F1M5J4 (F1M5J4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein Wnt RuleBase RU003500

Gene names

Name:

Wnt10b Ensembl ENSRNOP00000061756 RGD 1304988

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000061756

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	239 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors By similarity. RuleBase RU003500
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity RuleBase RU003500.
Sequence similarities	Belongs to the Wnt family. RuleBase RU003500
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000061756

Ontologies

Keywords
Biological process	Wnt signaling pathway RuleBase RU003500 SAAS SAAS005817
Cellular component	Extracellular matrix SAAS SAAS005817 Secreted
Molecular function	Developmental protein RuleBase RU003500 SAAS SAAS005817
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome bone trabecula formation Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cellular response to hydrostatic pressure Inferred from expression pattern PubMed 19118527. Source: RGD female gonad development Inferred from Biological aspect of Ancestor. Source: RefGenome hematopoietic stem cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome midbrain-hindbrain boundary development Inferred from Biological aspect of Ancestor. Source: RefGenome myoblast cell differentiation involved in skeletal muscle regeneration Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of epithelial cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of fat cell differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of anagen Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of bone mineralization Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of epithelial cell differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of osteoblast differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of skeletal muscle tissue development Inferred from Biological aspect of Ancestor. Source: RefGenome skeletal muscle fiber development Inferred from Biological aspect of Ancestor. Source: RefGenome smoothened signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome tongue development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	Ensembl ENSRNOP00000061756

Sequences

	Sequence		Length	Mass (Da)
	F1M5J4 [UniParc]. Last modified May 3, 2011. Version 1. Checksum: 4CCF726C1CFD3014	FASTA	239	26,865
	10 20 30 40 50 60 RESAFSFSML AAGVMHAVAT ACSLGKLVSC GCGWKGSASG TDTWEWGGCN HDMDFGEKFS 70 80 90 100 110 120 RDFLDSREAP RDIQARMRIH NNRVGRQVVT ENLKRKCKCH GTSGSCQFKT CWRAAPEFRA 130 140 150 160 170 180 IGAALRERLG RAIFIDTHNR NSGVFQPRLR PRRLSGELVY FEKSPDFCER DPALGSPGTR 190 200 210 220 230 GRACNKTSRL LDGCGSLCCG RGHNVLRQTR VERCHCRFHW CCYVLCDECK VTEWVNVCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000061756.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000061756.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06107475 Genomic DNA. No translation available.
IPI	IPI00951869.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000064417; ENSRNOP00000061756; ENSRNOG00000014393.
UCSC	RGD:1304988. rat.
Organism-specific databases
RGD	1304988. Wnt10b.
Phylogenomic databases
GeneTree	ENSGT00690000101771.
Gene expression databases
ArrayExpress	F1M5J4.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013302. Wnt10. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF11. PTHR12027:SF11. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35581591.

Entry information

Entry name

F1M5J4_RAT

Accession

Primary (citable) accession number: F1M5J4

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	May 3, 2011
Last modified:	April 3, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)