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Protein

Poly [ADP-ribose] polymerase

Gene

Parp14

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
Short name:
PARPUniRule annotation
Gene namesi
Name:Parp14Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1310490. Parp14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiF1LZ05.
PeptideAtlasiF1LZ05.
PRIDEiF1LZ05.

PTM databases

iPTMnetiF1LZ05.
PhosphoSitePlusiF1LZ05.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023334.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046194.

Structurei

3D structure databases

ProteinModelPortaliF1LZ05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini782 – 969MacroInterPro annotationAdd BLAST188
Domaini990 – 1178MacroInterPro annotationAdd BLAST189
Domaini1203 – 1373MacroInterPro annotationAdd BLAST171
Domaini1591 – 1787PARP catalyticInterPro annotationAdd BLAST197

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili439 – 466Sequence analysisAdd BLAST28

Sequence similaritiesi

Contains 1 PARP catalytic domain.UniRule annotation
Contains 3 Macro domains.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
InParanoidiF1LZ05.
KOiK15261.
OMAiRRCHCEL.
OrthoDBiEOG091G00EB.
TreeFamiTF316072.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF01661. Macro. 3 hits.
PF00644. PARP. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 3 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 3 hits.
PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F1LZ05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGPFPLL VEGSWGPDPP KNLINKLQMY FQSRKKSGGG ECEVVPEPGN
60 70 80 90 100
PARFLVLFSP EDVRQNVLEK ENHELVWQGK GTFKMTVQLP ADPGQASVSK
110 120 130 140 150
KAIPEEESKT KEDAVKPGDL DTTPSPSSRS EEMEDVPKEC ENISSMVAFE
160 170 180 190 200
QLPEKVSEMV LTFLVENISG LPSDDFKVEL IRDFAVAVVT FQKPIDTKKF
210 220 230 240 250
IIDCISHRSN QQLQLVPRLL ETTNVVRVEN LPPGVDDYQL QLFFENPFNG
260 270 280 290 300
GGRVARVECF PEESSALVEF CDSKVLDTIM AKKHSFNKMP LSVFPYYPSL
310 320 330 340 350
GTALYGEEKP LVKLPASFQE SLDLPLWKFF QKNDHLMEEI NDEMRHCHCE
360 370 380 390 400
LTWSEINGKL TVRPAATLVS HRPSIKTWQR DASAALSGIR SKYDVMVFEV
410 420 430 440 450
CSPVWDIIKH ELGDDRVLIE FEKESLNVAG KSEDVQGISQ QIRELIERTT
460 470 480 490 500
EKLRREEQSL EEKVAISSGK HFLLYHSGFL KDLSKEYPEM EISYDATAQY
510 520 530 540 550
LCIKGLRADV YKVKCEIQEK VFSMAQKNVP VSSEVFRFLQ QVDGQRLSNA
560 570 580 590 600
LFKAQNILAT YELKDNALFL IGSSPKDLAE AEAKMLSALS HKHIEVEDKE
610 620 630 640 650
VLRSNVWKKK IHPLQKRHGS YAAIMVKNEL TSGVPAEVVI AGCVKEVNEI
660 670 680 690 700
HRQLFEFLEN HMKVERVVKI DPPLIIDYLK TDKRLLSKTK KANVSVSFKT
710 720 730 740 750
KDDPNSILLL GSKSKVLECL DTVKEIRDSV CVRKFQTDKA GARHFFQDKE
760 770 780 790 800
FYYKMEIRRL YGCIVELKEG EEGEEDSLKE QKCYLQRDIG PGVTLIVHEG
810 820 830 840 850
DLSLFPVDVV VNAANESLKH IDGLAGTLSK AAGPSLQAEC DLIVKKGGMV
860 870 880 890 900
PPGNAVISKA GKLPCRYVIH AVGPRWKGDK VLECVNLLKK AVKQSLTLAE
910 920 930 940 950
EYKCQSIAIP AISSGIFDFP LDLCVASIAS AIKDNVQQKQ NTHSVKKIYL
960 970 980 990 1000
VDVSAKVAKA FAEAVKTTYR DILSPASVKA LVPPGKMPQK QGKLLVSPEG
1010 1020 1030 1040 1050
LNIRLIEEGV QNAEAHAIVN SVSSDLILNK GPLSQAFLES AGPELQEELT
1060 1070 1080 1090 1100
KAGQGVSVSV GTVLQTSGCN LNSRSIFHVV TPPWKSNNSE WSLKIMKNII
1110 1120 1130 1140 1150
RDCLRTTEDL SLQSIAFPAI GTGNLGFPKP EFAKLIISEV LKFSSRNQLK
1160 1170 1180 1190 1200
TLQEVQFLLH PKDHENIQAF LDEFDKRSNG DPSSKNPKAE DTQGIYGSLS
1210 1220 1230 1240 1250
SPTLGVHEMN IGPILFQVAT GDIIKEVADV IVNSTSCTFN LKSGVSKAIL
1260 1270 1280 1290 1300
EGAGQNVEQE CSRLAQQGKE YIVTGGGLLK CKSIIHVDGG NDVKRSVSCI
1310 1320 1330 1340 1350
LEECEQRSFS SICLPAIGTG SAQQDPKVVA KAVLDAIEEF VQKKSVQAVK
1360 1370 1380 1390 1400
RVKVVIFQPH ILQFFYDNMK EREGSPAPVK PSVMSKIASF LGFPTQASPP
1410 1420 1430 1440 1450
KNTLVLEKKI ELTVFQICGP GVDSVEGTIS WLKSLITKEQ FSFTNEDECV
1460 1470 1480 1490 1500
RDFDTEEYRK LNEMQKRLNI IIELNQKKPL IKVSGISRDV VEARDEIDNM
1510 1520 1530 1540 1550
VKSIRLAKEK ENQADYVSTF VEWQYIANNT TRCFDKIANM QLEDAWKAKK
1560 1570 1580 1590 1600
KHTVVKIQNQ DFTVDLSTNT ATAPQGLSFT VQRLLKAEAE IPANWSDMKQ
1610 1620 1630 1640 1650
NKLLVVSLQT SDAEYTMVSR AFHQTCPNFV IEKIERIQNP ALWRRYQAYK
1660 1670 1680 1690 1700
KIMDEKNGNV INEKQLFHGT EFGSLAQLNS NGFNRSYAGK NATAYGKGTY
1710 1720 1730 1740 1750
FAVNASYSAH DTYSKPDANG KKYMYYVRVL TGNYTQGNAS LIVPPSRDPQ
1760 1770 1780
NATDLFDTVA DNVINPSIFV VFYDNQAYPE YLITFRK
Length:1,787
Mass (Da):199,531
Last modified:April 3, 2013 - v2
Checksum:iDBFA681204C82A48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034394 Genomic DNA. No translation available.
AABR07034395 Genomic DNA. No translation available.
RefSeqiNP_001178588.1. NM_001191659.1.
UniGeneiRn.54182.

