Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F1M077

- F1M077_RAT

UniProt

F1M077 - F1M077_RAT

Protein

Protein Wnt

Gene

Wnt3a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. axis elongation involved in somitogenesis Source: Ensembl
    2. axon guidance Source: Ensembl
    3. canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: Ensembl
    4. cell fate commitment Source: RefGenome
    5. cell proliferation in forebrain Source: Ensembl
    6. cellular protein localization Source: Ensembl
    7. COP9 signalosome assembly Source: Ensembl
    8. dorsal/ventral neural tube patterning Source: Ensembl
    9. extracellular matrix organization Source: Ensembl
    10. heart looping Source: Ensembl
    11. hemopoiesis Source: Ensembl
    12. hippocampus development Source: Ensembl
    13. inner ear morphogenesis Source: Ensembl
    14. in utero embryonic development Source: Ensembl
    15. mammary gland development Source: Ensembl
    16. negative regulation of axon extension involved in axon guidance Source: Ensembl
    17. negative regulation of fat cell differentiation Source: Ensembl
    18. negative regulation of heart induction by canonical Wnt signaling pathway Source: Ensembl
    19. negative regulation of neuron projection development Source: Ensembl
    20. neuron differentiation Source: RefGenome
    21. osteoblast differentiation Source: Ensembl
    22. palate development Source: Ensembl
    23. paraxial mesodermal cell fate commitment Source: Ensembl
    24. platelet aggregation Source: Ensembl
    25. positive regulation of B cell proliferation Source: Ensembl
    26. positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Source: Ensembl
    27. positive regulation of cardiac muscle cell differentiation Source: Ensembl
    28. positive regulation of catenin import into nucleus Source: Ensembl
    29. positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
    30. positive regulation of collateral sprouting in absence of injury Source: Ensembl
    31. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    32. positive regulation of dermatome development Source: Ensembl
    33. positive regulation of mesodermal cell fate specification Source: Ensembl
    34. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    35. positive regulation of protein binding Source: Ensembl
    36. positive regulation of protein tyrosine kinase activity Source: Ensembl
    37. positive regulation of receptor internalization Source: Ensembl
    38. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    40. post-anal tail morphogenesis Source: Ensembl
    41. regulation of cell differentiation Source: RGD
    42. regulation of cell growth Source: RGD
    43. regulation of microtubule cytoskeleton organization Source: Ensembl
    44. skeletal muscle cell differentiation Source: Ensembl
    45. spinal cord association neuron differentiation Source: Ensembl
    46. Wnt signaling pathway Source: RefGenome
    47. Wnt signaling pathway involved in forebrain neuroblast division Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinUniRule annotationSAAS annotation

    Keywords - Biological processi

    Wnt signaling pathwayUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein WntUniRule annotation
    Gene namesi
    Name:Wnt3aImported
    Synonyms:Wnt3Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi3972. Wnt3.
    1308057. Wnt3a.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix UniRule annotation

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: RGD
    3. extracellular space Source: RefGenome
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrixSAAS annotation, Secreted

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF1M077.
    SMRiF1M077. Positions 57-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110244.
    KOiK00312.
    OMAiCTTVNDS.
    OrthoDBiEOG7C8GJ8.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009141. Wnt3.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01843. WNT3PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F1M077-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLGYLLVL CSLKQALGSY PIWWSLAVGP QYSSLSTQPI LCASIPGLVP    50
    KQLRFCRNYV EIMPSVAEGV KAGIQECQHQ FRGRRWNCTT VSNSLAIFGP 100
    VLDKATRESA FVHAIASAGV AFAVTRSCAE GSAAICGCSS RLQGSPGEGW 150
    KWGGCSEDIE FGGMVSREFA DARENRPDAR SAMNRHNNEA GRQAIASHMH 200
    LKCKCHGLSG SCEVKTCWWS QPDFRTIGDF LKDKYDSASE MVVEKHRESR 250
    GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 300
    SHGIDGCDLL CCGRGHNART ERRREKCHCV FHWCCYVSCQ ECTRVYDVHT 350
    CK 352
    Length:352
    Mass (Da):39,258
    Last modified:April 3, 2013 - v2
    Checksum:i7ADFC5B38A8EFF63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06064066 Genomic DNA. No translation available.
    RefSeqiXP_006246549.1. XM_006246487.1.
    UniGeneiRn.234269.

    Genome annotation databases

    EnsembliENSRNOT00000064505; ENSRNOP00000063833; ENSRNOG00000003039.
    GeneIDi303181.
    KEGGirno:303181.
    UCSCiRGD:3972. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06064066 Genomic DNA. No translation available.
    RefSeqi XP_006246549.1. XM_006246487.1.
    UniGenei Rn.234269.

    3D structure databases

    ProteinModelPortali F1M077.
    SMRi F1M077. Positions 57-351.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000064505 ; ENSRNOP00000063833 ; ENSRNOG00000003039 .
    GeneIDi 303181.
    KEGGi rno:303181.
    UCSCi RGD:3972. rat.

    Organism-specific databases

    CTDi 89780.
    RGDi 3972. Wnt3.
    1308057. Wnt3a.

    Phylogenomic databases

    GeneTreei ENSGT00730000110244.
    KOi K00312.
    OMAi CTTVNDS.
    OrthoDBi EOG7C8GJ8.

    Miscellaneous databases

    NextBioi 35579744.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009141. Wnt3.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01843. WNT3PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF1M077_RAT
    AccessioniPrimary (citable) accession number: F1M077
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 3, 2011
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 31 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3