 150
AIDGKNTWWQ SPSIKNGVEY HYVTITLDLQ QVFQIAYVIV KAANSPRPGN
160 170 180 190 200
WILERSLDDE EYKPWQYHAV TDTECLTLYN IYPRTGPPSY AKDDEVICTS
210 220 230 240 250
FYSKIHPLEN GEIHISLING RPSADDPSPE LLEFTSARYI RLRFQRIRTL
260 270 280 290 300
NADLMMFAHK DPREIDPIVT RRYYYSVKDI SVGGMCICYG HARACPLDPA
310 320 330 340 350
TNKSRCECEH NTCGESCDRC CPGFHQKPWR AGTFLTKTEC EACNCHGKAE
360 370 380 390 400
ECYYDETVAS RNLSLNIHGK YIGGGVCINC THNTAGINCE TCIDGFFRPK
410 420 430 440 450
GVSPSYPRPC QPCHCDPAGS LSEVCIKDEK HTRRGLKPGS CYCKPGFGGM
460 470 480 490 500
NCDRCVRGYR GYPDCQPCNC SGLGSTNQDP CIGPCSCKEN VEGEDCSHCK
510 520 530 540 550
FGFFNLQEEN QKGCEECFCS GVSDRCQSSY WTYGNIQDMH GWYLTDLSGR
560 570 580 590 600
IQVAPQLDNP DAPQQISVSN SEARRSLPDS YYWSAPAPYL RNKLPAVGGQ
610 620 630 640 650
LSFTISYDLE EEEDDTEKIL QLMIILEGNN LRISTAYKEV HLEPSEEHVE
660 670 680 690 700
ELSLKEESFT IHGTNLPVSR KDFMILLTNL ERVLIQTTYN LGMDVIFRLS
710 720 730 740 750
SVNLESAVPY PTDRSIASAV EVCQCPPGYS GSSCEACWPR HRRVNGTIFG
760 770 780 790 800
GLCEPCQCFG HAEACNDVTG ECLSCKDHTG GPYCNECLPG FYGDPTRGTS
810 820 830 840 850
EDCQPCACPL NIPSNNFSPT CHLDRSLGLI CDECPVGYTG PRCERCAEGY
860 870 880 890 900
FGQPSIPGGS CQPCLCNDNL DFSIPGSCDS LSGSCLICKP GTTGRFCELC
910 920 930 940 950
ADGYFGDAVD AKNCQPCRCN VNGSFSEICH RKTGQCECRP NVQGQRCDEC
960 970 980 990 1000
KPETFGLQLG RGCIPCNCNS FGSKSFDCEA SGQCWCQPGV AGKKCDRCAH
1010 1020 1030 1040 1050
GYFNFQEGGC TACDCSHLGN NCNPKTGQCI CPPNTIGEKC SECLPNTWGH
1060 1070 1080 1090 1100
SIVTGCKVCN CSTVGSLSSQ CNINTGQCSC HPKFSGMKCS ECNRGHWNYP
1110 1120 1130 1140 1150
LCSLCDCFLP GTDATTCDSE TRKCSCSDQT GQCTCKVNVE GVHCDRCRPG
1160 1170 1180 1190 1200
KFGLEAKNPL GCSSCYCFGV TSQCSEAKGL VRTWVTLRDE QTILPLVDEA
1210 1220 1230 1240 1250
LQHTTTKGIA FQNPEIVAKM DEVRQDLHLE PFYWKLPEQF EGKKLMAYGG
1260 1270 1280 1290 1300
KLKYTIYFEA RDETGFATYK PQVIIRGGTP THARIITRHM AAPLIGQLTR
1310 1320 1330 1340 1350
HEIEMTEKEW KYYGDDPRIS RTVTREDFLD ILYDIHYILI KATYGNVVRQ
1360 1370 1380 1390 1400
SRISEISMEG AEPGQVSAAS PLANLIERCD CPPGYSGLSC ETCAPGFYRV
1410 1420 1430 1440 1450
HSEPGGRTPG PTLGTCVPCQ CHGHSSQCDP ETSVCQNCQH HTAGDFCERC
1460 1470 1480 1490 1500
ALGYYGIVRG LPNDCQPCAC PLISPSNNFS PSCVLEGLED YRCTACPRGY
1510 1520 1530 1540 1550
EGQYCERCAP GYAGSPSSPG GSCQECECDP YGSLPVPCDP VTGLCTCRPG
1560 1570 1580 1590 1600
ATGRKCDGCE HGHAREGAEC VFCGDECTGL LLGDLAHLEQ MAMNINLTGP
1610 1620 1630 1640 1650
LPAPYKILYG LENATQELKH LLSPQRAPER LLQLAEGNMN TLVMEMNELL
1660 1670 1680 1690 1700
TRATKVTADG EQTGQDAERT NSRAQSLEEF IKGLVQHAEA VNEKAIKLNE
1710 1720 1730 1740 1750
TLGSQDRTAE RNLQELQKEI DRMLKELRSK DLQTQKEVAE DELVAAEGLL
1760 1770 1780 1790 1800
KRVNKLFGEP RAQNEEMEKD LREKLAEYQN KLDDAWDLLR EATKKTKDAD
1810 1820 1830 1840 1850
RLSAANQKNM TILETKKEAI EGSKRQIENT LKEGNDILDE ANRLAGEITS
1860 1870 1880 1890 1900
VIDYVEDIKT KLPPMSEELS DKIDDLAQEI KDRRLAEKVF QAESHAAQLN
