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F1M084 (F1M084_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Plcb1 Ensembl ENSRNOP00000006389 RGD 3344
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000006389
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length966 AA.
Sequence statusFragment.
Protein existencePredicted

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412

Contains C2 domain. SAAS SAAS001192

Contains Cdomain. SAAS SAAS001192

Contains PI-PLC X-box domain. SAAS SAAS001192

Contains PI-PLC Y-box domain. SAAS SAAS001192

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSRNOP00000006389

Ontologies

Keywords
   Molecular functionTransducer SAAS SAAS001192
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled acetylcholine receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

activation of meiosis involved in egg activation

Inferred from electronic annotation. Source: Ensembl

cerebral cortex development

Inferred from electronic annotation. Source: Ensembl

fat cell differentiation

Inferred from electronic annotation. Source: Ensembl

glutamate receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

insulin-like growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

interleukin-1-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

interleukin-12-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

interleukin-15-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

lipid catabolic process

Inferred from electronic annotation. Source: InterPro

memory

Inferred from electronic annotation. Source: Ensembl

negative regulation of monocyte extravasation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of CD24 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of JNK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of acrosome reaction

Inferred from electronic annotation. Source: Ensembl

positive regulation of developmental growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of embryonic development

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of myoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

regulation of G-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of fertilization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nuclear speck

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: Ensembl

calcium ion binding

Inferred from electronic annotation. Source: InterPro

phosphatidylinositol phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

phosphatidylinositol-4,5-bisphosphate binding

Inferred from electronic annotation. Source: Ensembl

signal transducer activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 Ensembl ENSRNOP00000006389

Sequences

Sequence LengthMass (Da)Tools
F1M084 [UniParc].

Last modified April 3, 2013. Version 2.
Checksum: 94FD76C8A4B189D8

FASTA966109,374
        10         20         30         40         50         60 
DPKLRELLDV GNIGHLEQRM ITVVYGPDLV NISHLNLVAF QEEVAKEWTN EVFSLATNLL 

        70         80         90        100        110        120 
AQNMSRDAFL EKAYTKLKLQ VTPEGRIPLK NIYRLFSADR KRVETALEAC SLPSSRNDSI 

       130        140        150        160        170        180 
PQEDFTPDVY RVFLNNLCPR PEIDNIFSEF GAKSKPYLTV DQMMDFINLK QRDPRLNEIL 

       190        200        210        220        230        240 
YPPLKQEQVQ VLIEKYEPNS SLAKKGQMSV DGFMRYLSGE ENGVVSPEKL DLNEDMSQPL 

       250        260        270        280        290        300 
SHYFINSSHN TYLTAGQLAG NSSVEMYRQV LLSGCRCVEL DCWKGRTAEE EPVITHGFTM 

       310        320        330        340        350        360 
TTEISFKEVI EAIAECAFKT SPFPILLSFE NHVDSPKQQA KMAEYCRLIF GDALLMEPLE 

       370        380        390        400        410        420 
KYPLESGVPL PSPMDLMYKI LVKNKKKSHK SSEGSGKKKL SEQASNTYSD SSSVFEPSSP 

       430        440        450        460        470        480 
GAGEADTESD DDDDDDDCKK SSMDEGTAGS EAMATEEMSN LVNYIQPVKF ESFETSKKRN 

       490        500        510        520        530        540 
KSFEMSSFVE TKGLEQLTKS PVEFVEYNKM QLSRIYPKGT RVDSSNYMPQ LFWNAGCQMV 

       550        560        570        580        590        600 
ALNFQTVDLA MQINMGMYEY NGKSGYRLKP EFMRRPDKHF DPFTEGIVDG IVANTLSVKI 

       610        620        630        640        650        660 
ISGQFLSDKK VGTYVEVDMF GLPVDTRRKA FKTKTSQGNA VNPVWEEEPI VFKKVVLPSL 

       670        680        690        700        710        720 
ACLRIAAYEE GGKFIGHRIL PVQAIRPGYH YICLRNERNQ PLMLPAVFVY IEVKDYVPDT 

       730        740        750        760        770        780 
YADVIEALSN PIRYVNLMEQ RAKQLAALTL EDEEEVKKEA DPGETSSEAP SETRTTPAEN 

       790        800        810        820        830        840 
GVNHTATLAP KPPSQAPHSQ PAPGSVKAPA KTEDLIQSVL TEVEAQTIEE LKQQKSFVKL 

       850        860        870        880        890        900 
QKKHYKEMKD LVKRHHKKTT ELIKEHTTKY NEIQNDYLRR RAALEKSAKK DSKKKSEPSS 

       910        920        930        940        950        960 
PDHGSSAIEQ DLAALDAEMT QKLIDLKDKQ QQQLLNLRQE QYYSEKYQKR EHIKLVSQKL 


PGSAEE 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000006389.
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000006389.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06026332 Genomic DNA. No translation available.
AABR06026333 Genomic DNA. No translation available.
AABR06026334 Genomic DNA. No translation available.
AABR06026335 Genomic DNA. No translation available.
AABR06026336 Genomic DNA. No translation available.
AABR06026337 Genomic DNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006389; ENSRNOP00000006389; ENSRNOG00000004810.

Organism-specific databases

RGD3344. Plcb1.

Phylogenomic databases

GeneTreeENSGT00730000110266.
OMAMMDFINL.
OrthoDBEOG7WDN1N.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028400. PLC-beta1.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
PfamPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFPIRSF000956. PLC-beta. 1 hit.
PRINTSPR00390. PHPHLIPASEC.
SMARTSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35579751.

Entry information

Entry nameF1M084_RAT
AccessionPrimary (citable) accession number: F1M084
Entry history
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: April 16, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)