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F1M084

- F1M084_RAT

UniProt

F1M084 - F1M084_RAT

Protein

Phosphoinositide phospholipase C

Gene

Plcb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei249 – 2491UniRule annotation
    Active sitei296 – 2961UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. GTPase activator activity Source: Ensembl
    3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
    4. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    5. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. activation of meiosis involved in egg activation Source: Ensembl
    2. cerebral cortex development Source: Ensembl
    3. fat cell differentiation Source: Ensembl
    4. glutamate receptor signaling pathway Source: Ensembl
    5. G-protein coupled acetylcholine receptor signaling pathway Source: Ensembl
    6. insulin-like growth factor receptor signaling pathway Source: Ensembl
    7. interleukin-12-mediated signaling pathway Source: Ensembl
    8. interleukin-15-mediated signaling pathway Source: Ensembl
    9. interleukin-1-mediated signaling pathway Source: Ensembl
    10. intracellular signal transduction Source: InterPro
    11. lipid catabolic process Source: UniProtKB-KW
    12. memory Source: Ensembl
    13. negative regulation of monocyte extravasation Source: Ensembl
    14. negative regulation of transcription, DNA-templated Source: Ensembl
    15. positive regulation of acrosome reaction Source: Ensembl
    16. positive regulation of CD24 biosynthetic process Source: Ensembl
    17. positive regulation of developmental growth Source: Ensembl
    18. positive regulation of embryonic development Source: Ensembl
    19. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    20. positive regulation of interleukin-12 production Source: Ensembl
    21. positive regulation of JNK cascade Source: Ensembl
    22. positive regulation of myoblast differentiation Source: Ensembl
    23. positive regulation of transcription, DNA-templated Source: Ensembl
    24. regulation of fertilization Source: Ensembl
    25. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    HydrolaseUniRule annotation, TransducerSAAS annotation

    Keywords - Biological processi

    Lipid degradationUniRule annotation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
    Gene namesi
    Name:Plcb1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi3344. Plcb1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear chromatin Source: Ensembl
    3. nuclear speck Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains 1 PI-PLC X-box domain.UniRule annotation
    Contains 1 PI-PLC Y-box domain.UniRule annotation
    Contains C2 domain.SAAS annotation
    Contains PI-PLC X-box domain.SAAS annotation
    Contains PI-PLC Y-box domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110266.
    OMAiMMDFINL.
    OrthoDBiEOG7WDN1N.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR028400. PLC-beta1.
    IPR014815. PLC-beta_C.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF12. PTHR10336:SF12. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF08703. PLC-beta_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000956. PLC-beta. 1 hit.
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    F1M084-1 [UniParc]FASTAAdd to Basket

    « Hide

    DPKLRELLDV GNIGHLEQRM ITVVYGPDLV NISHLNLVAF QEEVAKEWTN    50
    EVFSLATNLL AQNMSRDAFL EKAYTKLKLQ VTPEGRIPLK NIYRLFSADR 100
    KRVETALEAC SLPSSRNDSI PQEDFTPDVY RVFLNNLCPR PEIDNIFSEF 150
    GAKSKPYLTV DQMMDFINLK QRDPRLNEIL YPPLKQEQVQ VLIEKYEPNS 200
    SLAKKGQMSV DGFMRYLSGE ENGVVSPEKL DLNEDMSQPL SHYFINSSHN 250
    TYLTAGQLAG NSSVEMYRQV LLSGCRCVEL DCWKGRTAEE EPVITHGFTM 300
    TTEISFKEVI EAIAECAFKT SPFPILLSFE NHVDSPKQQA KMAEYCRLIF 350
    GDALLMEPLE KYPLESGVPL PSPMDLMYKI LVKNKKKSHK SSEGSGKKKL 400
    SEQASNTYSD SSSVFEPSSP GAGEADTESD DDDDDDDCKK SSMDEGTAGS 450
    EAMATEEMSN LVNYIQPVKF ESFETSKKRN KSFEMSSFVE TKGLEQLTKS 500
    PVEFVEYNKM QLSRIYPKGT RVDSSNYMPQ LFWNAGCQMV ALNFQTVDLA 550
    MQINMGMYEY NGKSGYRLKP EFMRRPDKHF DPFTEGIVDG IVANTLSVKI 600
    ISGQFLSDKK VGTYVEVDMF GLPVDTRRKA FKTKTSQGNA VNPVWEEEPI 650
    VFKKVVLPSL ACLRIAAYEE GGKFIGHRIL PVQAIRPGYH YICLRNERNQ 700
    PLMLPAVFVY IEVKDYVPDT YADVIEALSN PIRYVNLMEQ RAKQLAALTL 750
    EDEEEVKKEA DPGETSSEAP SETRTTPAEN GVNHTATLAP KPPSQAPHSQ 800
    PAPGSVKAPA KTEDLIQSVL TEVEAQTIEE LKQQKSFVKL QKKHYKEMKD 850
    LVKRHHKKTT ELIKEHTTKY NEIQNDYLRR RAALEKSAKK DSKKKSEPSS 900
    PDHGSSAIEQ DLAALDAEMT QKLIDLKDKQ QQQLLNLRQE QYYSEKYQKR 950
    EHIKLVSQKL PGSAEE 966
    Length:966
    Mass (Da):109,374
    Last modified:April 3, 2013 - v2
    Checksum:i94FD76C8A4B189D8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06026332 Genomic DNA. No translation available.
    AABR06026333 Genomic DNA. No translation available.
    AABR06026334 Genomic DNA. No translation available.
    AABR06026335 Genomic DNA. No translation available.
    AABR06026336 Genomic DNA. No translation available.
    AABR06026337 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000006389; ENSRNOP00000006389; ENSRNOG00000004810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06026332 Genomic DNA. No translation available.
    AABR06026333 Genomic DNA. No translation available.
    AABR06026334 Genomic DNA. No translation available.
    AABR06026335 Genomic DNA. No translation available.
    AABR06026336 Genomic DNA. No translation available.
    AABR06026337 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006389 ; ENSRNOP00000006389 ; ENSRNOG00000004810 .

    Organism-specific databases

    RGDi 3344. Plcb1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110266.
    OMAi MMDFINL.
    OrthoDBi EOG7WDN1N.

    Miscellaneous databases

    NextBioi 35579751.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR028400. PLC-beta1.
    IPR014815. PLC-beta_C.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF12. PTHR10336:SF12. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF08703. PLC-beta_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000956. PLC-beta. 1 hit.
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1M084_RAT
    AccessioniPrimary (citable) accession number: F1M084
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 32 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3