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Protein

Phosphoinositide phospholipase C

Gene

Plcb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei249 – 2491UniRule annotation
Active sitei296 – 2961UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. GTPase activator activity Source: Ensembl
  3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
  4. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  5. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. activation of meiosis involved in egg activation Source: Ensembl
  2. cerebral cortex development Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. glutamate receptor signaling pathway Source: Ensembl
  5. G-protein coupled acetylcholine receptor signaling pathway Source: Ensembl
  6. insulin-like growth factor receptor signaling pathway Source: Ensembl
  7. interleukin-12-mediated signaling pathway Source: Ensembl
  8. interleukin-15-mediated signaling pathway Source: Ensembl
  9. interleukin-1-mediated signaling pathway Source: Ensembl
  10. intracellular signal transduction Source: InterPro
  11. lipid catabolic process Source: UniProtKB-KW
  12. memory Source: Ensembl
  13. negative regulation of monocyte extravasation Source: Ensembl
  14. negative regulation of transcription, DNA-templated Source: Ensembl
  15. positive regulation of acrosome reaction Source: Ensembl
  16. positive regulation of CD24 biosynthetic process Source: Ensembl
  17. positive regulation of developmental growth Source: Ensembl
  18. positive regulation of embryonic development Source: Ensembl
  19. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  20. positive regulation of interleukin-12 production Source: Ensembl
  21. positive regulation of JNK cascade Source: Ensembl
  22. positive regulation of myoblast differentiation Source: Ensembl
  23. positive regulation of transcription, DNA-templated Source: Ensembl
  24. regulation of fertilization Source: Ensembl
  25. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_194690. Ca2+ pathway.
REACT_196412. Presynaptic function of Kainate receptors.
REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
REACT_208646. G beta:gamma signalling through PLC beta.
REACT_221588. PLC beta mediated events.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi3344. Plcb1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. nuclear chromatin Source: Ensembl
  4. nuclear speck Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiF1M084. baseline.

Interactioni

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains C2 domain.SAAS annotation
Contains Cdomain.SAAS annotation
Contains PI-PLC X-box domain.SAAS annotation
Contains PI-PLC Y-box domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118936.
OMAiMMDFINL.
OrthoDBiEOG7WDN1N.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028400. PLC-beta1.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F1M084-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DPKLRELLDV GNIGHLEQRM ITVVYGPDLV NISHLNLVAF QEEVAKEWTN
60 70 80 90 100
EVFSLATNLL AQNMSRDAFL EKAYTKLKLQ VTPEGRIPLK NIYRLFSADR
110 120 130 140 150
KRVETALEAC SLPSSRNDSI PQEDFTPDVY RVFLNNLCPR PEIDNIFSEF
160 170 180 190 200
GAKSKPYLTV DQMMDFINLK QRDPRLNEIL YPPLKQEQVQ VLIEKYEPNS
210 220 230 240 250
SLAKKGQMSV DGFMRYLSGE ENGVVSPEKL DLNEDMSQPL SHYFINSSHN
260 270 280 290 300
TYLTAGQLAG NSSVEMYRQV LLSGCRCVEL DCWKGRTAEE EPVITHGFTM
310 320 330 340 350
TTEISFKEVI EAIAECAFKT SPFPILLSFE NHVDSPKQQA KMAEYCRLIF
360 370 380 390 400
GDALLMEPLE KYPLESGVPL PSPMDLMYKI LVKNKKKSHK SSEGSGKKKL
410 420 430 440 450
SEQASNTYSD SSSVFEPSSP GAGEADTESD DDDDDDDCKK SSMDEGTAGS
460 470 480 490 500
EAMATEEMSN LVNYIQPVKF ESFETSKKRN KSFEMSSFVE TKGLEQLTKS
510 520 530 540 550
PVEFVEYNKM QLSRIYPKGT RVDSSNYMPQ LFWNAGCQMV ALNFQTVDLA
560 570 580 590 600
MQINMGMYEY NGKSGYRLKP EFMRRPDKHF DPFTEGIVDG IVANTLSVKI
610 620 630 640 650
ISGQFLSDKK VGTYVEVDMF GLPVDTRRKA FKTKTSQGNA VNPVWEEEPI
660 670 680 690 700
VFKKVVLPSL ACLRIAAYEE GGKFIGHRIL PVQAIRPGYH YICLRNERNQ
710 720 730 740 750
PLMLPAVFVY IEVKDYVPDT YADVIEALSN PIRYVNLMEQ RAKQLAALTL
760 770 780 790 800
EDEEEVKKEA DPGETSSEAP SETRTTPAEN GVNHTATLAP KPPSQAPHSQ
810 820 830 840 850
PAPGSVKAPA KTEDLIQSVL TEVEAQTIEE LKQQKSFVKL QKKHYKEMKD
860 870 880 890 900
LVKRHHKKTT ELIKEHTTKY NEIQNDYLRR RAALEKSAKK DSKKKSEPSS
910 920 930 940 950
PDHGSSAIEQ DLAALDAEMT QKLIDLKDKQ QQQLLNLRQE QYYSEKYQKR
960
EHIKLVSQKL PGSAEE
Length:966
Mass (Da):109,374
Last modified:April 3, 2013 - v2
Checksum:i94FD76C8A4B189D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06026332 Genomic DNA. No translation available.
AABR06026333 Genomic DNA. No translation available.
AABR06026334 Genomic DNA. No translation available.
AABR06026335 Genomic DNA. No translation available.
AABR06026336 Genomic DNA. No translation available.
AABR06026337 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000006389; ENSRNOP00000006389; ENSRNOG00000004810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06026332 Genomic DNA. No translation available.
AABR06026333 Genomic DNA. No translation available.
AABR06026334 Genomic DNA. No translation available.
AABR06026335 Genomic DNA. No translation available.
AABR06026336 Genomic DNA. No translation available.
AABR06026337 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiF1M084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006389; ENSRNOP00000006389; ENSRNOG00000004810.

Organism-specific databases

RGDi3344. Plcb1.

Phylogenomic databases

GeneTreeiENSGT00760000118936.
OMAiMMDFINL.
OrthoDBiEOG7WDN1N.

Enzyme and pathway databases

ReactomeiREACT_194690. Ca2+ pathway.
REACT_196412. Presynaptic function of Kainate receptors.
REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
REACT_208646. G beta:gamma signalling through PLC beta.
REACT_221588. PLC beta mediated events.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi35579751.

Gene expression databases

ExpressionAtlasiF1M084. baseline.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028400. PLC-beta1.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M084_RAT
AccessioniPrimary (citable) accession number: F1M084
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: February 4, 2015
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.