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Protein

Poly [ADP-ribose] polymerase

Gene

Parp14

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-197264 Nicotinamide salvaging

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
Short name:
PARPUniRule annotation
Gene namesi
Name:Parp14Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1310490 Parp14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF1LZ05
PeptideAtlasiF1LZ05
PRIDEiF1LZ05

PTM databases

iPTMnetiF1LZ05
PhosphoSitePlusiF1LZ05

Expressioni

Gene expression databases

BgeeiENSRNOG00000023334

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046194

Structurei

3D structure databases

ProteinModelPortaliF1LZ05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini782 – 969MacroInterPro annotationAdd BLAST188
Domaini990 – 1178MacroInterPro annotationAdd BLAST189
Domaini1203 – 1373MacroInterPro annotationAdd BLAST171
Domaini1591 – 1787PARP catalyticInterPro annotationAdd BLAST197

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili439 – 466Sequence analysisAdd BLAST28
Coiled coili1490 – 1510Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2633 Eukaryota
COG2110 LUCA
GeneTreeiENSGT00760000119084
InParanoidiF1LZ05
KOiK15261
OMAiHHVIHAV
OrthoDBiEOG091G00EB
TreeFamiTF316072

Family and domain databases

CDDicd12543 RRM2_PAR14, 1 hit
Gene3Di3.30.70.330, 2 hits
3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR002589 Macro_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034517 PAR14_RRM2
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF01661 Macro, 3 hits
PF00644 PARP, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 3 hits
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 3 hits
PS51059 PARP_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

F1LZ05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGPFPLL VEGSWGPDPP KNLINKLQMY FQSRKKSGGG ECEVVPEPGN
60 70 80 90 100
PARFLVLFSP EDVRQNVLEK ENHELVWQGK GTFKMTVQLP ADPGQASVSK
110 120 130 140 150
KAIPEEESKT KEDAVKPGDL DTTPSPSSRS EEMEDVPKEC ENISSMVAFE
160 170 180 190 200
QLPEKVSEMV LTFLVENISG LPSDDFKVEL IRDFAVAVVT FQKPIDTKKF
210 220 230 240 250
IIDCISHRSN QQLQLVPRLL ETTNVVRVEN LPPGVDDYQL QLFFENPFNG
260 270 280 290 300
GGRVARVECF PEESSALVEF CDSKVLDTIM AKKHSFNKMP LSVFPYYPSL
310 320 330 340 350
GTALYGEEKP LVKLPASFQE SLDLPLWKFF QKNDHLMEEI NDEMRHCHCE
360 370 380 390 400
LTWSEINGKL TVRPAATLVS HRPSIKTWQR DASAALSGIR SKYDVMVFEV
410 420 430 440 450
CSPVWDIIKH ELGDDRVLIE FEKESLNVAG KSEDVQGISQ QIRELIERTT
460 470 480 490 500
EKLRREEQSL EEKVAISSGK HFLLYHSGFL KDLSKEYPEM EISYDATAQY
510 520 530 540 550
LCIKGLRADV YKVKCEIQEK VFSMAQKNVP VSSEVFRFLQ QVDGQRLSNA
560 570 580 590 600
LFKAQNILAT YELKDNALFL IGSSPKDLAE AEAKMLSALS HKHIEVEDKE
610 620 630 640 650
VLRSNVWKKK IHPLQKRHGS YAAIMVKNEL TSGVPAEVVI AGCVKEVNEI
660 670 680 690 700
HRQLFEFLEN HMKVERVVKI DPPLIIDYLK TDKRLLSKTK KANVSVSFKT
710 720 730 740 750
KDDPNSILLL GSKSKVLECL DTVKEIRDSV CVRKFQTDKA GARHFFQDKE
760 770 780 790 800
FYYKMEIRRL YGCIVELKEG EEGEEDSLKE QKCYLQRDIG PGVTLIVHEG
810 820 830 840 850
DLSLFPVDVV VNAANESLKH IDGLAGTLSK AAGPSLQAEC DLIVKKGGMV
860 870 880 890 900
PPGNAVISKA GKLPCRYVIH AVGPRWKGDK VLECVNLLKK AVKQSLTLAE
910 920 930 940 950
EYKCQSIAIP AISSGIFDFP LDLCVASIAS AIKDNVQQKQ NTHSVKKIYL
960 970 980 990 1000
VDVSAKVAKA FAEAVKTTYR DILSPASVKA LVPPGKMPQK QGKLLVSPEG
1010 1020 1030 1040 1050
LNIRLIEEGV QNAEAHAIVN SVSSDLILNK GPLSQAFLES AGPELQEELT
1060 1070 1080 1090 1100
KAGQGVSVSV GTVLQTSGCN LNSRSIFHVV TPPWKSNNSE WSLKIMKNII
1110 1120 1130 1140 1150
RDCLRTTEDL SLQSIAFPAI GTGNLGFPKP EFAKLIISEV LKFSSRNQLK
1160 1170 1180 1190 1200
TLQEVQFLLH PKDHENIQAF LDEFDKRSNG DPSSKNPKAE DTQGIYGSLS
1210 1220 1230 1240 1250
SPTLGVHEMN IGPILFQVAT GDIIKEVADV IVNSTSCTFN LKSGVSKAIL
1260 1270 1280 1290 1300
EGAGQNVEQE CSRLAQQGKE YIVTGGGLLK CKSIIHVDGG NDVKRSVSCI
1310 1320 1330 1340 1350
LEECEQRSFS SICLPAIGTG SAQQDPKVVA KAVLDAIEEF VQKKSVQAVK
1360 1370 1380 1390 1400
RVKVVIFQPH ILQFFYDNMK EREGSPAPVK PSVMSKIASF LGFPTQASPP
1410 1420 1430 1440 1450
KNTLVLEKKI ELTVFQICGP GVDSVEGTIS WLKSLITKEQ FSFTNEDECV
1460 1470 1480 1490 1500
RDFDTEEYRK LNEMQKRLNI IIELNQKKPL IKVSGISRDV VEARDEIDNM
1510 1520 1530 1540 1550
VKSIRLAKEK ENQADYVSTF VEWQYIANNT TRCFDKIANM QLEDAWKAKK
1560 1570 1580 1590 1600
KHTVVKIQNQ DFTVDLSTNT ATAPQGLSFT VQRLLKAEAE IPANWSDMKQ
1610 1620 1630 1640 1650
NKLLVVSLQT SDAEYTMVSR AFHQTCPNFV IEKIERIQNP ALWRRYQAYK
1660 1670 1680 1690 1700
KIMDEKNGNV INEKQLFHGT EFGSLAQLNS NGFNRSYAGK NATAYGKGTY
1710 1720 1730 1740 1750
FAVNASYSAH DTYSKPDANG KKYMYYVRVL TGNYTQGNAS LIVPPSRDPQ
1760 1770 1780
NATDLFDTVA DNVINPSIFV VFYDNQAYPE YLITFRK
Length:1,787
Mass (Da):199,531
Last modified:April 3, 2013 - v2
Checksum:iDBFA681204C82A48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034394 Genomic DNA No translation available.
AABR07034395 Genomic DNA No translation available.
RefSeqiNP_001178588.1, NM_001191659.1
UniGeneiRn.54182

Genome annotation databases

EnsembliENSRNOT00000046888; ENSRNOP00000046194; ENSRNOG00000023334
GeneIDi303903
KEGGirno:303903

Similar proteinsi

Entry informationi

Entry nameiF1LZ05_RAT
AccessioniPrimary (citable) accession number: F1LZ05
Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: May 23, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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