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F1M077

- F1M077_RAT

UniProt

F1M077 - F1M077_RAT

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Protein
Protein Wnt
Gene
Wnt3a, Wnt3
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors By similarity.UniRule annotation

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. transcription coactivator activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. COP9 signalosome assembly Source: Ensembl
  2. Wnt signaling pathway Source: RefGenome
  3. Wnt signaling pathway involved in forebrain neuroblast division Source: Ensembl
  4. axis elongation involved in somitogenesis Source: Ensembl
  5. axon guidance Source: Ensembl
  6. canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: Ensembl
  7. cell fate commitment Source: RefGenome
  8. cell proliferation in forebrain Source: Ensembl
  9. cellular protein localization Source: Ensembl
  10. dorsal/ventral neural tube patterning Source: Ensembl
  11. extracellular matrix organization Source: Ensembl
  12. heart looping Source: Ensembl
  13. hemopoiesis Source: Ensembl
  14. hippocampus development Source: Ensembl
  15. in utero embryonic development Source: Ensembl
  16. inner ear morphogenesis Source: Ensembl
  17. mammary gland development Source: Ensembl
  18. negative regulation of axon extension involved in axon guidance Source: Ensembl
  19. negative regulation of fat cell differentiation Source: Ensembl
  20. negative regulation of heart induction by canonical Wnt signaling pathway Source: Ensembl
  21. negative regulation of neuron projection development Source: Ensembl
  22. neuron differentiation Source: RefGenome
  23. osteoblast differentiation Source: Ensembl
  24. palate development Source: Ensembl
  25. paraxial mesodermal cell fate commitment Source: Ensembl
  26. platelet aggregation Source: Ensembl
  27. positive regulation of B cell proliferation Source: Ensembl
  28. positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Source: Ensembl
  29. positive regulation of cardiac muscle cell differentiation Source: Ensembl
  30. positive regulation of catenin import into nucleus Source: Ensembl
  31. positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
  32. positive regulation of collateral sprouting in absence of injury Source: Ensembl
  33. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  34. positive regulation of dermatome development Source: Ensembl
  35. positive regulation of mesodermal cell fate specification Source: Ensembl
  36. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  37. positive regulation of protein binding Source: Ensembl
  38. positive regulation of protein tyrosine kinase activity Source: Ensembl
  39. positive regulation of receptor internalization Source: Ensembl
  40. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  41. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  42. post-anal tail morphogenesis Source: Ensembl
  43. regulation of cell differentiation Source: RGD
  44. regulation of cell growth Source: RGD
  45. regulation of microtubule cytoskeleton organization Source: Ensembl
  46. skeletal muscle cell differentiation Source: Ensembl
  47. spinal cord association neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotations

Keywords - Biological processi

Wnt signaling pathwayUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WntUniRule annotation
Gene namesi
Name:Wnt3aImported
Synonyms:Wnt3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi3972. Wnt3.
1308057. Wnt3a.

Subcellular locationi

Secretedextracellular spaceextracellular matrix By similarity UniRule annotation

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: RGD
  3. extracellular space Source: RefGenome
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrixSAAS annotations, Secreted

Structurei

3D structure databases

ProteinModelPortaliF1M077.
SMRiF1M077. Positions 57-351.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110244.
KOiK00312.
OMAiCTTVNDS.
OrthoDBiEOG7C8GJ8.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009141. Wnt3.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01843. WNT3PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1M077-1 [UniParc]FASTAAdd to Basket

« Hide

MAPLGYLLVL CSLKQALGSY PIWWSLAVGP QYSSLSTQPI LCASIPGLVP    50
KQLRFCRNYV EIMPSVAEGV KAGIQECQHQ FRGRRWNCTT VSNSLAIFGP 100
VLDKATRESA FVHAIASAGV AFAVTRSCAE GSAAICGCSS RLQGSPGEGW 150
KWGGCSEDIE FGGMVSREFA DARENRPDAR SAMNRHNNEA GRQAIASHMH 200
LKCKCHGLSG SCEVKTCWWS QPDFRTIGDF LKDKYDSASE MVVEKHRESR 250
GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 300
SHGIDGCDLL CCGRGHNART ERRREKCHCV FHWCCYVSCQ ECTRVYDVHT 350
CK 352
Length:352
Mass (Da):39,258
Last modified:April 3, 2013 - v2
Checksum:i7ADFC5B38A8EFF63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06064066 Genomic DNA. No translation available.
RefSeqiXP_006246549.1. XM_006246487.1.
UniGeneiRn.234269.

Genome annotation databases

EnsembliENSRNOT00000064505; ENSRNOP00000063833; ENSRNOG00000003039.
GeneIDi303181.
KEGGirno:303181.
UCSCiRGD:3972. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06064066 Genomic DNA. No translation available.
RefSeqi XP_006246549.1. XM_006246487.1.
UniGenei Rn.234269.

3D structure databases

ProteinModelPortali F1M077.
SMRi F1M077. Positions 57-351.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000064505 ; ENSRNOP00000063833 ; ENSRNOG00000003039 .
GeneIDi 303181.
KEGGi rno:303181.
UCSCi RGD:3972. rat.

Organism-specific databases

CTDi 89780.
RGDi 3972. Wnt3.
1308057. Wnt3a.

Phylogenomic databases

GeneTreei ENSGT00730000110244.
KOi K00312.
OMAi CTTVNDS.
OrthoDBi EOG7C8GJ8.

Miscellaneous databases

NextBioi 35579744.

Family and domain databases

InterProi IPR005817. Wnt.
IPR009141. Wnt3.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01843. WNT3PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF1M077_RAT
AccessioniPrimary (citable) accession number: F1M077
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: June 11, 2014
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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