1910 1920 1930 1940 1950
DSSAVLDGIL DEAKNISFNA TAAFRAYSNI KDYIDEAEKV AREAKELAHE
1960 1970 1980 1990 2000
ATKLATSPQG LLKEDAKGSL QKSFRILNEA KKLANDVKEN HNDLSGLKTR
2010 2020 2030 2040 2050
LETADLRNSG LLGALNDTMD KLSAIPNDTA AKLQAVKEKA REANDTAKAV
2060 2070 2080 2090 2100
LAQVKDLHQN LDGLKQNYNK LADSVAKTNA VVKDPSKNSV VADAGATVRN
2110 2120 2130 2140 2150
LEQEADRLID KLKPIKELED NLKKNISEIK ELINQARKQA NSIKVSVSSG
2160 2170 2180 2190 2200
GDCIRTYKPE IKKGSYNNIV VHVKTAVADN LLFYLGSAKF IDFLAIEMRK
2210 2220 2230 2240 2250
GKVSFLWDVG SGVGRVEYPD LTIDDSYWYR IEASRTGRNG SISVRALDGP
2260 2270 2280 2290 2300
KASMVPSTHH SVSPPGYTIL DVDANAMLFV GGLTGKIKKA DAVRVTTFTG
2310 2320 2330 2340 2350
CMGETYFDNK PIGLWNFREK EGDCKGCTVS PQVEDSEGTI QFDGEGYALV
2360 2370 2380 2390 2400
SRPIRWYPNI STVMFKFRTF SSNALLMYLA TRDLKDFMSV ELSDGHVKVS
2410 2420 2430 2440 2450
YDLGSGMASV VSNQNHNDGK WKSFTLSRIQ KQANISIVDI DSNQEENIAT
2460 2470 2480 2490 2500
SSSGNNFGLD LKADDKIYFG GLPTLRNLSM KARPEVNVKK YSGCLKDIEI
2510 2520 2530 2540 2550
SRTPYNILSS PNYVGVTKGC SLENVYTVSF PKPGFVELAA VSIDVGTEIN
2560 2570 2580 2590 2600
LSFSTRNESG IILLGSGGTL TPPRRKRRQT TQAYYAIFLN KGRLEVHLSS
2610 2620 2630 2640 2650
GTRTMRKIVI KPEPNLFHDG REHSVHVERT RGVFTVQVDE NRRHMQNLTE
2660 2670 2680 2690 2700
EQPIEVKKLF VGGAPPEFQP SPLRNIPAFQ GCVWNLVINS IPMDFAQPIA
2710 2720 2730 2740 2750
FKNADIGRCA YQKPREEEDD AVPAEVTVQP QPVPTPAFPF PAPTMVHGPC
2760 2770 2780 2790 2800
VAESEPAFLS GSKQFGLSRN SHIALAFDDT KVKNRLTIEL EVRTEAESGL
2810 2820 2830 2840 2850
LFYMARINHA DFATVQLRNG FPYFSYDLGS GDTSTMIPTR INDGQWHKIK
2860 2870 2880 2890 2900
ITRVKQEGIL SVDDASNQTI SPKKADILDV VGILYVGGLP INYTTRRIGP
2910 2920 2930 2940 2950
VTYSLDGCVR NLYMEQAPVD LDQPTSSFHV GTCFANAEKG TYFDGTGFAK
2960 2970 2980 2990 3000
AVGGFKVGLD LLVEFEFRTT RPTGVLLGVS SQKMDGMGIE MIDEKLMFHV
3010 3020 3030 3040 3050
DNGAGRFTAV YDAGSPGHMC DGRWHKVTAK KIKNRLELVV DGNQVDAQSP
3060 3070 3080 3090 3100
NAASTSADTN DPVFVGGFPD GLNQFGLTTN VRFRGCIRSL KLTKGTGKPL
3110 3120
EVNFAKALEL RGVQPVSCPT T
Length:3,121
Mass (Da):343,859
Last modified:July 22, 2015 - v3
Checksum:i7EE6BD571EBF679E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07000583 Genomic DNA No translation available.
AABR07000584 Genomic DNA No translation available.
AABR07000585 Genomic DNA No translation available.
AABR07000586 Genomic DNA No translation available.
AABR07000587 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000014917; ENSRNOP00000014917; ENSRNOG00000011134
ENSRNOT00000079138; ENSRNOP00000070049; ENSRNOG00000011134

Similar proteinsi

Entry informationi

Entry nameiF1M614_RAT
AccessioniPrimary (citable) accession number: F1M614
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: May 23, 2018
This is version 68 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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