Genome annotation databases

EnsembliENSRNOT00000046888; ENSRNOP00000046194; ENSRNOG00000023334.
GeneIDi303903.
KEGGirno:303903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034394 Genomic DNA. No translation available.
AABR07034395 Genomic DNA. No translation available.
RefSeqiNP_001178588.1. NM_001191659.1.
UniGeneiRn.54182.

3D structure databases

ProteinModelPortaliF1LZ05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046194.

PTM databases

iPTMnetiF1LZ05.
PhosphoSitePlusiF1LZ05.

Proteomic databases

PaxDbiF1LZ05.
PeptideAtlasiF1LZ05.
PRIDEiF1LZ05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046888; ENSRNOP00000046194; ENSRNOG00000023334.
GeneIDi303903.
KEGGirno:303903.

Organism-specific databases

CTDi54625.
RGDi1310490. Parp14.

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
InParanoidiF1LZ05.
KOiK15261.
OMAiRRCHCEL.
OrthoDBiEOG091G00EB.
TreeFamiTF316072.

Gene expression databases

BgeeiENSRNOG00000023334.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF01661. Macro. 3 hits.
PF00644. PARP. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 3 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 3 hits.
PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF1LZ05_RAT
AccessioniPrimary (citable) accession number: F1LZ05
Entry historyi
Integrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: April 3, 2013
Last modified: November 30, 2016
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.