SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

F1M084

- F1M084_RAT

UniProt

F1M084 - F1M084_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphoinositide phospholipase C
Gene
Plcb1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei249 – 2491 By similarityUniRule annotation
Active sitei296 – 2961 By similarityUniRule annotation

GO - Molecular functioni

  1. GTPase activator activity Source: Ensembl
  2. calcium ion binding Source: InterPro
  3. phosphatidylinositol phospholipase C activity Source: Ensembl
  4. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
  5. signal transducer activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled acetylcholine receptor signaling pathway Source: Ensembl
  2. activation of meiosis involved in egg activation Source: Ensembl
  3. cerebral cortex development Source: Ensembl
  4. fat cell differentiation Source: Ensembl
  5. glutamate receptor signaling pathway Source: Ensembl
  6. insulin-like growth factor receptor signaling pathway Source: Ensembl
  7. interleukin-1-mediated signaling pathway Source: Ensembl
  8. interleukin-12-mediated signaling pathway Source: Ensembl
  9. interleukin-15-mediated signaling pathway Source: Ensembl
  10. intracellular signal transduction Source: InterPro
  11. lipid catabolic process Source: InterPro
  12. memory Source: Ensembl
  13. negative regulation of monocyte extravasation Source: Ensembl
  14. negative regulation of transcription, DNA-templated Source: Ensembl
  15. positive regulation of CD24 biosynthetic process Source: Ensembl
  16. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  17. positive regulation of JNK cascade Source: Ensembl
  18. positive regulation of acrosome reaction Source: Ensembl
  19. positive regulation of developmental growth Source: Ensembl
  20. positive regulation of embryonic development Source: Ensembl
  21. positive regulation of interleukin-12 production Source: Ensembl
  22. positive regulation of myoblast differentiation Source: Ensembl
  23. positive regulation of transcription, DNA-templated Source: Ensembl
  24. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  25. regulation of fertilization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotations

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi3344. Plcb1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear chromatin Source: Ensembl
  3. nuclear speck Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains C2 domain.SAAS annotations
Contains Cdomain.SAAS annotations
Contains PI-PLC X-box domain.SAAS annotations
Contains PI-PLC Y-box domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110266.
OMAiMMDFINL.
OrthoDBiEOG7WDN1N.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028400. PLC-beta1.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F1M084-1 [UniParc]FASTAAdd to Basket

« Hide

DPKLRELLDV GNIGHLEQRM ITVVYGPDLV NISHLNLVAF QEEVAKEWTN    50
EVFSLATNLL AQNMSRDAFL EKAYTKLKLQ VTPEGRIPLK NIYRLFSADR 100
KRVETALEAC SLPSSRNDSI PQEDFTPDVY RVFLNNLCPR PEIDNIFSEF 150
GAKSKPYLTV DQMMDFINLK QRDPRLNEIL YPPLKQEQVQ VLIEKYEPNS 200
SLAKKGQMSV DGFMRYLSGE ENGVVSPEKL DLNEDMSQPL SHYFINSSHN 250
TYLTAGQLAG NSSVEMYRQV LLSGCRCVEL DCWKGRTAEE EPVITHGFTM 300
TTEISFKEVI EAIAECAFKT SPFPILLSFE NHVDSPKQQA KMAEYCRLIF 350
GDALLMEPLE KYPLESGVPL PSPMDLMYKI LVKNKKKSHK SSEGSGKKKL 400
SEQASNTYSD SSSVFEPSSP GAGEADTESD DDDDDDDCKK SSMDEGTAGS 450
EAMATEEMSN LVNYIQPVKF ESFETSKKRN KSFEMSSFVE TKGLEQLTKS 500
PVEFVEYNKM QLSRIYPKGT RVDSSNYMPQ LFWNAGCQMV ALNFQTVDLA 550
MQINMGMYEY NGKSGYRLKP EFMRRPDKHF DPFTEGIVDG IVANTLSVKI 600
ISGQFLSDKK VGTYVEVDMF GLPVDTRRKA FKTKTSQGNA VNPVWEEEPI 650
VFKKVVLPSL ACLRIAAYEE GGKFIGHRIL PVQAIRPGYH YICLRNERNQ 700
PLMLPAVFVY IEVKDYVPDT YADVIEALSN PIRYVNLMEQ RAKQLAALTL 750
EDEEEVKKEA DPGETSSEAP SETRTTPAEN GVNHTATLAP KPPSQAPHSQ 800
PAPGSVKAPA KTEDLIQSVL TEVEAQTIEE LKQQKSFVKL QKKHYKEMKD 850
LVKRHHKKTT ELIKEHTTKY NEIQNDYLRR RAALEKSAKK DSKKKSEPSS 900
PDHGSSAIEQ DLAALDAEMT QKLIDLKDKQ QQQLLNLRQE QYYSEKYQKR 950
EHIKLVSQKL PGSAEE 966
Length:966
Mass (Da):109,374
Last modified:April 3, 2013 - v2
Checksum:i94FD76C8A4B189D8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06026332 Genomic DNA. No translation available.
AABR06026333 Genomic DNA. No translation available.
AABR06026334 Genomic DNA. No translation available.
AABR06026335 Genomic DNA. No translation available.
AABR06026336 Genomic DNA. No translation available.
AABR06026337 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000006389; ENSRNOP00000006389; ENSRNOG00000004810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06026332 Genomic DNA. No translation available.
AABR06026333 Genomic DNA. No translation available.
AABR06026334 Genomic DNA. No translation available.
AABR06026335 Genomic DNA. No translation available.
AABR06026336 Genomic DNA. No translation available.
AABR06026337 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006389 ; ENSRNOP00000006389 ; ENSRNOG00000004810 .

Organism-specific databases

RGDi 3344. Plcb1.

Phylogenomic databases

GeneTreei ENSGT00730000110266.
OMAi MMDFINL.
OrthoDBi EOG7WDN1N.

Miscellaneous databases

NextBioi 35579751.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028400. PLC-beta1.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
Pfami PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000956. PLC-beta. 1 hit.
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M084_RAT
AccessioniPrimary (citable) accession number: F1M084
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: July 9, 2014
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi