F1M0B4 (F1M0B4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Mef2c Ensembl ENSRNOP00000042938

Gene names

Name:

Mef2c Ensembl ENSRNOP00000042938 RGD 1563119

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000042938

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000042938

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell homeostasis Inferred from electronic annotation. Source: Compara B cell proliferation Inferred from electronic annotation. Source: Compara B cell receptor signaling pathway Inferred from electronic annotation. Source: Compara MAPK cascade Inferred from electronic annotation. Source: Compara blood vessel development Inferred from electronic annotation. Source: Compara blood vessel remodeling Inferred from electronic annotation. Source: Compara cardiac muscle hypertrophy in response to stress Inferred from electronic annotation. Source: Compara cardiac ventricle formation Inferred from electronic annotation. Source: Compara cartilage morphogenesis Inferred from electronic annotation. Source: Compara cellular response to calcium ion Inferred from electronic annotation. Source: Compara cellular response to drug Inferred from electronic annotation. Source: Compara cellular response to fluid shear stress Inferred from electronic annotation. Source: Compara cellular response to glucose stimulus Inferred from expression pattern PubMed 18413674. Source: RGD cellular response to lipopolysaccharide Inferred from electronic annotation. Source: Compara cellular response to organic cyclic compound Inferred from expression pattern PubMed 11073966. Source: RGD cellular response to retinoic acid Inferred from direct assay PubMed 17568621. Source: RGD cellular response to trichostatin A Inferred from electronic annotation. Source: Compara chondrocyte differentiation Inferred from electronic annotation. Source: Compara dentate gyrus development Inferred from expression pattern PubMed 18949272. Source: RGD embryonic viscerocranium morphogenesis Inferred from electronic annotation. Source: Compara endochondral ossification Inferred from electronic annotation. Source: Compara epithelial cell proliferation involved in renal tubule morphogenesis Inferred from electronic annotation. Source: Compara germinal center formation Inferred from electronic annotation. Source: Compara glomerulus morphogenesis Inferred from electronic annotation. Source: Compara heart looping Inferred from electronic annotation. Source: Compara humoral immune response Inferred from electronic annotation. Source: Compara learning or memory Inferred from electronic annotation. Source: Compara melanocyte differentiation Inferred from electronic annotation. Source: Compara monocyte differentiation Inferred from electronic annotation. Source: Compara muscle cell fate determination Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara nephron tubule epithelial cell differentiation Inferred from electronic annotation. Source: Compara neural crest cell differentiation Inferred from electronic annotation. Source: Compara neuron development Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara platelet formation Inferred from electronic annotation. Source: Compara positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of alkaline phosphatase activity Inferred from electronic annotation. Source: Compara positive regulation of behavioral fear response Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation in bone marrow Inferred from electronic annotation. Source: Compara positive regulation of macrophage apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of protein homodimerization activity Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 19654000. Source: RGD primary heart field specification Inferred from electronic annotation. Source: Compara regulation of germinal center formation Inferred from electronic annotation. Source: Compara regulation of megakaryocyte differentiation Inferred from electronic annotation. Source: Compara regulation of sarcomere organization Inferred from electronic annotation. Source: Compara regulation of synaptic activity Inferred from electronic annotation. Source: Compara response to vitamin E Inferred from expression pattern PubMed 16534476. Source: RGD secondary heart field specification Inferred from electronic annotation. Source: Compara sinoatrial valve morphogenesis Inferred from electronic annotation. Source: Compara skeletal muscle cell differentiation Inferred from electronic annotation. Source: Compara smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara ventricular cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay PubMed 19654000. Source: RGD nucleus Inferred from direct assay PubMed 19654000. Source: RGD
Molecular_function	DNA binding Inferred from direct assay PubMed 11782488. Source: RGD RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara RNA polymerase II regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara chromatin binding Inferred from electronic annotation. Source: Compara core promoter proximal region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara core promoter sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from direct assay PubMed 19654000. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F1M0B4 [UniParc]. Last modified April 3, 2013. Version 2. Checksum: 907A33EC27E610F5	FASTA	471	51,117
	10 20 30 40 50 60 MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS TNKLFQYAST 70 80 90 100 110 120 DMDKVLLKYT EYNEPHESRT NSDIVEALNK KENKGSESPD PDSSYALTPR TEEKYKKINE 130 140 150 160 170 180 EFDNMIKSHK IPAVPPPNFE MPVTIPVSSH NSLVYSNPVS SLGNPNLLPL AHPSLQRNSM 190 200 210 220 230 240 SPGVTHRPPS AGNTGGLMGG DLTSGAGTSA GNGYGNPRNS PGLLVSPGNL NKNIQAKSPP 250 260 270 280 290 300 PMNLGMNNRK PDLRVLIPPG SKNTMPSVVM HNSVLNNQRI NNSQSAQSLA TPVVSVATPT 310 320 330 340 350 360 LPGQGMGGYP SAISTTYGTE YSLSSADLSS LSGFNTASAL HLGSVTGWQQ QHLHNMPPSA 370 380 390 400 410 420 LSQLGACTST HLSQSSNLSL PSTQSLNIKS EPVSPPRDRT TTPSRYPQHT RHEAGRSPVD 430 440 450 460 470 SLSSCSSSYD GSDREDHRNE FHSPIGLTRP SPDERESPSV KRMRLSEGWA T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000042938.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000042938.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06011618 Genomic DNA. No translation available. AABR06011619 Genomic DNA. No translation available.
IPI	IPI00763707.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000041538; ENSRNOP00000042938; ENSRNOG00000033134.
Organism-specific databases
RGD	1563119. Mef2c.
Phylogenomic databases
GeneTree	ENSGT00390000011828.
Family and domain databases
ProtoNet	Search...
Other
NextBio	35579780.

Entry information

Entry name

F1M0B4_RAT

Accession

Primary (citable) accession number: F1M0B4

Entry history

Integrated into UniProtKB/TrEMBL:	May 3, 2011
Last sequence update:	April 3, 2013
Last modified:	May 1, 2013
This is version 13 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)