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Protein

Phosphoinositide phospholipase C

Gene

Plcb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_275454. Ca2+ pathway.
REACT_313204. PLC beta mediated events.
REACT_337837. Synthesis of IP3 and IP4 in the cytosol.
REACT_344733. G beta:gamma signalling through PLC beta.
REACT_345409. Presynaptic function of Kainate receptors.
REACT_353304. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3344. Plcb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiF1M084. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006389.

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Phylogenomic databases

OMAiMMDFINL.
OrthoDBiEOG7WDN1N.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028400. PLC-beta1.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1M084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QDPKLRELLD VGNIGHLEQR MITVVYGPDL VNISHLNLVA FQEEVAKEWT
60 70 80 90 100
NEVFSLATNL LAQNMSRDAF LEKAYTKLKL QVTPEGRIPL KNIYRLFSAD
110 120 130 140 150
RKRVETALEA CSLPSSRNDS IPQEDFTPDV YRVFLNNLCP RPEIDNIFSE
160 170 180 190 200
FGAKSKPYLT VDQMMDFINL KQRDPRLNEI LYPPLKQEQV QVLIEKYEPN
210 220 230 240 250
SSLAKKGQMS VDGFMRYLSG EENGVVSPEK LDLNEDMSQP LSHYFINSSH
260 270 280 290 300
NTYLTAGQLA GNSSVEMYRQ VLLSGCRCVE LDCWKGRTAE EEPVITHGFT
310 320 330 340 350
MTTEISFKEV IEAIAECAFK TSPFPILLSF ENHVDSPKQQ AKMAEYCRLI
360 370 380 390 400
FGDALLMEPL EKYPLESGVP LPSPMDLMYK ILVKNKKKSH KSSEGSGKKK
410 420 430 440 450
LSEQASNTYS DSSSVFEPSS PGAGEADTES DDDDDDDDCK KSSMDEGTAG
460 470 480 490 500
SEAMATEEMS NLVNYIQPVK FESFETSKKR NKSFEMSSFV ETKGLEQLTK
510 520 530 540 550
SPVEFVEYNK MQLSRIYPKG TRVDSSNYMP QLFWNAGCQM VALNFQTVDL
560 570 580 590 600
AMQINMGMYE YNGKSGYRLK PEFMRRPDKH FDPFTEGIVD GIVANTLSVK
610 620 630 640 650
IISGQFLSDK KVGTYVEVDM FGLPVDTRRK AFKTKTSQGN AVNPVWEEEP
660 670 680 690 700
IVFKKVVLPS LACLRIAAYE EGGKFIGHRI LPVQAIRPGY HYICLRNERN
710 720 730 740 750
QPLMLPAVFV YIEVKDYVPD TYADVIEALS NPIRYVNLME QRAKQLAALT
760 770 780 790 800
LEDEEEVKKE ADPGETSSEA PSETRTTPAE NGVNHTATLA PKPPSQAPHS
810 820 830 840 850
QPAPGSVKAP AKTEDLIQSV LTEVEAQTIE ELKQQKSFVK LQKKHYKEMK
860 870 880 890 900
DLVKRHHKKT TELIKEHTTK YNEIQNDYLR RRAALEKSAK KDSKKKSEPS
910 920 930 940 950
SPDHGSSAIE QDLAALDAEM TQKLIDLKDK QQQQLLNLRQ EQYYSEKYQK
960 970 980 990 1000
REHIKLLIQK LTDVAEECQN NQLKKLKEIC EKEKKELKKK MDKKRQEKIT
1010 1020 1030 1040 1050
EAKSKDKSQM EEEKTEMIRS YIQEVVQYIK RLEEAQSKRQ EKLVEKHKEI
1060 1070 1080 1090 1100
RQQILDEKPK LQMELEQEYQ DKFKRLPLEI LEFVQEAMKG KVSEDSNHGS
1110 1120 1130
APPSLASDPA KVNLKSPSSE EVQGENAGRE FDTPL
Length:1,135
Mass (Da):129,345
Last modified:July 22, 2015 - v3
Checksum:iEFA4BD33C6219088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053816 Genomic DNA. No translation available.
AABR07053817 Genomic DNA. No translation available.
AABR07053818 Genomic DNA. No translation available.
AABR07053819 Genomic DNA. No translation available.
AABR07053820 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000006389; ENSRNOP00000006389; ENSRNOG00000004810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053816 Genomic DNA. No translation available.
AABR07053817 Genomic DNA. No translation available.
AABR07053818 Genomic DNA. No translation available.
AABR07053819 Genomic DNA. No translation available.
AABR07053820 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006389.

Chemistry

BindingDBiF1M084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006389; ENSRNOP00000006389; ENSRNOG00000004810.

Organism-specific databases

RGDi3344. Plcb1.

Phylogenomic databases

OMAiMMDFINL.
OrthoDBiEOG7WDN1N.

Enzyme and pathway databases

ReactomeiREACT_275454. Ca2+ pathway.
REACT_313204. PLC beta mediated events.
REACT_337837. Synthesis of IP3 and IP4 in the cytosol.
REACT_344733. G beta:gamma signalling through PLC beta.
REACT_345409. Presynaptic function of Kainate receptors.
REACT_353304. G alpha (q) signalling events.

Miscellaneous databases

NextBioi35579751.

Gene expression databases

ExpressionAtlasiF1M084. baseline.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028400. PLC-beta1.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF1M084_RAT
AccessioniPrimary (citable) accession number: F1M084
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: July 22, 2015
This is version 42 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.