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Protein

Protein Wnt

Gene

Wnt3a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotationSAAS annotation
Biological processWnt signaling pathwayUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-3238698 WNT ligand biogenesis and trafficking
R-RNO-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-RNO-4641263 Regulation of FZD by ubiquitination

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WntUniRule annotation
Gene namesi
Name:Wnt3aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1308057 Wnt3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixSAAS annotation, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500326714417 – 359Protein WntSequence analysisAdd BLAST343

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF1M077

Expressioni

Gene expression databases

BgeeiENSRNOG00000003039

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063833

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
KOiK00312
OMAiKCRCVFH
OrthoDBiEOG091G0OFF

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009141 Wnt3
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01843 WNT3PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

F1M077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNLCVVVVV VAEVLTQQLN DRALTSRVLL WSLAVGPQYS SLSTQPILCA
60 70 80 90 100
SIPGLVPKQL RFCRNYVEIM PSVAEGVKAG IQECQHQFRG RRWNCTTVSN
110 120 130 140 150
SLAIFGPVLD KATRESAFVH AIASAGVAFA VTRSCAEGSA AICGCSSRLQ
160 170 180 190 200
GSPGEGWKWG GCSEDIEFGG MVSREFADAR ENRPDARSAM NRHNNEAGRQ
210 220 230 240 250
AIASHMHLKC KCHGLSGSCE VKTCWWSQPD FRTIGDFLKD KYDSASEMVV
260 270 280 290 300
EKHRESRGWV ETLRPRYTYF KVPTERDLVY YEASPNFCEP NPETGSFGTR
310 320 330 340 350
DRTCNVSSHG IDGCDLLCCG RGHNARTERR REKCHCVFHW CCYVSCQECT

RVYDVHTCK
Length:359
Mass (Da):40,080
Last modified:July 22, 2015 - v3
Checksum:i68752584FE5DD77B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142478 Genomic DNA No translation available.
RefSeqiNP_001100475.2, NM_001107005.2
UniGeneiRn.234269

Genome annotation databases

EnsembliENSRNOT00000064505; ENSRNOP00000063833; ENSRNOG00000003039
GeneIDi303181
KEGGirno:303181
UCSCiRGD:3972 rat

Similar proteinsi

Entry informationi

Entry nameiF1M077_RAT
AccessioniPrimary (citable) accession number: F1M077
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: July 22, 2015
Last modified: April 25, 2018
This is version 61 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health